LOCUS       NM_001197                951 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens BCL2 interacting killer (BIK), mRNA.
ACCESSION   NM_001197
VERSION     NM_001197.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Xu,Z.Y., Li,X., Yao,R.H., Yang,L.M., Peng,H., Ren,W.J., Lu,H. and
            Wang,P.
  TITLE     Rhomboid domain containing 1 promotes the growth of non-small cell
            lung cancer through the activation of EGFR and regulation of the
            BIK-mediated apoptosis
  JOURNAL   Neoplasma 69 (2), 311-320 (2022)
   PUBMED   34962825
  REMARK    GeneRIF: Rhomboid domain containing 1 promotes the growth of
            non-small cell lung cancer through the activation of EGFR and
            regulation of the BIK-mediated apoptosis.
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Taniue,K., Tanu,T., Shimoura,Y., Mitsutomi,S., Han,H., Kakisaka,R.,
            Ono,Y., Tamamura,N., Takahashi,K., Wada,Y., Mizukami,Y. and
            Akimitsu,N.
  TITLE     RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is
            Required for the Cancer Cell Survival
  JOURNAL   Int J Mol Sci 23 (1), 496 (2022)
   PUBMED   35008922
  REMARK    GeneRIF: RNA Exosome Component EXOSC4 Amplified in Multiple Cancer
            Types Is Required for the Cancer Cell Survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 951)
  AUTHORS   Lopez-Munoz,E., Corres-Molina,M. and Garcia-Hernandez,N.
  TITLE     Correlation of the protein expression of GRP78 and BIK/NBK with
            prognostic markers in patients with breast cancer and neoadjuvant
            chemotherapy
  JOURNAL   J Obstet Gynaecol 40 (3), 419-426 (2020)
   PUBMED   31635499
  REMARK    GeneRIF: Correlation of the protein expression of GRP78 and BIK/NBK
            with prognostic markers in patients with breast cancer and
            neoadjuvant chemotherapy.
REFERENCE   6  (bases 1 to 951)
  AUTHORS   Huang,D.C., Adams,J.M. and Cory,S.
  TITLE     The conserved N-terminal BH4 domain of Bcl-2 homologues is
            essential for inhibition of apoptosis and interaction with CED-4
  JOURNAL   EMBO J 17 (4), 1029-1039 (1998)
   PUBMED   9463381
REFERENCE   7  (bases 1 to 951)
  AUTHORS   Chinnaiyan,A.M., O'Rourke,K., Lane,B.R. and Dixit,V.M.
  TITLE     Interaction of CED-4 with CED-3 and CED-9: a molecular framework
            for cell death
  JOURNAL   Science 275 (5303), 1122-1126 (1997)
   PUBMED   9027312
REFERENCE   8  (bases 1 to 951)
  AUTHORS   Han,J., Sabbatini,P. and White,E.
  TITLE     Induction of apoptosis by human Nbk/Bik, a BH3-containing protein
            that interacts with E1B 19K
  JOURNAL   Mol Cell Biol 16 (10), 5857-5864 (1996)
   PUBMED   8816500
REFERENCE   9  (bases 1 to 951)
  AUTHORS   Chittenden,T., Flemington,C., Houghton,A.B., Ebb,R.G., Gallo,G.J.,
            Elangovan,B., Chinnadurai,G. and Lutz,R.J.
  TITLE     A conserved domain in Bak, distinct from BH1 and BH2, mediates cell
            death and protein binding functions
  JOURNAL   EMBO J 14 (22), 5589-5596 (1995)
   PUBMED   8521816
REFERENCE   10 (bases 1 to 951)
  AUTHORS   Boyd,J.M., Gallo,G.J., Elangovan,B., Houghton,A.B., Malstrom,S.,
            Avery,B.J., Ebb,R.G., Subramanian,T., Chittenden,T., Lutz,R.J. et
            al.
  TITLE     Bik, a novel death-inducing protein shares a distinct sequence
            motif with Bcl-2 family proteins and interacts with viral and
            cellular survival-promoting proteins
  JOURNAL   Oncogene 11 (9), 1921-1928 (1995)
   PUBMED   7478623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP329261.1, BC001599.1 and
            U34584.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001197.4.
            
            Summary: The protein encoded by this gene shares a critical BH3
            domain with other death-promoting proteins, such as BID, BAK, BAD
            and BAX, that is required for its pro-apoptotic activity, and for
            interaction with anti-apoptotic members of the BCL2 family, and
            viral survival-promoting proteins. Since the activity of this
            protein is suppressed in the presence of survival-promoting
            proteins, it is suggested as a likely target for anti-apoptotic
            proteins. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.81286.1,
                                           SRR1163657.62147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216115.3/ ENSP00000216115.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP329261.1         3-20
            19-948              BC001599.1         1-930
            949-951             U34584.1           908-910
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..951
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /note="BCL2 interacting killer"
                     /db_xref="GeneID:638"
                     /db_xref="HGNC:HGNC:1051"
                     /db_xref="MIM:603392"
     exon            1..54
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /inference="alignment:Splign:2.1.0"
     exon            55..222
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..544
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /note="apoptosis-inducing NBK; apoptosis inducer NBK;
                     BCL2-interacting killer (apoptosis-inducing); natural born
                     killer"
                     /codon_start=1
                     /product="bcl-2-interacting killer"
                     /protein_id="NP_001188.1"
                     /db_xref="CCDS:CCDS14044.1"
                     /db_xref="GeneID:638"
                     /db_xref="HGNC:HGNC:1051"
                     /db_xref="MIM:603392"
                     /translation="MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMED
                     FDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSLGLAFIYDQTEDIRD
                     VLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK
                     "
     exon            223..321
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /inference="alignment:Splign:2.1.0"
     exon            322..451
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /inference="alignment:Splign:2.1.0"
     exon            452..951
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      930..935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /note="hexamer: AATAAA"
     polyA_site      951
                     /gene="BIK"
                     /gene_synonym="BIP1; BP4; NBK"
                     /note="major polyA site"
ORIGIN      
        1 agacacgaag cctcccgggt ggcttacaga cgctgccagc atcgccgccg ccagaggaga
       61 aatgtctgaa gtaagacccc tctccagaga catcttgatg gagaccctcc tgtatgagca
      121 gctcctggaa cccccgacca tggaggttct tggcatgact gactctgaag aggacctgga
      181 ccctatggag gacttcgatt ctttggaatg catggagggc agtgacgcat tggccctgcg
      241 gctggcctgc atcggggacg agatggacgt gagcctcagg gccccgcgcc tggcccagct
      301 ctccgaggtg gccatgcaca gcctgggtct ggctttcatc tacgaccaga ctgaggacat
      361 cagggatgtt cttagaagtt tcatggacgg tttcaccaca cttaaggaga acataatgag
      421 gttctggaga tccccgaacc ccgggtcctg ggtgtcctgc gaacaggtgc tgctggcgct
      481 gctgctgctg ctggcgctgc tgctgccgct gctcagcggg ggcctgcacc tgctgctcaa
      541 gtgaggcccc ggcggctcag ggcggggctg gccccacccc catgaccact gccctggagg
      601 tggcggcctg ctgctgttat ctttttaact gttttctcat gatgcctttt tatatttaaa
      661 ccccgagata gtgctggaac actgctgagg ttttatactc aggttttttg tttttttttt
      721 attccagttt tcgttttttc taaaagatga attcctatgg ctctgcaatt gtcaccggtt
      781 aactgtggcc tgtgcccagg aagagccatt cactcctgcc cctgcccaca cggcaggtag
      841 cagggggagt gctggtcaca cccctgtgtg atatgtgatg ccctcggcaa agaatctact
      901 ggaatagatt ccgaggagca ggagtgctca ataaaatgtt ggtttccagc a
//
