LOCUS       NM_005868               1481 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Bet1 golgi vesicular membrane trafficking protein
            (BET1), transcript variant 1, mRNA.
ACCESSION   NM_005868
VERSION     NM_005868.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Garcia,G., Bar-Ziv,R., Averbukh,M., Dasgupta,N., Dutta,N.,
            Zhang,H., Fan,W., Moaddeli,D., Tsui,C.K., Castro Torres,T.,
            Alcala,A., Moehle,E.A., Hoang,S., Shalem,O., Adams,P.D.,
            Thorwald,M.A. and Higuchi-Sanabria,R.
  TITLE     Large-scale genetic screens identify BET-1 as a cytoskeleton
            regulator promoting actin function and life span
  JOURNAL   Aging Cell 22 (1), e13742 (2023)
   PUBMED   36404134
  REMARK    GeneRIF: Large-scale genetic screens identify BET-1 as a
            cytoskeleton regulator promoting actin function and life span.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Donkervoort,S., Krause,N., Dergai,M., Yun,P., Koliwer,J.,
            Gorokhova,S., Geist Hauserman,J., Cummings,B.B., Hu,Y., Smith,R.,
            Uapinyoying,P., Ganesh,V.S., Ghosh,P.S., Monaghan,K.G.,
            Edassery,S.L., Ferle,P.E., Silverstein,S., Chao,K.R., Snyder,M.,
            Ellingwood,S., Bharucha-Goebel,D., Iannaccone,S.T., Dal Peraro,M.,
            Foley,A.R., Savas,J.N., Bolduc,V., Fasshauer,D., Bonnemann,C.G. and
            Schwake,M.
  TITLE     BET1 variants establish impaired vesicular transport as a cause for
            muscular dystrophy with epilepsy
  JOURNAL   EMBO Mol Med 13 (12), e13787 (2021)
   PUBMED   34779586
  REMARK    GeneRIF: BET1 variants establish impaired vesicular transport as a
            cause for muscular dystrophy with epilepsy.
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Zhang,T. and Hong,W.
  TITLE     Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and
            participates in a late stage in endoplasmic reticulum-Golgi
            transport
  JOURNAL   J Biol Chem 276 (29), 27480-27487 (2001)
   PUBMED   11323436
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Waters,M.G. and Pfeffer,S.R.
  TITLE     Membrane tethering in intracellular transport
  JOURNAL   Curr Opin Cell Biol 11 (4), 453-459 (1999)
   PUBMED   10449330
  REMARK    Review article
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Zhang,T., Wong,S.H., Tang,B.L., Xu,Y., Peter,F., Subramaniam,V.N.
            and Hong,W.
  TITLE     The mammalian protein (rbet1) homologous to yeast Bet1p is
            primarily associated with the pre-Golgi intermediate compartment
            and is involved in vesicular transport from the endoplasmic
            reticulum to the Golgi apparatus
  JOURNAL   J Cell Biol 139 (5), 1157-1168 (1997)
   PUBMED   9382863
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Hay,J.C., Hirling,H. and Scheller,R.H.
  TITLE     Mammalian vesicle trafficking proteins of the endoplasmic reticulum
            and Golgi apparatus
  JOURNAL   J Biol Chem 271 (10), 5671-5679 (1996)
   PUBMED   8621431
  REMARK    GeneRIF: The distinct localizations of rsec22 and rbet1 may reflect
            their participation in opposite directions of membrane flow between
            the endoplasmic reticulum and Golgi apparatus.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313984.1, BC000899.1 and
            AA812913.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005868.5.
            
            Summary: This gene encodes a golgi-associated membrane protein that
            participates in vesicular transport from the endoplasmic reticulum
            (ER) to the Golgi complex. The encoded protein functions as a
            soluble N-ethylaleimide-sensitive factor attachment protein
            receptor and may be involved in the docking of ER-derived vesicles
            with the cis-Golgi membrane. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.21423.1,
                                           SRR3476690.67067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222547.8/ ENSP00000222547.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AK313984.1         1-496
            497-1476            BC000899.1         413-1392
            1477-1481           AA812913.1         16-20               c
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..1481
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="Bet1 golgi vesicular membrane trafficking protein"
                     /db_xref="GeneID:10282"
                     /db_xref="HGNC:HGNC:14562"
                     /db_xref="MIM:605456"
     exon            1..158
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..496
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="isoform 1 is encoded by transcript variant 1; Golgi
                     vesicular membrane trafficking protein p18; Bet1p homolog;
                     golgi vesicular membrane-trafficking protein p18; BET1
                     homolog; blocked early in transport 1 homolog"
                     /codon_start=1
                     /product="BET1 homolog isoform 1"
                     /protein_id="NP_005859.1"
                     /db_xref="CCDS:CCDS5635.1"
                     /db_xref="GeneID:10282"
                     /db_xref="HGNC:HGNC:14562"
                     /db_xref="MIM:605456"
                     /translation="MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVT
                     AIKSLSIEIGHEVKTQNKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMML
                     FSLFVFFIIYWIIKLR"
     exon            159..283
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            284..340
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            341..1481
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      482..487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="hexamer: ATTAAA"
     polyA_site      505
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="major polyA site"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="BET1"
                     /gene_synonym="HBET1; MDRP"
                     /note="major polyA site"
ORIGIN      
        1 actgatgtcg tggcgcttta ggggaagaag ttggtgtttc gctgggccct ggtactgaag
       61 acgcggtccg ggtcgcccct agctgtttcc tactcaccca aagccccgca cccgcctttt
      121 ctctctctcc tctggcagga tgaggcgtgc aggcctgggt gaaggagtac ctcctggcaa
      181 ctatgggaac tatggctatg ctaatagtgg gtatagtgcc tgtgaagaag aaaatgagag
      241 gctcactgaa agtctgagaa gcaaagtaac tgctataaaa tctctttcca ttgaaatagg
      301 ccatgaagtt aaaacccaga ataaattatt agctgaaatg gattcacaat ttgattccac
      361 aactggattt ctaggtaaaa ctatgggcaa actgaagatt ttatccagag ggagccaaac
      421 aaagctgctg tgctatatga tgctgttttc tttatttgtc ttttttatca tttattggat
      481 tattaaactg aggtgatgca tgtaattgtg aatttggaat ttgttccaac ttaatggctt
      541 gcagtaccac tttgataaaa atcagcatca aaacattcct agtgttcaaa tactgtggca
      601 ttttccattg aaaattgctg aattttgctt attttataaa tcacattagt taatacagtg
      661 gtctttgaat actgtttctt aatgactcat tttagcccct attttcaggg gtagtgagag
      721 ggtgtggctc cactaatttc cagtttgttt ttctattgtt tgccaactgt cagattaaat
      781 agcattataa tattttgttg taatcataaa tgcaggttta tgtcccatgt aaggaaactt
      841 agtgggagag taacagaatg cctggagagc ctgactctga gctcttgaag tagtcagcca
      901 gtttgtggta aaatggtaat tgaattttcc taactgcatc aactgtaatg atatactccc
      961 ttctcctcct ttatttagtt aaaattgtag gctgatttct ttttacctac aatcttccta
     1021 ataatttttg atgataatga cccctcattt ctttctgccc aaagacctca ttctttaaat
     1081 aaaacttgtt attttggcat atttctggta gggcccattg cacatgtgta tcagtatagt
     1141 tattatttca tattaacttt atgaattctc ttgacttggc ttataatagt tttatgattt
     1201 ttactacata ggtagcacat ttatcatttg tgacagaata atgtgaagtt aagtaattac
     1261 tgaactttaa atggaaatag tatgcaagaa actcaggcat tgaacttgaa gataagagta
     1321 ttattgcttt aatccagtgt atttgtttat ggaaagaaaa acacaaaggc agactgttga
     1381 gtaaaaaata ttaaatattg ttaaatattc tgtattttgg aatttatcca tttataggct
     1441 tcaaaagtaa atttttaaat aaaatatatt agtcgactgt g
//
