LOCUS       NM_177455               3262 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens basic helix-loop-helix family member a15 (BHLHA15),
            mRNA.
ACCESSION   NM_177455
VERSION     NM_177455.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Zhou,H., Du,Y., Wei,X., Song,C., Song,J., Xu,N., Huang,W., Chen,L.,
            Yao,F., Du,D., Qiu,C., Zhong,L., Liu,Y., Gu,D., Wang,J. and Xu,Y.
  TITLE     DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis
            of HCC through PTEN-AKT signaling
  JOURNAL   Theranostics 12 (14), 6069-6087 (2022)
   PUBMED   36168636
  REMARK    GeneRIF: DDX56 transcriptionally activates MIST1 to facilitate
            tumorigenesis of HCC through PTEN-AKT signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Nagashima,T., Oshima,T., Hiroshima,Y., Yokose,T., Woo,T., Rino,Y.,
            Masuda,M., Miyagi,Y., Ito,H. and Nakayama,H.
  TITLE     Clinical Significance of Tumour CD44v and MIST1 Expression in
            Patients With Non-small-cell Lung Cancer
  JOURNAL   Anticancer Res 40 (11), 6407-6416 (2020)
   PUBMED   33109579
  REMARK    GeneRIF: Clinical Significance of Tumour CD44v and MIST1 Expression
            in Patients With Non-small-cell Lung Cancer.
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Yamada,S., Yamanoi,K., Sato,Y. and Nakayama,J.
  TITLE     Diffuse MIST1 expression and decreased alpha1,4-linked
            N-acetylglucosamine (alphaGlcNAc) glycosylation on MUC6 are
            distinct hallmarks for gastric neoplasms showing oxyntic gland
            differentiation
  JOURNAL   Histopathology 77 (3), 413-422 (2020)
   PUBMED   32502322
  REMARK    GeneRIF: Diffuse MIST1 expression and decreased alpha1,4-linked
            N-acetylglucosamine (alphaGlcNAc) glycosylation on MUC6 are
            distinct hallmarks for gastric neoplasms showing oxyntic gland
            differentiation.
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Freiin Grote,A., Halske,C., Behrens,H.M., Kruger,S., Wilhelm,F.,
            Egberts,J.H. and Rocken,C.
  TITLE     Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively
            Treated Gastric Carcinomas and Correlation with Therapy Response
  JOURNAL   Dis Markers 2019, 8154926 (2019)
   PUBMED   31827644
  REMARK    GeneRIF: High MIST1 expression is associated with lymph node
            metastasis in Gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Tian,X., Jin,R.U., Bredemeyer,A.J., Oates,E.J., Blazewska,K.M.,
            McKenna,C.E. and Mills,J.C.
  TITLE     RAB26 and RAB3D are direct transcriptional targets of MIST1 that
            regulate exocrine granule maturation
  JOURNAL   Mol Cell Biol 30 (5), 1269-1284 (2010)
   PUBMED   20038531
  REMARK    GeneRIF: MIST1 binds to highly conserved CATATG E-boxes to directly
            activate transcription of 6 genes, including those encoding the
            small GTPases RAB26 and RAB3D.
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Zhao,Y., Johansson,C., Tran,T., Bettencourt,R., Itahana,Y.,
            Desprez,P.Y. and Konieczny,S.F.
  TITLE     Identification of a basic helix-loop-helix transcription factor
            expressed in mammary gland alveolar cells and required for
            maintenance of the differentiated state
  JOURNAL   Mol Endocrinol 20 (9), 2187-2198 (2006)
   PUBMED   16645041
  REMARK    GeneRIF: Mist1 within the hierarchy of known helix-loop-helix/basic
            helix-loop-helix proteins that control mammary epithelial cell
            development
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   McLellan,A.S., Langlands,K. and Kealey,T.
  TITLE     Exhaustive identification of human class II basic helix-loop-helix
            proteins by virtual library screening
  JOURNAL   Mech Dev 119 Suppl 1, S285-S291 (2002)
   PUBMED   14516699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091654.4.
            
            On May 1, 2020 this sequence version replaced NM_177455.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.26372.1,
                                           SRR11853560.26352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609256.2/ ENSP00000476312.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC091654.4         35970-36029
            61-3262             AC091654.4         36787-39988
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..3262
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /note="basic helix-loop-helix family member a15"
                     /db_xref="GeneID:168620"
                     /db_xref="HGNC:HGNC:22265"
                     /db_xref="MIM:608606"
     exon            1..60
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..3262
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..684
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /note="basic helix-loop-helix domain containing, class B,
                     8; muscle, intestine and stomach expression 1; class B
                     basic helix-loop-helix protein 8; class II bHLH protein
                     MIST1; MIST-1"
                     /codon_start=1
                     /product="class A basic helix-loop-helix protein 15"
                     /protein_id="NP_803238.1"
                     /db_xref="CCDS:CCDS5655.1"
                     /db_xref="GeneID:168620"
                     /db_xref="HGNC:HGNC:22265"
                     /db_xref="MIM:608606"
                     /translation="MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSR
                     PARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVI
                     PHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVA
                     GGALGATEAQPQGHLQRYSTQIHSFREGT"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /note="hexamer: AATAAA"
     polyA_site      3262
                     /gene="BHLHA15"
                     /gene_synonym="BHLHB8; MIST1"
                     /note="major polyA site"
ORIGIN      
        1 aaagcgacgt gtccttgtcc cccgtgggca gcctcggcgc gtgtggccgc ggatccccag
       61 ctccaagggc ctcaccttcc tgccgccacc tcctaggaca gccagtccag ggccatgaag
      121 accaagaacc ggcccccacg gcgccgggcc ccggtgcagg acacagaggc cacccccggg
      181 gaggggacgc ccgacgggtc cctgccgaac ccggggccag agccggccaa gggtctgcgg
      241 agccggccgg cccgggccgc agcaagggct ccgggcgagg gcaggcgcag gcggccagga
      301 ccctccgggc ccggtggccg tcgtgacagc agcatccagc ggcggctgga gagcaacgag
      361 agggagcggc agcggatgca caagctaaat aacgccttcc aggccctgcg tgaagtcatc
      421 ccccacgtgc gcgcggacaa gaagctctcc aagatcgaga cgctcacgct ggccaagaac
      481 tacatcaaat cgctgacggc caccatcctg accatgtcca gcagccgcct cccaggcctg
      541 gaggggccgg gccccaagct ctaccagcac taccagcagc agcagcaggt ggctgggggt
      601 gcgttggggg ccacggaggc ccagccccag ggccacctgc agaggtactc cacgcagatc
      661 cacagcttcc gagagggcac ctagcgccca gtcctgggtg ggggtggcgg tggccgcagc
      721 tgcctggcct gctcctccca gccccagtcc ctccaagcca cgagccccag atgggcggtg
      781 acaccccaca aggacacggc ctcagcggtt ccattttccc ccgaacattc agccacttcc
      841 ctggagcaat ttttcctgcc ccgctgggga ccagcgagtg gcctagttgc ggctgtggcc
      901 ctggacagcg gcgtgaggcc caaacctcta ggtagggccc agttggatcc tgatttttca
      961 ttgagccagg cagtctcagc ccgagttgaa aggcctcctt agccttggaa ctaacgtctc
     1021 ttcaccctga cttctgggca aggggagatc ccaggaaaag gtttacctgc aggttttcca
     1081 aggccaaagc cccagcaagg accccctctc caacctttgt tatagggcta catggggcct
     1141 gggctcagca tcctcatttg gggtaaactg aggcccggga caagcccggc agagcctaag
     1201 gctgctcggg gagtggggcc aatcagagat gattggagct gccagaaact ctaatcagat
     1261 gacctccaat tcatccttaa aagttgaatg gtggggaggg gctggagtct cttcctccct
     1321 cctcccaagt tggggctcct ggatgtgttg actccaggct gtgcctggtt gtggagggtc
     1381 tggggcaggg tgtgaggggt gctgtggaac tggagcagga gacagggctg ggtgttcctg
     1441 gtgcagccct tctgggcatg ggagagaagc cccaaggccc tgggttgctc cccaagagca
     1501 gctctgaggc ctcctgctca gccctggcct gtgtggggag cgagtgtgcc ccccacccag
     1561 cccctgccac cgccgttact tattctcact gatgtggggt tatcatataa ttggcaccat
     1621 gctgtctgta ggacattatg acgtgcttgg gttctggttt gagttggcag cccgttgggt
     1681 ctctctgcct ggtggagcct tggggtggca ggtacgtccc ttcccccgcc caggtgcttc
     1741 atcctcatgg ccaggcctgg tggcttggca cgtctctgct gccccaagcc cagcttcctt
     1801 ctgctgggcg ttcctgcccc actggctctg ccggacttgg ctactggact ctcccctccc
     1861 tcatgcctct gcccagagat gtcccaaagg ccctcagggc caagccgggc cagggatgtg
     1921 gctgccacag ctgagaccaa gggctctggc tggcccgtcc ccaccaggtg gccctgccct
     1981 ccccaagttg ggggttgtgg cacttggggt caggcctagc cacgtaagga cacaggtaac
     2041 accctgagga tctggcattg gcagcttcag gcctaacttt cctggtcagg gccccttaag
     2101 gtggcccggg cacattggtt tcatttcgat gagactttgt cagaggcctg gtctggtcct
     2161 ggccctaccg ccccagctgt ccttcagcac agctcggggt ggggactcca ggatgctggg
     2221 tctgcccctt gggaggggca ctctggaagg tcagggtgat ccacaactgt gagctgaggt
     2281 tggatgcagc tgggagcttg ggacagagag agcccagggc tcccctgctg tggggcacct
     2341 gcccagcggg gacatgagat gacagagacc tccccggcgg gggtactcag gtgctacgaa
     2401 catggcagct cttgtttccg gctgagccat ggccagagca gggctcagtc tgcccctgaa
     2461 cttgctgaat ggaccgacga gctgagcctg aaagcccaga agagcctcgg tccagaagac
     2521 ggagactcgg cccggtgtcc agcgcagccc agggcttcct ggggggcagc aggagtgcct
     2581 gggggtcacc gccttcagga caatggcctc agtggctctt tctttctgcc ctgaactggc
     2641 acctgcacct cctctgcttc ctagagggtg acctgggccg agccgcccag tccttcttcc
     2701 cctgaggcca gaggggacgc cccgcggcca catcacacag gatcctcagc agccatagtc
     2761 tcgcttcagg gtgtccagtg tttcgaggag gagaggggac aggggccagg tccactccct
     2821 tggccctcct cttggacccc aaggccaggc cggatccttt tatcccgtgg ggagcccctg
     2881 cctcggccat cgggatgagg tccctcaagt ccctgcacaa gcaggtcaga gacccaccca
     2941 catgccgttc ctgggctacg ccacgcgcca tcccccgggg ctgtggacgc acccagcccc
     3001 cgacagacag gcgccctgag agctccgaag gcgcgatccc catccccacc agtggagaag
     3061 ccagaaccgc gattgttgca tctgggaaaa cccagctgga gccgaacggc ccgtgccccc
     3121 actgtaattg tgctgaaaat gtttctcaaa tgacccaaat tggctcttat tttttctaat
     3181 ggccctttca aagtattcat gaaattgatg ctgtgtcata aaacaaaaat aaaagatttc
     3241 acagcaatgt ctgcttcagg ca
//
