LOCUS       NM_016252              15687 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens baculoviral IAP repeat containing 6 (BIRC6),
            transcript variant 1, mRNA.
ACCESSION   NM_016252
VERSION     NM_016252.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15687)
  AUTHORS   Zhao,B., Yang,J., Ran,F., Shi,Y., Yang,L., Duan,Y., Shi,Z., Li,X.,
            Zhang,J., Li,Z. and Wang,J.
  TITLE     CircBIRC6 affects prostate cancer progression by regulating
            miR-574-5p and DNAJB1
  JOURNAL   Cancer Biol Ther 25 (1), 2399363 (2024)
   PUBMED   39258752
  REMARK    GeneRIF: CircBIRC6 affects prostate cancer progression by
            regulating miR-574-5p and DNAJB1.
REFERENCE   2  (bases 1 to 15687)
  AUTHORS   Tang,Z., Li,J., Lu,B., Zhang,X., Yang,L., Qi,Y., Jiang,S., Wu,Q.,
            Wang,Y., Cheng,T., Xu,M., Sun,P., Wang,X., Miao,K., Wu,H. and
            Huang,J.
  TITLE     CircBIRC6 facilitates the malignant progression via
            miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric
            cancer
  JOURNAL   Pharmacol Res 202, 107127 (2024)
   PUBMED   38438090
  REMARK    GeneRIF: CircBIRC6 facilitates the malignant progression via
            miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric
            cancer.
REFERENCE   3  (bases 1 to 15687)
  AUTHORS   Dietz,L., Ellison,C.J., Riechmann,C., Cassidy,C.K., Felfoldi,F.D.,
            Pinto-Fernandez,A., Kessler,B.M. and Elliott,P.R.
  TITLE     Structural basis for SMAC-mediated antagonism of caspase inhibition
            by the giant ubiquitin ligase BIRC6
  JOURNAL   Science 379 (6637), 1112-1117 (2023)
   PUBMED   36758106
  REMARK    GeneRIF: Structural basis for SMAC-mediated antagonism of caspase
            inhibition by the giant ubiquitin ligase BIRC6.
REFERENCE   4  (bases 1 to 15687)
  AUTHORS   Ehrmann,J.F., Grabarczyk,D.B., Heinke,M., Deszcz,L., Kurzbauer,R.,
            Hudecz,O., Shulkina,A., Gogova,R., Meinhart,A., Versteeg,G.A. and
            Clausen,T.
  TITLE     Structural basis for regulation of apoptosis and autophagy by the
            BIRC6/SMAC complex
  JOURNAL   Science 379 (6637), 1117-1123 (2023)
   PUBMED   36758105
  REMARK    GeneRIF: Structural basis for regulation of apoptosis and autophagy
            by the BIRC6/SMAC complex.
REFERENCE   5  (bases 1 to 15687)
  AUTHORS   Hunkeler,M., Jin,C.Y. and Fischer,E.S.
  TITLE     Structures of BIRC6-client complexes provide a mechanism of
            SMAC-mediated release of caspases
  JOURNAL   Science 379 (6637), 1105-1111 (2023)
   PUBMED   36758104
  REMARK    GeneRIF: Structures of BIRC6-client complexes provide a mechanism
            of SMAC-mediated release of caspases.
REFERENCE   6  (bases 1 to 15687)
  AUTHORS   Hao,Y., Sekine,K., Kawabata,A., Nakamura,H., Ishioka,T., Ohata,H.,
            Katayama,R., Hashimoto,C., Zhang,X., Noda,T., Tsuruo,T. and
            Naito,M.
  TITLE     Apollon ubiquitinates SMAC and caspase-9, and has an essential
            cytoprotection function
  JOURNAL   Nat Cell Biol 6 (9), 849-860 (2004)
   PUBMED   15300255
  REMARK    GeneRIF: Apollon binds to, ubiquitinates and facilitates
            proteasomal degradation of SMAC and caspase-9, results suggesting
            that Apollon has an essential function in preventing SMAC-induced
            apoptosis
REFERENCE   7  (bases 1 to 15687)
  AUTHORS   Bartke,T., Pohl,C., Pyrowolakis,G. and Jentsch,S.
  TITLE     Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3
            ubiquitin ligase
  JOURNAL   Mol Cell 14 (6), 801-811 (2004)
   PUBMED   15200957
REFERENCE   8  (bases 1 to 15687)
  AUTHORS   Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J 23 (4), 800-810 (2004)
   PUBMED   14765125
  REMARK    GeneRIF: Overexpression of Nrdp1 promotes ubiquitination and
            proteasomal degradation of BRUCE.
REFERENCE   9  (bases 1 to 15687)
  AUTHORS   Chen,Z., Naito,M., Hori,S., Mashima,T., Yamori,T. and Tsuruo,T.
  TITLE     A human IAP-family gene, apollon, expressed in human brain cancer
            cells
  JOURNAL   Biochem Biophys Res Commun 264 (3), 847-854 (1999)
   PUBMED   10544019
REFERENCE   10 (bases 1 to 15687)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133245.4, AL133243.3,
            KF456651.1, KF456657.1 and AL133246.3.
            
            On Jan 7, 2021 this sequence version replaced NM_016252.3.
            
            Summary: This gene encodes a protein with a BIR (baculoviral
            inhibition of apoptosis protein repeat) domain and a UBCc
            (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein
            inhibits apoptosis by facilitating the degradation of apoptotic
            proteins by ubiquitination. [provided by RefSeq, Jul 2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF265555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421745.7/ ENSP00000393596.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               AL133245.4         67867-68330
            465-646             AL133245.4         88432-88613
            647-784             AL133245.4         90997-91134
            785-978             AL133245.4         99594-99787
            979-1090            AL133245.4         102883-102994
            1091-1173           AL133245.4         106355-106437
            1174-1396           AL133245.4         112007-112229
            1397-1557           AL133245.4         112307-112467
            1558-1616           AL133245.4         117343-117401
            1617-3011           AL133245.4         125613-127007
            3012-3161           AL133243.3         24088-24237
            3162-3387           AL133243.3         25807-26032
            3388-3548           AL133243.3         28586-28746
            3549-3638           AL133243.3         30438-30527
            3639-3770           AL133243.3         30995-31126
            3771-3949           AL133243.3         34450-34628
            3950-4083           AL133243.3         36271-36404
            4084-4214           KF456651.1         11-141
            4215-4245           AL133243.3         37138-37168
            4246-4377           AL133243.3         37266-37397
            4378-4475           AL133243.3         38433-38530
            4476-4623           AL133243.3         40463-40610
            4624-4757           AL133243.3         43737-43870
            4758-4892           AL133243.3         48750-48884
            4893-5080           AL133243.3         58136-58323
            5081-5395           AL133243.3         59451-59765
            5396-5495           AL133243.3         60007-60106
            5496-5710           AL133243.3         62467-62681
            5711-5919           AL133243.3         62845-63053
            5920-6266           AL133243.3         63379-63725
            6267-6486           AL133243.3         64337-64556
            6487-6620           AL133243.3         65110-65243
            6621-6731           AL133243.3         65956-66066
            6732-6859           AL133243.3         68054-68181
            6860-6991           AL133243.3         71155-71286
            6992-7207           AL133243.3         72310-72525
            7208-7391           AL133243.3         73577-73760
            7392-7547           AL133243.3         74404-74559
            7548-7681           AL133243.3         76262-76395
            7682-7835           AL133243.3         77371-77524
            7836-7952           AL133243.3         80584-80700
            7953-7985           AL133243.3         82588-82620
            7986-8107           KF456657.1         1-122
            8108-8234           AL133243.3         83529-83655
            8235-8345           AL133243.3         84982-85092
            8346-8479           AL133243.3         86366-86499
            8480-8607           AL133243.3         88481-88608
            8608-9170           AL133243.3         94488-95050
            9171-9346           AL133243.3         96654-96829
            9347-9443           AL133243.3         97736-97832
            9444-9638           AL133243.3         97983-98177
            9639-9839           AL133243.3         99946-100146
            9840-10119          AL133243.3         102921-103200
            10120-10376         AL133243.3         104679-104935
            10377-10485         AL133243.3         105467-105575
            10486-10707         AL133243.3         107874-108095
            10708-11488         AL133243.3         109931-110711
            11489-11632         AL133243.3         113195-113338
            11633-11762         AL133243.3         113758-113887
            11763-11894         AL133243.3         119829-119960
            11895-12059         AL133243.3         120405-120569
            12060-12233         AL133243.3         124592-124765
            12234-12430         AL133243.3         126296-126492
            12431-12731         AL133243.3         138182-138482
            12732-12949         AL133243.3         140584-140801
            12950-13114         AL133243.3         142791-142955
            13115-13283         AL133243.3         144254-144422
            13284-13494         AL133246.3         1497-1707
            13495-13640         AL133246.3         20256-20401
            13641-13751         AL133246.3         21375-21485
            13752-13969         AL133246.3         24092-24309
            13970-14131         AL133246.3         26080-26241
            14132-14209         AL133246.3         29347-29424
            14210-14398         AL133246.3         33796-33984
            14399-14533         AL133246.3         37789-37923
            14534-15687         AL133246.3         44066-45219
FEATURES             Location/Qualifiers
     source          1..15687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..15687
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /note="baculoviral IAP repeat containing 6"
                     /db_xref="GeneID:57448"
                     /db_xref="HGNC:HGNC:13516"
                     /db_xref="MIM:605638"
     exon            1..464
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..14713
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /EC_number="2.3.2.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-conjugating BIR-domain enzyme apollon;
                     baculoviral IAP repeat-containing protein 6; BIR
                     repeat-containing ubiquitin-conjugating enzyme; RING-type
                     E3 ubiquitin transferase BIRC6; dual E2
                     ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase
                     BIRC6"
                     /codon_start=1
                     /product="dual E2 ubiquitin-conjugating enzyme/E3
                     ubiquitin-protein ligase BIRC6 isoform 1"
                     /protein_id="NP_057336.3"
                     /db_xref="CCDS:CCDS33175.2"
                     /db_xref="GeneID:57448"
                     /db_xref="HGNC:HGNC:13516"
                     /db_xref="MIM:605638"
                     /translation="MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSA
                     AGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATL
                     QASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDV
                     VQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWAT
                     VTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPELGVGPGR
                     SVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVC
                     LVCWEPTDEPWSEHERHSPNCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFG
                     SGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR
                     RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDIT
                     ALSILQQPEKLQWEIVANVLEDTVKDLEELGANPCLTNSKSEKTKEKHQEQHNIPFPC
                     LLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVR
                     RTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQD
                     PPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCLRLPKFAEEENLCIDSITPCA
                     DGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISV
                     IQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTI
                     TSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTLGHLVITTQGGYVKI
                     LDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDD
                     IDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTR
                     FETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDE
                     HVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNG
                     KPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLT
                     SPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLASL
                     LAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
                     MLQFSEFHEKLLNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLL
                     SKTRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNM
                     SFLPAATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQT
                     RYGLYSSPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEG
                     SFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALS
                     SAAQVALQSLSHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASA
                     VGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQ
                     LFPGSVIDPPAVNLAAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMH
                     SGARRFVTLDFGRPILLTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSL
                     ILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKG
                     EGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLR
                     KPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQ
                     TSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVLQSTFHAQACEELFKHLCISGTPKI
                     RLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNS
                     GVLESLLNLLDNLLSPLQPQLPMHRRTEGVLDIPMISWVVMLVSRLLDYVATVEDEAA
                     AAKKPLNGNQWSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAK
                     QKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSRSNLDTE
                     VTTAKESPEIEPLPFTLAHERCISVVQKLVLFLLSMDFTCHADLLLFVCKVLARIANA
                     TRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGELLA
                     PVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETIDEPLTHDITGAPPLSSLEKD
                     KEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIG
                     GLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQ
                     ALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSMLQVHH
                     VQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQASITSFLTVLAWYP
                     NTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIHVLVKFLSGTS
                     PHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQT
                     GQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSS
                     VGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARV
                     SVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGLCN
                     SSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
                     MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAI
                     VNTARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTA
                     QPAEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLAT
                     CPSSVSVEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLG
                     LSQIKLLGLTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMAS
                     AAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASG
                     SDPTDLNSPLLFGRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAM
                     KRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFEL
                     LFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDD
                     SKKQDLSSSLTDDSKNAQAPLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLA
                     SFCFSHISSSESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHI
                     MKDWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQR
                     TAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQ
                     LMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDR
                     VSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASGLKSQSKRAVSA
                     TPPRPPSRRGRTIPDKIGSTSGAEAANKIITVPVFHLFHKLLAGQPLPAEMTLAQLLT
                     LLYDRKLPQGYRSIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEAL
                     TPGDECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVVT
                     STTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTMSPIPAHSLAAFG
                     LFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSL
                     FSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHN
                     PTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSS
                     AVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRA
                     LLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNRLR
                     SKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQEKKLGEYSKK
                     AAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYMSQVKNAND
                     ANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCF
                     EFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQ
                     TSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLE
                     QIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
                     TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL"
     exon            465..646
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            647..784
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            785..978
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1090
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1173
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1396
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1557
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1616
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..3011
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3161
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3387
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3548
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3638
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3770
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3949
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4083
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4245
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4377
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4475
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4623
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4757
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4892
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..5080
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5395
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5396..5495
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5710
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..5919
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6266
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..6486
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6487..6620
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6621..6731
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6732..6859
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..6991
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            6992..7207
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7208..7391
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7392..7547
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7548..7681
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7682..7835
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7836..7952
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            7953..8107
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            8108..8234
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            8235..8345
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            8346..8479
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            8480..8607
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            8608..9170
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            9171..9346
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            9347..9443
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            9444..9638
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            9639..9839
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            9840..10119
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            10120..10376
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            10377..10485
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            10486..10707
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            10708..11488
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            11489..11632
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            11633..11762
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            11763..11894
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            11895..12059
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            12060..12233
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            12234..12430
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            12431..12731
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            12732..12949
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            12950..13114
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13115..13283
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13284..13494
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13495..13640
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13641..13751
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13752..13969
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            13970..14131
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            14132..14209
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            14210..14398
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            14399..14533
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     exon            14534..15687
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15377..15382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /note="hexamer: AATGAA"
     polyA_site      15405
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /note="major polyA site"
     regulatory      15670..15675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /note="hexamer: AATAAA"
     polyA_site      15687
                     /gene="BIRC6"
                     /gene_synonym="APOLLON; BRUCE"
                     /note="major polyA site"
ORIGIN      
        1 ctccctccct gcttctcccc ctctcccgtc agcctccctc cgagtttggc ccctccggcc
       61 gggcgatcga cgttccgcgt gcgtgcgggc gcctgacttc acttccggct aacgcgctcg
      121 gcttgccccc tggccccgga tggtgactgg tggtggtgct gcacctcccg ggactgtcac
      181 tgagccgctt cccagtgtga ttgtgctgag cgcaggccgg aagatggcgg ctgcggctgc
      241 ggcggcctcg ggccccggct gctcctcggc ggcgggggcg ggggcggccg gggtctcaga
      301 gtggctggtg ctgcgggacg gctgcatgca ctgcgacgcc gacgggctgc acagcctgtc
      361 ctaccaccct gcgctcaacg ccatcctggc cgtcactagc cgcgggacca tcaaagtcat
      421 cgacggcacc tcgggggcca cactgcaggc ctccgcgctc agtgctaaac caggtggaca
      481 ggtgaaatgt cagtatatct ctgctgtgga taaagttata tttgtggatg attatgcagt
      541 agggtgtagg aaggacctta atggaatctt gttgttagac actgctctgc aaactccagt
      601 ttcaaagcag gatgatgtgg ttcagcttga attacccgtt acagaggcac agcagctctt
      661 atcagcatgt ttagaaaagg tagatatttc tagtacagag ggttatgatt tgttcatcac
      721 acagctcaaa gatggtttaa aaaatacatc tcatgagact gcagcaaacc acaaagttgc
      781 taagtgggcc acagttacat ttcatcttcc tcatcatgtg ttgaagtcca ttgccagtgc
      841 cattgtaaat gaactcaaga aaataaatca aaatgttgct gccttacctg tggcgtcctc
      901 agtgatggac agattgtctt acctcttacc tagtgcacgt ccagaactcg gagtggggcc
      961 aggccgttct gtagacagat cactgatgta tagtgaagct aacagacggg agacatttac
     1021 ctcatggcct catgtaggct ataggtgggc acaaccagat cccatggctc aagctggatt
     1081 ttatcatcag cctgcctcat ctggagatga tagagccatg tgttttactt gtagtgtatg
     1141 cctcgtttgt tgggaaccta ctgatgaacc ttggtctgaa cacgaaagac attccccaaa
     1201 ctgcccattt gtgaaaggtg agcacacaca gaatgtgcca ttgtcagtca ctcttgcaac
     1261 aagtcctgca cagtttcctt gtacggatgg aactgacaga atatcttgct ttgggtcggg
     1321 gagctgccct cattttctag ctgctgcaac taaacgagga aagatctgca tatgggatgt
     1381 ttccaaactt atgaaggtgc acttaaagtt tgaaattaat gcctatgatc cagcaattgt
     1441 acaacagctt attctatcag gagacccaag ctcaggagtt gattcaagga gaccaacttt
     1501 ggcgtggctg gaggactcct ctagttgctc agatatacca aaattggaag gagatagtga
     1561 tgatttactg gaggattcag acagtgaaga gcattccaga tcagattctg tgacagggca
     1621 tacatcacag aaggaagcca tggaagtaag ccttgatata acagcactca gcattctcca
     1681 acagccagaa aaacttcagt gggagattgt tgcaaatgtg cttgaagata ctgttaagga
     1741 tcttgaagaa cttggggcaa atccttgttt aacaaactct aagagtgaaa agacaaagga
     1801 aaagcaccag gagcaacaca acattccttt tccatgttta ttagctggag gtttattaac
     1861 atataaatct cctgctacct cacccattag tagtaattct cacaggtcac tggatggttt
     1921 aagcagaact cagggtgaaa gtatatcaga acaagggtca actgacaatg aatcctgcac
     1981 taattcagaa ctaaattctc ctctggtaag gaggacttta ccggttttgc ttctttatag
     2041 catcaaggaa tctgatgaga aagcaggaaa gatcttttca cagatgaaca atattatgag
     2101 taaaagtttg catgatgatg gttttactgt tccacagatt attgaaatgg agctggatag
     2161 tcaggagcag ttgttattgc aggatcctcc tgtgacttac attcagcaat ttgcagatgc
     2221 agcagccaac cttacctctc cggattctga gaagtggaac tctgtgtttc ccaagcctgg
     2281 gactttggtt cagtgcttga ggctgccaaa gtttgcagag gaggagaatc tttgtataga
     2341 ctcaataact ccttgtgctg acggaattca tttgttggta ggactgcgga catgccctgt
     2401 tgaatccttg agtgcaataa atcaagtaga ggccttgaat aatttaaata aattaaactc
     2461 tgcactatgt aatagacgga aaggtgagct ggaatcaaat cttgctgtag tgaatggtgc
     2521 aaatattagt gtaatccaac atgaatcacc agcagatgta cagactcctt taataattca
     2581 gcctgagcag aggaatgtta gtggtggata tttagtgctt tataaaatga attatgccac
     2641 tcggatagtg actttagaag aggagccaat aaaaatacaa catatcaaag atccccagga
     2701 cacaattacc tcgctcattt tgcttccacc cgatatattg gataatcgag aggatgactg
     2761 tgaggaacct attgaggaca tgcagttaac ctcaaagaat ggttttgaga gagaaaaaac
     2821 gtctgacatt tctactcttg gacacctggt aataaccact cagggaggat atgtaaaaat
     2881 actagatctt tcaaactttg aaattttggc caaagtggag cctcccaaaa aggagggcac
     2941 tgaggaacag gacacatttg tttctgtgat ttactgttct ggcacagaca ggctgtgtgc
     3001 atgcaccaaa ggtggtgagc ttcattttct ccaaattgga ggaacctgtg atgatattga
     3061 tgaagctgat atactagtgg atggatctct ttctaaagga atagaaccat cttcagaagg
     3121 ttccaaacct ttatcaaatc cttcaagtcc tggcatttca ggagttgatt tattggtgga
     3181 ccagccattc acccttgaaa tcttgacatc cctagtggag ctaacccgct ttgagacttt
     3241 gactccaagg ttttcagcga ctgttcctcc atgctgggta gaagttcaac aagaacagca
     3301 gcaaaggagg catcctcaac atttgcatca gcaacaccat ggtgatgctg ctcagcatac
     3361 tcgaacttgg aaactacaga ccgacagcaa cagctgggat gaacatgtat ttgaattagt
     3421 actacctaaa gcttgtatgg ttggacatgt ggacttcaaa ttcgttttga actcaaacat
     3481 caccaatatt ccacagatac aagtgacact gctgaaaaat aaagctccag gattagggaa
     3541 agtcaatgct cttaacattg aagtggaaca aaatgggaaa ccgtccctgg ttgatttgaa
     3601 tgaagaaatg cagcacatgg atgtagagga atcacagtgt cttagattat gtccattttt
     3661 ggaggatcat aaagaagaca ttctatgtgg gccagtatgg cttgctagtg gccttgatct
     3721 atcagggcat gctggaatgt tgacgttaac aagccccaaa cttgttaaag gtatggcagg
     3781 aggaaaatat cgttcgtttt taatccatgt caaggcagtg aatgaaagag gaacagaaga
     3841 gatttgtaat ggtggtatgc gtcctgtagt aaggcttcca tccctaaaac accagagtaa
     3901 caagggttat tcacttgctt cacttttggc taaagttgca gcaggcaagg aaaaatcatc
     3961 taatgttaag aatgaaaata caagtggcac ccgtaaatct gaaaacctcc ggggctgtga
     4021 tttacttcaa gaggtctcag tcaccattcg aagatttaag aaaacctcaa tttctaagga
     4081 aagagtgcaa cgatgtgcca tgttacagtt ttcagaattt catgagaagc ttcttaatac
     4141 tctttgcaga aaaacagatg atggccagat cacagaacat gcccagagcc ttgtgttgga
     4201 tactctctgt tggttagctg gagttcattc aaatggaccc ggaagctcaa aggaaggaaa
     4261 tgagaaccta ctttcaaaaa cacgaaaatt tctgtcagac atcgtacgtg tttgcttctt
     4321 tgaggcagga cgaagtatag cccataagtg tgcccgattt ctagccttgt gcattagtaa
     4381 tggcaaatgt gacccatgtc aaccagcatt tggacctgtt ctgttgaagg ctttacttga
     4441 taatatgtca tttttacctg cagcaacaac tggtggttct gtctattggt attttgtctt
     4501 actgaattat gtgaaagatg aagatctggc tggatgcagt acagcttgtg catctttgct
     4561 tactgcagtg tccagacagt tacaggacag gctaacacca atggaggctt tacttcagac
     4621 aagatatgga ttatatagct caccatttga tccagtcctc tttgatttgg agatgagtgg
     4681 ctcttcttgt aaaaatgttt ataacagcag cattggtgtc cagtcagatg aaattgattt
     4741 atcagatgtc ctttcaggaa atggaaaggt cagtagttgc acagctgctg agggtagttt
     4801 cacatctctc actggacttt tggaagttga acctctgcac tttacttgtg tgtcaactag
     4861 tgatggaacc agaatagaaa gggatgatgc aatgagttcc ttcggggtta ctcctgcagt
     4921 aggtggacta tcatctggga cagttgggga agcctcgaca gccctgagtt cagcagccca
     4981 ggtagctttg cagtctctct ctcatgcaat ggcttcagcc gagcaacagc tacaggtgct
     5041 gcaagagaaa cagcagcagc ttttgaagct tcagcaacag aaagcaaagc tggaagccaa
     5101 gttacatcag acaacagctg cagcagctgc agcagcatca gcagtaggtc ctgttcacaa
     5161 ctctgtgcct tccaacccag tggctgcccc tggattcttc attcatccat ctgatgttat
     5221 tccacccact ccaaaaacaa cacctctttt tatgactcca ccactcactc cacccaatga
     5281 agcagtttcc gttgtgatta atgccgaact tgcacagctt ttcccaggct cagtcattga
     5341 tcccccagca gtcaatcttg ctgcacataa caaaaattcc aacaagtcca gaatgaatcc
     5401 acttggttct ggtctagccc ttgcaatttc tcatgcttca cattttcttc aacctccgcc
     5461 tcaccagtcc attattatag agcgaatgca ttcaggagca agaagatttg tgaccttgga
     5521 ttttgggagg cctatattgt tgactgatgt attgattccc acttgtggag acttggcctc
     5581 tttgtcaatt gacatttgga cattaggaga agaggtggat ggaaggcggt tggtagtggc
     5641 aactgatata agcactcatt cactaattct tcatgactta ataccacctc ccgtgtgcag
     5701 attcatgaag atcactgtta ttggacgtta cgggagtaca aatgccagag ccaaaatccc
     5761 attaggattt tactatggtc atacctacat cttgccttgg gaaagtgaac tgaagttaat
     5821 gcatgatcct ctaaagggag agggagaatc tgcaaaccag ccagaaattg accagcattt
     5881 agcaatgatg gttgctttgc aggaggatat acagtgcagg tataacttgg cttgtcatcg
     5941 tctggaaacc cttttgcaaa gtattgatct tcctcctcta aacagtgcta acaatgcaca
     6001 gtacttttta cgaaaaccag ataaggcagt tgaggaagac agtagggttt tttctgctta
     6061 tcaagattgt attcagctac agcttcaact aaatttggct cataatgcag tgcagaggct
     6121 caaagtggcg ctaggtgcaa gccggaagat gttgagtgaa acatcaaatc cagaagattt
     6181 aattcagaca tcttccacag agcagttacg tactatcatc agatatttac tggacacttt
     6241 gctcagcctg cttcatgctt ctaatggaca ctctgttcct gcagttttgc agagcacatt
     6301 tcatgcccag gcctgtgaag agctctttaa acacttgtgc atcagtggaa ccccaaagat
     6361 acggttacat actggtcttc ttcttgttca actgtgtggt ggtgaaaggt ggtggggtca
     6421 atttctttct aatgtccttc aggaattgta caattcggaa cagcttctca tctttccaca
     6481 ggatagggtc ttcatgttac tttcctgcat tggtcaaaga tcacttagta atagtggagt
     6541 attagaaagc ttacttaatc tcttggataa tttattgtca cctcttcagc cacagttacc
     6601 catgcatagg aggacagaag gagtactaga tattcccatg atcagttggg ttgttatgct
     6661 ggtgtccagg ttgctggatt atgtggcaac tgttgaagat gaagcagcag ctgcaaagaa
     6721 acctttgaat ggtaatcagt ggagttttat taacaataat ctacacactc agagcttaaa
     6781 tagatcttct aaaggcagca gtagccttga tagattatat tccagaaaaa tcagaaagca
     6841 gcttgttcat cataaacagc aacttaacct actaaaagca aagcagaagg cattggtaga
     6901 acagatggaa aaagaaaaaa tacaaagtaa caaaggatca tcatataaac tcctggtaga
     6961 acaagcaaaa ctaaagcagg ccacttcaaa gcactttaag gatttaattc gtttacgtcg
     7021 gacagcagaa tggtcccgtt ctaatttaga cacagaagtt acaacagcaa aagaaagtcc
     7081 tgagatagaa ccacttccat ttactctggc ccatgagcgt tgtatctcag tagtccagaa
     7141 acttgttctg tttcttctct ccatggactt tacatgtcat gcagatctct tattgtttgt
     7201 ttgtaaggtt cttgcacgca ttgcaaatgc cacgaggcca actattcatc tgtgtgagat
     7261 tgtgaacgaa ccccagctgg aaagactgct gttacttttg gttggaactg acttcaatag
     7321 aggagatata tcttggggtg gtgcttgggc tcagtattcc ttaacttgca tgctacaaga
     7381 tattttagca ggagaattac tggctccagt agccgcagaa gccatggagg aaggaacagt
     7441 gggtgatgat gtaggtgcga cagctggtga ctctgatgac tcccttcaac agtcctcagt
     7501 tcagttgctg gaaactatag atgaaccttt gacacatgac ataacaggtg cacctcctct
     7561 gtcctctttg gaaaaagata aagaaattga ccttgagtta cttcaggatc taatggaagt
     7621 tgacattgat cctttagata ttgatttgga aaaggaccct cttgcagcca aggtttttaa
     7681 gccaataagc agtacatggt atgattattg gggtgctgat tatgggacct acaattacaa
     7741 cccttacatt ggaggtctgg gaattcctgt agcaaagcca ccagcaaaca cggagaagaa
     7801 cggatcacag acagttagcg tttcagtctc tcaggccctg gatgctcgcc tagaagttgg
     7861 acttgaacag caagcagaac tgatgttgaa aatgatgtct actctggagg cagattccat
     7921 tttacaggca ttaacaaata catctcctac attatcacag tctcccactg gaacagatga
     7981 ttcacttcta gggggtttac aagcagcaaa ccaaaccagc cagcttatta tacagttatc
     8041 atctgtccca atgttaaatg tttgtttcaa caaacttttt tccatgcttc aagtccatca
     8101 tgttcagttg gagtcacttc tccaattgtg gctcacactg agcctgaatt ctagttcaac
     8161 tggaaacaaa gaaaatggag cagacatatt tttatataat gctaatagga tacctgttat
     8221 ttcattaaat caagcatcaa taactagctt tctcacagtg ttagcttggt atcccaatac
     8281 tttgctccgg acatggtgcc ttgtgcttca tagcctaaca ctcatgacaa acatgcagct
     8341 taattctggt tccagcagtg ccattggaac tcaggagagt actgctcatt tgttggtttc
     8401 agatccaaac ctaattcatg tattagtgaa atttctttct ggcaccagtc cacatggaac
     8461 aaatcaacac agtccacagg ttggtcctac agctacacaa gctatgcaag aatttcttac
     8521 tcgattacaa gtgcatcttt cttcaacatg tcctcagata ttcagtgaat ttttgctcaa
     8581 gctaattcat atactttcaa ctgaaagggg tgctttccag acaggccaag gacctctcga
     8641 tgcccaagtg aagctcttag aattcactct ggagcagaat tttgaagtcg tttcagttag
     8701 tactatttct gccgtgatag aatcggttac atttttagtg caccactata tcacttgctc
     8761 agacaaagta atgtcaagaa gtggatcaga tagctccgtg ggtgctcgag catgctttgg
     8821 gggactcttt gccaatctta ttcgtccggg tgatgcaaaa gcagtttgtg gcgaaatgac
     8881 aagagatcaa ctcatgtttg atttgttaaa acttgttaac attttagtgc agctgcctct
     8941 ttcaggcaat agggaataca gtgcaagagt gtctgtgacc acaaatacaa cagatagtgt
     9001 ttcagatgaa gaaaaagtct caggaggcaa agatggcaat ggaagcagta ccagtgttca
     9061 aggatcgcct gcatatgttg ctgacttagt cttagccaac caacaaatta tgagccagat
     9121 tttgtctgct ctgggcctgt gtaatagcag tgccatggca atgataattg gagcaagtgg
     9181 attacatctc actaaacatg aaaactttca tggtgggttg gatgccatat cagttgggga
     9241 tggattattt accatactga caacccttag taaaaaagct tctacagtcc acatgatgct
     9301 gcagccaatt ttaacataca tggcctgtgg atatatgggc agacaaggct ctcttgctac
     9361 ttgccagtta tctgagccat tattgtggtt cattttgaga gtattggata ctagtgatgc
     9421 cttgaaagca tttcatgata tgggtggtgt tcagctcata tgcaataata tggttactag
     9481 tacaagggct attgtgaaca ctgcaagaag tatggtatca actattatga aatttcttga
     9541 ctctggtcca aataaagctg ttgacagcac attgaaaaca agaatactag cttctgagcc
     9601 tgacaatgct gaagggattc ataactttgc acccctcggt acaatcacat ctagcagtcc
     9661 tactgcccaa ccagctgaag tgctattgca ggccacacct cctcacagaa gagctcgctc
     9721 tgctgcttgg tcctacatct ttcttccaga ggaggcttgg tgtgacctta ccattcacct
     9781 tcctgcagca gtgctgctta aggagataca tatccagcct catcttgcat ctcttgcaac
     9841 ctgcccttcc tcagtgtctg ttgaagtaag tgcagatggg gtaaatatgc tacctttgtc
     9901 cactcctgtt gtcacaagtg gcctcaccta cataaaaatt cagcttgtaa aagccgaagt
     9961 agcttctgct gtctgcctta gactacatcg tccacgggat gccagcacat taggcctttc
    10021 acaaattaaa ttattggggc tcactgcttt tggtaccacc tcttctgcaa cagttaataa
    10081 tccattcctt ccatctgaag atcaggtatc caaaacaagt attggatggt tacggttatt
    10141 acatcattgc cttactcaca taagtgatct agaaggaatg atggcaagtg cagctgcacc
    10201 tactgctaat ctgctgcaga cttgtgcggc cttattgatg tcaccttact gtggaatgca
    10261 ttcacccaac atcgaggttg tgcttgtaaa gataggactg cagtctacta gaattggcct
    10321 gaagctcata gacattctcc tgagaaattg tgcagcatca ggcagtgatc ctacagattt
    10381 gaatagtcct ttactttttg gaagactaaa tggactctct tctgactcta cgatagatat
    10441 tctttaccag cttggaacaa ctcaggatcc tggtacaaaa gacagaattc aggccttgtt
    10501 aaaatgggtt agtgattctg caagagtggc tgctatgaag agaagtggca ggatgaacta
    10561 catgtgtcct aactcctcaa cagtagagta tggtcttctg atgccatctc cttctcattt
    10621 gcactgtgta gcagccattc tgtggcatag ttatgagctg cttgtagaat atgacttacc
    10681 agcactcctg gaccaagagc tctttgagtt actttttaat tggtccatgt ctcttccctg
    10741 caatatggtt ttgaagaaag ctgttgacag tctactttgc tcaatgtgtc acgtacaccc
    10801 aaactatttt tctttgctca tgggctggat gggaattacc cctcctccag tgcaatgtca
    10861 tcatagactg tccatgacag atgatagcaa aaagcaggat cttagttcat ctttaacaga
    10921 tgactctaaa aatgcacaag cacctctcgc attaactgaa tcacatttgg ctacccttgc
    10981 ttcctcttct caatctcctg aagctattaa acaattacta gactcaggtt tgccttctct
    11041 tcttgtgagg agtctggcta gtttctgctt tagccacatt tctagctcag aaagcattgc
    11101 ccagtcaata gatatttccc aggacaaact caggcgccat catgtcccac aacaatgtaa
    11161 taagatgcct atcacagccg acctagttgc tcctattctt aggtttttga cagaagttgg
    11221 caatagccat attatgaaag attggcttgg tggttctgaa gtcaatccac tatggacagc
    11281 acttctgttt ttattgtgtc actctgggtc cacttctgga agccataatt taggtgcaca
    11341 acagaccagt gcaagatcag cttctctttc ttcagctgct acaacaggac tgactactca
    11401 acagcgcaca gcaattgaga atgcaactgt tgcgttcttt ctacagtgca tttcatgcca
    11461 tcctaataat caaaagctga tggcacaggt tctttgtgaa ctatttcaga catctcctca
    11521 aagagggaac cttccaacat ctgggaacat ttcagggttt atacgaagat tatttttaca
    11581 gttgatgctg gaagatgaga aagtgacaat gtttcttcag tctccatgtc cactgtacaa
    11641 aggtagaatt aatgctacta gccacgtcat ccagcatcca atgtatggag caggccacaa
    11701 attccgtact cttcatttgc cagtctcaac aacattatca gatgttcttg acagagtgtc
    11761 agatactcca agtatcacag ctaaattaat tagtgaacaa aaagatgaca aagaaaagaa
    11821 aaaccatgaa gagaaagaaa aagttaaagc ggaaaatgga tttcaagaca attacagtgt
    11881 tgttgttgcc tctgggctga agtctcaatc taaacgtgct gtgtcagcta caccacctcg
    11941 cccaccatcc aggaggggga ggacaatacc tgataaaata ggaagtactt caggagcaga
    12001 ggctgccaac aaaataatta ctgtcccagt gtttcacctg tttcacaaac tcttggcagg
    12061 ccagccattg ccagctgaaa tgacacttgc ccagctttta actctcctat atgaccgaaa
    12121 acttcctcag ggttaccgct caatagatct gactgttaaa ttgggatcaa gagttataac
    12181 agaccccagt ctatcaaaaa cagattctta taaaagacta caccctgaaa aagatcatgg
    12241 agacttactt gctagctgtc cagaagatga ggctctcact ccaggtgatg aatgcatgga
    12301 tgggatactg gatgaatctt tgcttgaaac ctgtccaatt cagtcaccat tacaagtttt
    12361 tgcaggaatg ggtggactgg ctcttattgc tgaaagacta cccatgctat atccagaagt
    12421 aattcaacag gtgagtgctc cagttgtaac atctaccact caggaaaagc cgaaggatag
    12481 cgatcagttt gaatgggtga ccattgaaca gtcaggggag ttagtttatg aagcaccaga
    12541 aactgttgcg gctgaacctc cacctatcaa gtcagcagta cagaccatgt ctcccatacc
    12601 tgcccattct ttggctgctt ttggattatt tcttcgtctt ccgggctatg cggaagtgct
    12661 actgaaagag agaaaacatg cccagtgcct tcttcgattg gtattgggag tgacagatga
    12721 tggagaagga agtcatattc ttcaatctcc atcagccaat gtgcttccaa cccttccttt
    12781 ccacgtcctt cgtagcttgt ttagcactac acctttgaca actgatgatg gtgtacttct
    12841 aaggcggatg gcattggaaa ttggagcctt acacctcatt cttgtctgtc tctctgcttt
    12901 gagccaccat tccccacgag ttccaaactc tagcgtgaat caaactgagc cacaggtgtc
    12961 aagctctcat aaccctacat caacagaaga acaacagtta tattgggcca aagggactgg
    13021 ctttggaaca ggctctacag cttctgggtg ggatgtggaa caagccttaa ctaagcaaag
    13081 gctggaagag gaacatgtta cctgccttct gcaggttctt gccagttaca taaatcccgt
    13141 cagtagtgcg gtaaatggag aagctcagtc atctcatgag actagagggc agaacagtaa
    13201 tgcccttcct tctgtacttc tcgagcttct cagtcagtcc tgcctcatcc cagccatgtc
    13261 atcttatcta cgaaatgatt cagttctgga catggcaaga catgtgccac tctatcgggc
    13321 actgctggaa ttgcttcggg ccattgcttc ttgtgctgcc atggtgcccc tattgttgcc
    13381 cctttctaca gagaacggtg aagaggaaga agaacagtca gaatgtcaaa cttctgttgg
    13441 tacattgtta gccaaaatga agacctgtgt tgatacctat accaaccgtt taagatctaa
    13501 aagggaaaat gttaaaacag gagtaaaacc agatgcgtct gatcaagaac cagaaggact
    13561 tactcttttg gtaccagaca tccaaaagac tgctgagata gtttatgcag ccaccaccag
    13621 tttgcggcaa gcaaatcagg aaaaaaaact gggtgaatac tccaagaagg cggctatgaa
    13681 acccaaacct ttgtcagtat taaagtcact tgaagaaaaa tatgtggctg ttatgaagaa
    13741 attacagttt gatacgtttg aaatggtttc tgaagatgaa gatgggaaat tgggatttaa
    13801 agtaaattac cactacatgt ctcaggtgaa aaatgctaat gatgcgaaca gtgctgccag
    13861 agctcgccgc cttgcccagg aagctgtgac gctttcaacc tcactgcctc tgtcttcatc
    13921 ctctagtgtg tttgtacgct gtgatgagga gcgacttgat atcatgaagg ttctaataac
    13981 tggtccagcg gacacccctt atgcaaatgg ctgctttgag tttgatgtgt attttcctca
    14041 agattatccc agttcacccc ctcttgtgaa tctagagaca actggtggtc atagcgtgcg
    14101 attcaatcca aacctttata atgatggcaa ggtttgttta agcatcttaa acacgtggca
    14161 tggaagacca gaagagaagt ggaatcctca gacctcaagc tttttgcaag tgttggtgtc
    14221 tgtccagtcc cttatattag tagctgagcc ttattttaat gaaccgggat atgaacggtc
    14281 tagaggcact cccagtggca cacagagttc tcgagaatat gatggaaaca ttcgacaagc
    14341 aacagttaag tgggcaatgc tagaacaaat cagaaaccct tcaccatgtt ttaaagaggt
    14401 aatacacaaa catttttact tgaaaagagt tgagataatg gcccaatgtg aggagtggat
    14461 tgcggatatc cagcagtaca gcagtgataa gcgggtaggc aggactatgt ctcaccatgc
    14521 agcagctctc aagcgtcaca ctgctcagct ccgcgaagag ttgctgaaac ttccctgccc
    14581 tgaaggcttg gatcctgaca ctgacgatgc cccagaggtg tgcagagcca caacaggtgc
    14641 tgaggagact ctaatgcatg atcaggttaa acccagcagc agcaaagaac tccccagtga
    14701 cttccagtta tgagctgcat tgatgtggac ttcatagaca caaaggcttc gaagcacaag
    14761 ccaaatatgt caatatttgt atgtaagaaa ctaattatgt aataggtaat gaaactgaaa
    14821 ctatactatg cccttaagga gatccagttt aattcaaggt gatcttttat ttacctgtac
    14881 aggagtgtaa acttttttgt gcttttattt ttcaattgtg agaaccactg attggtatgt
    14941 tcaacaaatt tgtgtataca aagaaatgga taaatcactg ctatataagg gaaactacct
    15001 taggaaagaa tgtttactga atgtttattt tattttattt tttttttact atagagtgag
    15061 gggttgttaa caaagaatat atattggtca ttcttacaac tactatttaa agtcagcaac
    15121 ttttcactga atttgataga ttttatgttt ggccatatct tcatgctcac atttgatttc
    15181 tgaagacctc ctacatacac ttcaataaaa gttaaatgga catactccct cttttttgat
    15241 ttactggtac atttttaaaa taataaatct gccataaaat gcattatatc tggagacttg
    15301 cacttgtatg gatgaattta ttacattcaa catatttaat tttatgcctt ctaattctaa
    15361 gatgcagaaa aaaataaatg aacatgattt tattctatgc caacatttgg gcctctgaat
    15421 gtatctgtta tttgaattta agtatttgaa aaggaatggt caatttgaaa gtcattctaa
    15481 actgattttt tttttctaaa gggctccttt tttcctggac tatgtggttt tatgactaaa
    15541 gtcacatgta tgtattaaac attgaggctc tgtagaggag agaggatgta cctctctggt
    15601 gctgttacag tacattctgt acctgccata caggctcatt ttcatgcaaa ttcttcctag
    15661 agccaaataa ataaagactt aggtgaa
//
