LOCUS       NM_001711               2353 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens biglycan (BGN), mRNA.
ACCESSION   NM_001711
VERSION     NM_001711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2353)
  AUTHORS   Wu,C., Hou,X., Li,S. and Luo,S.
  TITLE     Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric
            cancer cells through modulating miR-429/BGN axis
  JOURNAL   J Biochem Mol Toxicol 37 (8), e23381 (2023)
   PUBMED   37128782
  REMARK    GeneRIF: Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of
            gastric cancer cells through modulating miR-429/BGN axis.
REFERENCE   2  (bases 1 to 2353)
  AUTHORS   Yu,M., He,X., Song,X., Gao,J., Pan,J., Zhou,T., Wang,Q., Zhu,W.,
            Ma,H., Zeng,H., Xu,C. and Yu,C.
  TITLE     Biglycan promotes hepatic fibrosis through activating heat shock
            protein 47
  JOURNAL   Liver Int 43 (2), 500-512 (2023)
   PUBMED   36371672
  REMARK    GeneRIF: Biglycan promotes hepatic fibrosis through activating heat
            shock protein 47.
REFERENCE   3  (bases 1 to 2353)
  AUTHORS   Furumido,J., Maishi,N., Yanagawa-Matsuda,A., Kikuchi,H.,
            Matsumoto,R., Osawa,T., Abe,T., Matsuno,Y., Shinohara,N., Hida,Y.
            and Hida,K.
  TITLE     Stroma biglycan expression can be a prognostic factor in prostate
            cancers
  JOURNAL   Int J Urol 30 (2), 147-154 (2023)
   PUBMED   36305810
  REMARK    GeneRIF: Stroma biglycan expression can be a prognostic factor in
            prostate cancers.
REFERENCE   4  (bases 1 to 2353)
  AUTHORS   He,Z., Lin,J., Chen,C., Chen,Y., Yang,S., Cai,X., He,Y. and Liu,S.
  TITLE     Identification of BGN and THBS2 as metastasis-specific biomarkers
            and poor survival key regulators in human colon cancer by
            integrated analysis
  JOURNAL   Clin Transl Med 12 (11), e973 (2022)
   PUBMED   36377223
  REMARK    GeneRIF: Identification of BGN and THBS2 as metastasis-specific
            biomarkers and poor survival key regulators in human colon cancer
            by integrated analysis.
REFERENCE   5  (bases 1 to 2353)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   6  (bases 1 to 2353)
  AUTHORS   Traupe,H., van den Ouweland,A.M., van Oost,B.A., Vogel,W.,
            Vetter,U., Warren,S.T., Rocchi,M., Darlison,M.G. and Ropers,H.H.
  TITLE     Fine mapping of the human biglycan (BGN) gene within the Xq28
            region employing a hybrid cell panel
  JOURNAL   Genomics 13 (2), 481-483 (1992)
   PUBMED   1612609
REFERENCE   7  (bases 1 to 2353)
  AUTHORS   Fisher,L.W., Heegaard,A.M., Vetter,U., Vogel,W., Just,W.,
            Termine,J.D. and Young,M.F.
  TITLE     Human biglycan gene. Putative promoter, intron-exon junctions, and
            chromosomal localization
  JOURNAL   J Biol Chem 266 (22), 14371-14377 (1991)
   PUBMED   1860845
REFERENCE   8  (bases 1 to 2353)
  AUTHORS   Fleischmajer,R., Fisher,L.W., MacDonald,E.D., Jacobs,L. Jr.,
            Perlish,J.S. and Termine,J.D.
  TITLE     Decorin interacts with fibrillar collagen of embryonic and adult
            human skin
  JOURNAL   J Struct Biol 106 (1), 82-90 (1991)
   PUBMED   2059554
REFERENCE   9  (bases 1 to 2353)
  AUTHORS   McBride,O.W., Fisher,L.W. and Young,M.F.
  TITLE     Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40)
            genes on human chromosomes Xq13-qter and 12q, respectively
  JOURNAL   Genomics 6 (2), 219-225 (1990)
   PUBMED   1968422
REFERENCE   10 (bases 1 to 2353)
  AUTHORS   Fisher,L.W., Termine,J.D. and Young,M.F.
  TITLE     Deduced protein sequence of bone small proteoglycan I (biglycan)
            shows homology with proteoglycan II (decorin) and several
            nonconnective tissue proteins in a variety of species
  JOURNAL   J Biol Chem 264 (8), 4571-4576 (1989)
   PUBMED   2647739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC299956.1, BC002416.2,
            AK297966.1, BQ180984.1 and AI538325.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001711.5.
            
            Summary: This gene encodes a member of the small leucine-rich
            proteoglycan (SLRP) family of proteins. The encoded preproprotein
            is proteolytically processed to generate the mature protein, which
            plays a role in bone growth, muscle development and regeneration,
            and collagen fibril assembly in multiple tissues. This protein may
            also regulate inflammation and innate immunity. Additionally, the
            encoded protein may contribute to atherosclerosis and aortic valve
            stenosis in human patients. This gene and the related gene decorin
            are thought to be the result of a gene duplication. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.73748.1,
                                           SRR3476690.369034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331595.9/ ENSP00000327336.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                DC299956.1         92-188
            98-285              BC002416.2         82-269
            286-286             AK297966.1         286-286
            287-1907            BC002416.2         271-1891
            1908-2093           BQ180984.1         287-472             c
            2094-2094           AI538325.1         283-283             c
            2095-2353           BQ180984.1         27-285              c
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2353
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /note="biglycan"
                     /db_xref="GeneID:633"
                     /db_xref="HGNC:HGNC:1044"
                     /db_xref="MIM:301870"
     exon            1..134
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            135..383
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1252
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /note="small leucine-rich protein 1A; dermatan sulphate
                     proteoglycan I; bone/cartilage proteoglycan-I"
                     /codon_start=1
                     /product="biglycan preproprotein"
                     /protein_id="NP_001702.1"
                     /db_xref="CCDS:CCDS14721.1"
                     /db_xref="GeneID:633"
                     /db_xref="HGNC:HGNC:1044"
                     /db_xref="MIM:301870"
                     /translation="MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGA
                     DTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDI
                     SELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSS
                     LVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEA
                     KLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFL
                     PTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNG
                     ISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK"
     exon            384..496
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            497..710
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            711..821
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            822..915
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1054
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..2353
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2353
                     /gene="BGN"
                     /gene_synonym="DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A"
                     /note="major polyA site"
ORIGIN      
        1 ctctctccac aaactgccca ggagtgagta gctgctttcg gtccgccgga cacaccggac
       61 agatagacgt gcggacggcc caccacccca gcccgccaac tagtcagcct gcgcctggcg
      121 cctcccctct ccaggtccat ccgccatgtg gcccctgtgg cgcctcgtgt ctctgctggc
      181 cctgagccag gccctgccct ttgagcagag aggcttctgg gacttcaccc tggacgatgg
      241 gccattcatg atgaacgatg aggaagcttc gggcgctgac acctcgggcg tcctggaccc
      301 ggactctgtc acacccacct acagcgccat gtgtcctttc ggctgccact gccacctgcg
      361 ggtggttcag tgctccgacc tgggtctgaa gtctgtgccc aaagagatct cccctgacac
      421 cacgctgctg gacctgcaga acaacgacat ctccgagctc cgcaaggatg acttcaaggg
      481 tctccagcac ctctacgccc tcgtcctggt gaacaacaag atctccaaga tccatgagaa
      541 ggccttcagc ccactgcgga agctgcagaa gctctacatc tccaagaacc acctggtgga
      601 gatcccgccc aacctaccca gctccctggt ggagctccgc atccacgaca accgcatccg
      661 caaggtgccc aagggagtgt tcagcgggct ccggaacatg aactgcatcg agatgggcgg
      721 gaacccactg gagaacagtg gctttgaacc tggagccttc gatggcctga agctcaacta
      781 cctgcgcatc tcagaggcca agctgactgg catccccaaa gacctccctg agaccctgaa
      841 tgaactccac ctagaccaca acaaaatcca ggccatcgaa ctggaggacc tgcttcgcta
      901 ctccaagctg tacaggctgg gcctaggcca caaccagatc aggatgatcg agaacgggag
      961 cctgagcttc ctgcccaccc tccgggagct ccacttggac aacaacaagt tggccagggt
     1021 gccctcaggg ctcccagacc tcaagctcct ccaggtggtc tatctgcact ccaacaacat
     1081 caccaaagtg ggtgtcaacg acttctgtcc catgggcttc ggggtgaagc gggcctacta
     1141 caacggcatc agcctcttca acaaccccgt gccctactgg gaggtgcagc cggccacttt
     1201 ccgctgcgtc actgaccgcc tggccatcca gtttggcaac tacaaaaagt agaggcagct
     1261 gcagccaccg cggggcctca gtgggggtct ctggggaaca cagccagaca tcctgatggg
     1321 gaggcagagc caggaagcta agccagggcc cagctgcgtc caacccagcc ccccacctcg
     1381 ggtccctgac cccagctcga tgccccatca ccgcctctcc ctggctccca agggtgcagg
     1441 tgggcgcaag gcccggcccc catcacatgt tcccttggcc tcagagctgc ccctgctctc
     1501 ccaccacagc cacccagagg caccccatga agcttttttc tcgttcactc ccaaacccaa
     1561 gtgtccaagg ctccagtcct aggagaacag tccctgggtc agcagccagg aggcggtcca
     1621 taagaatggg gacagtgggc tctgccaggg ctgccgcacc tgtccagaca cacatgttct
     1681 gttcctcctc ctcatgcatt tccagccttt caaccctccc cgactctgcg gctcccctca
     1741 gcccccttgc aagttcatgg cctgtccctc ccagacccct gctccactgg cccttcgacc
     1801 agtcctccct tctgttctct ctttccccgt ccttcctctc tctctctctc tctctctctc
     1861 tctctttctg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtcttgtgc
     1921 ttcctcagac ctttctcgct tctgagcttg gtggcctgtt ccctccatct ctccgaacct
     1981 ggcttcgcct gtccctttca ctccacaccc tctggccttc tgccttgagc tgggactgct
     2041 ttctgtctgt ccggcctgca cccagcccct gcccacaaaa ccccagggac agcagtctcc
     2101 ccagcctgcc ctgctcaggc cttgccccca aacctgtact gtcccggagg aggttgggag
     2161 gtggaggccc agcatcccgc gcagatgaca ccatcaaccg ccagagtccc agacaccggt
     2221 tttcctagaa gcccctcacc cccactggcc cactggtggc taggtctccc cttatccttc
     2281 tggtccagcg caaggagggg ctgcttctga ggtcggtggc tgtctttcca ttaaagaaac
     2341 accgtgcaac gtg
//
