LOCUS       NM_018688               1836 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens bridging integrator 3 (BIN3), transcript variant 1,
            mRNA.
ACCESSION   NM_018688
VERSION     NM_018688.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Thalappilly,S., Suliman,M., Gayet,O., Soubeyran,P., Hermant,A.,
            Lecine,P., Iovanna,J.L. and Dusetti,N.J.
  TITLE     Identification of multi-SH3 domain-containing protein interactome
            in pancreatic cancer: a yeast two-hybrid approach
  JOURNAL   Proteomics 8 (15), 3071-3081 (2008)
   PUBMED   18654987
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Ren,G., Vajjhala,P., Lee,J.S., Winsor,B. and Munn,A.L.
  TITLE     The BAR domain proteins: molding membranes in fission, fusion, and
            phagy
  JOURNAL   Microbiol Mol Biol Rev 70 (1), 37-120 (2006)
   PUBMED   16524918
  REMARK    Review article
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Habermann,B.
  TITLE     The BAR-domain family of proteins: a case of bending and binding?
  JOURNAL   EMBO Rep 5 (3), 250-255 (2004)
   PUBMED   14993925
  REMARK    Review article
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Routhier,E.L., Burn,T.C., Abbaszade,I., Summers,M., Albright,C.F.
            and Prendergast,G.C.
  TITLE     Human BIN3 complements the F-actin localization defects caused by
            loss of Hob3p, the fission yeast homolog of Rvs161p
  JOURNAL   J Biol Chem 276 (24), 21670-21677 (2001)
   PUBMED   11274158
  REMARK    GeneRIF: BIN3 is a BAR domain adapter protein implicated in actin
            regulation; it is homologous to budding yeast Rvs161 and fission
            yeast Hob3.
            GeneRIF: like RVS161, hob3+ and BIN3 regulate F-actin localization,
            but other roles for these genes have diverged somewhat during
            evolution
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA480525.1, AC105046.10,
            BC009824.2, BM670487.1 and AC037459.16.
            
            On May 17, 2019 this sequence version replaced NM_018688.5.
            
            Summary: The product of this gene is a member of the BAR domain
            protein family. The encoded protein is comprised solely of a BAR
            domain which is predicted to form coiled-coil structures and
            proposed to mediate dimerization, sense and induce membrane
            curvature, and bind small GTPases. BAR domain proteins have been
            implicated in endocytosis, intracellular transport, and a diverse
            set of other processes. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.81939.1, BC009824.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276416.11/ ENSP00000276416.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                DA480525.1         28-102
            76-76               AC105046.10        56907-56907
            77-1541             BC009824.2         38-1502
            1542-1543           BM670487.1         18-19               c
            1544-1836           AC037459.16        141220-141512       c
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1836
                     /gene="BIN3"
                     /note="bridging integrator 3"
                     /db_xref="GeneID:55909"
                     /db_xref="HGNC:HGNC:1054"
                     /db_xref="MIM:606396"
     exon            1..78
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..832
                     /gene="BIN3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="bridging integrator 3 isoform 1"
                     /protein_id="NP_061158.1"
                     /db_xref="CCDS:CCDS47825.1"
                     /db_xref="GeneID:55909"
                     /db_xref="HGNC:HGNC:1054"
                     /db_xref="MIM:606396"
                     /translation="MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTRRLQKD
                     MKKSTDADLAMSKSAVKISLDLLSNPLCEQDQDLLNMVTALDTAMKRMDAFNQEKVNQ
                     IQKTVIEPLKKFGSVFPSLNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQ
                     AREELRPVREDFEAKNRQLLEEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGD
                     LSHQLDQPGHSDEQRERENEAKLSELRALSIVADD"
     exon            79..127
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            128..168
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..230
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..367
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..408
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..550
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..685
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1836
                     /gene="BIN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1519..1524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIN3"
                     /note="hexamer: AGTAAA"
     polyA_site      1541
                     /gene="BIN3"
                     /note="major polyA site"
ORIGIN      
        1 gaatccggaa gtgaccctag agaaacgagt tgtggctgag gaccccggcg gcagacgcag
       61 gttcgggacc atgagctgga ttccttttaa gattgggcag cccaagaaac agattgtgcc
      121 caaaacagtg gagagagact ttgaaaggga gtatggaaaa cttcagcagc tggaagagca
      181 gacccggagg ctgcagaaag acatgaagaa gagcaccgac gcagacctgg ccatgtcaaa
      241 atctgccgtg aagatatcct tggacttact ctccaatccc ctctgtgagc aagaccagga
      301 ccttctgaac atggtgacgg ccctggacac ggccatgaag cggatggatg ccttcaatca
      361 ggaaaaggtg aaccagatcc agaagactgt gatcgagccc ttaaaaaagt tcggcagtgt
      421 cttcccgagc ctcaacatgg ctgtgaagag gcgggaacag gccttgcagg actacaggag
      481 gctgcaggcc aaggtggaga agtatgagga aaaggagaag acggggccag tgctggccaa
      541 gctccaccag gcacgagagg agctgcggcc tgtgcgggag gactttgaag ccaagaacag
      601 gcagctgctg gaggagatgc cgcgcttcta cggcagccgc ctcgactact tccagcccag
      661 ctttgagtcc ctcatccgag ctcaggttgt gtactactcg gaaatgcaca agatctttgg
      721 agacctgtcc catcagcttg accagccagg ccactccgat gagcagcggg agcgggagaa
      781 cgaggccaaa ctcagtgagc tccgggccct ctccattgtg gccgatgact gaatccccgt
      841 cactcttgga ggactcctgt gacgtggtca gcctcattca tccttgccct tctcagggct
      901 agctgctcct ctcacaggct ggggacagag gtggccctgg ttcacttgcc ggccctttgc
      961 aatgaatgac tcttcctgag cctggcacca ggagccctag gcaggccgcc gtctccccac
     1021 tcacagcccc agcaggtaag cagtgtagac aaacccttgg ggctttttta tttggagaac
     1081 cgtccagcat gcatcctggc ccacggcctg agcaagctgc agcccttctg aggccatggg
     1141 cttcgttggc taagttgggg gtcttagcct tgcatgcgtt gtgggcatca aatctacctc
     1201 caaaagaccc atcctgggga gccctctggc ccctcgttgc cttttcactt caaaacctct
     1261 tttttctggg agaggccctg aaccctgtgc gggagagctg gtcctccagc cctggcaggc
     1321 cctcagccag cttcccagca agacaaaggg cacccttgtg gctttgggac ctaagtggtt
     1381 ggggttcccg aggtcactga ggactggtac ctcgggaacg caagctgtca gtggaactgt
     1441 cccacaagaa ttcacaggtc tcaaagcagg aacagtgggt ttgtgtctca cctgagtatc
     1501 tggaatttta ttttttcaag taaaattttc aatgaaacgt ccacatagta ttgtgctgta
     1561 acttaggcga gcagaggaaa ccccttcctg ggcctgctgc cctccacgga gcagcagcac
     1621 cctccagcag gcagcccagc atgccagggg tgtgtgcgca cctccccggc cctggcccac
     1681 cttctggagc gaactgcacc gtggtccagc agaggcgctg ggtgggaggg cacgcgggca
     1741 agcctaggag agtaggaaga gctgtggagg acacactctc agtttgtttt tgactttggt
     1801 ttatttaaaa aacaagccaa aaaaaaaaaa aaaaaa
//
