LOCUS       NM_001080425            1312 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens brain expressed X-linked 4 (BEX4), transcript variant
            2, mRNA.
ACCESSION   NM_001080425 XM_043653
VERSION     NM_001080425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Zhu,C. and Xiao,D.
  TITLE     Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel
            prognostic biomarker in gastric cancer
  JOURNAL   Medicine (Baltimore) 99 (47), e23133 (2020)
   PUBMED   33217815
  REMARK    GeneRIF: Aberrant brain-expressed X-linked 4 (BEX4) expression is a
            novel prognostic biomarker in gastric cancer.
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Lee,J.K., Ha,G.H., Kim,H.S. and Lee,C.W.
  TITLE     Oncogenic potential of BEX4 is conferred by Polo-like kinase
            1-mediated phosphorylation
  JOURNAL   Exp Mol Med 50 (10), 1-12 (2018)
   PUBMED   30367032
  REMARK    GeneRIF: these results suggest that the oncogenicity of BEX4 is
            conferred by PLK1-mediated phosphorylation, and thus, the BEX4-PLK1
            interaction is a novel oncogenic signal that enables the
            acquisition of chromosomal aneuploidy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1312)
  AUTHORS   Zhao,Z., Li,J., Tan,F., Gao,S. and He,J.
  TITLE     mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell
            proliferation by potentiating OCT4
  JOURNAL   Biochem Biophys Res Commun 500 (2), 302-309 (2018)
   PUBMED   29660335
  REMARK    GeneRIF: BEX4 positively regulated the expression of OCT4,
            silencing of which reduced the proliferation of A549 and H1975cells
            with over-expressed BEX4.
REFERENCE   5  (bases 1 to 1312)
  AUTHORS   Lee,J.K., Lee,J., Go,H., Lee,C.G., Kim,S., Kim,H.S., Cho,H.,
            Choi,K.S., Ha,G.H. and Lee,C.W.
  TITLE     Oncogenic microtubule hyperacetylation through BEX4-mediated
            sirtuin 2 inhibition
  JOURNAL   Cell Death Dis 7 (8), e2336 (2016)
   PUBMED   27512957
  REMARK    GeneRIF: BEX4 overexpression causes an imbalance between TUB
            acetylation and deacetylation by SIRT2 inhibition and induces
            oncogenic aneuploidy transformation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1312)
  AUTHORS   Gao,W., Li,J.Z., Chen,S.Q., Chu,C.Y., Chan,J.Y. and Wong,T.S.
  TITLE     Decreased brain-expressed X-linked 4 (BEX4) expression promotes
            growth of oral squamous cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 35 (1), 92 (2016)
   PUBMED   27297407
  REMARK    GeneRIF: Study provides evidence that BEX4 functions as tumor
            suppressor by inhibiting proliferation and growth of oral squamous
            cell carcinoma (OSCC). Decreased BEX4 contributes to the increased
            proliferative propensity of OSCC.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1312)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1312)
  AUTHORS   Alvarez,E., Zhou,W., Witta,S.E. and Freed,C.R.
  TITLE     Characterization of the Bex gene family in humans, mice, and rats
  JOURNAL   Gene 357 (1), 18-28 (2005)
   PUBMED   15958283
REFERENCE   9  (bases 1 to 1312)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV726729.1, AL035494.8,
            BC068069.1, BC015794.2 and AI199874.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080425.3.
            
            Summary: This gene is a member of the brain expressed X-linked gene
            family. The proteins encoded by some of the other members of this
            family act as transcription elongation factors which allow RNA
            polymerase II to escape pausing during elongation. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2) contains an alternate
            non-coding exon in the 5' UTR. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.494872.1,
                                           SRR1803617.164318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372695.6/ ENSP00000361780.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AV726729.1         17-26
            11-39               AL035494.8         63257-63285
            40-849              BC068069.1         1-810
            850-1261            BC015794.2         827-1238
            1262-1266           AI199874.1         1-5                 c
            1267-1312           AL035494.8         65340-65385
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1312
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /note="brain expressed X-linked 4"
                     /db_xref="GeneID:56271"
                     /db_xref="HGNC:HGNC:25475"
                     /db_xref="MIM:300692"
     exon            1..131
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..214
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1312
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..582
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /note="BEX family member 4; brain expressed X-linked-like
                     1; BEX1-like protein 1; nerve growth factor
                     receptor-associated protein 3"
                     /codon_start=1
                     /product="protein BEX4"
                     /protein_id="NP_001073894.1"
                     /db_xref="CCDS:CCDS35355.1"
                     /db_xref="GeneID:56271"
                     /db_xref="HGNC:HGNC:25475"
                     /db_xref="MIM:300692"
                     /translation="MESKEELAANNLNGENAQQENEGGEQAPTQNEEESRHLGGGEGQ
                     KPGGNIRRGRVRRLVPNFRWAIPNRHIEHNEARDDVERFVGQMMEIKRKTREQQMRHY
                     MRFQTPEPDNHYDFCLIP"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /note="hexamer: AATAAA"
     polyA_site      1261
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /note="major polyA site"
     regulatory      1290..1295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
                     /note="hexamer: AAGAAA"
     polyA_site      1312
                     /gene="BEX4"
                     /gene_synonym="BEXL1"
ORIGIN      
        1 gagtgttgtc tcgctctggc gtcagagccg tcgtggctcg ttccattctc ggcggtggta
       61 cctgctcccg gtggccctga ggacgtgtgg gccaggggcg gccccgaaat taggaagcgg
      121 agggggagca gtctgcaggt ctgcggggct aagtgtcgcg gcggcgcacc tcgcgtcaag
      181 aatccggagg aggagactgc aaggataggc ccaggagtaa tggagtccaa agaggaacta
      241 gcggcaaaca atctcaacgg ggaaaatgcc caacaagaaa acgaaggagg ggagcaggcc
      301 cccacgcaga atgaagaaga atcccgccat ttgggagggg gtgaaggcca gaagcctgga
      361 ggaaatatca ggcgggggcg agttaggcga cttgtcccta attttcgatg ggccatacct
      421 aataggcata ttgagcacaa tgaagcgaga gatgatgtag aaaggtttgt agggcagatg
      481 atggaaatca agagaaagac tagggaacag cagatgaggc actatatgcg cttccaaact
      541 cctgaacctg acaaccatta tgacttttgc ctcatacctt gaatcctaaa agttttcgct
      601 gaggttaatg tgaacactgc tttacaagct tgtatttttg tgatttactt tttctgtaag
      661 ccttttgggg tttacactta ccagtttcta atggaaatta gaattctaat tgaatattgt
      721 tttgtctcag cctaaaagtt acggtcagca tggcaattca cctattttag gaaaaatact
      781 cttttcataa tatgaaatgc ataaagcagt tcaaaaagca gtctgtattc catcatcttc
      841 ctttttcatt ccagtcctta tttttgtaag tattactttt cctcctccgg ctacctggac
      901 tcaaaatctc agttgtcttt gacagttttt ttcttgtccc tgaccaaaaa agaatgatca
      961 tacccagaat tcaatgtttg atattttaag aatgtatgtt ctagtgtttt tcagagtgag
     1021 tctaccatct gtataaaaac accttggggg caggcagggg catttaaaaa tgtaggacct
     1081 atcgtccaga ctcacagagt ggggctccag aatctccatt tttaacaaac tctcttaagt
     1141 aattctgatg tgtaccaaaa tcagtgccat tggtgtgtgt gtacgtaact atatacatat
     1201 gtgtgtgtgt gtatatatat aatgtgtcat aaccgtaaac aataaacaat atcaagataa
     1261 atctgacttt gatgggcaag taattaaaaa agaaaagtat gagaccttaa aa
//
