LOCUS       NM_001369667            2032 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BICD family like cargo adaptor 2 (BICDL2), transcript
            variant 1, mRNA.
ACCESSION   NM_001369667
VERSION     NM_001369667.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108134.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279876.664.1, DRR138512.3298.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000572449.6/ ENSP00000459043.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC108134.3         48418-48468         c
            52-363              AC108134.3         46739-47050         c
            364-579             AC108134.3         42459-42674         c
            580-696             AC108134.3         42220-42336         c
            697-843             AC108134.3         41973-42119         c
            844-1038            AC108134.3         41069-41263         c
            1039-1188           AC108134.3         40804-40953         c
            1189-1319           AC108134.3         40224-40354         c
            1320-1440           AC108134.3         39872-39992         c
            1441-2032           AC108134.3         39206-39797         c
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2032
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="BICD family like cargo adaptor 2"
                     /db_xref="GeneID:146439"
                     /db_xref="HGNC:HGNC:33584"
                     /db_xref="MIM:617003"
     exon            1..51
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            52..363
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1608
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="coiled-coil domain-containing protein 64B; bicaudal
                     D-related protein 2; BICD-related protein 2; coiled-coil
                     domain containing 64B"
                     /codon_start=1
                     /product="BICD family-like cargo adapter 2"
                     /protein_id="NP_001356596.1"
                     /db_xref="CCDS:CCDS45393.1"
                     /db_xref="GeneID:146439"
                     /db_xref="HGNC:HGNC:33584"
                     /db_xref="MIM:617003"
                     /translation="MSSPDGPSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGP
                     EEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHE
                     LRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRL
                     SQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEA
                     QIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRV
                     SELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQP
                     SPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRA
                     QEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELE
                     AWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRLGPGPAGGFLSNLFRRT
                     "
     exon            364..579
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            580..696
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            697..843
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1038
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1188
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1319
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1440
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..2032
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1843
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="major polyA site"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="hexamer: AATATA"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="hexamer: TATAAA"
     polyA_site      1930
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
     polyA_site      1941
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="hexamer: AAGAAA"
     polyA_site      1970
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
     regulatory      2008..2013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
                     /note="hexamer: AATGAA"
     polyA_site      2032
                     /gene="BICDL2"
                     /gene_synonym="BICDR-2; BICDR2; CCDC64B"
ORIGIN      
        1 aagaggggac cggagaccgc ggggacctcg gagggagccc ggcggcttcg gccacctgtc
       61 cccgcagatg ctgcaggtga catgagctct ccagatgggc ccagcttccc gtccgggccg
      121 ctctcagggg gcgcctctcc cagcggcgac gagggcttct tcccctttgt gctggagcgg
      181 cgggactcat tcctgggagg gggcccaggg cctgaggagc ccgaggacct agccttgcag
      241 ctgcagcaga aggagaaaga cctgctgttg gccgcggagc tcggcaagat gcttctggag
      301 cgaaatgaag agctgcggcg gcagctggag acgctgagcg cccagcactt ggagcgtgag
      361 gaacggctcc agcaggagaa ccatgagctc cggcgaggcc tggcagcccg aggagccgag
      421 tgggaggccc gggccgtgga gctggagggg gacgtggagg ccctgcgggc ccagcttggg
      481 gagcagcgct cagagcagca ggacagtggg cgagaacggg cacgggccct cagcgagctc
      541 agcgagcaga acctccggct cagccagcag ctggctcagg cctcccagac tgagcaggaa
      601 cttcagaggg aactggacgc ccttcgggga cagtgccagg ctcaggcact ggctggagca
      661 gagctgagga cgcggctgga gagtctgcag ggggaaaacc agatgctgca gagccgccgg
      721 caggacctgg aggcccagat ccgaggcctg cgtgaggagg tggagaaggg tgagggcaga
      781 ctgcagacca cccacgagga gttgctgctg ctgaggcggg agcggcggga gcacagcctg
      841 gagctggaac gcgcacggtc agaggctggg gaggcgctga gtgcgctgcg gaggctgcag
      901 cggcgcgtct ccgagctgga ggaggagtca cgcctccagg acgccgacgt gtcggctgcc
      961 tcgttgcagt cagaactggc ccacagcctc gacgacggcg accagggcca gggcgccgac
     1021 gcacccggag acaccccgac cacccggtcc ccaaagaccc gaaaggcgtc cagcccccag
     1081 ccttcacccc cggaagagat cttagagccc cccaagaagc gaacatccct cagtccagcg
     1141 gagatactgg aggagaagga ggtggaagtg gccaagctgc aagatgagat ctcgctgcag
     1201 caggcagagc tgcagtccct gcgggaagag ctgcagaggc agaaggagct gcgggcgcag
     1261 gaagaccctg gggaggccct gcacagtgcc ctctcagacc gggacgaggc cgtgaacaag
     1321 gccctggagc tgtccctgca gctcaaccgc gtctcgctgg agcgagactc cctgtctcgg
     1381 gagctgctgc gcgccatccg ccagaaggtg gcgctcacgc aggagctgga ggcctggcag
     1441 gacgacatgc aggtggtgat cgggcagcag ctgcgctcac agcgccagaa ggagctgagc
     1501 gcctccgcgt cgtcgtcgac cccgcgccgt gccgcgcccc gcttctcgct gcgcctgggc
     1561 cccgggcccg ccggtggctt tctcagtaac ctcttccgaa ggacctgacg gctgggccca
     1621 gagggctgcc cttgcccact taggggctca ctttcctctt caggccaatg gagcgacagg
     1681 gcccagattg tcttccaaaa gaagctgatg ccctccccgc cccaggatgc tgggcaaggg
     1741 ctcatcggga gcaggggctc atccggagca ggggccagct ttgtggggca ggagctccag
     1801 gtgggtggca ggggcaggtg aacagagcta ttttccgaat taatatacgt ctatcttttc
     1861 tagggcaggg atggggctgg gtatttatgt atcaagatcg gacagagtaa tatataaatc
     1921 actccaccga tttggccccc attcatagaa agaaagagca tggtaaaaaa gcctgaaact
     1981 ttattgtaaa aaaaaaaaaa aaaagaaaat gaaaaacact ctaaaaccct ga
//
