LOCUS       NM_001098787            2792 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Bet1 golgi vesicular membrane trafficking protein like
            (BET1L), transcript variant 1, mRNA.
ACCESSION   NM_001098787
VERSION     NM_001098787.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Li,S., Du,M., Xu,K., Ben,S., Zhu,T., Guo,M., Xin,J., Zhu,L., Gu,D.,
            Zhang,Z. and Wang,M.
  TITLE     Genetic Modulation of BET1L Confers Colorectal Cancer
            Susceptibility by Reducing miRNA Binding and m6A Modification
  JOURNAL   Cancer Res 83 (13), 2142-2154 (2023)
   PUBMED   37115853
  REMARK    GeneRIF: Genetic Modulation of BET1L Confers Colorectal Cancer
            Susceptibility by Reducing miRNA Binding and m6A Modification.
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Lee,S.C., Chou,Y.H., Tantoh,D.M., Hsu,S.Y., Nfor,O.N., Tyan,Y.S.
            and Liaw,Y.P.
  TITLE     Risk of uterine leiomyoma based on BET1L rs2280543 single
            nucleotide polymorphism and vegetarian diet
  JOURNAL   BMC Womens Health 22 (1), 139 (2022)
   PUBMED   35477381
  REMARK    GeneRIF: Risk of uterine leiomyoma based on BET1L rs2280543 single
            nucleotide polymorphism and vegetarian diet.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Lynch,E.M., Robertson,S., FitzGibbons,C., Reilly,M., Switalski,C.,
            Eckardt,A., Tey,S.R., Hayakawa,K. and Suzuki,M.
  TITLE     Transcriptome analysis using patient iPSC-derived skeletal
            myocytes: Bet1L as a new molecule possibly linked to neuromuscular
            junction degeneration in ALS
  JOURNAL   Exp Neurol 345, 113815 (2021)
   PUBMED   34310943
  REMARK    GeneRIF: Transcriptome analysis using patient iPSC-derived skeletal
            myocytes: Bet1L as a new molecule possibly linked to neuromuscular
            junction degeneration in ALS.
REFERENCE   4  (bases 1 to 2792)
  AUTHORS   Linders,P.T.A., Gerretsen,E.C.F., Ashikov,A., Vals,M.A., de
            Boer,R., Revelo,N.H., Arts,R., Baerenfaenger,M., Zijlstra,F.,
            Huijben,K., Raymond,K., Muru,K., Fjodorova,O., Pajusalu,S.,
            Ounap,K., Ter Beest,M., Lefeber,D. and van den Bogaart,G.
  TITLE     Congenital disorder of glycosylation caused by starting
            site-specific variant in syntaxin-5
  JOURNAL   Nat Commun 12 (1), 6227 (2021)
   PUBMED   34711829
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2792)
  AUTHORS   Chen,Y. and Sima,X.
  TITLE     Replication of GWAS Loci Revealed an Increased Risk of BET1L and
            H19 Polymorphisms with Intracranial Aneurysm
  JOURNAL   Dis Markers 2019, 9490639 (2019)
   PUBMED   31275455
  REMARK    GeneRIF: BET1L rs2280543 polymorphisms are associated with an
            increased risk of intracranial aneurysm.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2792)
  AUTHORS   Oka,T., Ungar,D., Hughson,F.M. and Krieger,M.
  TITLE     The COG and COPI complexes interact to control the abundance of
            GEARs, a subset of Golgi integral membrane proteins
  JOURNAL   Mol Biol Cell 15 (5), 2423-2435 (2004)
   PUBMED   15004235
REFERENCE   7  (bases 1 to 2792)
  AUTHORS   Xu,Y., Martin,S., James,D.E. and Hong,W.
  TITLE     GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is
            implicated in traffic in the early cisternae of the Golgi apparatus
  JOURNAL   Mol Biol Cell 13 (10), 3493-3507 (2002)
   PUBMED   12388752
  REMARK    GeneRIF: Data suggest that GS15 exists in a distinct SNARE complex
            that contains syntaxin5, GS28, and Ykt6, and may be involved in
            both ER-to-Golgi and intra-Golgi transport.
REFERENCE   8  (bases 1 to 2792)
  AUTHORS   Shorter,J., Beard,M.B., Seemann,J., Dirac-Svejstrup,A.B. and
            Warren,G.
  TITLE     Sequential tethering of Golgins and catalysis of SNAREpin assembly
            by the vesicle-tethering protein p115
  JOURNAL   J Cell Biol 157 (1), 45-62 (2002)
   PUBMED   11927603
REFERENCE   9  (bases 1 to 2792)
  AUTHORS   Zhang,T. and Hong,W.
  TITLE     Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and
            participates in a late stage in endoplasmic reticulum-Golgi
            transport
  JOURNAL   J Biol Chem 276 (29), 27480-27487 (2001)
   PUBMED   11323436
REFERENCE   10 (bases 1 to 2792)
  AUTHORS   Xu,Y., Wong,S.H., Zhang,T., Subramaniam,V.N. and Hong,W.
  TITLE     GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive
            factor attachment protein receptor (SNARE) homologous to rbet1
  JOURNAL   J Biol Chem 272 (32), 20162-20166 (1997)
   PUBMED   9242691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA875317.1, BC008971.1, DA880679.1 and BX648752.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001098787.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The sequence BX648752.1 is from a chimeric clone.
            Only the blocked early in transport 1 homolog (S. cerevisiae) like
            sequence region was propagated into this RefSeq record.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022958.1, SRR11853562.4672.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382762.8/ ENSP00000372210.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA875317.1         24-39
            17-517              BC008971.1         31-531
            518-900             DA880679.1         175-557
            901-2792            BX648752.1         1102-2993
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2792
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /note="Bet1 golgi vesicular membrane trafficking protein
                     like"
                     /db_xref="GeneID:51272"
                     /db_xref="HGNC:HGNC:19348"
                     /db_xref="MIM:615417"
     exon            1..97
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..414
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /note="isoform 1 is encoded by transcript variant 1; golgi
                     integral membrane protein 3; BET1-like protein; golgi
                     SNARE 15 kDa protein; GOS-15; vesicle transport protein
                     GOS15; golgi SNARE with a size of 15 kDa; blocked early in
                     transport 1 homolog-like"
                     /codon_start=1
                     /product="BET1-like protein isoform 1"
                     /protein_id="NP_001092257.1"
                     /db_xref="CCDS:CCDS41582.1"
                     /db_xref="GeneID:51272"
                     /db_xref="HGNC:HGNC:19348"
                     /db_xref="MIM:615417"
                     /translation="MADWARAQSPGAVEEILDRENKRMADSLASKVTRLKSLALDIDR
                     DAEDQNRYLDGMDSDFTSMTSLLTGSVKRFSTMARSGQDNRKLLCGMAVGLIVAFFIL
                     SYFLSRART"
     exon            98..189
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /inference="alignment:Splign:2.1.0"
     exon            190..246
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /inference="alignment:Splign:2.1.0"
     exon            247..2792
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2753..2758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /note="hexamer: AATAAA"
     regulatory      2766..2771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /note="hexamer: AGTAAA"
     polyA_site      2776
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
     polyA_site      2792
                     /gene="BET1L"
                     /gene_synonym="BET1L1; GOLIM3; GS15; HSPC197"
                     /note="major polyA site"
ORIGIN      
        1 ctttccccgc gactgcgcca cgtctgaggc ggctgtggcc gcgtcggtgt ccgcgtcgag
       61 gagccggggc agggcacgat ggcggactgg gctcgggctc agagcccggg cgctgtggaa
      121 gagattctag accgggagaa caagcgaatg gctgacagcc tggcctccaa agtcaccagg
      181 ctcaaatcgc tcgccctgga catcgatagg gatgcagagg atcagaaccg gtacctggat
      241 ggcatggact cggatttcac aagcatgacc agcctgctta cagggagcgt gaagcgcttt
      301 tccacaatgg caaggtccgg acaagacaac cggaagcttc tatgtggcat ggccgtgggt
      361 ctaattgtgg ccttcttcat cctctcctac ttcttgtcca gggcaaggac gtgagccagt
      421 gggagctggt gtctgtgggt gccaagggca gccagggtct tccctgcctg gtgttttggg
      481 ctccagagga cttacctaca aaatactcct ttgcaatgat aattgtgggt caggaatctt
      541 cttcctgtgt ggcaggaggc tgcggctgcc tgtgacctga tgagctcatg ttggctggtc
      601 ccatgtgtga aagggactct ctcggggaaa ccaaggccca gcccctcccc cctcccccag
      661 gtgctagaga gccaggcaga gctggggcca cagcgtgtct ggagaagcca ggtctgagca
      721 gagcagctgg tgaatcccag acgtggccac ctgtggcttg cagcccttct ccccgcgctt
      781 gggactctga catcttaagg ctgcacggtc gtgtccttgt ctgggtgagg ccatgtctgt
      841 gatccaaggt tcctggaact gacacaggaa ggggctgtga accctaagtg ggtgtcatct
      901 cctccgaccg aggcttctca ccctggagat ggcagttact cctggccatg gttgctgagc
      961 atgggcagac cagtggaggc caccctactg tgttatctgc gccttcgatg aagtgagacc
     1021 cttggggaga acgggctgtg gatgaaggag tggactgcag ccttggccta gccactgggc
     1081 tgggatcttc tgggtcatgt gactgtgtat ccaggagcag aaacttgtat tctcaggatt
     1141 caggatctac ccagcaccaa agatgtattt tcaggagaac agacctagaa atgggcctgt
     1201 ctggcatttc agagtcaggc aaagcaggca gggccaggga gcttctgtgg gtctacacaa
     1261 gaaggttcct gtgagggcta tcagttgttg ccttctagct tgctggtaac tttggcgcct
     1321 ccgccaagcc ctgccagact cccctggctg tgatggcatt ctgtgccatc ctccttgtcc
     1381 ccagcctctg caggatgccc tccctaccca cctctccctg ggccttccct gtccactggg
     1441 ctggattcat gttcaaacca ctggactggc agggcaacga cttcttccca cctcaagatg
     1501 aggtcctcgc ccccttgtct tggcataaaa acacctttaa agcatgagcc atgtgcttct
     1561 ttgcccttct ctgtcctgtt ccaatcttct gcctcccagt cactccctgg ggactatggg
     1621 atcactgtcc ccccacctgt gtggccacac catatgtcct gtcaatccag aactgcctct
     1681 gagctccagg ctgaccacag atcagccaca gcctgatgcc tgcagcccca ctttgctcac
     1741 ccttcccctc ccctcctcct tccttccaca cagcaagcct acctttctcc atccatgctc
     1801 accatagccc ccttccttgt gacctggacc ctccattgta cctggctgag actgtcagcc
     1861 tcctggagga gtggggtcca ccttcttctt gccctatgca gtgcaagctc acttctcacc
     1921 cagcaaggtt gactcatctg cctccatgtc tctggggctt tgctgttgcc ctgaaaccta
     1981 gctgggctgg tcttgctccc agcttgcttc cccctcctcg gatgtccctt tgcaggcccc
     2041 tgtcgttcct ccggcaccag tgtccttggc tgccatggca agctcatcag gggcttgtac
     2101 cctggtcacc aagcatggta gcagctgcct gcattgtatc tccatctggt cactgcaggt
     2161 gccaaccctt catcccccat gttttcctgg gccatggagg gctgacctcc gtttctgggg
     2221 aatgtggctg agctgtggta accagctaca ccccaggtgc tctttccatg gtggtgcctg
     2281 ctcatcttgc tgatgcaaac taggaagtta ggctgcatct cggagtggct ttcgctggag
     2341 aggtgctttg ctgtctctca gactcagtca ctgtgttccc tccccgcctc tcttatctcc
     2401 atggctgttt gcagctctcc caggtacttt ggggtctgag ctggaattcc tttgtggttt
     2461 gctcttctgc ttctcactct tgtattaaga aggattccac aaagggagag tggcatccct
     2521 gctgctgctg tgccagacca gagtttcctg aggggccctg accctaaccc tccagctcag
     2581 ccctgtacac ctgaccctgt aaatgagtgg ggtttgctga ctgtaatccc tgacaccagt
     2641 aaaaccaaaa ggactcttgg gggctcagtg tgagagccag ggttacctac tctgccaagt
     2701 gaggacaaac tgctaggctg tatcccataa tttcaggatg agaaacatta acaataaaaa
     2761 tttgtagtaa acataacctc atgaagaact aa
//
