LOCUS       NM_207406               8627 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens BEN domain containing 4 (BEND4), transcript variant 1,
            mRNA.
ACCESSION   NM_207406 XM_941085
VERSION     NM_207406.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8627)
  AUTHORS   Kara,B., Uyguner,O., Maras Genc,H., Islek,E.E., Kasap,M.,
            Toksoy,G., Akpinar,G., Uyur Yalcin,E., Anik,Y. and Ustek,D.
  TITLE     BEND4 as a Candidate Gene for an Infection-Induced Acute
            Encephalopathy Characterized by a Cyst and Calcification of the
            Pons and Cerebellar Atrophy
  JOURNAL   Mol Syndromol 13 (1), 12-22 (2022)
   PUBMED   35221871
REFERENCE   2  (bases 1 to 8627)
  AUTHORS   .
  TITLE     Genetic Variants May Play Role in Opioid Dependence
  JOURNAL   Am J Med Genet A 182 (6), 1296-1297 (2020)
   PUBMED   32453508
  REMARK    GeneRIF: Genetic Variants May Play Role in Opioid Dependence.
REFERENCE   3  (bases 1 to 8627)
  AUTHORS   Kettunen,E., Hernandez-Vargas,H., Cros,M.P., Durand,G., Le
            Calvez-Kelm,F., Stuopelyte,K., Jarmalaite,S., Salmenkivi,K.,
            Anttila,S., Wolff,H., Herceg,Z. and Husgafvel-Pursiainen,K.
  TITLE     Asbestos-associated genome-wide DNA methylation changes in lung
            cancer
  JOURNAL   Int J Cancer 141 (10), 2014-2029 (2017)
   PUBMED   28722770
  REMARK    GeneRIF: BEND4 hypermethylation is associated with lung cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB126828.1 and AA757195.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207406.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB126828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502486.6/ ENSP00000421169.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8540              AB126828.1         224-8763
            8541-8627           AA757195.1         1-87                c
FEATURES             Location/Qualifiers
     source          1..8627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p13"
     gene            1..8627
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /note="BEN domain containing 4"
                     /db_xref="GeneID:389206"
                     /db_xref="HGNC:HGNC:23815"
     exon            1..124
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            125..844
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1962
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /note="isoform a is encoded by transcript variant 1;
                     coiled-coil domain containing 4; BEN domain-containing
                     protein 4; coiled-coil domain-containing protein 4"
                     /codon_start=1
                     /product="BEN domain-containing protein 4 isoform a"
                     /protein_id="NP_997289.2"
                     /db_xref="CCDS:CCDS47048.1"
                     /db_xref="GeneID:389206"
                     /db_xref="HGNC:HGNC:23815"
                     /translation="MEEEMQPAEEGPSVPKIYKQRSPYSVLKTFPSKRPALAKRYERP
                     TLVELPHVRAPPPPPPPFAPHAAVSISSSEPPPQQFQAQSSYPPGPGRAAAAASSSSP
                     SCTPATSQGHLRTPAQPPPASPAASSSSSFAAVVRYGPGAAAAAGTGGTGSDSASLEL
                     SAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYNERQEHCHIG
                     KGVHSQTSDNVDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNPSSASEYGHL
                     ADVDPLSTSPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEDEEGYCPRCQELEQEVI
                     SLQQENEELRRKLESIPVPCQTVLDYLKMVLQHHNQLLIPQPADQPTEGSKQLLNNYP
                     VYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPER
                     RPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGG
                     SFYEGIDHQASQDEVFNKSSQDGSGD"
     exon            845..1411
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1503
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1744
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..8627
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8520..8525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /note="hexamer: AATAAA"
     polyA_site      8551
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /note="major polyA site"
     regulatory      8603..8608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
                     /note="hexamer: AATACA"
     polyA_site      8627
                     /gene="BEND4"
                     /gene_synonym="CCDC4"
ORIGIN      
        1 gtttcggaag ccggaccccg cccgcagccg cagaagcctc gagtccacat ctgggtctct
       61 aaagtctcgc cgtagccaga tcccggatcc ccaccttctt caccagttcc cgggcgtcct
      121 ccaggcattg gcgaggcagc ctgtcaatca ggagctcggg cggcagcccc ccgcgcgggg
      181 gctcggcgat gccagcctca gcgacaggcg gcggcggcgg cggccacggc acagacacac
      241 accctcccac acgcgcgcac cagggcagac ccggcgggca ggcggcggag gcaccctcgg
      301 agcccggcgc ccggcgggga ggggacgtgc tccgagggac cggccccgag gcgccggatg
      361 gaggaagaga tgcagccggc agaggagggg cccagcgtcc ccaaaatcta caagcagcgc
      421 agcccctaca gcgtcctcaa gacgttcccc agcaagagac cggcgctggc caagcgctac
      481 gagcgaccca ccctggtgga gctgccgcac gtgcgggcgc ccccgccgcc cccgccgccc
      541 ttcgcgccgc acgccgccgt ctccatcagc agcagcgagc cgccgccgca gcagttccag
      601 gcgcagagct cctacccccc cgggcccggc cgggccgccg ccgccgcttc gtcgtcgtcg
      661 ccgtcctgca cgcccgccac atcccagggc cacttgagga ctccggcgca gccgccgccc
      721 gcgtcccccg ccgcctcctc gtcgtcttcg ttcgccgctg tcgtcaggta tggcccaggc
      781 gcggcggcgg ccgccggcac cggcggcacg ggtagcgaca gcgccagcct ggagctcagc
      841 gcagagagtc gaatgatctt ggatgccttt gcccagcagt gcagtcgagt tcttagcctc
      901 ttaaattgtg gaggaaaact cctggactcc aaccattctc agtccatgat ttcttgcgta
      961 aagcaggaag gctcaagtta caacgaaaga caggagcact gtcacattgg gaaaggggtc
     1021 cacagtcaga cctcagacaa tgtagacata gagatgcagt atatgcaaag gaaacaacaa
     1081 acttctgcct ttttgagggt tttcactgac tctctacaaa attacctgct ctcgggaagc
     1141 tttccaactc caaacccctc gtcagccagt gaatatggcc atctggccga cgtggatcct
     1201 ctgtcaacct ctcctgtgca tacattaggt ggctggactt ccccagcaac gtccgaatcc
     1261 catggccacc catcttcatc tacactgcca gaagaggagg aggaggagga cgaggaaggc
     1321 tattgtcctc gatgccaaga gctggagcag gaggttattt cactgcaaca agaaaatgaa
     1381 gagctcagaa ggaaattaga gagcatccca gtgccctgcc agaccgtttt agattacttg
     1441 aagatggttc tgcagcacca caaccaactc ctgataccac agccagctga ccagccgaca
     1501 gagggaagca agcagctgtt gaacaactat cctgtctaca taacgagcaa acagtgggat
     1561 gaggctgtaa attcttcaaa gaaagatggg agacggctcc ttcgatacct catcagattt
     1621 gttttcacaa ccgatgagct taagtactca tgcggccttg ggaaaaggaa aaggtcagtg
     1681 cagtcaggag agacaggtcc cgaaagacgc cctctggatc cagttaaagt aacatgcctc
     1741 cgagaattca ttaggatgca ttgtacctcc aaccccgatt ggtggatgcc ctcggaagag
     1801 cagataaaca aagtgttcag cgacgctgtc ggtcacgccc gacaggggcg ggcggtgggg
     1861 actttcctgc acaacggtgg ctcattttat gaagggatcg atcaccaggc ttctcaggat
     1921 gaagtcttca ataaaagttc ccaggatgga tctggggatt agtggacaga atcttcctgt
     1981 tgtagcagct ggtcctctca agagttccaa ttgtgaatgt cctgttcctg tcacctgaga
     2041 gtccaaagcc tgtcattctg ccatagtcta cacattctca gctgccacag tacccaaata
     2101 gaaatccatt ttagggttgt ttgggaagtc tgtggcacct acaacagact tttggaatat
     2161 tatattataa aaagaaaaaa ctacatctga tttttaaatg attactagct agatcatgag
     2221 ggtgaaaaaa taggtgagct cctagttacc tttctgaaat cttcaaactc tgctacctgg
     2281 gcagagatag tccccaaggt aggctggggt agtgtttctg cccatgggag aaggtggaga
     2341 catggagttg tgttaaggga caagaagcaa acattctctt aattcaaata agttgtcttt
     2401 atgttttcca aagacttgac ttcatatttc tcggcaaaga cataggatag atgacatcat
     2461 ataccatttt gacattaata atgtctatta ctaaaaggaa accagagaac agaggcaaca
     2521 tctgcagaca gtgattaatt acaggtcaac tgtttttctg ttgtttaaaa accactgtgt
     2581 tgatcaagaa ggcactattt gatctctgga gtttacaaac agtagtcatt tttcattgtt
     2641 agtcaagaaa catccaaaga tccaaaacca ttttcaaatg ctcagttttg taggttaata
     2701 aatccgcagt ttccatagcc ttaaatcagg ctttgttgac acaatgccaa agtgatgggt
     2761 agaacaatga aaatttaaag caattagttg tttggtgcac tgaagaccaa acaagtggtg
     2821 tgactgatgg tattcgctga attgactaga tgttctggca ttgtatacac acagcttcaa
     2881 ggcgattctg acaactatgc aatgggcttg tcagtaattg ctctgaaatt tgagggtctt
     2941 tctctgctga gctgatcttt agaatttgta tgaaacttgt ttcccattgt ccttgatgaa
     3001 aacatttcat cccctccgtg cctcctttac cccaatgtac cccttagcta tggctaagtc
     3061 agcactgtgc cgctatcccc tggttaattt gttgagttcc atatgtgaaa ttagtggtat
     3121 ctttggaaac tttccatatt ggcaaatgct atagaggtgc tagagtcatc atttctgagg
     3181 gcttcctgtt tggactcagg agaggctttc tttaccaaac tagtccagat tactacattc
     3241 tttgtagagc aaagggctaa atggacagcg tttattgaag gctactaatg tcatctacag
     3301 acatgaccaa gggtttttga aaattggttg gagattcagg ttaatgagca tccattgata
     3361 aagggttttt gggctatttt tgtcaacata aactcataaa ttgtccttta gatttaatat
     3421 ttagtttgta ttcactatat acaaagtcct agaaacaggt ctttctgtag cttttgttta
     3481 ttagcttttt tgtattacta gaattcatcc attgaaaagt ttaatgttta tggaggtggt
     3541 catctgtcag atctgctcaa tgatgtagtg ggcactaata tttcaatcct gttttgagaa
     3601 aattaactaa aatttgtcat atcattcaat ggaataggga gaaccaatat tcaattctat
     3661 ttggggcaaa ttagctaaaa tttggaagta aaagaaatga tatgggcaaa tgccatgttc
     3721 ttacggcagc catgagacca gtctctttgg ctctccaagg aagaaagata cctcttaaag
     3781 cattttttag aggtccgaga agtcagtgtc tgtcttataa gattctttga caacatgaca
     3841 tcttcgctag aagaaaaaca ccaccatagc ctcatctgtt tttccatctt accttaattt
     3901 ttcattggcc ttaagttgtc cttactgctg aatacatcgt tctgtttttc taaagcaaca
     3961 atatttgatc actgctttta agaaaaacag actagccctt cttgtttttc tggaagtttg
     4021 agagtcctga atatttcttc atatccaaat atcatcttgg agccctatcg tgctggtctt
     4081 cgctgaggct gatgagagca ctttctgcac ccctgctcca tggccgtaca tgacaacgca
     4141 cctgcaccac tgctgcaagg gcggggggca gcagcctgtg ttttggctgt cactgttacc
     4201 tcctgagaag gctgctgtcc caggtttgca caccactttt gttccaaagt tacacatggt
     4261 ctcttcctcc ctcgcaccca ttccaggtta atcatttctc tatcagctgt ttctccatcc
     4321 acagattctg aatgttgaga ctaattgttg ggcatctctt ttgcacaagg ctgacagact
     4381 ccatactcag catcgcacag ccagttctaa ctcctctgct gggtctcgga cctacagctt
     4441 ttgcctgagt gaaatgttcc tacgactttt gctcctgagt gagatattcc attgtacttc
     4501 tactgtttgt gtatctgctg ggttccttta gccaagccta gcgtctgacg caggcactag
     4561 ccgccactga ggccgtgata cagcatcact gtggacactg ctggctcctc tccttgggac
     4621 atatccacac tgccccttga gcttcacctt taaggctggt atgtacgtaa gttcacggtg
     4681 gtcgtctgca tggtctcctc ttgtttaaat caggaccaac aaaggatgtt catttgtatt
     4741 ttggcaaggc ccattgggcc tctgtgtagc caggttaaaa gctcactcac taggatcgga
     4801 tgctgtcatt gctctgtgag cctttcagtt gaaatccttg gagacttgaa ggtgttgctt
     4861 attattttga tttgattttc tgcatcttta tctggcaaat ggacagattg ctctcacaag
     4921 aaacttagtc atgtcagctt ttagagtcct tcttgagtca tgttagcatt ggtagtgtaa
     4981 aatagattga gttaaaacag ctcaggatgc agctgtgccc ccacttaatt ggtgagagga
     5041 ggaggtcacg gggctggctt gacaacaaag actaaatgtg gcttttttgt cggtgactag
     5101 gtgtggtcca taagcagaag agccatacct acaaaaagtg acaactgtcc tgtgttttcc
     5161 aaattaaaat cttgttacaa agatcatgcc ggcttttcgc agtgagttga agccccaagc
     5221 tcagttccag ccaggctcag gatgaccctc aaatgatatg tattggatag tgtaggtcag
     5281 gagcctgtgg aggggaccag tattttgcaa gcagttacta aagtcacatt tctcactgac
     5341 tcttgacggt gcattgttca aaatctcatg gcttaacctt agtgttaaat gctttcaaga
     5401 aaaactgtaa ccatttcaat tttacaagta ctttctcatt ttacttgaac attttacaag
     5461 tactttctgt atttacttgt aaatatttcc tctagccctt gaacccgcgc atcacttttt
     5521 tggttttcct cattccacca cagcatttag gtgaccgtta ccatttatgt ttcattaagc
     5581 ttcactagga atgtaaggat aatattagag catttgcaga aaattgttat ctccttttgt
     5641 aggggattcg agacatattt gtagctactt cacggctgta gagttagtgg gtgatcgggt
     5701 attctgcatt gttccttatc cctttgtcag tgacagacac attgacataa gagattccta
     5761 caggattata aggagagata aattattaac cattttttta cttgatccaa ctactccatg
     5821 tcccatcaac tagtggtaac tgatgttgat aggatttttt ttaagtccag taactattct
     5881 tgcagtatca gatgtttacc ccaaattagg caataaccca gacttcgaat ctgtaggttt
     5941 atgattccta cattcccctg ccgctctcaa tggcttgttg cctcccttct gttgctctca
     6001 gaaaacagat ggagatcagg taaagatgaa acgtgcacta tatgttcaga aaagcaaaca
     6061 tccattgtcc tcatttagat tccatccttc aatttatgct ctagaaccta aacctaatac
     6121 ccattgacta cctcctgagt ttcttaggtt tcaattattt ttttgaaatg tcatccatgg
     6181 ataatagctt caattttagg aaagatttaa atgtataact ttcctcattc agtgctgtgt
     6241 catttcacag tacagatctg cgttaatttt tgacagctca tatatacaga tttttagaaa
     6301 tgtaatagaa aatgattttg cacatatggt gcaagtcttg ctggtgtatg tttaatgtgg
     6361 caacacgtgc cagaactgtt tggcaaaaca tgtcaaatgg agtgcttgag tcagaactct
     6421 aatgtaaatg tgtctaaaca gcagtatgta tcattatgat gtatttttgt aaacatagtg
     6481 atggctgctt tcagtcatgt aagtgctgga taaaaataac cacttcagtt ggagtaatgt
     6541 aggaaaacgt cacccagcag atgggtagtc ctctgcaaag ttacactgtc agccagtggc
     6601 actggttctt ttatttatgt tgggtttttg tttttttttt agaggagagt gaagaattga
     6661 catcagacaa catggagtgc aaaaataata acccatcaat atttgccttc taaatgtaaa
     6721 atgtaaaagt ttaactgatc tgtgtacaca ttagagacca ctttcacacg ccacaatatg
     6781 ttcagttgca ggttaacact gagaggttga gacttccctc atctgatgac cagcttggtt
     6841 aatttgactt ctgaaggcac taaattacca agtatttgca gtaatgggga ccggattaat
     6901 tttcctcaca attctctata gctgtctgat ataagggctg tgtttttatt gaatcacaga
     6961 tcctcaaatt acagtgaaag catgtcttgc tagtaagact catttgaaaa cctctttatt
     7021 cttggaataa ttgggccagt acaagtggcc agatgtatcc tggccacatt ggaaaactat
     7081 ttgggcccgt tcagaaccac ttaactgcaa caacagtagt aactatagtt aatatctatc
     7141 tattgagtta ttgtgtgaca gttacttgga taagtacttt aatgcattct cattttaatc
     7201 ctcacagcta ccctatgagg ctgttactgt tcttatcccc attgtattga taaggaaact
     7261 gcccagggta ctcagctaag aagaggattg ctttgggcat aggaagcaga atgacgagtt
     7321 cagtcttcct cagtagttgg agcacagttc tcaaagccca tcaacacttt ggaatggatt
     7381 tgttgtttta tttatgccat caagggagag ttgatatttg tgtattgcta aaaactacta
     7441 aagtatgtcg atgcttaggt aggaacatac aaaccatata tcctctggga tctgcccagg
     7501 tttctgtata aggcttgacc tacgtaagat cctatgatga agaccagaaa acttttttta
     7561 aaagtaggta aattaaaatt aaaatcacga gtttgttcac atttgtccca taggttccta
     7621 gtgcaaaaat gcagggagat aaaagcaaac atttgaactc agtgaagtga gagtctttgg
     7681 gaactcctag atgttagaaa tagcaccggg gcatcaggta gccaacgttc aattcacttt
     7741 tcacgtttgt gtctttgtag ctttagagct gatgagtctg attggtttgg aagagagagt
     7801 tttaatttat gatgtcactg tgagaactgt tgtgaaaatt ttgtaagaaa atacagtaat
     7861 ctgttgattt tttcctgtag ttttggcttt cacatccctt tggctgtgtt taagttcaag
     7921 agcatgccaa ggccatgagg gtcctggctt gcacttcttg ggaacagggc atgctagagg
     7981 tgggtcatga agctttcaag gtcactgttc cagcccgacc ctgcgcaatt taggcattgc
     8041 ctttatgtct ctcctctctg gaacttcatg tagcagccta acaccggggc cgagttgcct
     8101 ttactctatt ttctatgatg aatacttgtg gagaaactgt gacaaatcca ttgatcctga
     8161 tatttttatt gttggagtct tgttgattct ctatgaataa tttctatttg attgtactgt
     8221 gtagagttaa tacccactag ggatatgtta ataaagctac aaatgcatag tgtaatatag
     8281 aatagcaaga tttttttgtg aacaatttat atagaagagt aagttgtttt ttaagtgtta
     8341 ggctcatttc ttttagaaac ttaaaatgtt ataaaagttt tttaaacatt caatattttt
     8401 aattataaga gacatttgtt actagagcca attatttcag gtgttctaat tggagtgttg
     8461 attttattac ctcatatacc tctagaatgc cacgtgttct gttggggata aaattgcaca
     8521 ataaatgtca agtctctgtt aagtgtttta acttggtttt tgcatctttc taattcattg
     8581 taaatacttt tctgtttctt tgaatacata acttttctct ccctgaa
//
