LOCUS       NM_024603               1693 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BEN domain containing 5 (BEND5), transcript variant 1,
            mRNA.
ACCESSION   NM_024603
VERSION     NM_024603.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Shi,Y., Zhang,D., Chen,J., Jiang,Q., Song,S., Mi,Y., Wang,T. and
            Ye,Q.
  TITLE     Interaction between BEND5 and RBPJ suppresses breast cancer growth
            and metastasis via inhibiting Notch signaling
  JOURNAL   Int J Biol Sci 18 (10), 4233-4244 (2022)
   PUBMED   35844785
  REMARK    GeneRIF: Interaction between BEND5 and RBPJ suppresses breast
            cancer growth and metastasis via inhibiting Notch signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Dai,Q., Ren,A., Westholm,J.O., Serganov,A.A., Patel,D.J. and
            Lai,E.C.
  TITLE     The BEN domain is a novel sequence-specific DNA-binding domain
            conserved in neural transcriptional repressors
  JOURNAL   Genes Dev 27 (6), 602-614 (2013)
   PUBMED   23468431
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Bussow,K., Cahill,D., Nietfeld,W., Bancroft,D., Scherzinger,E.,
            Lehrach,H. and Walter,G.
  TITLE     A method for global protein expression and antibody screening on
            high-density filters of an arrayed cDNA library
  JOURNAL   Nucleic Acids Res 26 (21), 5007-5008 (1998)
   PUBMED   9776767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007932.2, CD579580.2, BX096297.1 and AC097062.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024603.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007932.2, SRR3476690.1145220.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371833.4/ ENSP00000360899.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-792               BC007932.2         31-822
            793-793             CD579580.2         696-696
            794-1341            BC007932.2         824-1371
            1342-1489           BX096297.1         46-193
            1490-1490           AC097062.2         48673-48673         c
            1491-1689           BX096297.1         195-393
            1690-1693           AC097062.2         48470-48473         c
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..1693
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /note="BEN domain containing 5"
                     /db_xref="GeneID:79656"
                     /db_xref="HGNC:HGNC:25668"
     exon            1..286
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1326
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /note="isoform 1 is encoded by transcript variant 1; BEN
                     domain-containing protein 5"
                     /codon_start=1
                     /product="BEN domain-containing protein 5 isoform 1"
                     /protein_id="NP_078879.2"
                     /db_xref="CCDS:CCDS552.2"
                     /db_xref="GeneID:79656"
                     /db_xref="HGNC:HGNC:25668"
                     /translation="MYAFVRFLEDNVCYALPVSCVRDFSPRSRLDFDNQKVYAVYRGP
                     EELGAGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEE
                     DGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVF
                     VEASPGTEDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKL
                     KEYGALVSEMKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEA
                     NTSSYYPAPAPVMDKYILDNGKVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWG
                     TDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIAQRLSK
                     VNKYICEKIMDINKSCKNEERREAKYNLQ"
     exon            287..420
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     exon            421..805
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     exon            806..954
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1168
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1693
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /note="hexamer: AATAAA"
     polyA_site      1345
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /note="major polyA site"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="BEND5"
                     /gene_synonym="C1orf165"
ORIGIN      
        1 acctccgcgc ccgccccgcg ggctgagctg cccgaccggg gcccgccccc ggcgcccacc
       61 atgtacgcct ttgtgcggtt cctggaggac aacgtctgct acgcgctgcc cgtgtcgtgc
      121 gtgcgcgact tcagcccccg ctcgcggctg gattttgaca accagaaggt gtacgccgtg
      181 taccggggcc cggaggaatt gggcgccggg cccgagagcc ccccgcgcgc cccccgcgac
      241 tggggcgcgc tgttgctcca caaggcccag atcctggcgc tggcagaaga caaatctgac
      301 cttgaaaaca gtgtgatgca gaagaaaata aaaatcccca agctttctct taatcatgta
      361 gaagaagatg gagaggttaa agattatggg gaagaagatt tacagcttag acacatcaag
      421 agacctgagg ggcggaagcc gagcgaagtg gcgcacaaga gcatcgaggc agtggtggct
      481 cggctagaga agcagaacgg cctgagcctg ggccatagca cgtgtccgga agaggtcttc
      541 gtggaggcct cgccaggcac agaggacatg gacagtctag aagatgctgt ggtgccccgg
      601 gctctgtatg aggagctgct gcgcaactac cagcagcaac aggaagagat gcgccacctc
      661 cagcaggagc tggagcggac tcggaggcag ctggtacaac aggccaagaa gctcaaggag
      721 tacggggcac ttgtgtctga aatgaaggag ctccgtgacc ttaaccggag gctccaggac
      781 gtgctgctcc tgcggcttgg cagcggtccc gccattgatc tggaaaaagt aaagtcagaa
      841 tgtctcgagc ccgagccgga gttacggagc actttcagtg aggaagcaaa tacgtcgtcc
      901 tattaccccg ctcctgcgcc tgtcatggac aagtatatcc tagacaatgg caaggtccat
      961 ctgggaagcg ggatttgggt tgatgaggag aaatggcacc agctacaagt aacccaagga
     1021 gattccaagt acacgaagaa cttggcagtt atgatttggg gaacagatgt tctgaaaaac
     1081 agaagcgtca caggcgtcgc cacaaaaaaa aagaaagatg cagtccctaa accacccctc
     1141 tcgcctcaca aactaagcat cgtcagagag tgtttgtatg acagaatagc acaagaaact
     1201 gtggatgaaa ctgaaattgc acagagactc tccaaagtca acaagtacat ctgtgaaaaa
     1261 atcatggata tcaataaatc ctgtaaaaat gaagaacgaa gggaagcaaa atacaatttg
     1321 caataaactt tggatttttc ataaagcttt cgtgttttcc ttgtgtggca tgtgatttgc
     1381 gagcgatggt gccgtccaaa tcagacccca ccgtgcatgg tggtgtgtgt gcagggatcc
     1441 atcgggttct ggggtcagcg gcttgttctg aatgtggaca ctccaaagac gacagatggc
     1501 tttgctgaga ctcaggagca gcctggcact ggtgtccttc tgggaatggg gaaaacactc
     1561 ttcttggagg gggataaggt tgcctgagtt gcctgtcact tgactggggt ttgaatggat
     1621 atttttacta tccaaggact tctttgttgc tctattttgt tctataataa attttcatta
     1681 attctttgat gta
//
