LOCUS       NM_001003800            6448 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BICD cargo adaptor 2 (BICD2), transcript variant 1,
            mRNA.
ACCESSION   NM_001003800
VERSION     NM_001003800.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6448)
  AUTHORS   Xie,S., Kuang,W., Guo,M., Yang,F., Jin,H., Chen,X., Yi,L., Huo,C.,
            Xu,Z., Lin,A., Liu,W., Mao,J., Shu,Q. and Zhou,T.
  TITLE     m6Am methyltransferase PCIF1 negatively regulates ciliation by
            inhibiting BICD2 expression
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38526325
  REMARK    GeneRIF: m6Am methyltransferase PCIF1 negatively regulates
            ciliation by inhibiting BICD2 expression.
REFERENCE   2  (bases 1 to 6448)
  AUTHORS   Zhao,X., Quintremil,S., Rodriguez Castro,E.D., Cui,H., Moraga,D.,
            Wang,T., Vallee,R.B. and Solmaz,S.R.
  TITLE     Molecular mechanism for recognition of the cargo adapter Rab6GTP by
            the dynein adapter BicD2
  JOURNAL   Life Sci Alliance 7 (7), e202302430 (2024)
   PUBMED   38719748
  REMARK    GeneRIF: Molecular mechanism for recognition of the cargo adapter
            Rab6[GTP] by the dynein adapter BicD2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6448)
  AUTHORS   Unger,A., Roos,A., Gangfuss,A., Hentschel,A., Glaser,D., Krause,K.,
            Doering,K., Schara-Schmidt,U., Hoffjan,S., Vorgerd,M. and
            Guttsches,A.K.
  TITLE     Microscopic and Biochemical Hallmarks of BICD2-Associated Muscle
            Pathology toward the Evaluation of Novel Variants
  JOURNAL   Int J Mol Sci 24 (7), 6808 (2023)
   PUBMED   37047781
  REMARK    GeneRIF: Microscopic and Biochemical Hallmarks of BICD2-Associated
            Muscle Pathology toward the Evaluation of Novel Variants.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6448)
  AUTHORS   Yi,J., Zhao,X., Noell,C.R., Helmer,P., Solmaz,S.R. and Vallee,R.B.
  TITLE     Role of Nesprin-2 and RanBP2 in BICD2-associated brain
            developmental disorders
  JOURNAL   PLoS Genet 19 (3), e1010642 (2023)
   PUBMED   36930595
  REMARK    GeneRIF: Role of Nesprin-2 and RanBP2 in BICD2-associated brain
            developmental disorders.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6448)
  AUTHORS   Fagiewicz,R., Crucifix,C., Klos,T., Deville,C., Kieffer,B.,
            Nomine,Y., Busselez,J., Rossolillo,P. and Schmidt,H.
  TITLE     In vitro characterization of the full-length human dynein-1 cargo
            adaptor BicD2
  JOURNAL   Structure 30 (11), 1470-1478 (2022)
   PUBMED   36150379
  REMARK    GeneRIF: In vitro characterization of the full-length human
            dynein-1 cargo adaptor BicD2.
REFERENCE   6  (bases 1 to 6448)
  AUTHORS   Matanis,T., Akhmanova,A., Wulf,P., Del Nery,E., Weide,T.,
            Stepanova,T., Galjart,N., Grosveld,F., Goud,B., De Zeeuw,C.I.,
            Barnekow,A. and Hoogenraad,C.C.
  TITLE     Bicaudal-D regulates COPI-independent Golgi-ER transport by
            recruiting the dynein-dynactin motor complex
  JOURNAL   Nat Cell Biol 4 (12), 986-992 (2002)
   PUBMED   12447383
  REMARK    Erratum:[Nat Cell Biol. 2003 Jan;5(1):84.]
REFERENCE   7  (bases 1 to 6448)
  AUTHORS   Short,B., Preisinger,C., Schaletzky,J., Kopajtich,R. and Barr,F.A.
  TITLE     The Rab6 GTPase regulates recruitment of the dynactin complex to
            Golgi membranes
  JOURNAL   Curr Biol 12 (20), 1792-1795 (2002)
   PUBMED   12401177
REFERENCE   8  (bases 1 to 6448)
  AUTHORS   Holland,P.M., Milne,A., Garka,K., Johnson,R.S., Willis,C.,
            Sims,J.E., Rauch,C.T., Bird,T.A. and Virca,G.D.
  TITLE     Purification, cloning, and characterization of Nek8, a novel
            NIMA-related kinase, and its candidate substrate Bicd2
  JOURNAL   J Biol Chem 277 (18), 16229-16240 (2002)
   PUBMED   11864968
  REMARK    GeneRIF: isolation, cloning, and characterization of human Nek8, a
            new mammalian NIMA-related kinase, and its candidate substrate
            Bicd2
REFERENCE   9  (bases 1 to 6448)
  AUTHORS   Hoogenraad,C.C., Akhmanova,A., Howell,S.A., Dortland,B.R., De
            Zeeuw,C.I., Willemsen,R., Visser,P., Grosveld,F. and Galjart,N.
  TITLE     Mammalian Golgi-associated Bicaudal-D2 functions in the
            dynein-dynactin pathway by interacting with these complexes
  JOURNAL   EMBO J 20 (15), 4041-4054 (2001)
   PUBMED   11483508
REFERENCE   10 (bases 1 to 6448)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136981.22, BC073970.1,
            BC010428.1 and BC004296.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001003800.1.
            
            Summary: This gene is one of two human homologs of Drosophila
            bicaudal-D and a member of the Bicoid family. It has been
            implicated in dynein-mediated, minus end-directed motility along
            microtubules. It has also been reported to be a phosphorylation
            target of NIMA related kinase 8. Two alternative splice variants
            have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073970.1, SRR1803612.239662.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356884.11/ ENSP00000349351.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL136981.22        34440-34471         c
            33-4445             BC073970.1         16-4428
            4446-6373           BC010428.1         609-2536
            6374-6448           BC004296.1         3782-3856
FEATURES             Location/Qualifiers
     source          1..6448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..6448
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /note="BICD cargo adaptor 2"
                     /db_xref="GeneID:23299"
                     /db_xref="HGNC:HGNC:17208"
                     /db_xref="MIM:609797"
     exon            1..329
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2657
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of Drosophila bicaudal D; cytoskeleton-like
                     bicaudal D protein homolog 2; bicaudal D homolog 2;
                     protein bicaudal D homolog 2; coiled-coil protein BICD2;
                     bic-D 2"
                     /codon_start=1
                     /product="protein bicaudal D homolog 2 isoform 1"
                     /protein_id="NP_001003800.1"
                     /db_xref="CCDS:CCDS35064.1"
                     /db_xref="GeneID:23299"
                     /db_xref="HGNC:HGNC:17208"
                     /db_xref="MIM:609797"
                     /translation="MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAA
                     EYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREES
                     LIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQR
                     GRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEE
                     TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL
                     HVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVS
                     DLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTE
                     NLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR
                     EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKK
                     VSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR
                     TSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREP
                     MNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSL
                     LSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDA
                     ATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEL
                     LELDHEQTRRGRAKAAPKTKPATPSVSHTCACASDRAEGTGLANQVFCSEKHSIYCD"
     exon            330..542
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     exon            543..695
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1151
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..2195
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2347
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..6448
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6430..6435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /note="hexamer: AATAAA"
     polyA_site      6448
                     /gene="BICD2"
                     /gene_synonym="bA526D8.1; SMALED2; SMALED2A; SMALED2B"
                     /note="major polyA site"
ORIGIN      
        1 agggcggcgg cggcggcggc agcggcggcg gctgaggagg gcccggcctg cgagagcctc
       61 agtgggagcc ggctcagccc tcggccacca tgtcggcgcc gtcggaggag gaggagtacg
      121 cgcggctggt gatggaggcg cagccggagt ggctgcgcgc cgaggtgaag cggctgtccc
      181 acgagctggc cgagaccacg cgtgagaaga tccaggcggc cgagtacggg ctggcggtgc
      241 tcgaggagaa gcaccagctc aagctgcagt tcgaggagct cgaggtggac tatgaggcta
      301 tccgcagcga gatggagcag ctcaaggagg cctttggaca agcacacaca aaccacaaga
      361 aggtggctgc tgacggagag agccgggagg agagcctgat ccaggagtcg gcctccaagg
      421 agcagtacta cgtgcggaag gtgctagagc tgcagacgga gctgaagcag ttgcgcaatg
      481 tcctcaccaa cacgcagtcg gagaatgagc gcctggcctc tgtggcccag gagctgaagg
      541 agatcaacca gaatgtggag atccagcgtg gccgcctgcg ggatgacatc aaggagtaca
      601 aattccggga agctcgtctg ctgcaggact actcggaact ggaggaggag aacatcagcc
      661 tgcagaagca agtgtctgtg ctcagacaga accaggtgga gtttgagggc ctcaagcatg
      721 agatcaagcg tctggaggag gagaccgagt acctcaacag ccagctggag gatgccatcc
      781 gcctcaagga gatctcagag cggcagctgg aggaggcgct ggagaccctg aagacggagc
      841 gcgaacagaa gaacagcctg cgcaaggagc tgtcacacta catgagcatc aatgactcct
      901 tctacaccag ccacctgcat gtctcgctgg atggcctcaa gttcagtgac gatgctgccg
      961 agcccaacaa cgatgccgag gccctggtca atggctttga gcacggcggc ctggccaagc
     1021 tgccactgga caacaagacc tccacgccca agaaggaggg cctcgcaccg ccctccccca
     1081 gcctcgtctc cgacctactc agtgagctca acatctctga gatccagaag ctgaagcagc
     1141 agctgatgca gatggagcgg gaaaaggcgg gcctgctggc aacgctgcag gacacacaga
     1201 agcagctgga gcacacgcgg ggctccctgt cagaacagca ggagaaggtg acccgcctca
     1261 cagagaatct gagtgccctg cggcgcctgc aggccagcaa ggagcggcag acagccctgg
     1321 acaacgagaa ggaccgtgac agccatgagg atggggacta ctacgaggtg gacatcaacg
     1381 ggcctgagat cttggcctgc aagtaccatg tggctgtggc tgaggctggc gagctccgcg
     1441 agcagctcaa ggcactgcgc agcacgcacg aggctcgtga ggcccagcac gccgaggaga
     1501 agggccgcta tgaggctgag ggccaggcac tcacggagaa ggtctccctg ctagagaagg
     1561 ccagccgcca ggaccgcgag ctgctggccc ggctggagaa ggagctaaag aaggtgagcg
     1621 acgtcgccgg cgagacacag ggcagcctga gtgtggccca ggatgagctg gtgaccttca
     1681 gtgaggagct ggccaatctc taccaccacg tgtgcatgtg caacaatgag acacccaacc
     1741 gtgtcatgct ggactactac cgcgagggcc agggcggggc cggccgcacc agtcccgggg
     1801 gccgcaccag ccccgaggcg cgtggccggc gctcacccat cctcctaccc aaggggctgc
     1861 tggctcctga ggcgggccga gcagatggtg ggacggggga cagcagcccc tcgcctggct
     1921 cctcactgcc atcacccctg agtgacccac gccgggagcc catgaacatc tacaacctga
     1981 tcgctatcat ccgtgaccag atcaagcacc tgcaggcagc cgtggaccgc accacggagc
     2041 tgtcacgcca gcgcattgcc tctcaggagc tgggccccgc cgtggacaag gacaaggaag
     2101 cgcttatgga ggagatcctc aagctgaagt cgctgctcag caccaagcgg gagcagatca
     2161 ccacgctgcg cactgtgctc aaggccaaca agcagacggc cgaggtggcc cttgccaacc
     2221 tgaagagcaa gtatgagaat gagaaggcca tggttaccga gaccatgatg aagctgcgca
     2281 atgagctcaa ggccctcaag gaggacgcag ccaccttctc ctcgctgcgt gctatgtttg
     2341 ccaccaggtg tgacgagtac attacacagc tggatgagat gcagcggcag ctggcggctg
     2401 ctgaggacga gaagaagacg ctgaactcgc tgctgcgcat ggccatccag cagaagctgg
     2461 cgctgaccca gcggctggag ctgctcgagc tggaccatga gcagacccgg cgtggccgtg
     2521 ccaaagccgc cccgaagacc aagccagcca caccgagcgt aagtcacacc tgtgcctgtg
     2581 ccagcgacag ggccgagggc accgggctgg ccaaccaggt gttctgcagc gagaagcaca
     2641 gcatttactg tgattagggg ctgtggggcg ccgcacgctg cagctaacat ctgcttcacc
     2701 tcaactaacc cagcagcagc gggacggcgg tgctaggtca atcttaacgt gactaatgca
     2761 cagagggtag gagtctagcc gaggcgccat ggggcgttgc atcagcagga cacttgtgag
     2821 agctttgtgt cgcttctcac tcctcaaagc cccctcagga gcacccagtc ctcagctgct
     2881 ctcttaggtg ggggtcagag gtggggatag agctgcacat tcttgcagca gatgtgtgat
     2941 gaaagcatct tctaagccct gcgcacccgt ggggaaaccc aagggaggag tcctggtcct
     3001 gctccctcag cacccaaaag gggcagaacc tgagttgaga cttgcatgtt cctcgcatgt
     3061 gtctaatgtc agcactagaa agcagtttta ggaggttcca gcctgcagca taggtacgac
     3121 ctcagaggat ggctttgcac ttggcatagt ttcatggaaa ggagtacgtt gtagtttatg
     3181 cagtatctga ctgcaaatca tattcaggaa agaagtgcag aatttcttcc ccaagcccag
     3241 agaagagcag ccctgagccc ctgtattctg ctggccagac acacatggca cagacacagc
     3301 tgaccataac ccaggaatcc agagctcggt ttctcatttc tgagatcagg atgcttgtat
     3361 agtggcctgt gaggtgacag attggcaggg cccaaggccc caggttttca tttttcatga
     3421 gaaaagcttt ccaagtgcct ggccagacct tggtccttag tgcagagccc gtccttttgt
     3481 acttggggtg accccagcag ccaattatcc ggccttccat agggggttca gtcccaaaga
     3541 catggggctt tgaaaaccct agcctgaagt ctgagccacc aagggcttgg ctgggttgga
     3601 cacccacagg tgtatccaga gcccagcccg gtgctgggaa agctttgcat agggccaggg
     3661 ccacttgtca ggattcacag gtaggagatg tttaggtctc tttatttagt gcaatctggg
     3721 ggatggcaac agagaaagag gaaaggtagc tgtagggttc tcccatttcc agaggctcca
     3781 tccacacctg ccttcccaca ttctgagcag aacttttctc agtacttttt tcccgatcac
     3841 cctgtgggac cagctggacc tgaggctgca gtcttctctc ctgcaggctg cttgccttgt
     3901 ctctcatgcg gaagaggcat tcgagttacc tggtgagaga ccgtgttgcc ccctcccaca
     3961 gctctctgcc ctgcgcgttc ttccctttgg tgccgagtat gtttcggtcc cctccagact
     4021 ccaggacacg cccatgtatg tcccctgcgt gttcatcctg ggcccagatc cccctgcccc
     4081 agcaagactc gcagtgggat ggctgctggc atgcccaccc tgcatgcgct ttgccctctc
     4141 cttgcaagcc tggcacatag cttctctcca tactcctaag ggactttgca gacacccaag
     4201 ccactgggac ccctgctaac acatgcaggt cttctcttct gccaactaac gtgctcgcgc
     4261 cctcccagca cgtggagagc ttcaattgtc agataaacag gaagcgacag atgaccgctt
     4321 tctaacgctc tcttttctcc cgttttcagc tgtagagtag ctgccaggag gacttggcca
     4381 cccggccctg tcacactgca gccccttccc cttccctctc gtggcccaca aggaggaagg
     4441 aagggcaacc taaaagccca cttagaaact ttttggatat gccactgcaa ttcttttcaa
     4501 aatagcattc cccaggtttt taatgggagg aaaaaaagct ttaatgttga gcatgctgcg
     4561 agctgctgcg tggaaaggcc tctgtatggg ccgaagaccc ttcttccctg gctgccaggc
     4621 tcgccaggag cccactggaa acgcccacca cgggggctcc ttgttacaca tgttcttttt
     4681 ttatccgatc aacctgtgca cttttgatat tttgatatta tatttgcttc cttaattcct
     4741 cgcgtagaga cggtctcagg tgccgtggtc tatgctcgtg gtcctgtagc tgtccgcctc
     4801 agctcccacc gtgtttgtct ggtgtcagca cgaggcagag ctgtgtgctc catagcgtgt
     4861 agctttagac tcggagatga gtgctttgac ccagcgagga gctcagctaa gtgtatccac
     4921 gctgtggttc agcagccttt agatcatacg gcattgtggt tcatgtttga aattacagat
     4981 tttaaatgcc atgttcatta agaaatccag ggtattcaga ttctggggtt tttcatattg
     5041 tattattatt attcttagga atagttcaat gtaacaagaa gaaaacttga cctttgctct
     5101 ggttaaaaca gtaataggca cttgaaaaaa aaagataaat tattgaatga gtagtattac
     5161 ctacaaattc cagaattttc tgggttttag gacgttgtga agcatgactg attaacagaa
     5221 ttttatacaa ctgtaccaat aaaattccaa attggaattg ttttgttact ctggttgttg
     5281 tgccaaattg tggtacactt agaaaattct acagtcgtcg atttttaggg tgttctcttt
     5341 caacaccttt ttgttagtaa tcattgccag tagtgccttc atcagttaag ggaggtgtcc
     5401 cagcacagat cattctcaaa agcgagcagg gaagagctag tgggcatgct gaaggccagc
     5461 gtggacagca ggtgaggcag gtgctcctca cacccagacc tgggcatctt cattgaggga
     5521 aagaaaacag tcattgtgca aaattctgtt agtcagtgat tctttacttg caaattcagg
     5581 ggcttagaaa atgaaagcaa acacaaaacc ttgagtgtgc tttgggaacc aaatggacct
     5641 tctgggacaa gctgagcaag ctgtatgaac gccacgtttg tgaagagctg agggtatcag
     5701 gagggccgac gctgtgttgg catgcgcagt aggggatgag ggttagccat agtattcttt
     5761 gcaaatgtga aagcgagaca ttatatcttc tcttgcttgg tgtaactaat cactgttaat
     5821 ttcaggaaac agaactcatt aaaactcctt agcaaaccag gtctacatcc tgttttgttt
     5881 gctgagtgag gttagtggga gtggtcaaat tggtactctt ggaggaagaa aaactgtcct
     5941 tccttctcca aaaaaggaaa aattataata atataaatga caaaaataaa agaattctgt
     6001 ttcctggaat aagcatttct tattcctagt tgtagggact cctattttta ccttccgtta
     6061 cagtgttgat tcataagaaa tattgttaca tttgagataa cttcatctgt atggggtatt
     6121 tatttgcaat gatgtctgag tactgtattt tttctgtgca ttaccttagt gtcagaatgt
     6181 tggtctttat tttaaagtca tatgcatgtt ctcctgccaa ggaaccttta cacagaccca
     6241 aacaaaaaaa taataatcaa atgccttcaa tttctgagaa aatgaggcag agcatggaaa
     6301 aggaatagga aggagaaatt aattgagatt ttcaggacac agacatatga tgtgaatgcc
     6361 tacaaagcca gtgcgcatag gaacagtggg cctgggtaaa gagtcacatt ggtaggacca
     6421 ataaagaata ataaaaagac aaagcaca
//
