LOCUS       NM_001714               9419 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BICD cargo adaptor 1 (BICD1), transcript variant 1,
            mRNA.
ACCESSION   NM_001714
VERSION     NM_001714.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9419)
  AUTHORS   Hirsch,Y., Chung,W.K., Novoselov,S., Weimer,L.H., Rossor,A.,
            LeDuc,C.A., McPartland,A.J., Cabrera,E., Ekstein,J., Scher,S.,
            Nelson,R.F., Schiavo,G., Henderson,L.B. and Booth,K.T.A.
  TITLE     Biallelic Loss-of-Function Variants in BICD1 Are Associated with
            Peripheral Neuropathy and Hearing Loss
  JOURNAL   Int J Mol Sci 24 (10), 8897 (2023)
   PUBMED   37240244
  REMARK    GeneRIF: Biallelic Loss-of-Function Variants in BICD1 Are
            Associated with Peripheral Neuropathy and Hearing Loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9419)
  AUTHORS   Jiang,Y., Yao,B., Chen,T., Mo,H., Chen,S., Liu,Q. and Sun,Y.
  TITLE     BICD1 functions as a prognostic biomarker and promotes
            hepatocellular carcinoma progression
  JOURNAL   Pathol Res Pract 216 (4), 152858 (2020)
   PUBMED   32088084
  REMARK    GeneRIF: BICD1 functions as a prognostic biomarker and promotes
            hepatocellular carcinoma progression.
REFERENCE   3  (bases 1 to 9419)
  AUTHORS   Kim,H.J., Seo,Y.S., Sung,J., Chae,J., Yun,J.M., Kwon,H., Cho,B.,
            Kim,J.I. and Park,J.H.
  TITLE     A genome-wide by PM10 interaction study identifies novel loci for
            lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults
  JOURNAL   Chemosphere 245, 125581 (2020)
   PUBMED   31846791
  REMARK    GeneRIF: BICD1 genes may contribute to the decrease in forced vital
            capacity levels by interacting with PM10 exposure
REFERENCE   4  (bases 1 to 9419)
  AUTHORS   Budzinska,M.I., Villarroel-Campos,D., Golding,M., Weston,A.,
            Collinson,L., Snijders,A.P. and Schiavo,G.
  TITLE     PTPN23 binds the dynein adaptor BICD1 and is required for endocytic
            sorting of neurotrophin receptors
  JOURNAL   J Cell Sci 133 (6) (2020)
   PUBMED   32079660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9419)
  AUTHORS   Hoogenraad,C.C. and Akhmanova,A.
  TITLE     Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to
            Cargo Binding
  JOURNAL   Trends Cell Biol 26 (5), 327-340 (2016)
   PUBMED   26822037
  REMARK    Review article
REFERENCE   6  (bases 1 to 9419)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   7  (bases 1 to 9419)
  AUTHORS   Matanis,T., Akhmanova,A., Wulf,P., Del Nery,E., Weide,T.,
            Stepanova,T., Galjart,N., Grosveld,F., Goud,B., De Zeeuw,C.I.,
            Barnekow,A. and Hoogenraad,C.C.
  TITLE     Bicaudal-D regulates COPI-independent Golgi-ER transport by
            recruiting the dynein-dynactin motor complex
  JOURNAL   Nat Cell Biol 4 (12), 986-992 (2002)
   PUBMED   12447383
  REMARK    Erratum:[Nat Cell Biol. 2003 Jan;5(1):84.]
REFERENCE   8  (bases 1 to 9419)
  AUTHORS   Short,B., Preisinger,C., Schaletzky,J., Kopajtich,R. and Barr,F.A.
  TITLE     The Rab6 GTPase regulates recruitment of the dynactin complex to
            Golgi membranes
  JOURNAL   Curr Biol 12 (20), 1792-1795 (2002)
   PUBMED   12401177
REFERENCE   9  (bases 1 to 9419)
  AUTHORS   Baens,M. and Marynen,P.
  TITLE     A human homologue (BICD1) of the Drosophila bicaudal-D gene
  JOURNAL   Genomics 45 (3), 601-606 (1997)
   PUBMED   9367685
REFERENCE   10 (bases 1 to 9419)
  AUTHORS   Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
            Marynen,P.
  TITLE     Isolation and regional assignment of human chromosome 12p cDNAs
  JOURNAL   Genomics 29 (1), 44-52 (1995)
   PUBMED   8530100
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC048344.44, AK290188.1 and
            AC087245.29.
            
            On Nov 22, 2018 this sequence version replaced NM_001714.3.
            
            Summary: This gene encodes an adaptor protein that belongs to the
            bicaudal D family of dynein cargo adaptors. The encoded protein
            acts as an intracellular cargo transport cofactor that regulates
            the microtubule-based loading of cargo onto the dynein motor
            complex. It also controls dynein motor activity and coordination.
            It has a domain architecture consisting of coiled-coil domains at
            the N- and C-termini that are highly conserved in other family
            members. Naturally occurring mutations in this gene are associated
            with short telomere length and emphysema. [provided by RefSeq, Aug
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290188.1, U90028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652176.1/ ENSP00000498700.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AC048344.44        99458-99839
            383-3431            AK290188.1         1-3049
            3432-3432           AC087245.29        18676-18676
            3433-3662           AK290188.1         3051-3280
            3663-9419           AC087245.29        18907-24663
FEATURES             Location/Qualifiers
     source          1..9419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..9419
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /note="BICD cargo adaptor 1"
                     /db_xref="GeneID:636"
                     /db_xref="HGNC:HGNC:1049"
                     /db_xref="MIM:602204"
     exon            1..698
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..3413
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytoskeleton-like bicaudal D protein homolog 1; bicaudal D
                     homolog 1"
                     /codon_start=1
                     /product="protein bicaudal D homolog 1 isoform 1"
                     /protein_id="NP_001705.2"
                     /db_xref="CCDS:CCDS8726.1"
                     /db_xref="GeneID:636"
                     /db_xref="HGNC:HGNC:1049"
                     /db_xref="MIM:602204"
                     /translation="MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEE
                     KLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKE
                     AYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIRE
                     YKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLE
                     DAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDG
                     SEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLM
                     QVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELD
                     GEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTD
                     EKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDEL
                     VTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARR
                     GVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN
                     IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLS
                     TKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAAT
                     FSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLE
                     FDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRK
                     RQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESFLLKGPPSMSEFIQGHRLSKEK
                     RLTVAPPDCQQPAASVPPQCSQLAGRQDCPTVSPDTALPEEQPHSSSQCAPLHCLSKP
                     PHP"
     exon            699..911
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1064
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1490
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2585
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2737
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..3055
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3249
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3325
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..9419
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3678
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
     regulatory      9391..9396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /note="hexamer: AATAAA"
     polyA_site      9419
                     /gene="BICD1"
                     /gene_synonym="bic-D 1; BICD"
                     /note="major polyA site"
ORIGIN      
        1 atcattccgc accggctgct gcagggccag agggagcagg tggagcgaga gagcgagccg
       61 cgagccggag cgcgccagac ccagggcgag actgcagtga cgcggcccgg gagacatggc
      121 ggacgggcgt ctctgaataa gcagaatccg gagcccctcg ctacccgcgg ccgccgcagc
      181 ccgggccatg ccgcacggct gctgaccgca cgcaggggcc ggccccgagg acacatgcgg
      241 cggcctttgc cgcctcgccc ctgaccctct gccctgttct ccatgttgca tttctcgtca
      301 gtttctcggg cggtgtagct gccgctgcca ccagagccgg cggggcatcg cgctgctcat
      361 tcatccggcc gcactttctt ttccgtttcc acccatccct tcccatttcc ttctcccttt
      421 ccccgccagc ttcgcatcca tctcccccac cccgtaaccc cctcctgcct ccatccaccg
      481 gggctatggc cgcagaagag gtattgcaga cggtggacca ttataagact gagatagaga
      541 ggctaaccaa ggagctcacg gagaccaccc acgagaagat ccaggctgcc gagtacgggc
      601 tggtggtgct ggaggagaag ctgaccctca aacagcagta tgatgaactg gaggctgagt
      661 acgacagcct caaacaggag ctggagcagc tcaaagaggc atttgggcag tccttctcca
      721 tccaccggaa ggttgctgaa gatggagaga ctcgggagga aacgcttctg caggagtcag
      781 catcgaagga ggcttactat ctggggaaga tcttggagat gcagaacgag ctgaaacaga
      841 gccgggctgt ggtcactaat gtacaggcag aaaacgagag gctcaccgca gtcgtgcagg
      901 atctgaagga gaacaatgag atggtggagc tacagagaat acggatgaag gatgaaatcc
      961 gagaatataa gttccgggag gcacggctcc ttcaggacta tactgaattg gaagaagaaa
     1021 atatcacatt gcagaaacta gtgtccacgt tgaagcagaa ccaggttgaa tacgaaggct
     1081 taaagcatga gattaagcga tttgaggagg agacggtact gctgaacagc cagctggaag
     1141 atgccatccg attgaaagag attgctgagc accaactgga agaagccctc gagactttaa
     1201 aaaatgaaag agagcaaaag aacaacctgc ggaaggagct ctcccagtat atcagcctca
     1261 atgataacca tatcagcatc tcagtagatg gactcaaatt tgccgaggat gggagtgaac
     1321 caaacaatga tgacaaaatg aacggtcata tccatgggcc tcttgtgaaa ctgaatggag
     1381 actatcggac tcccacctta aggaaaggag agtctctgaa ccctgtctct gacttattca
     1441 gtgagctgaa catttcagaa atacagaagt tgaagcagca gcttatgcag gtagagcggg
     1501 aaaaggccat tcttttggcc aacctacagg agtcacagac acagctggaa cacaccaagg
     1561 gggcactgac ggagcagcat gagcgggtgc accggctcac agagcacgtc aatgccatga
     1621 ggggcctgca aagcagcaag gagctcaagg ctgagctgga cggggagaag ggccgggact
     1681 caggggagga ggcccatgac tatgaggtgg acatcaatgg tttagagatc cttgaatgca
     1741 aatacagggt ggcagtaact gaggtgattg atctgaaagc tgaaattaag gccttaaagg
     1801 agaaatataa taaatctgta gaaaactaca ctgatgagaa ggccaagtat gagagtaaaa
     1861 tccagatgta tgatgagcag gtgacaagcc ttgagaagac caccaaggag agtggtgaga
     1921 agatggccca catggagaag gagttgcaaa agatgaccag catagccaac gaaaatcaca
     1981 gtacccttaa tacggcccag gatgagttag tgacattcag tgaggagtta gctcagcttt
     2041 accaccatgt gtgtctatgt aataatgaaa ctcccaacag ggtcatgctg gattactata
     2101 ggcagagcag agtcacccgc agtggcagcc tgaaagggcc cgatgatccc agaggacttt
     2161 tgtccccacg attagccagg cggggtgtgt catccccggt agaaacaagg acctcatctg
     2221 aaccagttgc aaaagaaagc acagaggcca gcaaagaacc aagtccaact aagaccccca
     2281 caatctctcc tgttattact gccccaccgt catctccagt attggataca agtgacatcc
     2341 gcaaagagcc aatgaatatc tacaacctta atgccataat ccgggaccaa atcaagcatc
     2401 tgcagaaagc tgtggaccgg tccttgcaac tgtctcgtca aagagcagcg gctcgggagc
     2461 tagcccccat gattgataaa gacaaggaag ccttaatgga agagatcctc aagctaaagt
     2521 ccctgctgag caccaaacgg gagcagatcg ccacattgag ggcggtgttg aaagccaaca
     2581 agcagacagc tgaggtggcg ctagctaatc tcaagaacaa atatgaaaat gaaaaagcaa
     2641 tggtgactga aaccatgacg aagcttagaa atgaactgaa ggctttgaaa gaagatgctg
     2701 caaccttctc atccctgaga gcaatgtttg caacaagatg tgatgaatat gtcacccagt
     2761 tggatgagat gcagagacag ttagcagctg cagaggatga gaagaagact ctgaacactt
     2821 tgttacgaat ggctatccag caaaaactcg ccctgaccca gaggctggag gacttagagt
     2881 ttgaccatga gcagtcccga cgcagcaaag gcaaacttgg aaagagcaag atcggcagcc
     2941 ctaaagtaag tggggaggca tcagtcaccg tgcccaccat agacacttac ctcctgcata
     3001 gtcagggccc acagacaccc aacattcggg tcagcagtgg cactcagagg aaaagacaat
     3061 tttcaccttc cctttgtgat cagagccgtc ccaggacttc aggggcttcc tacctacaga
     3121 atttattaag agttccccct gatcccacct ccacagaatc atttcttctg aagggccccc
     3181 cttccatgag tgaattcatc caagggcacc ggctcagcaa ggaaaaaagg ttaaccgtgg
     3241 ctccaccaga ttgtcagcag cctgctgcct ccgtaccgcc acagtgctca caactagccg
     3301 ggaggcaaga ctgcccaact gtcagtcctg acacagctct ccctgaggag cagccacatt
     3361 ccagctccca gtgcgcccct ctccactgtc tctccaagcc tcctcacccc tagtcttcat
     3421 ctcctgtgga cgaacatctg gggtggaagt tttgtagcca cacacaggat actgcccaag
     3481 atccagcggg tgttttcttc tcggttgtta gatgtacaat tggattaatg tccatcgttt
     3541 tggaagacga gagaaagttg agaagaacac gaagcacaga ccctgatgtg ataaaacatt
     3601 ttgtggtttc tctgagtcac agataaactt ctgccatcaa atggctacag ttcatttaaa
     3661 tttaaaaaaa agaaaaaaga aacagaaaac gtgtctcaga tggctggctt tacctcgata
     3721 gcataagaga gacctaagac atgtaaaata cgtatattgc agtatcatct ttcctcacac
     3781 tccaaattca gctagggaag ttgattccaa tatgtttgtc attgatattt attttgtact
     3841 ttatttgcta catgatttat gtctatacaa ataatttctc tgaggtgaat ttaattcatt
     3901 tattttcaaa taagcataat ttgctcaatt aagtatgagt ttgaatttag tttgaaatct
     3961 ggaattggcc agactgtggt catttttctt gcacaaaatg ataaatgagg tgcatcagaa
     4021 tgttaacaat aactgtattt tgctgctacg ctggtattgt ttaggcactt actttctaat
     4081 cagtagctca ttaactgctg ggttttgttt ttgtattttt aactagagtt cttcactgga
     4141 cattactaag taaatctaag aaagagacta agttatgatt tattgactta ttcaagtttt
     4201 gatggcatct ttacttttat tttttcattg cagttgagta gatgtactgg tgctgctcct
     4261 ttgtatgtgt gtatgtgtgt gataacgtta aagaaggctc aataacttga agggaaaaaa
     4321 atggtgtgtt tatttaatga ccagaatttt ttttacttct cccaaaatca gggtcctact
     4381 gagtctttcc tgataaaagg tatcaagtac aaatgggaaa atatatacat atatagatgt
     4441 aagatagcct ttaattaatt aatttaccca gagagtgttc aaagtttgat taaaattgta
     4501 tgttttgttg ttgttagttt ttttcataac gaatcttcct tgccaaaaaa acaatagata
     4561 ataaacctta gctcattgtc tacttttgac aaacactcag gtgcctacaa acattctatt
     4621 atcttgagat aatacatgtt cctggttaat ttacagattc tgctgggtaa cttttatgac
     4681 ttgatttaag gcagtggatt ttcatagcaa aatttatttt gcacataatc tgacaaacaa
     4741 ggaaaacagc taactgagct gaaaggtcta acactctcgg gctccttaac catcaagtgc
     4801 tgcccacaca attgctccta gccctgattc cttgtctttg tcaggtagcc ttaacttatt
     4861 taaaaccata agggtttgac cttttcatat aaagacatct gtaacttctc ttcaaaacaa
     4921 aaatgaccct cactgttaac acaaaggaca gttaccagtg tagggcactg agaaaggaga
     4981 tccaggagcc actcagctta ttgagcggac atgggtggca cagaaatgga gtggtccatc
     5041 agagaccaaa tggtaagtcg taaagcacat tgcaggagct ttcgttagtc atacgcctat
     5101 taagtagtgg tcgctattac caaagcaacc aggacgtttt gtgttcttta tatgagtgct
     5161 attttccaca gtgtcattta ttatgcaacg tggagtaaag agttgaaatc ttcaccaaaa
     5221 taagggttca ggttaaagta cagaaacaga aacaaaacga ttcgacatga agttcccaac
     5281 catagcagcc taaccttctg ctcttttcta cctgcatggc cttgctgttc ctaaacattg
     5341 tcttcatttc actggcgttg tatctgccta gtaccagtat tagtgagact gtggatttta
     5401 tcagagttca atgaaagaaa gcttacccct gccctcactt tgtgtttttt atttttcccc
     5461 ctttctcaag caccacgtat ttggacctga gaagtggcat agctgctaag ttgactttta
     5521 ataaaaaact gtttgtgcct gagggaaata tatgcctttt taaaaagtac ctcagaacat
     5581 gttcgtagat cgtctcatcg gttttgtttg gtgggactgg gagttcagca ggaagtattg
     5641 tctgtgtgtg atgacggggc agtattgcca gtcggcaatg ttgtatttgc attctttatc
     5701 cctaactctg aatctaggac tccatgaaaa gccgggtcac ccacaaaaca tttcttccaa
     5761 tacaaagtgt attattacgt ctattataaa ctagtttcat ttcagttatt tatcttcata
     5821 gagtgggaaa gtctttttct gaaatactaa ttctatgaaa ataataattt tagtgaatct
     5881 ttgccaagaa gttatagaaa cttggaaata aatttctcat tttcagcaca aaattaagtg
     5941 atagtcccta agcagtaaga gagaatacca tgtatttaca ctgtggcatc atttagtata
     6001 gtttacactg agccatattt atttataggc atttaaagtg aatcagtatg tgtagtgttg
     6061 ataaaaatca gtatctgtaa agataacatc aggaattcaa aaggaaattg aaaaggggca
     6121 gaactagtga gaaccaaaaa gaatgaactc cagtaagact aattgaagac atacttggag
     6181 aggaaaaata aacagcagaa atgcactaaa aaatactggc taattattgc aaacagagtg
     6241 agcaaagatt aatgctaact agtaaaagta gttagcaaag taaacaggta gttttttaaa
     6301 agtaagcaca attacaatat tgaatagtat ggagaaatgc ttttctcctg aggattttcc
     6361 ttaatcaaaa aataagaaga agcaataaat tgtctttggc ctgagtgctg agtggcataa
     6421 ataaaggagc ttggcttaat ctttctggtc cacacataat ccattagatc ccattcatat
     6481 atccaactct ggattctaat aaaataattt ggagaacttt gagaaaaagg aaaactgtta
     6541 aataagaaaa gacctattta gaaattatac tttagtctaa cgaagaggag gtacaatagt
     6601 agtcttcaag aaaagaatat ttaacaaatg atagatatca gctatagata ttgttactaa
     6661 gtctagaata aaaaaggctt cagtgtgaag gatgtatagt aactctagga aagagatttt
     6721 taacactggg aaattaacgt ggaaattgat aatcataaag aatatttgtt ttgtaaaaat
     6781 tgaatatcat tggtggtcta gtaagtatta agtggcaaga taggagaatg catttcagtt
     6841 ctgggagctc ataatcctgt gattctttta ttttaagttt taaaatacat taaaatttta
     6901 ctggttaatc ataaaatatt ttatatttga aaataggatg gcaatcttta tttttccaag
     6961 atatttgttg gaaaaaaatg atcgttggta ttattttttc tttcagctat attccatggt
     7021 atctttaaaa ttgttcagaa tataggactt ttactaaaaa aattcaattg tcagagtcta
     7081 aaaaaacaat gtcctcagga atacttcaga aatagaaggt atgcaatccc ttagtggggg
     7141 gcaaacacat ttcagatttc gtctttattt aaaaggatct tcagtctaca acatttgctt
     7201 ttttcgtgct ttggaaaata tccttgtgca gataagttct tctgtttgaa acaagcatga
     7261 aacattggtc caataaccta agaatgtgga gatttcttga tattctgtat taattaaagt
     7321 tctctacatg tctcaaatgg agatcacaaa acatgaaaag gaagaaatga aatatctttt
     7381 cttctgggat gagtgtcaat tttaatgtat aattgtcata atcaatcagc caaaagttac
     7441 aatctgtccc tcagagacat tgggggaagc tgatggattt ccagtaagga actgtggtgg
     7501 gttcaaactc aggctgccac aaatacattg atatggtagg taggaagtag gactaaattt
     7561 gaaagaaact tatgggataa agttcacaat tttaaaaagg ttgccctcca gtttttttgt
     7621 ttgtttataa actagagtga tttttaagta acccttatat ttaaggctgc aaaaaatgta
     7681 caagagtatg ttttcaagta aagggaacat aattcttcaa aaagctgttg aactggagtt
     7741 atgataggtt atgacagaga gcatgatcag tgctgatact gacaagtact tttttacctt
     7801 aaaatcaact tctatggaac tacaagatca atctagctcc cgagtgacat tttccattgt
     7861 ctgtaataat gccctcggat gagttgtgtc taaaattaag ttcatcttta tttatatgcg
     7921 aacttaactg ccatagtccc taatgtattg cgtttgtaac ctgatcgtat tatgtttaca
     7981 gctgaaagat ttcatctaga catgtctttc gtccttatta ttcaaagtgt aattgaaaga
     8041 gatatttagt attaagacat gttccccaat tgagaatttt ccagaatatt ctacttaaga
     8101 agaagaagag caattaactg cctttagtgt aagggcgaga gtgcatagaa atatgcaatg
     8161 taaaatgttt gcatgaatta tttcacatca tgtaagcttt cccatattca taagatgaac
     8221 actatagaag tctcatttct ctgtgatctt ctgtccatta ggaaagtaag gagattgtta
     8281 tctatatcta gtctcctttc catattgaac tgcatggctc taatcctcag tgtattttta
     8341 tcccttctcg agttatttaa aatttgccct atttaagctg aagcctggat aaactgctga
     8401 gccagattat tcctgtgatt ggagtttaat tgctgtagaa cacttgttga gaacacattt
     8461 tttacttttt ttctttcaga attattcctc aatcattgtt ctctaatgaa aacaccgaga
     8521 agtaaatctg gtgcttctta gtgtaaatat gtttttcttt ttaaaaagtc attttaaaac
     8581 aaagatgaga gaactataaa gtaaggggaa atatcatttt atttaaaaat aattattcaa
     8641 tgatagataa tggagataca gaatgactca ttgggttcat aggtatgatt tgtgcagcca
     8701 gtcttagagg aaatacatca ttttaacatt attcccacaa aatgttaaag ctcaatggtt
     8761 tgactatgag agtcaaacaa ttactatttg aaaatctctt atgacatttt tataatctac
     8821 tctgttttta tttgcatgat tatgcttatg tgatgaacca tccatgattc tgatattgta
     8881 tttctttcca gtattaacat gtgtattgtg tggccaactc tgatttgtac accgtattat
     8941 tgttgtaatg attcaactgt tcctacattt aattgcagtt taattattat gccttttggg
     9001 gttaaatgat gtgaagtgtt tccacctact gataaatacc atatgaaaac acgactaaaa
     9061 gactgattta agaaacttgt tatttttaaa aatatgaatt tcaaaagaaa tgttctcaaa
     9121 gacacatgca tttattttaa attcaaaaaa ttcttatgaa tttattattg cttgtacttt
     9181 aacttttttt attgtagaca atcctaagtg aataatgtct catgggagaa cacatgatat
     9241 gtgcttgtat ttgtgtaatc tgatcatgca ctcaatggtt ggaaaaggca ctccagtgct
     9301 aagaaaataa ccagaagcca atatatcgat tcttatatct cggtttatgt taccaactga
     9361 atatggtgta atgcataact ttttccagta aataaactgg ttattttttg ttcatttca
//
