LOCUS       NM_001165               6877 bp    mRNA    linear   PRI 29-APR-2025
DEFINITION  Homo sapiens baculoviral IAP repeat containing 3 (BIRC3),
            transcript variant 1, mRNA.
ACCESSION   NM_001165 XM_005271534
VERSION     NM_001165.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6877)
  AUTHORS   Gao,B., Qiao,Y., Zhu,S., Yang,N., Zou,S.S., Liu,Y.J. and Chen,J.
  TITLE     USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in
            colorectal cancer cells
  JOURNAL   J Biol Chem 300 (7), 107463 (2024)
   PUBMED   38876304
  REMARK    GeneRIF: USP36 inhibits apoptosis by deubiquitinating cIAP1 and
            survivin in colorectal cancer cells.
REFERENCE   2  (bases 1 to 6877)
  AUTHORS   Tang,C., Zhuang,H., Wang,W., Wang,Q., Ma,X., Wang,B., Zhang,Z.,
            Jiang,J., Xie,Z., Tan,W., Yang,L., Liu,S., Hua,Y., Xiao,Y.,
            Ding,B., Chen,Y. and Shang,C.
  TITLE     CircNUP54 promotes hepatocellular carcinoma progression via
            facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA
  JOURNAL   Cell Death Dis 15 (3), 191 (2024)
   PUBMED   38443362
  REMARK    GeneRIF: CircNUP54 promotes hepatocellular carcinoma progression
            via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6877)
  AUTHORS   Wei,K., Zhang,X. and Yang,D.
  TITLE     Identification and validation of prognostic and tumor
            microenvironment characteristics of necroptosis index and BIRC3 in
            clear cell renal cell carcinoma
  JOURNAL   PeerJ 11, e16643 (2023)
   PUBMED   38130918
  REMARK    GeneRIF: Identification and validation of prognostic and tumor
            microenvironment characteristics of necroptosis index and BIRC3 in
            clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6877)
  AUTHORS   Xie,C., Zhong,L., Luo,J., Luo,J., Wu,Y., Zheng,S., Jiang,L.,
            Zhang,J. and Shi,Y.
  TITLE     Identification of mutation gene prognostic biomarker in multiple
            myeloma through gene panel exome sequencing and transcriptome
            analysis in Chinese population
  JOURNAL   Comput Biol Med 163, 107224 (2023)
   PUBMED   37406588
  REMARK    GeneRIF: Identification of mutation gene prognostic biomarker in
            multiple myeloma through gene panel exome sequencing and
            transcriptome analysis in Chinese population.
REFERENCE   5  (bases 1 to 6877)
  AUTHORS   Zhang,H., Ma,B., Li,N., Zhang,L., Xu,J., Zhang,S., Guo,Z., Han,C.,
            Xu,S., Li,X. and Zhang,B.
  TITLE     SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and
            tumorigenesis under endoplasmic reticulum stress by upregulating
            BIRC3 expression
  JOURNAL   J Cell Mol Med 27 (13), 1806-1819 (2023)
   PUBMED   37243389
  REMARK    GeneRIF: SNHG1, a KLF4-upregulated gene, promotes glioma cell
            survival and tumorigenesis under endoplasmic reticulum stress by
            upregulating BIRC3 expression.
REFERENCE   6  (bases 1 to 6877)
  AUTHORS   Sherrill,K.W. and Lloyd,R.E.
  TITLE     Translation of cIAP2 mRNA is mediated exclusively by a
            stress-modulated ribosome shunt
  JOURNAL   Mol Cell Biol 28 (6), 2011-2022 (2008)
   PUBMED   18195037
  REMARK    GeneRIF: cIAP2 mRNA mediates translation only via ribosome
            bypassing 62 uAUGs. Shunting efficiency was altered by stress & was
            facilitated by a conserved RNA folding domain (1,470 to 1,877
            nucleotides upstream) in a region not scanned by shunting
            ribosomes.
REFERENCE   7  (bases 1 to 6877)
  AUTHORS   Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
  TITLE     Assignment of human inhibitor of apoptosis protein (IAP) genes
            xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 37 (3), 404-406 (1996)
   PUBMED   8938457
REFERENCE   8  (bases 1 to 6877)
  AUTHORS   Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.
  TITLE     Cloning and expression of apoptosis inhibitory protein homologs
            that function to inhibit apoptosis and/or bind tumor necrosis
            factor receptor-associated factors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4974-4978 (1996)
   PUBMED   8643514
REFERENCE   9  (bases 1 to 6877)
  AUTHORS   Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
            Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
            and Korneluk,R.G.
  TITLE     Suppression of apoptosis in mammalian cells by NAIP and a related
            family of IAP genes
  JOURNAL   Nature 379 (6563), 349-353 (1996)
   PUBMED   8552191
REFERENCE   10 (bases 1 to 6877)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG569841.1, AF070674.1,
            BU428906.1, BX475964.1, U37546.1, BC037420.1, U45878.1, AI880555.1,
            BE907592.1, BX415415.2, AA805622.1 and AA873008.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 18, 2019 this sequence version replaced NM_001165.4.
            
            Summary: This gene encodes a member of the IAP family of proteins
            that inhibit apoptosis by binding to tumor necrosis factor
            receptor-associated factors TRAF1 and TRAF2, probably by
            interfering with activation of ICE-like proteases. The encoded
            protein inhibits apoptosis induced by serum deprivation but does
            not affect apoptosis resulting from exposure to menadione, a potent
            inducer of free radicals. It contains 3 baculovirus IAP repeats and
            a ring finger domain. Transcript variants encoding the same isoform
            have been identified. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF070674.1, SRR14038197.1787411.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263464.9/ ENSP00000263464.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            regulatory uORF        :: PMID: 18195037
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG569841.1         89-99
            12-1055             AF070674.1         1-1044
            1056-1323           AF070674.1         1046-1313
            1324-1664           BU428906.1         20-360
            1665-2091           BX475964.1         105-531
            2092-3960           U37546.1           55-1923
            3961-4593           BC037420.1         1336-1968
            4594-4823           U45878.1           2281-2510
            4824-5202           BC037420.1         2199-2577
            5203-5606           AI880555.1         1-404               c
            5607-5922           BE907592.1         250-565
            5923-6655           BX415415.2         115-847             c
            6656-6796           AA805622.1         11-151              c
            6797-6877           AA873008.1         22-102              c
FEATURES             Location/Qualifiers
     source          1..6877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..6877
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="baculoviral IAP repeat containing 3"
                     /db_xref="GeneID:330"
                     /db_xref="HGNC:HGNC:591"
                     /db_xref="MIM:601721"
     exon            1..88
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            89..3614
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     CDS             2762..4576
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /EC_number="2.3.2.27"
                     /note="apoptosis inhibitor 2; TNFR2-TRAF signaling complex
                     protein; mammalian IAP homolog C; inhibitor of apoptosis
                     protein 1; RING finger protein 49; TNFR2-TRAF-signaling
                     complex protein 1; cellular inhibitor of apoptosis 2;
                     RING-type E3 ubiquitin transferase BIRC3"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 3"
                     /protein_id="NP_001156.1"
                     /db_xref="CCDS:CCDS8315.1"
                     /db_xref="GeneID:330"
                     /db_xref="HGNC:HGNC:591"
                     /db_xref="MIM:601721"
                     /translation="MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVP
                     VSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSV
                     NNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRS
                     SYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPK
                     DNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQL
                     ASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQV
                     QASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSR
                     SLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKN
                     RMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAAT
                     VFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVS
                     IVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS"
     exon            3615..3714
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3793
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3842
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..4085
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4340
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4382
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..6877
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5184..5189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="hexamer: AATAAA"
     polyA_site      5208
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="major polyA site"
     regulatory      6775..6780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="hexamer: AATAAA"
     regulatory      6786..6791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="hexamer: ATTATA"
     polyA_site      6796
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="major polyA site"
     polyA_site      6810
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
     regulatory      6856..6861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
                     /note="hexamer: AATAAA"
     polyA_site      6877
                     /gene="BIRC3"
                     /gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
                     IAP-1; MALT2; MIHC; RNF49"
ORIGIN      
        1 ggcacggaaa aggccaggcg acaggtgtcg cttgaaaaga ctgggcttgt ccttgctggt
       61 gcatgcgtcg tcggcctctg ggcagcaggt ttacaaagga ggaaaacgac ttcttctaga
      121 tttttttttc agtttcttct ataaatcaaa acatctcaaa atggagacct aaaatcctta
      181 aagggactta gtctaatctc gggaggtagt tttgtgcatg ggtaaacaaa ttaagtatta
      241 actggtgttt tactatccaa agaatgctaa ttttataaac atgatcgagt tatataaggt
      301 ataccataat gagtttgatt ttgaatttga tttgtggaaa taaaggaaaa gtgattctag
      361 ctggggcata ttgttaaagc atttttttca gagttggcca ggcagtctcc tactggcaca
      421 ttctcccatt atgtagaata gaaatagtac ctgtgtttgg gaaagatttt aaaatgagtg
      481 acagttattt ggaacaaaga gctaataatc aatccactgc aaattaaaga aacatgcaga
      541 tgaaagtttt gacacattaa aatacttcta cagtgacaaa gaaaaatcaa gaacaaagct
      601 ttttgatatg tgcaacaaat ttagaggaag taaaaagata aatgtgatga ttggtcaaga
      661 aattatccag ttatttacaa ggccactgat attttaaacg tccaaaagtt tgtttaaatg
      721 ggctgttacc gctgagaatg atgaggatga gaatgatggt tgaaggttac attttaggaa
      781 atgaagaaac ttagaaaatt aatataaaga cagtgatgaa tacaaagaag atttttataa
      841 caatgtgtaa aatttttggc cagggaaagg aatattgaag ttagatacaa ttacttacct
      901 ttgagggaaa taattgttgg taatgagatg tgatgtttct cctgccacct ggaaacaaag
      961 cattgaagtc tgcagttgaa aagcccaacg tctgtgagat ccaggaaacc atgcttgcaa
     1021 accactggta aaaaaaaaaa aaaaaaaaaa aaaaagccac agtgacttgc ttattggtca
     1081 ttgctagtat tatcgactca gaacctcttt actaatggct agtaaatcat aattgagaaa
     1141 ttctgaattt tgacaaggtc tctgctgttg aaatggtaaa tttattattt tttttgtcat
     1201 gataaattct ggttcaaggt atgctatcca tgaaataatt tctgaccaaa actaaattga
     1261 tgcaatttga ttatccatct tagcctacag atggcatctg gtaacttttg actgttttaa
     1321 aaaataaatc cactatcaga gtagatttga tgttggcttc agaaacattt agaaaaacaa
     1381 aagttcaaaa atgttttcag gaggtgataa gttgaataac tctacaatgt tagttctttg
     1441 agggggacaa aaaatttaaa atctttgaaa ggtcttattt tacagccata tctaaattat
     1501 cttaagaaaa tttttaacaa agggaatgaa atatatatca tgattctgtt tttccaaaag
     1561 taacctgaat atagcaatga agttcagttt tgttattggt agtttgggca gagtctcttt
     1621 ttgcagcacc tgttgtctac cataattaca gaggacattt ccatgttcta gccaagtata
     1681 ctattagaat aaaaaaactt aacattgagt tgcttcaaca gcatgaaact gagtccaaaa
     1741 gaccaaatga acaaacacat taatctctga ttatttattt taaatagaat atttaattgt
     1801 gtaagatcta atagtatcat tatacttaag caatcatatt cctgatgatc tatgggaaat
     1861 aactattatt taattaatat tgaaaccagg ttttaagatg tgttagccag tcctgttact
     1921 agtaaatctc tttatttgga gagaaatttt agattgtttt gttctcctta ttagaaggat
     1981 tgtagaaaga aaaaaatgac taattggaga aaaattgggg atatatcata tttcactgaa
     2041 ttcaaaatgt cttcagttgt aaatcttacc attattttac gtacctctaa gaaataaaag
     2101 tgcttctaat taaaatatga tgtcattaat tatgaaatac ttcttgataa cagaagtttt
     2161 aaaatagcca tcttagaatc agtgaaatat ggtaatgtat tattttcctc ctttgagtta
     2221 ggtcttgtgc ttttttttcc tggccactaa atttcacaat ttccaaaaag caaaataaac
     2281 atattctgaa tatttttgct gtgaaacact tgacagcaga gctttccacc atgaaaagaa
     2341 gcttcatgag tcacacatta catctttggg ttgattgaat gccactgaaa cattctagta
     2401 gcctggagaa gttgacctac ctgtggagat gcctgccatt aaatggcatc ctgatggctt
     2461 aatacacatc actcttctgt gaagggtttt aattttcaac acagcttact ctgtagcatc
     2521 atgtttacat tgtatgtata aagattatac aaaggtgcaa ttgtgtattt cttccttaaa
     2581 atgtatcagt ataggattta gaatctccat gttgaaactc taaatgcata gaaataaaaa
     2641 taataaaaaa tttttcattt tggcttttca gcctagtatt aaaactgata aaagcaaagc
     2701 catgcacaaa actacctccc tagagaaagg ctagtccctt ttcttcccca ttcatttcat
     2761 tatgaacata gtagaaaaca gcatattctt atcaaatttg atgaaaagcg ccaacacgtt
     2821 tgaactgaaa tacgacttgt catgtgaact gtaccgaatg tctacgtatt ccacttttcc
     2881 tgctggggtt cctgtctcag aaaggagtct tgctcgtgct ggtttctatt acactggtgt
     2941 gaatgacaag gtcaaatgct tctgttgtgg cctgatgctg gataactgga aaagaggaga
     3001 cagtcctact gaaaagcata aaaagttgta tcctagctgc agattcgttc agagtctaaa
     3061 ttccgttaac aacttggaag ctacctctca gcctactttt ccttcttcag taacaaattc
     3121 cacacactca ttacttccgg gtacagaaaa cagtggatat ttccgtggct cttattcaaa
     3181 ctctccatca aatcctgtaa actccagagc aaatcaagat ttttctgcct tgatgagaag
     3241 ttcctaccac tgtgcaatga ataacgaaaa tgccagatta cttacttttc agacatggcc
     3301 attgactttt ctgtcgccaa cagatctggc aaaagcaggc ttttactaca taggacctgg
     3361 agacagagtg gcttgctttg cctgtggtgg aaaattgagc aattgggaac cgaaggataa
     3421 tgctatgtca gaacacctga gacattttcc caaatgccca tttatagaaa atcagcttca
     3481 agacacttca agatacacag tttctaatct gagcatgcag acacatgcag cccgctttaa
     3541 aacattcttt aactggccct ctagtgttct agttaatcct gagcagcttg caagtgcggg
     3601 tttttattat gtgggtaaca gtgatgatgt caaatgcttt tgctgtgatg gtggactcag
     3661 gtgttgggaa tctggagatg atccatgggt tcaacatgcc aagtggtttc caaggtgtga
     3721 gtacttgata agaattaaag gacaggagtt catccgtcaa gttcaagcca gttaccctca
     3781 tctacttgaa cagctgctat ccacatcaga cagcccagga gatgaaaatg cagagtcatc
     3841 aattatccat tttgaacctg gagaagacca ttcagaagat gcaatcatga tgaatactcc
     3901 tgtgattaat gctgccgtgg aaatgggctt tagtagaagc ctggtaaaac agacagttca
     3961 gagaaaaatc ctagcaactg gagagaatta tagactagtc aatgatcttg tgttagactt
     4021 actcaatgca gaagatgaaa taagggaaga ggagagagaa agagcaactg aggaaaaaga
     4081 atcaaatgat ttattattaa tccggaagaa tagaatggca ctttttcaac atttgacttg
     4141 tgtaattcca atcctggata gtctactaac tgccggaatt attaatgaac aagaacatga
     4201 tgttattaaa cagaagacac agacgtcttt acaagcaaga gaactgattg atacgatttt
     4261 agtaaaagga aatattgcag ccactgtatt cagaaactct ctgcaagaag ctgaagctgt
     4321 gttatatgag catttatttg tgcaacagga cataaaatat attcccacag aagatgtttc
     4381 agatctacca gtggaagaac aattgcggag actacaagaa gaaagaacat gtaaagtgtg
     4441 tatggacaaa gaagtgtcca tagtgtttat tccttgtggt catctagtag tatgcaaaga
     4501 ttgtgctcct tctttaagaa agtgtcctat ttgtaggagt acaatcaagg gtacagttcg
     4561 tacatttctt tcatgaagaa gaaccaaaac atcgtctaaa ctttagaatt aatttattaa
     4621 atgtattata actttaactt ttatcctaat ttggtttcct taaaattttt atttatttac
     4681 aactcaaaaa acattgtttt gtgtaacata tttatatatg tatctaaacc atatgaacat
     4741 atatttttta gaaactaaga gaatgatagg cttttgttct tatgaacgaa aaagaggtag
     4801 cactacaaac acaatattca atcaaaattt cagcattatt gaaattgtaa gtgaagtaaa
     4861 acttaagata tttgagttaa cctttaagaa ttttaaatat tttggcattg tactaatacc
     4921 gggaacatga agccaggtgt ggtggtatgt gcctgtagtc ccaggctgag gcaagagaat
     4981 tacttgagcc caggagtttg aatccatcct gggcagcata ctgagaccct gcctttaaaa
     5041 acaaacagaa caaaaacaaa acaccaggga cacatttctc tgtctttttt gatcagtgtc
     5101 ctatacatcg aaggtgtgca tatatgttga atgacatttt agggacatgg tgtttttata
     5161 aagaattctg tgagaaaaaa tttaataaag caacaaaaat tactcttatt cttcattgct
     5221 ttatttcaat gacattggat agtttagtca ctcccagact ctttccatac cttcttaaag
     5281 cctctcaaat attgaactac agtttatact ccttcccata agatgcttct tcattgacac
     5341 ttgtagaaca cggggtcaac acatcataaa atctattatg gaatgcctga gacaagaatc
     5401 aaacagtccc tttagtaagt ttgtttattc acttctctat tgattcattc aagaagtctc
     5461 atgccagccc cacctattgg aagaaggtct gagttttatt cttatctctt tggtattaat
     5521 tctgaaactt agaaagtaca ctggttagca atgcttggga ccaacaggtt gttctggtaa
     5581 ataaatctgt ttcatattgt cagtgcaaca aaatgtcccc ctctgcatta tgttattggt
     5641 actcaacacg tccgagtcat aactctgtcc tttgcttctt atagaggtat taggtcttca
     5701 agagcagaag taagactgta atagggaata ctcaggggaa ggcaggcaaa ggctagtcat
     5761 ctaaaccagt tctagatgtc tgtatagggg cagatggctc tgtaagggca gaagggaaag
     5821 accccttcat aagggtcaca gctgacaatc ctataacaaa agacaggtta acaagagaaa
     5881 aacttaacaa atttatttaa tcacagattt acatcaccgg ggagccttcg taatgaagat
     5941 ccaaaattac aggggaaact gtgcattttt atgcttaggt ttgataatga atggacagcc
     6001 ctgaagaata gtgattggaa aaaaaggata tgatctaatg ggaatagaca caggttgggg
     6061 acccagcaag gcctgtctgt tcagattatt cttggtctct gtgcagcatt ccttcctcct
     6121 ggatataggg cagggcctgt atgggatggg gatattataa cctgctatca agcaaggtag
     6181 gtcagagaat ttatttatgg ccagctctta catagttagg tgaggaaaga ttagagtact
     6241 atctttaaga tgtaagtctg gcattgtgga aagatggttc cagtttctat gacctacctt
     6301 ggggaagagg aattcaagtt tctgtggctt gccttcaggg agaatgaggc tgagacagga
     6361 gggcaggata acatcagaga aaaactttgc ttctgaggcc ttcactttgg gttttctgag
     6421 ccccaacatc tgctagtgtt gtaaagagaa caattaggga ccaagtgagg ggaggaaaga
     6481 atccatctct gcattctgat gctgggagac ttatttcctt gaaatgcaat tgattttgcc
     6541 tctgctaaga ggctctgctg gctacccatg tactagccag tgtcctgcat gggtgctagg
     6601 ctgaattatt tgtaattgtg cttaggtgat ttgtaactca ggtatagggt atttaaatag
     6661 taggcaccct ttttgcacca tgtgtttttt tttttatcta gttcttgtat actacagata
     6721 atatttgaac tttgtcatct cactgtaaaa cttttgttca tttctcatta tggtaataaa
     6781 tagctattat aaccaaccca tttattcaaa tatgttattt ccctaagtgt tattttgaca
     6841 ttttgttttg gaaaaaataa atcaccatag ataataa
//
