LOCUS       NM_152731               2568 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens BEN domain containing 6 (BEND6), transcript variant 1,
            mRNA.
ACCESSION   NM_152731
VERSION     NM_152731.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Dai,Q., Andreu-Agullo,C., Insolera,R., Wong,L.C., Shi,S.H. and
            Lai,E.C.
  TITLE     BEND6 is a nuclear antagonist of Notch signaling during
            self-renewal of neural stem cells
  JOURNAL   Development 140 (9), 1892-1902 (2013)
   PUBMED   23571214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI803591.1, AL590037.7, AK054724.1, DC411761.1 and BC022988.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152731.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.869996.1,
                                           SRR1660807.144665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370746.8/ ENSP00000359782.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AI803591.1         133-390
            259-259             AL590037.7         24830-24830
            260-639             AK054724.1         77-456
            640-1055            DC411761.1         142-557
            1056-2568           BC022988.1         583-2095
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..2568
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /note="BEN domain containing 6"
                     /db_xref="GeneID:221336"
                     /db_xref="HGNC:HGNC:20871"
     exon            1..354
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     exon            355..574
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..1294
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /note="isoform 1 is encoded by transcript variant 1; BEN
                     domain-containing protein 6"
                     /codon_start=1
                     /product="BEN domain-containing protein 6 isoform 1"
                     /protein_id="NP_689944.2"
                     /db_xref="CCDS:CCDS43476.1"
                     /db_xref="GeneID:221336"
                     /db_xref="HGNC:HGNC:20871"
                     /translation="MQKIVQTDEITNTQAFRKGKRKRTETMDSENANSDMDKGQRDPY
                     SGNAFLPGESSSEDEEPLAELSKEELCAKIKSLKEKLTNTRKENSRLRQSLVMLQVLP
                     QAVTQFEELVGMAEALLKGGGTMSTSASTLWRATNNSSPDSFASTCSNSNSNSSSPVS
                     LKPEEEHQTDEKQFQIEKWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSST
                     SRDKAVKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNLSKNLNSQ
                     DIK"
     exon            575..752
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     exon            753..973
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1166
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1303
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2568
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2544..2549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /note="hexamer: AATAAA"
     polyA_site      2568
                     /gene="BEND6"
                     /gene_synonym="C6orf65"
                     /note="major polyA site"
ORIGIN      
        1 gacatcacgg ccaggctgcg gcagcgcggg cgcgcggaca tggctgcggc ggtttcggcg
       61 gcgtccgcgg gctgcacccg ggcctgagag cccagcgccc tcccgcgggg ccgcccgcca
      121 gtccgcgccg tccgcgggtg cattggccgg gtgcctctag cttcccggac acccggagct
      181 tccgcctatc cagcctccct cggccaaatt gctgcggagc ccgtcgtcag ggggcgccaa
      241 ggagccaggg ggaaaaccga gaggcgctga caggagcctc ccggcggtgc taccctccac
      301 ctcccacctc cctgcgcccc gccccgaggt tggggctttg aagaatgcag ccggggaaag
      361 cattaacttt tgagctacgt ccagaatagc atcatcttca tgggtattcc ctactcctag
      421 gatttcagaa aacctttgat aactaattga gaaaatgcag aagatcgtgc agacagatga
      481 aattaccaat acacaagctt ttagaaaagg aaagaggaaa agaacagaga caatggactc
      541 agaaaatgca aatagtgaca tggataaagg acagagagac ccatattcgg gaaatgcctt
      601 tctgcctggt gaaagctcca gtgaggatga agagccttta gcagaattgt caaaggaaga
      661 attgtgcgcc aaaataaaaa gcctgaaaga aaaactaaca aacacccgga aagaaaacag
      721 ccgacttcga cagtctttgg tcatgcttca agtgttacca caagcagtca cccagtttga
      781 agaattggtt ggtatggccg aggctctgct taagggtggg ggaaccatgt ctacatctgc
      841 atccaccctc tggagagcaa caaacaactc ctcgccagat tcatttgcct caacatgcag
      901 taattctaat tctaactcca gttcaccagt ttccttaaag cctgaggaag agcatcagac
      961 tgatgagaaa cagttccaga ttgaaaaatg gcagattgcc cgttgtaaca agagcaagcc
     1021 tcagaagttt attaatgatt taatgcaagt actttacaca aatgaataca tggccactca
     1081 cagcctgaca ggggcaaaat cctctacttc aagggacaaa gctgtaaaac cagctatgaa
     1141 tcagaatgaa gtccaagaaa tcataggagt aacaaaacaa ttatttccca atacggatga
     1201 tgtttcaatt aggagaatga tagggcaaaa gctaaacaac tgtaccaaga agccaaattt
     1261 aagcaaaaat cttaactctc aggatattaa atagatcctt ttggtattac aggtatctga
     1321 aacaaagcac cttcaattct aaatctagca ctggattttg ttggagaatc tgcagccttc
     1381 ctggcagtga gaaagacaga catgtgcagt gacaggctgt aagacatatg taacattgct
     1441 gagctctcct aagggaccaa caagcttgct gaagaagctg catgtagatt ccaccctcag
     1501 tactagtgat gcatcaaacc agagaatttc tgccagtcaa ataagcatgc aatatggttt
     1561 ctttggaaat aagcatttcc caatccccaa atacccctct gtacagttaa tctaacagga
     1621 tagtcagagc tcttatcata gcagccaaaa cttcagccca taggttagtc attgtcctaa
     1681 ccaatcattg tacattgatt attaccagtg acttcccatt atagtttttg gatctttagc
     1741 ataagcacat gcttgcaaaa gtaaacagtg aaataattaa tgttggcaaa tatgagaaca
     1801 acaaagtcag cccaaaatct gataatcatg tctaaccaag taataatgtt ttagcaataa
     1861 aattacagga ttattctgtt atctaaaaat gtataaaatg ggaatatgaa aaaaatgaca
     1921 acagcaagat gttttatttt aatgttaagc aattccacca cacttctgaa gaataaacct
     1981 aagtttttgt gattgttaaa acaatgcatc aattttcagg gaaatctttt tgtttgttta
     2041 tttaccagac atgttctaac tttgtattgc ccaaagtata ttaaatacag atgtgtaata
     2101 taaagcatca atatcaccta acacatcgta tataagatat aacatgatag atagttggtc
     2161 gattacattg ctatactgct tagttttaac tggtttattt ttattgtagc agaaatgaac
     2221 tgaaaaaaaa tatgggtttg ataatcacac acatgaaagt accattttgt aactcaacaa
     2281 aagataaaac attcttcatc aaaaggcttc tcgcttggtg tcaggttgtc acatgtgacc
     2341 actgtgcaat gcgaagccat acttcttcag tgcacaaagt catgtttaaa cttggaaaag
     2401 aggatgctac agtagtttca aagttcagtg ttgtggaccc aggaaatttt ccataagtct
     2461 tgcttgataa caatgtgatt gtacaaaata aatgttctta aggaaacaac ttatgtaaca
     2521 tttgctacct ttatgtaaac ataaataaat cccatttaaa agataaaa
//
