LOCUS       NM_001168               2574 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens baculoviral IAP repeat containing 5 (BIRC5),
            transcript variant 1, mRNA.
ACCESSION   NM_001168
VERSION     NM_001168.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Zhang,H., Zheng,T., Qin,C., Zhang,X., Lin,H., Huang,X., Liu,Q.,
            Chang,S., Zhang,L., Guo,J., Zhang,Y., Bian,C. and Liu,H.
  TITLE     CCT6A promotes cell proliferation in colon cancer by targeting
            BIRC5 associated with p53 status
  JOURNAL   Cancer Gene Ther 31 (8), 1151-1163 (2024)
   PUBMED   38997438
  REMARK    GeneRIF: CCT6A promotes cell proliferation in colon cancer by
            targeting BIRC5 associated with p53 status.
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Kim,H., Son,S., Ko,Y., Lim,H., Lee,J., Lee,K.M. and Shin,I.
  TITLE     CYR61 confers chemoresistance by upregulating survivin expression
            in triple-negative breast cancer
  JOURNAL   Carcinogenesis 45 (7), 510-519 (2024)
   PUBMED   38446998
  REMARK    GeneRIF: CYR61 confers chemoresistance by upregulating survivin
            expression in triple-negative breast cancer.
REFERENCE   3  (bases 1 to 2574)
  AUTHORS   Gao,B., Qiao,Y., Zhu,S., Yang,N., Zou,S.S., Liu,Y.J. and Chen,J.
  TITLE     USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in
            colorectal cancer cells
  JOURNAL   J Biol Chem 300 (7), 107463 (2024)
   PUBMED   38876304
  REMARK    GeneRIF: USP36 inhibits apoptosis by deubiquitinating cIAP1 and
            survivin in colorectal cancer cells.
REFERENCE   4  (bases 1 to 2574)
  AUTHORS   Benaiges,E., Ceperuelo-Mallafre,V., Guaita,S., Maymo-Masip,E.,
            Madeira,A., Gomez,D., Hernandez,V., Vilaseca,I., Merma,C., Leon,X.,
            Terra,X., Vendrell,J., Aviles-Jurado,F.X. and Fernandez-Veledo,S.
  TITLE     Survivin/BIRC5 as a novel molecular effector at the crossroads of
            glucose metabolism and radioresistance in head and neck squamous
            cell carcinoma
  JOURNAL   Head Neck 46 (7), 1752-1765 (2024)
   PUBMED   38305029
  REMARK    GeneRIF: Survivin/BIRC5 as a novel molecular effector at the
            crossroads of glucose metabolism and radioresistance in head and
            neck squamous cell carcinoma.
REFERENCE   5  (bases 1 to 2574)
  AUTHORS   Chen,C., Liu,H., Li,Y., Xu,Q. and Liu,J.
  TITLE     Downregulation of PTPRT elevates the expression of survivin and
            promotes the proliferation, migration, and invasion of lung
            adenocarcinoma
  JOURNAL   BMC Cancer 24 (1), 63 (2024)
   PUBMED   38216925
  REMARK    GeneRIF: Downregulation of PTPRT elevates the expression of
            survivin and promotes the proliferation, migration, and invasion of
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2574)
  AUTHORS   Tamm,I., Wang,Y., Sausville,E., Scudiero,D.A., Vigna,N.,
            Oltersdorf,T. and Reed,J.C.
  TITLE     IAP-family protein survivin inhibits caspase activity and apoptosis
            induced by Fas (CD95), Bax, caspases, and anticancer drugs
  JOURNAL   Cancer Res 58 (23), 5315-5320 (1998)
   PUBMED   9850056
REFERENCE   7  (bases 1 to 2574)
  AUTHORS   Ambrosini,G., Adida,C., Sirugo,G. and Altieri,D.C.
  TITLE     Induction of apoptosis and inhibition of cell proliferation by
            survivin gene targeting
  JOURNAL   J Biol Chem 273 (18), 11177-11182 (1998)
   PUBMED   9556606
REFERENCE   8  (bases 1 to 2574)
  AUTHORS   Ambrosini,G., Adida,C. and Altieri,D.C.
  TITLE     A novel anti-apoptosis gene, survivin, expressed in cancer and
            lymphoma
  JOURNAL   Nat Med 3 (8), 917-921 (1997)
   PUBMED   9256286
REFERENCE   9  (bases 1 to 2574)
  AUTHORS   Altieri,D.C.
  TITLE     Splicing of effector cell protease receptor-1 mRNA is modulated by
            an unusual retained intron
  JOURNAL   Biochemistry 33 (46), 13848-13855 (1994)
   PUBMED   7947793
REFERENCE   10 (bases 1 to 2574)
  AUTHORS   Altieri,D.C.
  TITLE     Molecular cloning of effector cell protease receptor-1, a novel
            cell surface receptor for the protease factor Xa
  JOURNAL   J Biol Chem 269 (5), 3139-3142 (1994)
   PUBMED   8106347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI520186.1, BC034148.1,
            BG759111.1, BC008718.2, AL519719.3, BI254058.1 and AI800528.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001168.2.
            
            Summary: This gene is a member of the inhibitor of apoptosis (IAP)
            gene family, which encode negative regulatory proteins that prevent
            apoptotic cell death. IAP family members usually contain multiple
            baculovirus IAP repeat (BIR) domains, but this gene encodes
            proteins with only a single BIR domain. The encoded proteins also
            lack a C-terminus RING finger domain. Gene expression is high
            during fetal development and in most tumors, yet low in adult
            tissues. Alternatively spliced transcript variants encoding
            distinct isoforms have been found for this gene. [provided by
            RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) represents the most frequently
            occurring transcript and it encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.44791.1,
                                           SRR1163658.154211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350051.8/ ENSP00000324180.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BI520186.1         68-87
            21-448              BC034148.1         1-428
            449-984             BG759111.1         57-592
            985-1638            BC008718.2         954-1607
            1639-2227           AL519719.3         269-857
            2228-2553           BI254058.1         14-339              c
            2554-2574           AI800528.1         25-45               c
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2574
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="baculoviral IAP repeat containing 5"
                     /db_xref="GeneID:332"
                     /db_xref="HGNC:HGNC:593"
                     /db_xref="MIM:603352"
     exon            1..175
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..493
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis inhibitor 4; baculoviral IAP repeat-containing
                     protein 5; apoptosis inhibitor survivin"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 5
                     isoform 1"
                     /protein_id="NP_001159.2"
                     /db_xref="CCDS:CCDS11755.1"
                     /db_xref="GeneID:332"
                     /db_xref="HGNC:HGNC:593"
                     /db_xref="MIM:603352"
                     /translation="MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFI
                     HCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFL
                     KLDRERAKNKIAKETNNKKKEFEETAEKVRRAIEQLAAMD"
     exon            176..285
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..403
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..2574
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="major polyA site"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      2290
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
     polyA_site      2311
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
     regulatory      2549..2554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      2574
                     /gene="BIRC5"
                     /gene_synonym="API4; EPR-1"
ORIGIN      
        1 gcggcgcgcc attaaccgcc agatttgaat cgcgggaccc gttggcagag gtggcggcgg
       61 cggcatgggt gccccgacgt tgccccctgc ctggcagccc tttctcaagg accaccgcat
      121 ctctacattc aagaactggc ccttcttgga gggctgcgcc tgcaccccgg agcggatggc
      181 cgaggctggc ttcatccact gccccactga gaacgagcca gacttggccc agtgtttctt
      241 ctgcttcaag gagctggaag gctgggagcc agatgacgac cccatagagg aacataaaaa
      301 gcattcgtcc ggttgcgctt tcctttctgt caagaagcag tttgaagaat taacccttgg
      361 tgaatttttg aaactggaca gagaaagagc caagaacaaa attgcaaagg aaaccaacaa
      421 taagaagaaa gaatttgagg aaactgcgga gaaagtgcgc cgtgccatcg agcagctggc
      481 tgccatggat tgaggcctct ggccggagct gcctggtccc agagtggctg caccacttcc
      541 agggtttatt ccctggtgcc accagccttc ctgtgggccc cttagcaatg tcttaggaaa
      601 ggagatcaac attttcaaat tagatgtttc aactgtgctc ttgttttgtc ttgaaagtgg
      661 caccagaggt gcttctgcct gtgcagcggg tgctgctggt aacagtggct gcttctctct
      721 ctctctctct tttttggggg ctcatttttg ctgttttgat tcccgggctt accaggtgag
      781 aagtgaggga ggaagaaggc agtgtccctt ttgctagagc tgacagcttt gttcgcgtgg
      841 gcagagcctt ccacagtgaa tgtgtctgga cctcatgttg ttgaggctgt cacagtcctg
      901 agtgtggact tggcaggtgc ctgttgaatc tgagctgcag gttccttatc tgtcacacct
      961 gtgcctcctc agaggacagt ttttttgttg ttgtgttttt ttgttttttt ttttttggta
     1021 gatgcatgac ttgtgtgtga tgagagaatg gagacagagt ccctggctcc tctactgttt
     1081 aacaacatgg ctttcttatt ttgtttgaat tgttaattca cagaatagca caaactacaa
     1141 ttaaaactaa gcacaaagcc attctaagtc attggggaaa cggggtgaac ttcaggtgga
     1201 tgaggagaca gaatagagtg ataggaagcg tctggcagat actccttttg ccactgctgt
     1261 gtgattagac aggcccagtg agccgcgggg cacatgctgg ccgctcctcc ctcagaaaaa
     1321 ggcagtggcc taaatccttt ttaaatgact tggctcgatg ctgtggggga ctggctgggc
     1381 tgctgcaggc cgtgtgtctg tcagcccaac cttcacatct gtcacgttct ccacacgggg
     1441 gagagacgca gtccgcccag gtccccgctt tctttggagg cagcagctcc cgcagggctg
     1501 aagtctggcg taagatgatg gatttgattc gccctcctcc ctgtcataga gctgcagggt
     1561 ggattgttac agcttcgctg gaaacctctg gaggtcatct cggctgttcc tgagaaataa
     1621 aaagcctgtc atttcaaaca ctgctgtgga ccctactggg tttttaaaat attgtcagtt
     1681 tttcatcgtc gtccctagcc tgccaacagc catctgccca gacagccgca gtgaggatga
     1741 gcgtcctggc agagacgcag ttgtctctgg gcgcttgcca gagccacgaa ccccagacct
     1801 gtttgtatca tccgggctcc ttccgggcag aaacaactga aaatgcactt cagacccact
     1861 tatttctgcc acatctgagt cggcctgaga tagacttttc cctctaaact gggagaatat
     1921 cacagtggtt tttgttagca gaaaatgcac tccagcctct gtactcatct aagctgctta
     1981 tttttgatat ttgtgtcagt ctgtaaatgg atacttcact ttaataactg ttgcttagta
     2041 attggctttg tagagaagct ggaaaaaaat ggttttgtct tcaactcctt tgcatgccag
     2101 gcggtgatgt ggatctcggc ttctgtgagc ctgtgctgtg ggcagggctg agctggagcc
     2161 gcccctctca gcccgcctgc cacggccttt ccttaaaggc catccttaaa accagaccct
     2221 catggctacc agcacctgaa agcttcctcg acatctgtta ataaagccgt aggcccttgt
     2281 ctaagtgcaa ccgcctagac tttctttcag atacatgtcc acatgtccat ttttcaggtt
     2341 ctctaagttg gagtggagtc tgggaagggt tgtgaatgag gcttctgggc tatgggtgag
     2401 gttccaatgg caggttagag cccctcgggc caactgccat cctggaaagt agagacagca
     2461 gtgcccgctg cccagaagag accagcaagc caaactggag cccccattgc aggctgtcgc
     2521 catgtggaaa gagtaactca caattgccaa taaagtctca tgtggtttta tcta
//
