LOCUS       NM_032621                843 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens brain expressed X-linked 2 (BEX2), transcript variant
            3, mRNA.
ACCESSION   NM_032621
VERSION     NM_032621.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 843)
  AUTHORS   Mu,N., Wang,Y., Li,X., Du,Z., Wu,Y., Su,M., Wang,Y., Sun,X., Su,L.
            and Liu,X.
  TITLE     Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to
            modulate chemotherapeutic agent-induced apoptosis in non-small-cell
            lung cancer cells
  JOURNAL   Cell Death Dis 14 (9), 645 (2023)
   PUBMED   37777549
  REMARK    GeneRIF: Crotonylated BEX2 interacts with NDP52 and enhances
            mitophagy to modulate chemotherapeutic agent-induced apoptosis in
            non-small-cell lung cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 843)
  AUTHORS   Fukushi,D., Shibuya-Takahashi,R., Mochizuki,M., Fujimori,H.,
            Kogure,T., Sugai,T., Iwai,W., Wakui,Y., Abue,M., Murakami,K.,
            Nakamura,Y., Yasuda,J., Yamaguchi,K., Sugamura,K., Shibata,C.,
            Katayose,Y., Satoh,K. and Tamai,K.
  TITLE     BEX2 is required for maintaining dormant cancer stem cell in
            hepatocellular carcinoma
  JOURNAL   Cancer Sci 112 (11), 4580-4592 (2021)
   PUBMED   34424582
  REMARK    GeneRIF: BEX2 is required for maintaining dormant cancer stem cell
            in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 843)
  AUTHORS   Yamamoto-Shimojima,K., Osawa,M., Saito,M.K. and Yamamoto,T.
  TITLE     Induced pluripotent stem cells established from a female patient
            with Xq22 deletion confirm that BEX2 escapes from X-chromosome
            inactivation
  JOURNAL   Congenit Anom (Kyoto) 61 (2), 63-67 (2021)
   PUBMED   33244819
  REMARK    GeneRIF: Induced pluripotent stem cells established from a female
            patient with Xq22 deletion confirm that BEX2 escapes from
            X-chromosome inactivation.
REFERENCE   4  (bases 1 to 843)
  AUTHORS   Tamai,K., Nakamura-Shima,M., Shibuya-Takahashi,R., Kanno,S.I.,
            Yasui,A., Mochizuki,M., Iwai,W., Wakui,Y., Abue,M., Yamamoto,K.,
            Miura,K., Mizuma,M., Unno,M., Kawamura,S., Sato,I., Yasuda,J.,
            Yamaguchi,K., Sugamura,K. and Satoh,K.
  TITLE     BEX2 suppresses mitochondrial activity and is required for dormant
            cancer stem cell maintenance in intrahepatic cholangiocarcinoma
  JOURNAL   Sci Rep 10 (1), 21592 (2020)
   PUBMED   33299012
  REMARK    GeneRIF: BEX2 suppresses mitochondrial activity and is required for
            dormant cancer stem cell maintenance in intrahepatic
            cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 843)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 843)
  AUTHORS   Foltz,G., Ryu,G.Y., Yoon,J.G., Nelson,T., Fahey,J., Frakes,A.,
            Lee,H., Field,L., Zander,K., Sibenaller,Z., Ryken,T.C.,
            Vibhakar,R., Hood,L. and Madan,A.
  TITLE     Genome-wide analysis of epigenetic silencing identifies BEX1 and
            BEX2 as candidate tumor suppressor genes in malignant glioma
  JOURNAL   Cancer Res 66 (13), 6665-6674 (2006)
   PUBMED   16818640
  REMARK    GeneRIF: Two novel brain expressed genes, BEX1 and BEX2 are
            identified; they are silenced in all glioma specimens and exhibit
            extensive promoter hypermethylation.
REFERENCE   7  (bases 1 to 843)
  AUTHORS   Han,C., Liu,H., Liu,J., Yin,K., Xie,Y., Shen,X., Wang,Y., Yuan,J.,
            Qiang,B., Liu,Y.J. and Peng,X.
  TITLE     Human Bex2 interacts with LMO2 and regulates the transcriptional
            activity of a novel DNA-binding complex
  JOURNAL   Nucleic Acids Res 33 (20), 6555-6565 (2005)
   PUBMED   16314316
  REMARK    GeneRIF: hBex2 may act as a specific regulator during embryonic
            development by modulating the transcriptional activity of a novel
            E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and
            LDB1.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 843)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 843)
  AUTHORS   Alvarez,E., Zhou,W., Witta,S.E. and Freed,C.R.
  TITLE     Characterization of the Bex gene family in humans, mice, and rats
  JOURNAL   Gene 357 (1), 18-28 (2005)
   PUBMED   15958283
REFERENCE   10 (bases 1 to 843)
  AUTHORS   Baldisseri,D.M., Margolis,J.W., Weber,D.J., Koo,J.H. and
            Margolis,F.L.
  TITLE     Olfactory marker protein (OMP) exhibits a beta-clam fold in
            solution: implications for target peptide interaction and olfactory
            signal transduction
  JOURNAL   J Mol Biol 319 (3), 823-837 (2002)
   PUBMED   12054873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU569325.1 and BC015522.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_032621.3.
            
            Summary: This gene belongs to the brain expressed X-linked gene
            family. The encoded protein interacts with the transcription factor
            LIM domain only 2 in a DNA-binding complex that recognizes the
            E-box element and promotes transcription. This gene has been found
            to be a tumor suppressor that is silenced in human glioma. In
            breast cancer cells, this gene product modulates apoptosis in
            response to estrogen and tamoxifen, and enhances the
            anti-proliferative effect of tamoxifen. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (3) has a shorter N-terminus, compared to isoform 1. Variants 3 and
            4 encode the same isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY833560.1, BC015522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372677.8/ ENSP00000361762.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BU569325.1         60-125
            67-843              BC015522.1         1-777
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..843
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /note="brain expressed X-linked 2"
                     /db_xref="GeneID:84707"
                     /db_xref="HGNC:HGNC:30933"
                     /db_xref="MIM:300691"
     exon            1..131
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..207
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..843
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..599
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein BEX2; hBex2; brain-expressed X-linked protein 2"
                     /codon_start=1
                     /product="protein BEX2 isoform 3"
                     /protein_id="NP_116010.1"
                     /db_xref="CCDS:CCDS14505.1"
                     /db_xref="GeneID:84707"
                     /db_xref="HGNC:HGNC:30933"
                     /db_xref="MIM:300691"
                     /translation="MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVS
                     EYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREK
                     QLSHSLRAVSTDPPHHDHHDEFCLMP"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /note="hexamer: AATAAA"
     polyA_site      843
                     /gene="BEX2"
                     /gene_synonym="BEX1; DJ79P11.1"
                     /note="major polyA site"
ORIGIN      
        1 gagtcttacc tcgttgtggc gtcagaaccg ccgtcgctcg ctcccttctc ggcagtggta
       61 cctgttcccg gtgtccctga ggacgtgcgg gccaggtacg gccccgaaag taggaagcgg
      121 agggggagca ggtttgcggg gccaagtgtt gcggcgacgc acctcacgtc gagaatcggg
      181 aggaggagac tgcaaggata ggcccaggag taatggagtc caaagaggaa cgagcgttaa
      241 acaatctcat cgtggaaaat gtcaaccagg aaaatgatga aaaagatgaa aaggagcaag
      301 ttgctaataa aggggagccc ttggccctac ctttgaatgt tagtgaatac tgtgtgccta
      361 gaggaaaccg taggcggttc cgcgttaggc agcccatcct gcagtataga tgggacataa
      421 tgcataggct tggagagcca caggcaagga tgagagagga gaatatggaa aggattgggg
      481 aggaggtgag acagctgatg gaaaagctga gggaaaagca gttgagtcat agtttgcggg
      541 cagtcagcac tgatccccct caccatgacc atcacgatga gttttgcctt atgccctgaa
      601 tcctgatggt ttccctgaag ttaataggga gacccctgct tcctaaactt acacatttgt
      661 ggtgtacctt tgtcgtaaac gttttgatgt tacctatttc ttgtgggtct cctattacca
      721 gcttctaaat gaatgttgtt tttgacccag tttgtaagtt tctgtcagca ggagagtttt
      781 acctattgca tggaaagatg ctcattatat attgtgaagt taataaaaca gttttaaaaa
      841 gca
//
