LOCUS       NM_018476                795 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens brain expressed X-linked 1 (BEX1), mRNA.
ACCESSION   NM_018476
VERSION     NM_018476.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Wang,Q., Liang,N., Liu,C., Li,J., Bai,Y., Lei,S., Huang,Q., Sun,L.,
            Tang,L., Zeng,C., Tang,Y., He,X., Yang,T. and Wang,G.
  TITLE     BEX1 supports the stemness of hepatoblastoma by facilitating
            Warburg effect in a PPARgamma/PDK1 dependent manner
  JOURNAL   Br J Cancer 129 (9), 1477-1489 (2023)
   PUBMED   37715024
  REMARK    GeneRIF: BEX1 supports the stemness of hepatoblastoma by
            facilitating Warburg effect in a PPARgamma/PDK1 dependent manner.
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Zhuang,N., Gu,Z., Feng,J., Chai,Z., Shan,J. and Qian,C.
  TITLE     BEX1 mediates sorafenib resistance in hepatocellular carcinoma by
            regulating AKT signaling
  JOURNAL   Cell Signal 108, 110722 (2023)
   PUBMED   37209973
  REMARK    GeneRIF: BEX1 mediates sorafenib resistance in hepatocellular
            carcinoma by regulating AKT signaling.
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Wang,Q., Liang,N., Yang,T., Li,Y., Li,J., Huang,Q., Wu,C., Sun,L.,
            Zhou,X., Cheng,X., Zhao,L., Wang,G., Chen,Z., He,X. and Liu,C.
  TITLE     DNMT1-mediated methylation of BEX1 regulates stemness and
            tumorigenicity in liver cancer
  JOURNAL   J Hepatol 75 (5), 1142-1153 (2021)
   PUBMED   34217777
  REMARK    GeneRIF: DNMT1-mediated methylation of BEX1 regulates stemness and
            tumorigenicity in liver cancer.
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Lee,S., Kang,H., Shin,E., Jeon,J., Youn,H. and Youn,B.
  TITLE     BEX1 and BEX4 Induce GBM Progression through Regulation of Actin
            Polymerization and Activation of YAP/TAZ Signaling
  JOURNAL   Int J Mol Sci 22 (18), 9845 (2021)
   PUBMED   34576008
  REMARK    GeneRIF: BEX1 and BEX4 Induce GBM Progression through Regulation of
            Actin Polymerization and Activation of YAP/TAZ Signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Yang,Y., Tetti,M., Vohra,T., Adolf,C., Seissler,J., Hristov,M.,
            Belavgeni,A., Bidlingmaier,M., Linkermann,A., Mulatero,P.,
            Beuschlein,F., Reincke,M. and Williams,T.A.
  TITLE     BEX1 Is Differentially Expressed in Aldosterone-Producing Adenomas
            and Protects Human Adrenocortical Cells From Ferroptosis
  JOURNAL   Hypertension 77 (5), 1647-1658 (2021)
   PUBMED   33745298
  REMARK    GeneRIF: BEX1 Is Differentially Expressed in Aldosterone-Producing
            Adenomas and Protects Human Adrenocortical Cells From Ferroptosis.
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 795)
  AUTHORS   Alvarez,E., Zhou,W., Witta,S.E. and Freed,C.R.
  TITLE     Characterization of the Bex gene family in humans, mice, and rats
  JOURNAL   Gene 357 (1), 18-28 (2005)
   PUBMED   15958283
REFERENCE   8  (bases 1 to 795)
  AUTHORS   Quentmeier,H., Tonelli,R., Geffers,R., Pession,A., Uphoff,C.C. and
            Drexler,H.G.
  TITLE     Expression of BEX1 in acute myeloid leukemia with MLL
            rearrangements
  JOURNAL   Leukemia 19 (8), 1488-1489 (2005)
   PUBMED   15920485
REFERENCE   9  (bases 1 to 795)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (bases 1 to 795)
  AUTHORS   Yang,Q.S., Xia,F., Gu,S.H., Yuan,H.L., Chen,J.Z., Yang,Q.S.,
            Ying,K., Xie,Y. and Mao,Y.M.
  TITLE     Cloning and expression pattern of a spermatogenesis-related gene,
            BEX1, mapped to chromosome Xq22
  JOURNAL   Biochem Genet 40 (1-2), 1-12 (2002)
   PUBMED   11989783
  REMARK    GeneRIF: This new human gene is mapped to the X chromosome and has
            an expression pattern of a spermatogenesis-related gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF237783.1, BM465948.1 and AL008708.4.
            
            On Nov 23, 2018 this sequence version replaced NM_018476.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.205770.1,
                                           SRR5189652.246368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372728.4/ ENSP00000361813.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AF237783.1         1-190
            191-793             BM465948.1         201-803
            794-795             AL008708.4         23735-23736         c
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..795
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /note="brain expressed X-linked 1"
                     /db_xref="GeneID:55859"
                     /db_xref="HGNC:HGNC:1036"
                     /db_xref="MIM:300690"
     exon            1..76
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /inference="alignment:Splign:2.1.0"
     exon            77..166
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /inference="alignment:Splign:2.1.0"
     exon            167..795
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..549
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /note="ovarian granulosa cell 13.0 kDa protein hGR74;
                     brain-expressed X-linked protein 1"
                     /codon_start=1
                     /product="protein BEX1"
                     /protein_id="NP_060946.3"
                     /db_xref="CCDS:CCDS35354.1"
                     /db_xref="GeneID:55859"
                     /db_xref="HGNC:HGNC:1036"
                     /db_xref="MIM:300690"
                     /translation="MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYC
                     VPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLS
                     HSLRAVSTDPPHHDHHDEFCLMP"
     regulatory      773..778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /note="hexamer: AATAAA"
     polyA_site      795
                     /gene="BEX1"
                     /gene_synonym="BEX2; HBEX2; HGR74-h"
                     /note="major polyA site"
ORIGIN      
        1 actcgtgtct cgctaccagc tccccgctgc cctgcgctcg gcgggctggc atccggcccg
       61 ggggaaagcg gaccagccct tctgcaggtc tgcggggcca agtgtcccgg cggcgcacct
      121 cgtggcgaga atcgggagaa ggaggagact acaaggatag gcccaggagt aatggagtcc
      181 aaagagaaac gagcagtaaa cagtctcagc atggaaaatg ccaaccaaga aaatgaagaa
      241 aaggagcaag ttgctaataa aggggagccc ttggccctcc ctttggatgc tggtgaatac
      301 tgtgtgccta gaggaaatcg taggcggttc cgcgttaggc agcccatcct gcagtataga
      361 tgggatatga tgcataggct tggagaacca caggcaagga tgagagaaga gaatatggaa
      421 aggattgggg aggaggtgag acagctgatg gaaaagctga gggaaaagca gttgagtcat
      481 agtctgcggg cagtcagcac tgacccccct caccatgacc atcatgatga gttttgcctt
      541 atgccctgaa tcctgatggt ttccctaaag ttattacgga aacagacccc tgctttcgaa
      601 tttacatgtt catgatgtgc ccttgttgta aacctttacc tgtcacttgt ttacgtgggt
      661 ctcctattac cagcttctaa ttgaatattg tgtttttgaa ccagtctgta agatttttgt
      721 tagcagaaga attttaccta ttgcatggaa agatgctcat tatagtgaag ttaataaagc
      781 acctttaaaa agcaa
//
