LOCUS       NM_016293               2231 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens bridging integrator 2 (BIN2), transcript variant 1,
            mRNA.
ACCESSION   NM_016293 NM_016187
VERSION     NM_016293.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Schindler,K.
  TITLE     Inhibition of BIN2 extends reproductive lifespan
  JOURNAL   Nat Aging 1 (11), 977-979 (2021)
   PUBMED   37118339
  REMARK    GeneRIF: Inhibition of BIN2 extends reproductive lifespan.
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Sanchez-Barrena,M.J., Vallis,Y., Clatworthy,M.R., Doherty,G.J.,
            Veprintsev,D.B., Evans,P.R. and McMahon,H.T.
  TITLE     Bin2 is a membrane sculpting N-BAR protein that influences
            leucocyte podosomes, motility and phagocytosis
  JOURNAL   PLoS One 7 (12), e52401 (2012)
   PUBMED   23285027
  REMARK    GeneRIF: Bin2 is a membrane-sculpting protein that influences
            podosome formation, motility and phagocytosis in leucocytes.
            Erratum:[PLoS One. 2013;8(8).
            doi:10.1371/annotation/3bdc487b-5e25-4cd7-a354-b2952eec943d]
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Janson,C., Kasahara,N., Prendergast,G.C. and Colicelli,J.
  TITLE     RIN3 is a negative regulator of mast cell responses to SCF
  JOURNAL   PLoS One 7 (11), e49615 (2012)
   PUBMED   23185384
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Walter,S., Atzmon,G., Demerath,E.W., Garcia,M.E., Kaplan,R.C.,
            Kumari,M., Lunetta,K.L., Milaneschi,Y., Tanaka,T., Tranah,G.J.,
            Volker,U., Yu,L., Arnold,A., Benjamin,E.J., Biffar,R.,
            Buchman,A.S., Boerwinkle,E., Couper,D., De Jager,P.L., Evans,D.A.,
            Harris,T.B., Hoffmann,W., Hofman,A., Karasik,D., Kiel,D.P.,
            Kocher,T., Kuningas,M., Launer,L.J., Lohman,K.K., Lutsey,P.L.,
            Mackenbach,J., Marciante,K., Psaty,B.M., Reiman,E.M., Rotter,J.I.,
            Seshadri,S., Shardell,M.D., Smith,A.V., van Duijn,C., Walston,J.,
            Zillikens,M.C., Bandinelli,S., Baumeister,S.E., Bennett,D.A.,
            Ferrucci,L., Gudnason,V., Kivimaki,M., Liu,Y., Murabito,J.M.,
            Newman,A.B., Tiemeier,H. and Franceschini,N.
  TITLE     A genome-wide association study of aging
  JOURNAL   Neurobiol Aging 32 (11), 2109 (2011)
   PUBMED   21782286
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Ge,K. and Prendergast,G.C.
  TITLE     Bin2, a functionally nonredundant member of the BAR adaptor gene
            family
  JOURNAL   Genomics 67 (2), 210-220 (2000)
   PUBMED   10903846
  REMARK    GeneRIF: Bin2 is a BAR domain adapter protein structurally related
            but functionally distinct from family members Bin1 and amphiphysin.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB035315.1, AF146531.1, AB032698.1 and BX281612.1.
            
            On Jul 8, 2018 this sequence version replaced NM_016293.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047686.1, SRR1163657.223207.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615107.6/ ENSP00000483983.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DB035315.1         25-85
            62-563              AF146531.1         1-502
            564-1656            AB032698.1         530-1622
            1657-2068           BX281612.1         71-482
            2069-2231           AB032698.1         2035-2197
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2231
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /note="bridging integrator 2"
                     /db_xref="GeneID:51411"
                     /db_xref="HGNC:HGNC:1053"
                     /db_xref="MIM:605936"
     exon            1..153
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1770
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer associated protein BRAP1; breast
                     cancer-associated protein 1"
                     /codon_start=1
                     /product="bridging integrator 2 isoform 1"
                     /protein_id="NP_057377.4"
                     /db_xref="CCDS:CCDS8811.3"
                     /db_xref="GeneID:51411"
                     /db_xref="HGNC:HGNC:1053"
                     /db_xref="MIM:605936"
                     /translation="MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFE
                     QSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAI
                     VWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQ
                     NAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRD
                     VFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLT
                     SPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEED
                     EPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTR
                     TASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRA
                     SLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVAS
                     EPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL"
     exon            154..234
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..289
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..384
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..480
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..588
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..674
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..750
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..833
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1587
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1668
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1740
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2231
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2231
                     /gene="BIN2"
                     /gene_synonym="BRAP-1"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcct cgggggcctc agaaaaccac agggcgcggg gccagggcgg cggcccccag
       61 ggagttggca ggatggcaga gggcaaggca ggcggcgcgg ccggcctctt cgccaagcag
      121 gtgcagaaga agtttagcag ggcccaggag aaggtgctgc agaaattggg gaaagctgta
      181 gaaaccaaag atgaacgatt tgaacaaagc gctagcaact tctaccaaca acaggcagaa
      241 ggccacaagc tgtacaagga cctgaagaac ttccttagtg cagtcaaagt gatgcatgaa
      301 agttcaaaaa gagtgtcaga aaccctgcag gagatctaca gcagcgagtg ggacggtcat
      361 gaggagctga aggccatcgt atggaataat gatctccttt gggaagacta cgaggagaaa
      421 ctggctgacc aggctgtaag gaccatggaa atctatgttg cccagttcag tgaaattaag
      481 gagagaattg ccaagcgggg tcggaaactc gtggactatg acagtgcccg acaccacctg
      541 gaggcagtgc agaatgccaa gaagaaagat gaggccaaga ctgccaaggc agaggaagag
      601 ttcaacaaag cccagactgt gtttgaagat ctgaaccaag aactactaga ggagctgcct
      661 attctttata atagtcgtat tggctgctat gtgaccatct tccaaaacat ttccaacttg
      721 agggatgtct tctacaggga aatgagcaag ctgaaccaca atctctacga ggtgatgagc
      781 aaactggaga agcaacattc caataaagtc tttgtggtga agggactgtc aagcagcagc
      841 aggcgctctt tagtcatttc tcccccagtt cgaacagcta cagtctccag tcctcttacc
      901 tcacctacta gtccctctac actttccttg aagagtgaga gtgaatctgt ctcagcaact
      961 gaagatctgg cacctgatgc agcccaaggg gaagacaatt ctgagatcaa ggagctctta
     1021 gaagaggagg aaatagagaa ggaaggatct gaagcaagct cctctgagga agatgagcct
     1081 ctaccagcct gcaatggccc cgcccaggcc cagccctctc ctaccactga aagggccaag
     1141 tcccaggagg aagttctccc cagctccaca actccatcac caggcggagc cctgagccct
     1201 tcagggcagc cttcatcatc tgccacagaa gtagtcctcc gaacccgcac cgcaagtgaa
     1261 ggatctgaac aaccaaagaa gagagcctct atccagagga cctcagcacc ccctagtagg
     1321 cctcctccac ccagagccac tgcaagcccc aggccctcct cagggaacat accttccagc
     1381 cctacagcct ctggaggggg ttcacccacc agccctaggg cctccttggg gactgggact
     1441 gcaagtccta ggacctccct agaggtctct cctaatccag aaccaccaga gaagccagta
     1501 agaactcctg aggccaaaga aaatgaaaac atccacaatc agaaccctga agaactttgt
     1561 acttccccca ccttaatgac atctcaggtt gcttcagagc ctggagaggc aaagaagatg
     1621 gaagacaagg aaaaggataa taagcttatc tcagctaact cctcggaggg ccaagaccag
     1681 cttcaagtct ccatggtacc agaaaacaac aacctcacag cacctgaacc tcaagaagag
     1741 gtatccacaa gtgaaaatcc acaactctga agagaaacta ccaagactcc tcctgcccca
     1801 aacctcgcca gagaagctct tcaaccagag ggtataggtc agagggatat aagagccagc
     1861 atccatccct gggttctcag taggaatgct ggtgctgtct aaagacctgg cattaatgga
     1921 ggcggaggag cagccttacg ggagggatgg agggaggcag gctggggaga agagaacatt
     1981 agactcaggg aatatttaat tctggtttta gcattattag aataagactt tatacattaa
     2041 ctaaagtgga gctttaatca ctataaaaag caaaagtatc tatagacaca gacacttgcc
     2101 tatacagaga cataaccaca cacactcaga ggatagtgaa caaatctgtc tttgacttac
     2161 gacccatttt gcaagactta aagccggaag aacacatttt cagattgtta aataaagtct
     2221 gattctgact a
//
