LOCUS       NM_001290693            1296 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens beclin 2 (BECN2), mRNA.
ACCESSION   NM_001290693
VERSION     NM_001290693.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Zhu,M., Deng,G., Tan,P., Xing,C., Guan,C., Jiang,C., Zhang,Y.,
            Ning,B., Li,C., Yin,B., Chen,K., Zhao,Y., Wang,H.Y., Levine,B.,
            Nie,G. and Wang,R.F.
  TITLE     Beclin 2 negatively regulates innate immune signaling and tumor
            development
  JOURNAL   J Clin Invest 130 (10), 5349-5369 (2020)
   PUBMED   32865519
  REMARK    GeneRIF: Beclin 2 negatively regulates innate immune signaling and
            tumor development.
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Zhong,L., Shu,W., Dai,W., Gao,B. and Xiong,S.
  TITLE     Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase
            Activation Contributes to Hepatitis B Virus X Protein-Induced
            Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction
  JOURNAL   J Virol 91 (15), e00001-17 (2017)
   PUBMED   28515304
  REMARK    GeneRIF: Further data showed that reactive oxygen species-c-Jun
            activation by HBx resulted in the release of beclin-1 from its
            association with beclin-2 to form a complex with VPS34, thus
            enhancing autophagosome formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Su,M., Li,Y., Wyborny,S., Neau,D., Chakravarthy,S., Levine,B.,
            Colbert,C.L. and Sinha,S.C.
  TITLE     BECN2 interacts with ATG14 through a metastable coiled-coil to
            mediate autophagy
  JOURNAL   Protein Sci 26 (5), 972-984 (2017)
   PUBMED   28218432
  REMARK    GeneRIF: polar BECN2 CCD interface residues result in a metastable
            homodimer, facilitating dissociation, but enable better
            interactions with polar ATG14 residues stabilizing the BECN2:ATG14
            heterodimer.
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Dong,X., Cheng,A., Zou,Z., Yang,Y.S., Sumpter,R.M. Jr., Huang,C.L.,
            Bhagat,G., Virgin,H.W., Lira,S.A. and Levine,B.
  TITLE     Endolysosomal trafficking of viral G protein-coupled receptor
            functions in innate immunity and control of viral oncogenesis
  JOURNAL   Proc Natl Acad Sci U S A 113 (11), 2994-2999 (2016)
   PUBMED   26929373
  REMARK    GeneRIF: Both transfected and endogenous beclin 2
            coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased
            HA-vGPCR steady-state levels. It regulates vGPCR levels by a
            lysosomal degradation pathway.
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Liu,J.L., Chen,F.F., Chang,S.F., Chen,C.N., Lung,J., Lo,C.H.,
            Lee,F.H., Lu,Y.C. and Hung,C.H.
  TITLE     Expression of Beclin Family Proteins Is Associated with Tumor
            Progression in Oral Cancer
  JOURNAL   PLoS One 10 (10), e0141308 (2015)
   PUBMED   26506105
  REMARK    GeneRIF: distinct patterns of Beclin 1 and Beclin 2 were associated
            with aggressive clinical outcomes. Beclin 1 overexpression, as well
            as Beclin 2 overexpression and depletion, contributed to tumor
            growth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   He,C., Wei,Y., Sun,K., Li,B., Dong,X., Zou,Z., Liu,Y., Kinch,L.N.,
            Khan,S., Sinha,S., Xavier,R.J., Grishin,N.V., Xiao,G.,
            Eskelinen,E.L., Scherer,P.E., Whistler,J.L. and Levine,B.
  TITLE     Beclin 2 functions in autophagy, degradation of G protein-coupled
            receptors, and metabolism
  JOURNAL   Cell 154 (5), 1085-1099 (2013)
   PUBMED   23954414
  REMARK    GeneRIF: Study identified a previously uncharacterized
            mammalian-specific protein, Beclin 2, which, like Beclin 1,
            functions in autophagy and interacts with class III PI3K complex
            components.[Beclin 2]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HM031116.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: HM031116.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419583.2/ ENSP00000488361.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1296              HM031116.1         1-1296
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1296
                     /gene="BECN2"
                     /gene_synonym="BECN1L1; BECN1P1"
                     /note="beclin 2"
                     /db_xref="GeneID:441925"
                     /db_xref="HGNC:HGNC:38606"
                     /db_xref="MIM:615687"
     CDS             1..1296
                     /gene="BECN2"
                     /gene_synonym="BECN1L1; BECN1P1"
                     /note="Beclin-1-like protein 1; beclin-1 autophagy-related
                     pseudogene 1"
                     /codon_start=1
                     /product="beclin-2"
                     /protein_id="NP_001277622.1"
                     /db_xref="CCDS:CCDS81433.1"
                     /db_xref="GeneID:441925"
                     /db_xref="HGNC:HGNC:38606"
                     /db_xref="MIM:615687"
                     /translation="MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTRE
                     PGVTTREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGD
                     IFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAA
                     ALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSAL
                     KRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLP
                     TVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLF
                     CYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRG
                     ECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRYQK"
     exon            1..1296
                     /gene="BECN2"
                     /gene_synonym="BECN1L1; BECN1P1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcttcca tccgcttcct gtgccagcgc tgccaccagg ccctgaagct gagcggctcc
       61 tcggagtcta ggagcctccc tgcagccccg gcgcccacct ctgggcaggc tgagcccgga
      121 gacacccggg agcccggcgt caccaccagg gaggtgacag acgctgagga gcaacaggac
      181 ggtgcctcta gcagatcccc tccaggcgat ggcagtgtgt ccaagggcca tgccaacatc
      241 ttcaccctgc tgggggagct tggcgccatg cacatgctca gtagcatcca gaaggcagct
      301 ggtgacattt ttgacatagt ctctggccaa gcagttgtgg accatcccct gtgtgaagaa
      361 tgcaccgaca gtcttttaga gcagctggac atccagctcg ctctcacaga agctgacagt
      421 cagaactacc aacgctgcct ggagaccggg gagctggcga ccagcgagga cgaggcggcg
      481 gcgctgcggg cggagctgcg ggacctggag ctggaggagg ccaggctggt gcaggagctg
      541 gaggatgtgg acaggaacaa tgcaagagca gcggcggatc tccaggcagc ccaggcagag
      601 gctgcggagc tggaccagca ggagaggcag cactacaggg actacagtgc cttgaagcgg
      661 cagcagctgg aactgcttga tcagctgggg aacgtggaga accagctgca gtatgccagg
      721 gtccagaggg accggctgaa ggaaatcaac tgtttcaccg ccacgtttga gatctgggtg
      781 gagggcccct tgggcgtcat caataacttc aggttgggcc gcctccccac tgtccgtgtg
      841 ggctggaatg agattaacac tgcctgggga caggcggcct tgctgctcct taccctggcc
      901 aatacaattg gactgcagtt tcagaggtat cgactcatcc cctgcggaaa ccattcgtat
      961 ctgaagtctt taacagatga ccgcactgag ctgccgttgt tctgttatgg ggggcaggat
     1021 gttttcctca ataacaagta tgaccgcgcg atggtggcct tcctggactg catgcagcag
     1081 ttcaaggaag aggctgagaa gggtgagctg ggcctctctc tgccctacgg gatccaggtg
     1141 gagacaggcc tgatggagga cgttggcggc cgaggggaat gctattccat cagaacccat
     1201 ctgaacacgc aggagctgtg gacaaaggca ctcaagttca tgcttataaa tttcaagtgg
     1261 agtctcatct gggttgcctc aaggtatcaa aagtag
//
