LOCUS       NM_001080512            5741 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BicC family RNA binding protein 1 (BICC1), mRNA.
ACCESSION   NM_001080512 XM_498431
VERSION     NM_001080512.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5741)
  AUTHORS   Meng,F., Hua,S., Chen,X., Meng,N. and Lan,T.
  TITLE     Lymph node metastasis related gene BICC1 promotes tumor progression
            by promoting EMT and immune infiltration in pancreatic cancer
  JOURNAL   BMC Med Genomics 16 (1), 263 (2023)
   PUBMED   37880742
  REMARK    GeneRIF: Lymph node metastasis related gene BICC1 promotes tumor
            progression by promoting EMT and immune infiltration in pancreatic
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5741)
  AUTHORS   Huang,C., Li,H., Xu,Y., Xu,C., Sun,H., Li,Z., Ge,Y., Wang,H.,
            Zhao,T., Gao,S., Wang,X., Yang,S., Sun,P., Liu,Z., Liu,J., Chang,A.
            and Hao,J.
  TITLE     BICC1 drives pancreatic cancer progression by inducing
            VEGF-independent angiogenesis
  JOURNAL   Signal Transduct Target Ther 8 (1), 271 (2023)
   PUBMED   37443111
  REMARK    GeneRIF: BICC1 drives pancreatic cancer progression by inducing
            VEGF-independent angiogenesis.
            Erratum:[Signal Transduct Target Ther. 2024 Jan 5;9(1):8. doi:
            10.1038/s41392-023-01721-z.. PMID: 38177109]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5741)
  AUTHORS   Zhao,R., Peng,C., Song,C., Zhao,Q., Rong,J., Wang,H., Ding,W.,
            Wang,F. and Xie,Y.
  TITLE     BICC1 as a novel prognostic biomarker in gastric cancer correlating
            with immune infiltrates
  JOURNAL   Int Immunopharmacol 87, 106828 (2020)
   PUBMED   32736193
  REMARK    GeneRIF: BICC1 as a novel prognostic biomarker in gastric cancer
            correlating with immune infiltrates.
REFERENCE   4  (bases 1 to 5741)
  AUTHORS   Wang,H., Guo,Y., Mi,N. and Zhou,L.
  TITLE     miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by
            targeting BICC1
  JOURNAL   Mol Cell Probes 52, 101567 (2020)
   PUBMED   32259627
  REMARK    GeneRIF: miR-101-3p and miR-199b-5p promote cell apoptosis in oral
            cancer by targeting BICC1.
REFERENCE   5  (bases 1 to 5741)
  AUTHORS   Xu,Z., Lie,R.T., Wilcox,A.J., Saugstad,O.D. and Taylor,J.A.
  TITLE     A comparison of DNA methylation in newborn blood samples from
            infants with and without orofacial clefts
  JOURNAL   Clin Epigenetics 11 (1), 40 (2019)
   PUBMED   30832715
  REMARK    GeneRIF: Data identified a significantly differentially methylated
            cg09696939 near gene BICC1 to be associated with cleft lip and
            cleft palate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5741)
  AUTHORS   Kraus,M.R., Clauin,S., Pfister,Y., Di Maio,M., Ulinski,T.,
            Constam,D., Bellanne-Chantelot,C. and Grapin-Botton,A.
  TITLE     Two mutations in human BICC1 resulting in Wnt pathway hyperactivity
            associated with cystic renal dysplasia
  JOURNAL   Hum Mutat 33 (1), 86-90 (2012)
   PUBMED   21922595
  REMARK    GeneRIF: The nonsense mutation identified in BICC1 and associated
            with cystic renal dysplasia results in a complete loss of Wnt
            inhibitory activity. The point mutation in the SAM domain results
            in a 22% loss of activity.
REFERENCE   7  (bases 1 to 5741)
  AUTHORS   Lewis,C.M., Ng,M.Y., Butler,A.W., Cohen-Woods,S., Uher,R.,
            Pirlo,K., Weale,M.E., Schosser,A., Paredes,U.M., Rivera,M.,
            Craddock,N., Owen,M.J., Jones,L., Jones,I., Korszun,A.,
            Aitchison,K.J., Shi,J., Quinn,J.P., Mackenzie,A., Vollenweider,P.,
            Waeber,G., Heath,S., Lathrop,M., Muglia,P., Barnes,M.R.,
            Whittaker,J.C., Tozzi,F., Holsboer,F., Preisig,M., Farmer,A.E.,
            Breen,G., Craig,I.W. and McGuffin,P.
  TITLE     Genome-wide association study of major recurrent depression in the
            U.K. population
  JOURNAL   Am J Psychiatry 167 (8), 949-957 (2010)
   PUBMED   20516156
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 5741)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5741)
  AUTHORS   Riemenschneider,M., Mahmoodzadeh,S., Eisele,T., Klopp,N.,
            Schwarz,S., Wagenpfeil,S., Diehl,J., Mueller,U., Foerstl,H.,
            Illig,T. and Kurz,A.
  TITLE     Association analysis of genes involved in cholesterol metabolism
            located within the linkage region on chromosome 10 and Alzheimer's
            disease
  JOURNAL   Neurobiol Aging 25 (10), 1305-1308 (2004)
   PUBMED   15465627
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5741)
  AUTHORS   Wessely,O., Tran,U., Zakin,L. and De Robertis,E.M.
  TITLE     Identification and expression of the mammalian homologue of
            Bicaudal-C
  JOURNAL   Mech Dev 101 (1-2), 267-270 (2001)
   PUBMED   11231089
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023170.10, AY726586.1,
            AC012168.10, AK225427.1, BM972104.1 and BQ014634.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001080512.2.
            
            Summary: This gene encodes an RNA-binding protein that is active in
            regulating gene expression by modulating protein translation during
            embryonic development. Mouse studies identified the corresponding
            protein to be under strict control during cell differentiation and
            to be a maternally provided gene product. [provided by RefSeq, Apr
            2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373886.8/ ENSP00000362993.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC023170.10        9782-10243          c
            463-656             AY726586.1         136-329
            657-659             AC012168.10        55827-55829         c
            660-2127            AY726586.1         333-1800
            2128-2805           AK225427.1         758-1435
            2806-3053           AY726586.1         2480-2727
            3054-3098           BM972104.1         318-362             c
            3099-5290           AC012168.10        9923-12114          c
            5291-5741           BQ014634.1         18-468              c
FEATURES             Location/Qualifiers
     source          1..5741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..5741
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /note="BicC family RNA binding protein 1"
                     /db_xref="GeneID:80114"
                     /db_xref="HGNC:HGNC:19351"
                     /db_xref="MIM:614295"
     exon            1..462
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..3197
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /note="FGFR2-BICC1 fusion kinase protein; bicaudal C
                     homolog 1"
                     /codon_start=1
                     /product="protein bicaudal C homolog 1"
                     /protein_id="NP_001073981.1"
                     /db_xref="CCDS:CCDS31206.1"
                     /db_xref="GeneID:80114"
                     /db_xref="HGNC:HGNC:19351"
                     /db_xref="MIM:614295"
                     /translation="MAAQGEPGYLAAQSDPGSNSERSTDSPVPGSEDDLVAGATLHSP
                     EWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKK
                     DPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVME
                     ETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQ
                     PVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLA
                     GSLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYL
                     QGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDVFISIKPKPKQPS
                     KSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGL
                     GLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSA
                     TGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKKI
                     SAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDA
                     FVEVGMPRSPSHSGNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHSTDRLLSDPE
                     LSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
                     AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSL
                     SRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHYLSSSNYMD
                     CISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKE
                     LGITTFGARRKMLLAISELNKNRRKLFESPNARTSFLEGGASGRLPRQYHSDIASVSG
                     RW"
     exon            463..509
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            510..579
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            580..659
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            660..818
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            819..872
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1067
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1319
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1451
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1638
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1800
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1997
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2130
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2287
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2453
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2493
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2648
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2805
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2966
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3066
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..5741
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /note="hexamer: AATAAA"
     polyA_site      5741
                     /gene="BICC1"
                     /gene_synonym="BICC"
                     /note="major polyA site"
ORIGIN      
        1 attccgcgcg ggcgttgctg gcggggggcg gcgcagccac tggacccgga ccggggccgc
       61 gacccggggt ggcgggtggc gtgggcggcg cccggggctg ggatgcgccg ggggctcagt
      121 ggcggcggcg gcgttggcgg tggcgtcggc ggctgcaggg ggacgagcta gcgccgcggc
      181 gctgggagcc agttgagccc ggccggcgag cggaggcggc agcgcaggca gagcggcggc
      241 ggcagcggga gcccgagcgc tgcgcgccca ccatggccgc ccagggagag cccggctacc
      301 tggcggcgca gtcggacccc ggctccaaca gcgagcgcag caccgactcc ccagtgcccg
      361 gctccgagga cgacttggtc gccggggcga ccctgcacag cccggagtgg agcgaggagc
      421 gcttccgcgt ggacaggaag aaacttgagg ccatgttaca agctgctgct gaagggaaag
      481 gcagaagtgg ggaagacttt tttcaaaaga tcatggagga aacaaatacg cagattgctt
      541 ggccatcaaa actgaagatc ggagccaaat ccaagaaaga tccccatatt aaggtttctg
      601 gaaagaaaga agatgttaaa gaagccaagg aaatgatcat gtctgtctta gacacaaaaa
      661 gcaatcgagt cacactgaag atggatgttt cacatacaga acattcacat gtaatcggca
      721 aaggtggcaa caatattaaa aaagtgatgg aagaaaccgg atgccatatc cactttccag
      781 attccaacag gaataaccaa gcagaaaaaa gcaaccaggt atctatagcg ggacaaccag
      841 caggagtaga atctgcccga gttagaattc gggagctgct tcctttggtg ctgatgtttg
      901 agctaccaat tgctggaatt cttcaaccgg ttcctgatcc taattccccc tctattcagc
      961 atatatcaca aacgtacaat atttcagtat catttaaaca gcgttcccga atgtatggtg
     1021 ctactgtcat agtacgaggg tctcagaata acactagtgc tgtgaaggaa ggaactgcca
     1081 tgctgttaga acatcttgct gggagcttag catcagctat tcctgtgagc acacaactag
     1141 atattgcagc tcaacatcat ctctttatga tgggtcgaaa tgggagcaac atcaaacata
     1201 tcatgcagag aacaggtgct cagatccact ttcctgatcc cagtaatcca caaaagaaat
     1261 ctaccgtcta cctccagggc accattgagt ctgtctgtct tgcaaggcaa tatctcatgg
     1321 gttgtcttcc tcttgtgttg atgtttgata tgaaggaaga aattgaagta gatccacaat
     1381 tcattgcgca gttgatggaa cagcttgatg tcttcatcag tattaaacca aagcccaaac
     1441 agccaagcaa gtctgtgatt gtgaaaagtg ttgagcgaaa tgccttaaat atgtatgaag
     1501 caaggaaatg tctcctcgga cttgaaagca gtggggttac catagcaacc agtccatccc
     1561 cagcatcctg ccctgccggc ctggcatgtc ccagcctgga tatcttagct tcagcaggcc
     1621 ttggactcac tggactaggt cttttgggac ccaccacctt atctctgaac acttcaacaa
     1681 ccccaaactc actcttgaat gctcttaata gctcagtcag tcctttgcaa agtccaagtt
     1741 ctggtacacc cagccccaca ttatgggcac ccccacttgc taatacttca agtgccacag
     1801 gtttttctgc tataccacac cttatgattc catctactgc ccaagccaca ttaactaata
     1861 ttttgttgtc tggagtgccc acctatgggc acacagctcc atctccccct cctggcttga
     1921 ctcctgttga tgtccatatc aacagtatgc agaccgaagg caaaaaaatc tctgctgctt
     1981 taaatggaca tgcacagtct ccagatataa aatatggtgc aatatccact tcatcacttg
     2041 gagaaaaagt gctgagtgca aatcacgggg atccgtccat ccagacaagt gggtctgagc
     2101 agacatctcc caaatcaagc cccactgaag gttgtaatga tgcttttgtt gaagtaggca
     2161 tgcctcgaag tccttcccat tctgggaatg ctggtgactt gaaacagatg atgtgtccct
     2221 ccaaggtttc ctgtgccaaa aggcagacag tggaactatt gcaaggcacg aaaaactcac
     2281 acttacacag cactgacagg ttgctctcag accctgaact gagtgctacc gaaagccctt
     2341 tggctgacaa gaaggctcca gggagtgagc gcgctgcaga gagggcagca gctgcccagc
     2401 aaaactccga aagggcccac cttgctccac ggtcatcata tgtcaacatg caggcatttg
     2461 actatgaaca gaagaagcta ttagccacca aagctatgtt aaagaaacca gtggtgacgg
     2521 aggtcagaac gcccacaaat acctggagtg gcctgggttt ttctaaatcc atgccagctg
     2581 aaactatcaa ggagttgaga agggccaatc atgtgtccta taagcccaca atgacaacca
     2641 cttatgaggg ctcatccatg tccctttcac ggtccaacag tcgtgagcac ttgggaggtg
     2701 gaagcgaatc tgataactgg agagaccgaa atggaattgg acctggaagt catagtgaat
     2761 ttgcagcttc tattggcagc cctaagcgta aacaaaacaa atcaacggaa cactatctca
     2821 gcagtagcaa ttacatggac tgcatttcct cgctgacagg aagcaatggc tgtaacttaa
     2881 atagctcttt caaaggttct gacctccctg agctcttcag caaactgggc ctgggcaaat
     2941 acacagatgt tttccagcaa caagagatcg atcttcagac attcctcact ctcacagatc
     3001 aggatctgaa ggagctggga ataactactt ttggtgccag gaggaaaatg ctgcttgcaa
     3061 tttcagaact aaataaaaac cgaagaaagc tttttgaatc gccaaatgca cgcacctctt
     3121 tcctggaagg tggagcgagt ggaaggctac cccgtcagta tcactcagac attgctagtg
     3181 tcagtggccg ctggtagcag caccctcttg gcacatgccc gctgactaac tgtaaagtgg
     3241 acacaggaga tgtatgaaca gccttcacag cacaccatcc ttagcactct gggtgtctgg
     3301 tatcaggacc aaagcatttt attcgcacct gtactttatg gcaaaaagga agaagagaga
     3361 gaagatgttc ttatgatgtc atacagaaca ccaaatatgg attacttttt taaaatggca
     3421 gttggacaga atttgcaata taaggatagg gctttatttc ctgtttttat ttacctatat
     3481 aacatatgca ctgatgattt tttttttttt tttttttttt ttttttttac ttaaaatgaa
     3541 ggatgaattg acatctggga tgccagaaga cttagaagtt attttgtttg cttgttttgt
     3601 ttgggtattt ggggattttt aaaaaataat caaagtggaa ttttctggta ctgctttaaa
     3661 ataattattg tggtctttca gcactttaca cgttctaatt tcttgtccta tggaagttct
     3721 cgctgtctcc atctctctca tttttgtgtc acctaatatg ttggtacaga taagagttag
     3781 tcacattttt ctgactgcat caaactttta tttgaaatgg tactggatct tagtttctgt
     3841 gcagaatatt ctgtgatttt gggaaatgta agtgagtcca cttgcttctg gaccaattct
     3901 gtttcatgta tgttagcatc ctagaaacac ctagcaatgg acctagttca cagtaatagg
     3961 tgcaaagaaa gaccaaatgg actttgcagt attaaccctt tgcagtcgtc atacttagct
     4021 gctgcctgta atgctaaaat gattttaatg gttgtctgga ggcaaagggc tgttttttag
     4081 tatattgcca ctaaaggaca tttatttata tcaaactttt atttttagat attataagca
     4141 tacagtacat aattgatgaa attgatattt actagagatt tatggtagag aatggacgac
     4201 attcaataac tggagcccga gattgtcact ttatttaaaa agacaaataa tcatctgaca
     4261 agacagcact gttgccatta taaggagaaa tagattacaa tccttatcat gtacacgtta
     4321 gctatgttcc gtatggccac aggactttcc tgaaaccgta tctgtctgct tgaagtagac
     4381 ttatgtttgt tgagaatgaa caggcttatt tgagcctcca gggtggcagt tcataaagac
     4441 agctaagttc tgaaggaaaa aaaaaatata tctttttaag tggctagagt cattattaca
     4501 atcttatact gtgaaagtcc aagaaatcag gcaacattgt ttcctgggtc ttttcagaga
     4561 tcttatagat ttatgaagtg tttttaatcc atgaagaaac actaaagtgc ctttctttct
     4621 tcaaagcaat attatttcca agtatattaa tttgttagaa aactttccca taggaaatgt
     4681 tgtcaagtta cctgtactgt aaagagttat ttatgttcag tagtcaagat tttctacatg
     4741 gacataaacc actctcacgt gctctcagca gaaggcatta gataagcata tacaagaatt
     4801 gggtactttt atacaaatat gggataagaa atacttgcct gacacttttc catggctgag
     4861 tctgaccatt acagtaagaa caagaattga agaggcattt tgcacacaga aacattctca
     4921 ctttaaaaaa tggtattggt taccttgaag gcatagataa tgggcctgtc ataaaattat
     4981 caattataac tggcaccgag ggactgccct ttttaagcta aactaagcct tatctgctta
     5041 aggatgttga actgaatcac tccctttact catcctgtgc atatgtgtac aaatggtcat
     5101 gtggatcatg tgatgatcat ccatcttatt tgattgtatt aatgcatcat gctaaacatg
     5161 tagtacaggt taacaatacc agatttatgt cctgttcaac aactcagtac tctaaatgtt
     5221 gttatgcttt taataagacc ttcccagata ataatcttgg agctcttttc ccagctgtct
     5281 accatgcatt tgcaacagga ggaagatgta atgaatatgc agtattaagt tgatttatga
     5341 acagtgcttt gatatgccaa agggaaaact gtcccactta aattagatta agtagggtgg
     5401 ctaaaaataa ataaaaacac tggaaattct ttctctcact ttctcttgat gcaatgaagg
     5461 gaatatgaca ctacagtata cagagttgtt gttatatgat gcacaaaata ttttgatgat
     5521 ttgaataaat gttaactttt aatctgcgcc ttaataatga ctggttatct gtaaatatag
     5581 aacagataca gattgtattt ttctgtgggt ttttgtcctt ttagtgattt ttttccaaaa
     5641 acgagagatg gaattaacat tgaaaatggg aaatttttct aactgaatca attgttacat
     5701 gaaaaataaa tttatataac ccctttgtat tgctcttgct a
//
