LOCUS       NM_001166               3764 bp    mRNA    linear   PRI 12-JUN-2025
DEFINITION  Homo sapiens baculoviral IAP repeat containing 2 (BIRC2),
            transcript variant 1, mRNA.
ACCESSION   NM_001166
VERSION     NM_001166.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Li,M., Wei,Y., Liu,Y., Wei,J., Zhou,X., Duan,Y., Chen,S., Xue,C.,
            Zhan,Y., Zheng,L., Deng,H., Tang,F., Fan,S., Xiong,W., Li,G.,
            Tan,M. and Zhou,M.
  TITLE     BRD7 inhibits enhancer activity and expression of BIRC2 to suppress
            tumor growth and metastasis in nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 14 (2), 121 (2023)
   PUBMED   36788209
  REMARK    GeneRIF: BRD7 inhibits enhancer activity and expression of BIRC2 to
            suppress tumor growth and metastasis in nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Ciuffa,R., Uliana,F., Mannion,J., Mehnert,M., Tenev,T., Marulli,C.,
            Satanowski,A., Keller,L.M.L., Rodilla Ramirez,P.N., Ori,A.,
            Gstaiger,M., Meier,P. and Aebersold,R.
  TITLE     Novel biochemical, structural, and systems insights into
            inflammatory signaling revealed by contextual interaction
            proteomics
  JOURNAL   Proc Natl Acad Sci U S A 119 (40), e2117175119 (2022)
   PUBMED   36179048
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Lee,M.K., Noh,J.K., Woo,S.R., Kong,M., Lee,Y.C., Lee,J.W., Ko,S.G.
            and Eun,Y.G.
  TITLE     Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Genomics Proteomics 19 (5), 591-605 (2022)
   PUBMED   35985688
  REMARK    GeneRIF: Prognostic Significance of the BIRC2-BIRC3 Gene Signature
            in Head and Neck Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Mo,X., Niu,Q., Ivanov,A.A., Tsang,Y.H., Tang,C., Shu,C., Li,Q.,
            Qian,K., Wahafu,A., Doyle,S.P., Cicka,D., Yang,X., Fan,D.,
            Reyna,M.A., Cooper,L.A.D., Moreno,C.S., Zhou,W., Owonikoko,T.K.,
            Lonial,S., Khuri,F.R., Du,Y., Ramalingam,S.S., Mills,G.B. and Fu,H.
  TITLE     Systematic discovery of mutation-directed neo-protein-protein
            interactions in cancer
  JOURNAL   Cell 185 (11), 1974-1985 (2022)
   PUBMED   35512704
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Zadoroznyj,A. and Dubrez,L.
  TITLE     Cytoplasmic and Nuclear Functions of cIAP1
  JOURNAL   Biomolecules 12 (2), 322 (2022)
   PUBMED   35204822
  REMARK    GeneRIF: Cytoplasmic and Nuclear Functions of cIAP1.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   Warnakulasuriyarachchi,D., Ungureanu,N.H. and Holcik,M.
  TITLE     The translation of an antiapoptotic protein HIAP2 is regulated by
            an upstream open reading frame
  JOURNAL   Cell Death Differ 10 (8), 899-904 (2003)
   PUBMED   12867997
REFERENCE   7  (bases 1 to 3764)
  AUTHORS   Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
  TITLE     Assignment of human inhibitor of apoptosis protein (IAP) genes
            xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 37 (3), 404-406 (1996)
   PUBMED   8938457
REFERENCE   8  (bases 1 to 3764)
  AUTHORS   Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.
  TITLE     Cloning and expression of apoptosis inhibitory protein homologs
            that function to inhibit apoptosis and/or bind tumor necrosis
            factor receptor-associated factors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4974-4978 (1996)
   PUBMED   8643514
REFERENCE   9  (bases 1 to 3764)
  AUTHORS   Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
            Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
            and Korneluk,R.G.
  TITLE     Suppression of apoptosis in mammalian cells by NAIP and a related
            family of IAP genes
  JOURNAL   Nature 379 (6563), 349-353 (1996)
   PUBMED   8552191
REFERENCE   10 (bases 1 to 3764)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000942.6.
            
            On Oct 26, 2020 this sequence version replaced NM_001166.4.
            
            Summary: The protein encoded by this gene is a member of a family
            of proteins that inhibits apoptosis by binding to tumor necrosis
            factor receptor-associated factors TRAF1 and TRAF2, probably by
            interfering with activation of ICE-like proteases. This encoded
            protein inhibits apoptosis induced by serum deprivation and
            menadione, a potent inducer of free radicals. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647978.1, SRR11853565.5812.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227758.7/ ENSP00000227758.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 12867997
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AP000942.6         122558-122720
            164-2315            AP000942.6         123942-126093
            2316-2415           AP000942.6         126188-126287
            2416-2494           AP000942.6         138240-138318
            2495-2543           AP000942.6         139012-139060
            2544-2786           AP000942.6         143650-143892
            2787-3041           AP000942.6         152840-153094
            3042-3083           AP000942.6         153201-153242
            3084-3764           AP000942.6         153334-154014
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..3764
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /note="baculoviral IAP repeat containing 2"
                     /db_xref="GeneID:329"
                     /db_xref="HGNC:HGNC:590"
                     /db_xref="MIM:601712"
     exon            1..163
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            164..2315
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1408..1476
                     /regulatory_class="uORF"
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:12867997]"
                     /note="this uORF is initiated from a CUG start codon and
                     encodes a 22 aa peptide (PMID:12867997)"
     CDS             1421..3277
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NFR2-TRAF signalling complex protein; apoptosis inhibitor
                     1; cellular inhibitor of apoptosis 1; baculoviral IAP
                     repeat-containing protein 2; IAP-2; IAP homolog B;
                     RING-type E3 ubiquitin transferase BIRC2; RING finger
                     protein 48; inhibitor of apoptosis protein 2;
                     TNFR2-TRAF-signaling complex protein 2"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 2
                     isoform 1"
                     /protein_id="NP_001157.1"
                     /db_xref="CCDS:CCDS8316.1"
                     /db_xref="GeneID:329"
                     /db_xref="HGNC:HGNC:590"
                     /db_xref="MIM:601712"
                     /translation="MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFS
                     CELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQK
                     HKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNP
                     LNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRV
                     ACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTF
                     MYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCE
                     FLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMN
                     TPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQA
                     EEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARE
                     LIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQ
                     EERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS"
     exon            2316..2415
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2494
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2543
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2786
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3041
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3083
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3764
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3745..3750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /note="hexamer: AATAAA"
     polyA_site      3764
                     /gene="BIRC2"
                     /gene_synonym="API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB;
                     RNF48"
                     /note="major polyA site"
ORIGIN      
        1 atcgtgcgtc agagtgagcc cggatggggc ggcgggcttc gggagcgccc gggctgatcc
       61 gagccgagcg ggccgtatct ccttgtcggc gccgctgatt cccggctctg cggaggcctc
      121 taggcagccg cgcagcttcc gtgtttgctg cgcccgcact gcgatttaca accctgaaga
      181 atctccctat ccctattttg tccccctgca gtaataaatc ccattatgga gatctcgaaa
      241 ctttataaag ggatatagtt tgaattctat ggagtgtaat tttgtgtatg aattatattt
      301 ttaaaacatt gaagagtttt cagaaagaag gctagtagag ttgattactg atactttatg
      361 ctaagcagta cttttttggt agtacaatat tttgttaggc gtttctgata acactagaaa
      421 ggacaagttt tatcttgtga taaattgatt aatgtttaca acatgactga taattatagc
      481 tgaatagtcc ttaaatgatg aacaggttat ttagttttta aatgcagtgt aaaaagtgtg
      541 ctgtggaaat tttatggcta actaagttta tggagaaaat accttcagtt gatcaagaat
      601 aatagtggta tacaaagtta ggaagaaagt caacatgatg ctgcaggaaa tggaaacaaa
      661 tacaaatgat atttaacaaa gatagagttt acagtttttg aactttaagc caaattcatt
      721 tgacatcaag cactatagca ggcacaggtt caacaaagct tgtgggtatt gacttccccc
      781 aaaagttgtc agctgaagta atttagccca cttaagtaaa tactatgatg ataagctgtg
      841 tgaacttagc ttttaaatag tgtgaccata tgaaggtttt aattactttt gtttattgga
      901 ataaaatgag attttttggg ttgtcatgtt aaagtgctta tagggaaaga agcctgcata
      961 taatttttta ccttgtggca taatcagtaa ttggtctgtt attcaggctt catagcttgt
     1021 aaccaaatat aaataaaagg cataatttag gtattctata gttgcttaga attttgttaa
     1081 tataaatctc tgtgaaaaat caaggagttt taatattttc agaagtgcat ccacctttca
     1141 gggctttaag ttagtattac tcaagattat gaacaaatag cacttaggtt acctgaaaga
     1201 gttactacaa ccccaaagag ttgtgttcta agtagtatct tggtaattca gagagatact
     1261 catcctacct gaatataaac tgagataaat ccagtaaaga aagtgtagta aattctacat
     1321 aagagtctat cattgatttc tttttgtggt aaaaatctta gttcatgtga agaaatttca
     1381 tgtgaatgtt ttagctatca aacagtactg tcacctactc atgcacaaaa ctgcctccca
     1441 aagacttttc ccaggtccct cgtatcaaaa cattaagagt ataatggaag atagcacgat
     1501 cttgtcagat tggacaaaca gcaacaaaca aaaaatgaag tatgactttt cctgtgaact
     1561 ctacagaatg tctacatatt caactttccc cgccggggtg cctgtctcag aaaggagtct
     1621 tgctcgtgct ggtttttatt atactggtgt gaatgacaag gtcaaatgct tctgttgtgg
     1681 cctgatgctg gataactgga aactaggaga cagtcctatt caaaagcata aacagctata
     1741 tcctagctgt agctttattc agaatctggt ttcagctagt ctgggatcca cctctaagaa
     1801 tacgtctcca atgagaaaca gttttgcaca ttcattatct cccaccttgg aacatagtag
     1861 cttgttcagt ggttcttact ccagcctttc tccaaaccct cttaattcta gagcagttga
     1921 agacatctct tcatcgagga ctaaccccta cagttatgca atgagtactg aagaagccag
     1981 atttcttacc taccatatgt ggccattaac ttttttgtca ccatcagaat tggcaagagc
     2041 tggtttttat tatataggac ctggagatag ggtagcctgc tttgcctgtg gtgggaagct
     2101 cagtaactgg gaaccaaagg atgatgctat gtcagaacac cggaggcatt ttcccaactg
     2161 tccatttttg gaaaattctc tagaaactct gaggtttagc atttcaaatc tgagcatgca
     2221 gacacatgca gctcgaatga gaacatttat gtactggcca tctagtgttc cagttcagcc
     2281 tgagcagctt gcaagtgctg gtttttatta tgtgggtcgc aatgatgatg tcaaatgctt
     2341 ttgttgtgat ggtggcttga ggtgttggga atctggagat gatccatggg tagaacatgc
     2401 caagtggttt ccaaggtgtg agttcttgat acgaatgaaa ggccaagagt ttgttgatga
     2461 gattcaaggt agatatcctc atcttcttga acagctgttg tcaacttcag ataccactgg
     2521 agaagaaaat gctgacccac caattattca ttttggacct ggagaaagtt cttcagaaga
     2581 tgctgtcatg atgaatacac ctgtggttaa atctgccttg gaaatgggct ttaatagaga
     2641 cctggtgaaa caaacagttc aaagtaaaat cctgacaact ggagagaact ataaaacagt
     2701 taatgatatt gtgtcagcac ttcttaatgc tgaagatgaa aaaagagaag aggagaagga
     2761 aaaacaagct gaagaaatgg catcagatga tttgtcatta attcggaaga acagaatggc
     2821 tctctttcaa caattgacat gtgtgcttcc tatcctggat aatcttttaa aggccaatgt
     2881 aattaataaa caggaacatg atattattaa acaaaaaaca cagatacctt tacaagcgag
     2941 agaactgatt gataccattt tggttaaagg aaatgctgcg gccaacatct tcaaaaactg
     3001 tctaaaagaa attgactcta cattgtataa gaacttattt gtggataaga atatgaagta
     3061 tattccaaca gaagatgttt caggtctgtc actggaagaa caattgagga ggttgcaaga
     3121 agaacgaact tgtaaagtgt gtatggacaa agaagtttct gttgtattta ttccttgtgg
     3181 tcatctggta gtatgccagg aatgtgcccc ttctctaaga aaatgcccta tttgcagggg
     3241 tataatcaag ggtactgttc gtacatttct ctcttaaaga aaaatagtct atattttaac
     3301 ctgcataaaa aggtctttaa aatattgttg aacacttgaa gccatctaaa gtaaaaaggg
     3361 aattatgagt ttttcaatta gtaacattca tgttctagtc tgctttggta ctaataatct
     3421 tgtttctgaa aagatggtat catatattta atcttaatct gtttatttac aagggaagat
     3481 ttatgtttgg tgaactatat tagtatgtat gtgtacctaa gggagtagtg tcactgcttg
     3541 ttatgcatca tttcaggagt tactggattt gttgttcttt cagaaagctt tgaatactaa
     3601 attatagtgt agaaaagaac tggaaaccag gaactctgga gttcatcaga gttatggtgc
     3661 cgaattgtct ttggtgcttt tcacttgtgt tttaaaataa ggatttttct cttatttctc
     3721 cccctagttt gtgagaaaca tctcaataaa gtgctttaaa aaga
//
