LOCUS       NM_001196               2177 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BH3 interacting domain death agonist (BID), transcript
            variant 2, mRNA.
ACCESSION   NM_001196
VERSION     NM_001196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Voinsky,I., Goldenberg-Bogner,O., Israel-Elgali,I., Volkov,H.,
            Puzianowska-Kuznicka,M., Shomron,N. and Gurwitz,D.
  TITLE     RNA sequencing comparing centenarian and middle-aged women
            lymphoblastoid cell lines identifies age-related dysregulated
            expression of genes encoding selenoproteins, heat shock proteins,
            CD99, and BID
  JOURNAL   Drug Dev Res 85 (7), e70011 (2024)
   PUBMED   39445501
  REMARK    GeneRIF: RNA sequencing comparing centenarian and middle-aged women
            lymphoblastoid cell lines identifies age-related dysregulated
            expression of genes encoding selenoproteins, heat shock proteins,
            CD99, and BID.
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Bertran-Alamillo,J., Gimenez-Capitan,A., Roman,R., Talbot,S.,
            Whiteley,R., Floc'h,N., Martinez-Perez,E., Martin,M.J., Smith,P.D.,
            Sullivan,I., Terp,M.G., Saeh,J., Marino-Buslje,C., Fabbri,G.,
            Guo,G., Xu,M., Tornador,C., Aguilar-Hernandez,A., Reguart,N.,
            Ditzel,H.J., Martinez-Bueno,A., Nabau-Moreto,N., Gasco,A.,
            Rosell,R., Pease,J.E., Polanska,U.M., Travers,J., Urosevic,J. and
            Molina-Vila,M.A.
  TITLE     BID expression determines the apoptotic fate of cancer cells after
            abrogation of the spindle assembly checkpoint by AURKB or TTK
            inhibitors
  JOURNAL   Mol Cancer 22 (1), 110 (2023)
   PUBMED   37443114
  REMARK    GeneRIF: BID expression determines the apoptotic fate of cancer
            cells after abrogation of the spindle assembly checkpoint by AURKB
            or TTK inhibitors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Flores-Romero,H., Hohorst,L., John,M., Albert,M.C., King,L.E.,
            Beckmann,L., Szabo,T., Hertlein,V., Luo,X., Villunger,A.,
            Frenzel,L.P., Kashkar,H. and Garcia-Saez,A.J.
  TITLE     BCL-2-family protein tBID can act as a BAX-like effector of
            apoptosis
  JOURNAL   EMBO J 41 (2), e108690 (2022)
   PUBMED   34931711
  REMARK    GeneRIF: BCL-2-family protein tBID can act as a BAX-like effector
            of apoptosis.
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Vasconcelos,J.C., Siqueira,I.B., Maia,F.F.R., Parisi,M.C.R. and
            Zantut-Wittmann,D.E.
  TITLE     Influence of thyroid hormone in the expression of the marker
            pro-apoptosis BID, in spite of the predominance of anti-apoptosis
            activation in intratiroidal lymphocytic infiltration in Hashimoto's
            thyroiditis
  JOURNAL   Mol Cell Endocrinol 537, 111421 (2021)
   PUBMED   34389447
  REMARK    GeneRIF: Influence of thyroid hormone in the expression of the
            marker pro-apoptosis BID, in spite of the predominance of
            anti-apoptosis activation in intratiroidal lymphocytic infiltration
            in Hashimoto's thyroiditis.
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Footz,T.K., Birren,B., Minoshima,S., Asakawa,S., Shimizu,N.,
            Riazi,M.A. and McDermid,H.E.
  TITLE     The gene for death agonist BID maps to the region of human 22q11.2
            duplicated in cat eye syndrome chromosomes and to mouse chromosome
            6
  JOURNAL   Genomics 51 (3), 472-475 (1998)
   PUBMED   9721221
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Huang,D.C., Adams,J.M. and Cory,S.
  TITLE     The conserved N-terminal BH4 domain of Bcl-2 homologues is
            essential for inhibition of apoptosis and interaction with CED-4
  JOURNAL   EMBO J 17 (4), 1029-1039 (1998)
   PUBMED   9463381
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J.
  TITLE     BID: a novel BH3 domain-only death agonist
  JOURNAL   Genes Dev 10 (22), 2859-2869 (1996)
   PUBMED   8918887
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Amagai,M., Wang,Y., Minoshima,S., Kawamura,K., Green,K.J.,
            Nishikawa,T. and Shimizu,N.
  TITLE     Assignment of the human genes for desmocollin 3 (DSC3) and
            desmocollin 4 (DSC4) to chromosome 18q12
  JOURNAL   Genomics 25 (1), 330-332 (1995)
   PUBMED   7774948
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Kawamura,K., Watanabe,K., Suzuki,T., Yamakawa,T., Kamiyama,T.,
            Nakagawa,H. and Tsurufuji,S.
  TITLE     cDNA cloning and expression of a novel human desmocollin
  JOURNAL   J Biol Chem 269 (42), 26295-26302 (1994)
   PUBMED   7929347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM561391.1, AK094795.1,
            AC006285.13 and BC036364.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001196.3.
            
            Summary: This gene encodes a death agonist that heterodimerizes
            with either agonist BAX or antagonist BCL2, and thus regulate
            apoptosis. The encoded protein is a member of the BCL-2 family of
            cell death regulators. It is a mediator of mitochondrial damage
            induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein,
            and the COOH-terminal part translocates to mitochondria where it
            triggers cytochrome c release. Multiple alternatively spliced
            transcript variants have been found. [provided by RefSeq, Aug
            2020].
            
            Transcript Variant: This variant (2) has an alternate 5' exon and
            uses a downstream in-frame start codon, as compared to variant 1.
            The encoded isoform 2 thus has a shorter N-terminus, as compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.123203.1,
                                           SRR1803613.189339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622694.5/ ENSP00000480414.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               BM561391.1         38-784
            748-795             AK094795.1         1033-1080
            796-796             AC006285.13        123432-123432       c
            797-2151            AK094795.1         1082-2436
            2152-2152           AC006285.13        122076-122076       c
            2153-2173           AK094795.1         2438-2458
            2174-2175           BC036364.1         2495-2496
            2176-2177           AC006285.13        122051-122052       c
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..2177
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="BH3 interacting domain death agonist"
                     /db_xref="GeneID:637"
                     /db_xref="HGNC:HGNC:1050"
                     /db_xref="MIM:601997"
     exon            1..89
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     exon            90..159
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..735
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="isoform 2 is encoded by transcript variant 2;
                     apoptic death agonist; Human BID coding sequence;
                     desmocollin type 4; p22 BID"
                     /codon_start=1
                     /product="BH3-interacting domain death agonist isoform 2"
                     /protein_id="NP_001187.1"
                     /db_xref="CCDS:CCDS13748.1"
                     /db_xref="GeneID:637"
                     /db_xref="HGNC:HGNC:1050"
                     /db_xref="MIM:601997"
                     /translation="MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHEL
                     PVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
                     PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVA
                     SHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD"
     exon            160..370
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     exon            371..510
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     exon            511..723
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     exon            724..2177
                     /gene="BID"
                     /gene_synonym="FP497"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="hexamer: AATATA"
     polyA_site      941
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="major polyA site"
     regulatory      1049..1054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="hexamer: ATTAAA"
     polyA_site      1076
                     /gene="BID"
                     /gene_synonym="FP497"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BID"
                     /gene_synonym="FP497"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="BID"
                     /gene_synonym="FP497"
ORIGIN      
        1 aaggaggaag cgggtagtcg accgtgtccg cgcgcctggg agacgctgcc tcggcccgga
       61 cgcgcccgcg cccccgcggc tggagggtgg tcgccactgg gacactgtga accaggagtg
      121 agtcggagct gccgcgctgc ccaggccatg gactgtgagg tcaacaacgg ttccagcctc
      181 agggatgagt gcatcacaaa cctactggtg tttggcttcc tccaaagctg ttctgacaac
      241 agcttccgca gagagctgga cgcactgggc cacgagctgc cagtgctggc tccccagtgg
      301 gagggctacg atgagctgca gactgatggc aaccgcagca gccactcccg cttgggaaga
      361 atagaggcag attctgaaag tcaagaagac atcatccgga atattgccag gcacctcgcc
      421 caggtcgggg acagcatgga ccgtagcatc cctccgggcc tggtgaacgg cctggccctg
      481 cagctcagga acaccagccg gtcggaggag gaccggaaca gggacctggc cactgccctg
      541 gagcagctgc tgcaggccta ccctagagac atggagaagg agaagaccat gctggtgctg
      601 gccctgctgc tggccaagaa ggtggccagt cacacgccgt ccttgctccg tgatgtcttt
      661 cacacaacag tgaattttat taaccagaac ctacgcacct acgtgaggag cttagccaga
      721 aatgggatgg actgaacgga cagttccaga agtgtgactg gctaaagctc gatgtggtca
      781 cagctgtata gctgcttcca gtgtagacgg agccctggca tgtcaacagc gttcctagag
      841 aagacaggct ggaagatagc tgtgacttct attttaaaga caatgttaaa cttataaccc
      901 actttaaaat atctacatta atatacttga atgaaaatgt ccatttacac gtatttgaat
      961 ggccttcata tcatccacac atgaatctgc acatctgtaa atctacacac ggtgccttta
     1021 tttccactgt gcaggttccc acttaaaaat taaattggaa agcaggtttc aaggaagtag
     1081 aaacaaaata caattttttt ggtaaaaaaa aattactgtt tattaaagta caaccataga
     1141 ggatggtctt acagcaggca gtatcctgtt tgaggaaagc aagaatcaga gaaggaacat
     1201 accccttaca aatgaaaaat tccactcaaa atagggacta tctatcttaa tactaaggaa
     1261 ccaacaatct tcctgtttaa aaaaccacat ggcacagaga ttctgaacta aagtgctgca
     1321 ctcaaatgat gggaagtccg gccccagtac acaggggctt gactttttca acttcgtttc
     1381 ctttgttgga gtcaaaaaga accacttgtg gttctaaaag gtgtgaaggt gatttaaggg
     1441 cccaggtcag ccactgtttg tttacaaaat caggtaacta actgcataca ctttttctct
     1501 ttccatgaca tcaagacttt gctaaagaca tgaagccacg ggtgccagaa gctactgcga
     1561 tgccccggga gttagccccc tggtaatagc tgtaaacttc caatttctag ccatacgctc
     1621 agctcatcca tgcctcagaa gtgcatctgg agagaacagg tttctaagca taaaagatga
     1681 aagagcagtt ggacttttta aaaattcagc aaagtggttc cctctcttag ggacagtcaa
     1741 aaccaagtca cttaggtagt accaaaataa ataaggaaaa gcttagcttt agaaacagtg
     1801 caacactggt ctgctgttcc agtggtaagc tatgtcccag gaatcagttt aaaagcacga
     1861 cagtggatgc tgggtccata tcacacacat tgctgtgaac aggaaactcc tgtgaccaca
     1921 acatgaggcc actggagacg catatgagta agggcactga cggactcatg atttcttctt
     1981 accagatgct ttcctgttct ttaagagttt aaaatcatca gaaaggaaaa acaaactcta
     2041 tattgttcag catgcaatac ataccacgct agggctggct caattgaaag tgggcaaaag
     2101 cttacaaata ctaaaaagaa gtgctgccgc gcagtgtgga ggccactgtt tggaaataaa
     2161 tcttcctaac actacga
//
