LOCUS       NM_206917                810 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens brain expressed X-linked 3 (BEX3), transcript variant
            1, mRNA.
ACCESSION   NM_206917
VERSION     NM_206917.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 810)
  AUTHORS   Navas-Perez,E., Vicente-Garcia,C., Mirra,S., Burguera,D.,
            Fernandez-Castillo,N., Ferran,J.L., Lopez-Mayorga,M.,
            Alaiz-Noya,M., Suarez-Pereira,I., Anton-Galindo,E., Ulloa,F.,
            Herrera-Ubeda,C., Cusco,P., Falcon-Moya,R., Rodriguez-Moreno,A.,
            D'Aniello,S., Cormand,B., Marfany,G., Soriano,E., Carrion,A.M.,
            Carvajal,J.J. and Garcia-Fernandez,J.
  TITLE     Characterization of an eutherian gene cluster generated after
            transposon domestication identifies Bex3 as relevant for advanced
            neurological functions
  JOURNAL   Genome Biol 21 (1), 267 (2020)
   PUBMED   33100228
  REMARK    GeneRIF: Characterization of an eutherian gene cluster generated
            after transposon domestication identifies Bex3 as relevant for
            advanced neurological functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 810)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 810)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 810)
  AUTHORS   Gao,W., Li,J.Z., Chen,S.Q., Chu,C.Y., Chan,J.Y. and Wong,T.S.
  TITLE     BEX3 contributes to cisplatin chemoresistance in nasopharyngeal
            carcinoma
  JOURNAL   Cancer Med 6 (2), 439-451 (2017)
   PUBMED   28083995
  REMARK    GeneRIF: Results showed that BEX3 was overexpressed in
            nasopharyngeal carcinoma (NPC), and indicated a unique functional
            role of BEX3 in mediating the sensitivity of NPC cells to
            cisplatin.
REFERENCE   5  (bases 1 to 810)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 810)
  AUTHORS   Bilderback,T.R., Gazula,V.R. and Dobrowsky,R.T.
  TITLE     Phosphoinositide 3-kinase regulates crosstalk between Trk A
            tyrosine kinase and p75(NTR)-dependent sphingolipid signaling
            pathways
  JOURNAL   J Neurochem 76 (5), 1540-1551 (2001)
   PUBMED   11238738
REFERENCE   7  (bases 1 to 810)
  AUTHORS   Mukai,J., Hachiya,T., Shoji-Hoshino,S., Kimura,M.T., Nadano,D.,
            Suvanto,P., Hanaoka,T., Li,Y., Irie,S., Greene,L.A. and Sato,T.A.
  TITLE     NADE, a p75NTR-associated cell death executor, is involved in
            signal transduction mediated by the common neurotrophin receptor
            p75NTR
  JOURNAL   J Biol Chem 275 (23), 17566-17570 (2000)
   PUBMED   10764727
REFERENCE   8  (bases 1 to 810)
  AUTHORS   Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y.,
            Reed,J.C., Bredesen,D.E. and Sato,T.A.
  TITLE     Functional interaction of Fas-associated phosphatase-1 (FAP-1) with
            p75(NTR) and their effect on NF-kappaB activation
  JOURNAL   FEBS Lett 460 (2), 191-198 (1999)
   PUBMED   10544233
REFERENCE   9  (bases 1 to 810)
  AUTHORS   Ye,X., Mehlen,P., Rabizadeh,S., VanArsdale,T., Zhang,H., Shin,H.,
            Wang,J.J., Leo,E., Zapata,J., Hauser,C.A., Reed,J.C. and
            Bredesen,D.E.
  TITLE     TRAF family proteins interact with the common neurotrophin receptor
            and modulate apoptosis induction
  JOURNAL   J Biol Chem 274 (42), 30202-30208 (1999)
   PUBMED   10514511
REFERENCE   10 (bases 1 to 810)
  AUTHORS   Rapp,G., Freudenstein,J., Klaudiny,J., Mucha,J., Wempe,F.,
            Zimmer,M. and Scheit,K.H.
  TITLE     Characterization of three abundant mRNAs from human ovarian
            granulosa cells
  JOURNAL   DNA Cell Biol 9 (7), 479-485 (1990)
   PUBMED   2171551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057859.1 and BQ068114.1.
            
            On Aug 31, 2019 this sequence version replaced NM_206917.2.
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ068114.1, AL703319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361298.9/ ENSP00000354843.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-717               AK057859.1         36-752
            718-810             BQ068114.1         721-813
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..810
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /note="brain expressed X-linked 3"
                     /db_xref="GeneID:27018"
                     /db_xref="HGNC:HGNC:13388"
                     /db_xref="MIM:300361"
     exon            1..76
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..155
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..810
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..473
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /note="isoform a is encoded by transcript variant 1;
                     protein BEX3; p75NTR-associated cell death executor;
                     brain-expressed X-linked protein 3; ovarian granulosa cell
                     13.0 kDa protein HGR74; nerve growth factor receptor
                     (TNFRSF16) associated protein 1"
                     /codon_start=1
                     /product="protein BEX3 isoform a"
                     /protein_id="NP_996800.1"
                     /db_xref="CCDS:CCDS14509.1"
                     /db_xref="GeneID:27018"
                     /db_xref="HGNC:HGNC:13388"
                     /db_xref="MIM:300361"
                     /translation="MEQPMQNGEEDRPLGGGEGHQPAGNRRGQARRLAPNFRWAIPNR
                     QINDGMGGDGDDMEIFMEEMREIRRKLRELQLRNCLRILMGELSNHHDHHDEFCLMP"
     regulatory      698..703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /note="hexamer: AATAAA"
     polyA_site      719
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /note="major polyA site"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
                     /note="hexamer: AATACA"
     polyA_site      810
                     /gene="BEX3"
                     /gene_synonym="Bex; DXS6984E; Hero20; HGR74; NADE;
                     NGFRAP1"
ORIGIN      
        1 actcgcgtct ggctaccagc tccccgctgc cctgagctcg gcgggctggc attcggcccg
       61 gggaaaagcg gagcaggtct gcgaggctaa gtgtctccgc ggcgcacctc gcggcgagaa
      121 tccggaggag aaggagactg caaggatagg cccaggaaaa cgaagagatg gagcagccta
      181 tgcagaatgg agaggaagac cgccctttgg gaggaggtga aggccaccag cctgcaggaa
      241 atcgacgggg acaggctcgc cgacttgccc ctaattttcg atgggccata cccaataggc
      301 agatcaatga tgggatgggt ggagatggag atgatatgga aatattcatg gaggagatga
      361 gagaaatcag aagaaaactt agggagctgc agttgaggaa ttgtctgcgt atccttatgg
      421 gggagctctc taatcaccat gaccatcatg atgaattttg ccttatgcct tgactcctgc
      481 catttatcat gagattaata ctgtgattcc cgctgttttc tttttccttg cattttccta
      541 atatgccttt actgatccgt ttgctgtgaa ccctatgtta tttccatgtg tcaagtgggt
      601 cttgtgttgc cagcttctat ttgaagattg cctttgcact cagtgtaagt ttctgtcagc
      661 agtagtttca cccatttgca tggaaaaatt taaagctaat aaagcaattt aaaaagcaat
      721 ctatacattt attgtctcat taaaaatgta tacttacata taacagatga actaaaaaaa
      781 aatctgagat taaatacact agagtgttaa
//
