LOCUS       NM_018429              11037 bp    mRNA    linear   PRI 29-SEP-2024
DEFINITION  Homo sapiens BDP1 general transcription factor IIIB subunit (BDP1),
            mRNA.
ACCESSION   NM_018429
VERSION     NM_018429.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11037)
  AUTHORS   Son,H.J., Mo,H.Y., Yoo,N.J. and Lee,S.H.
  TITLE     Somatic mutations of cancer-related genes PELP1 and BDP1 in
            colorectal cancers
  JOURNAL   Pathol Res Pract 216 (10), 153107 (2020)
   PUBMED   32853945
  REMARK    GeneRIF: Somatic mutations of cancer-related genes PELP1 and BDP1
            in colorectal cancers.
REFERENCE   2  (bases 1 to 11037)
  AUTHORS   Kramm,K., Schroder,T., Gouge,J., Vera,A.M., Gupta,K., Heiss,F.B.,
            Liedl,T., Engel,C., Berger,I., Vannini,A., Tinnefeld,P. and
            Grohmann,D.
  TITLE     DNA origami-based single-molecule force spectroscopy elucidates RNA
            Polymerase III pre-initiation complex stability
  JOURNAL   Nat Commun 11 (1), 2828 (2020)
   PUBMED   32504003
  REMARK    GeneRIF: DNA origami-based single-molecule force spectroscopy
            elucidates RNA Polymerase III pre-initiation complex stability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11037)
  AUTHORS   Gouge,J., Guthertz,N., Kramm,K., Dergai,O., Abascal-Palacios,G.,
            Satia,K., Cousin,P., Hernandez,N., Grohmann,D. and Vannini,A.
  TITLE     Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase
            III transcription initiation
  JOURNAL   Nat Commun 8 (1), 130 (2017)
   PUBMED   28743884
  REMARK    GeneRIF: Data indicate the crystal structure of a Brf2-TBP-Bdp1
            complex bound to a DNA promoter.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11037)
  AUTHORS   Girotto,G., Abdulhadi,K., Buniello,A., Vozzi,D., Licastro,D.,
            d'Eustacchio,A., Vuckovic,D., Alkowari,M.K., Steel,K.P., Badii,R.
            and Gasparini,P.
  TITLE     Linkage study and exome sequencing identify a BDP1 mutation
            associated with hereditary hearing loss
  JOURNAL   PLoS One 8 (12), e80323 (2013)
   PUBMED   24312468
  REMARK    GeneRIF: Linkage study and exome sequencing identify a BDP1
            mutation associated with hereditary hearing loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11037)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 11037)
  AUTHORS   Hu,P., Wu,S. and Hernandez,N.
  TITLE     A minimal RNA polymerase III transcription system from human cells
            reveals positive and negative regulatory roles for CK2
  JOURNAL   Mol Cell 12 (3), 699-709 (2003)
   PUBMED   14527415
REFERENCE   7  (bases 1 to 11037)
  AUTHORS   Kelter,A.R., Herchenbach,J. and Wirth,B.
  TITLE     The transcription factor-like nuclear regulator (TFNR) contains a
            novel 55-amino-acid motif repeated nine times and maps closely to
            SMN1
  JOURNAL   Genomics 70 (3), 315-326 (2000)
   PUBMED   11161782
REFERENCE   8  (bases 1 to 11037)
  AUTHORS   Schramm,L., Pendergrast,P.S., Sun,Y. and Hernandez,N.
  TITLE     Different human TFIIIB activities direct RNA polymerase III
            transcription from TATA-containing and TATA-less promoters
  JOURNAL   Genes Dev 14 (20), 2650-2663 (2000)
   PUBMED   11040218
REFERENCE   9  (bases 1 to 11037)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   10 (bases 1 to 11037)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     Three human RNA polymerase III-specific subunits form a subcomplex
            with a selective function in specific transcription initiation
  JOURNAL   Genes Dev 11 (10), 1315-1326 (1997)
   PUBMED   9171375
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP246483.1, BP347992.1,
            AB051476.3, AC138832.2 and AI537645.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018429.2.
            
            Summary: The product of this gene is a subunit of the TFIIIB
            transcription initiation complex, which recruits RNA polymerase III
            to target promoters in order to initiate transcription. The encoded
            protein localizes to concentrated aggregates in the nucleus, and is
            required for transcription from all three types of polymerase III
            promoters. It is phosphorylated by casein kinase II during mitosis,
            resulting in its release from chromatin and suppression of
            polymerase III transcription. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146792.1, AB051476.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358731.9/ ENSP00000351575.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BP246483.1         37-62
            27-571              BP347992.1         38-582
            572-2495            AB051476.3         355-2278
            2496-2496           AC138832.2         115589-115589
            2497-3956           AB051476.3         2280-3739
            3957-4266           AC138832.2         121763-122072
            4267-4631           AB051476.3         4050-4414
            4632-4632           AC138832.2         124283-124283
            4633-5191           AB051476.3         4416-4974
            5192-5192           AC138832.2         128367-128367
            5193-10830          AB051476.3         4976-10613
            10831-11037         AI537645.1         25-231              c
FEATURES             Location/Qualifiers
     source          1..11037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..11037
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /note="BDP1 general transcription factor IIIB subunit"
                     /db_xref="GeneID:55814"
                     /db_xref="HGNC:HGNC:13652"
                     /db_xref="MIM:607012"
     exon            1..439
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..8102
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase III, GTF3B subunit 1; transcription
                     factor-like nuclear regulator; transcription factor IIIB
                     150; RNA polymerase III transcription initiation factor
                     B''; B double prime 1, subunit of RNA polymerase III
                     transcription initiation factor IIIB"
                     /codon_start=1
                     /product="transcription factor TFIIIB component B''
                     homolog"
                     /protein_id="NP_060899.2"
                     /db_xref="CCDS:CCDS43328.1"
                     /db_xref="GeneID:55814"
                     /db_xref="HGNC:HGNC:13652"
                     /db_xref="MIM:607012"
                     /translation="MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSA
                     SKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTS
                     SLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELR
                     KEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQT
                     REQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVV
                     EENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRAR
                     IEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLK
                     EKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDA
                     EQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELK
                     EGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSD
                     LPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLS
                     RAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVS
                     VLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNEN
                     ESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKA
                     NKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTS
                     PKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREK
                     TPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPE
                     VTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVID
                     ATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIE
                     IDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLE
                     ETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETE
                     REISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDI
                     PIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRE
                     NELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVS
                     SHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRS
                     RFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEAS
                     LMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTN
                     NVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPK
                     DETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENK
                     PYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNT
                     QLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSS
                     VVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTR
                     GRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKA
                     PVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEE
                     NLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHV
                     HSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLME
                     KVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAE
                     METQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNE
                     NQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPE
                     YTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATA
                     QFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDL
                     VSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDI
                     FLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAA
                     PKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGL
                     RKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSA
                     QKRAPQGEATTVSEYFFNDIFIEVDETE"
     exon            440..716
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            717..826
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            827..886
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1012
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1146
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1241
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1296
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1440
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1719
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1867
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2026
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2183
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2275
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2468
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2599
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..4286
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4474
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4697
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..4876
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..5087
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5218
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            5219..5420
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            5421..5614
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            5615..5999
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6119
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6120..6156
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6157..6249
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6250..6478
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6479..6639
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6640..6790
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6791..6971
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            6972..7035
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7036..7222
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7223..7427
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7428..7467
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7468..7723
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7724..7970
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     exon            7971..11037
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11017..11022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /note="hexamer: AATAAA"
     polyA_site      11037
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /note="major polyA site"
ORIGIN      
        1 gagggtgaaa tttagccatc ggtgtgtggc agggtcatga aaaagcggcg gcggcgggag
       61 agaggaggag gcggcggcgg ggcagtgaaa ctacggtagc tgccccctga gctggtggtg
      121 tggctttgtg gggagggcgt agttcctaat cccctttccg ggcagccgcc ggggctcggg
      181 gctgtgagcg gccgtgaggc tgcctccccg ggccccctgc ctccgccatg ttccgcaggg
      241 cacgccttag cgtgaagccg aatgtcaggc ctggtgtagg cgccaggggc tccacagctt
      301 ccaatcccca gcgtggacgg gagtctccca ggccgccgga tcctgccacg gactctgctt
      361 ccaagcccgc ggagcccaca gatgtgccca cagtcgattt cggtggagcg gagccccaag
      421 aaaaggctcc taggagcagt actgaaaaga ctggtggtga caatgatgtt gaagaatcca
      481 gtagatcttc ctctactgtt tcacagagaa gaaagcgaat atcaagtact tctagcctgg
      541 ttaagtctag tgtcagtgtt ccttcagaat ctcatccctt atctacaatt aatcaagagg
      601 ctccacagcc aactgccact tcaacaaaag agaaacagcc atgctcagac agataccgaa
      661 tatacaaagc ccagaaactg agggaaatgt taaaagaaga attgagaaaa gagaagaaac
      721 aatggaaaaa caaatatgct ataaatgaaa gtcagaggcc accagatcgt tcaaaaatga
      781 ctatgagaga cttcatatat tatctaccag ataataatcc aatgacttct tcactggaac
      841 aagaaaagaa aactgaaaag ccatcgactc cagtccagac aagagagcaa gaaggtaaga
      901 gtactcctaa tgctgaagat aatgaaatgg aagaagagac agatgatggg ccattactgg
      961 ttcctcgagt aaaagtggca gaagatggtt ccattatttt ggatgaagaa agtttaactg
     1021 tagaagtttt aagaacaaaa ggcccttgtg ttgttgaaga aaatgacccc atatttgagc
     1081 gcggttctac aactacatac tccagcttta ggaaaaacta ttactctaaa ccatggtcaa
     1141 ataaagaaac agatatgttt tttttagcca tcagcatggt aggaactgac ttttctatga
     1201 tcggacaact ttttcctcac agagcaagga tagaaattaa gaataaattt aaacgggaag
     1261 agaaaacaaa tggatggaga atagacaaag cattccagga aaagcgccct tttgacttcg
     1321 atttttttgc tcatttgctt cagaaagttc ttgctgaaga agagaaaaga aaacaaaaat
     1381 ctgttaaaaa tcacagttta aaggagaaga aatccaccaa accacggaaa aatgtaaaag
     1441 tgaaaaaagt tgcctgtgaa ggagtgaata atgatccaga tgagtctatg agttctagaa
     1501 tttcagacac ggaaagatct cagaaggatg ctcagacagt tgaagaagag tctctgacct
     1561 tatcaaggga ggatgcagag caggttgcat tagaagtaga cctaaatcaa aagaaaagaa
     1621 ggaggaagaa gcaagatgga gctaatgaac tgggagtaaa caatctttta gaaaatgcca
     1681 ctgttcaggc gggtccttct aaaggagaaa aacacaagaa taaatgtcag gctataaggc
     1741 ctgagctaaa ggaaggtgaa tgcagtaagg agcagatgct ttcctgcaca caaaacatag
     1801 atggcattgt gggttttgcc tccactgaaa aagttgagaa aagaactgac cccatccttt
     1861 cattaagtaa tcaacaagat gccacatcag tagcaactga gtcttcagaa tcaagcactt
     1921 cagatttgcc ttcattcgaa gttggaatta gagcattgtg tgaggtgaat aatgctgagg
     1981 gtagttgtat agaagaaaga aatgttgacc taaaaaataa ttcactggaa attgatcaaa
     2041 cagaaaatgt taaaccaatg ttgagaggtc gcttccaaag acctaaaccc aatttgtcaa
     2101 gggctgggaa gaaatcagtt ctttcacaag gcaaaacaga gtcagagagc aagaattcac
     2161 attcaaaaac ttcagttgaa aagaaccacg tggaaaaaga taaaatgaat acattggaca
     2221 ttttgagaat ggagactaca gagagagaga atccagaagc tgaaactgta tctgttttgg
     2281 gtgaaaaaaa ttgtctgcag gaagggagtc aactaaaggc tttaagacct gtacaagtga
     2341 ggggccgatt gcaaaagcca aagccaaatg caggtaaagc tgctgaaaga aaagaaattc
     2401 tcatatcaca ggaagaaatt ggggccaatg tagagaagaa tgaaaatgaa tcctgtgctg
     2461 atagagatac tcctcaacac atggaagatc aatcgcgtaa agattttgaa gaggaagatg
     2521 tcatattaca gcctgagaaa aatgattctt ttcaaaatgt gcagccagat gagcccaagg
     2581 ttcttaatga atgtctaagc gttcaagaga ataataaggc aaataaactt aaccaagtcc
     2641 caattctaag gactcgattt cagaaaccaa agccaaatat aggaagagga actggaagga
     2701 gagaaatttc ctcaaaggaa gaggtactag agaagattct tgtctctggg gaaatggcgg
     2761 cagcattgag agaaactgta agactagaca cctcaccaaa ggagatggta ccagcagaga
     2821 ttaatactaa agaaatgcag tcagatttaa aagaaactgg aagaagagcc atttctccca
     2881 gggagaagat tctagatgtg attgatgaca ccatagaaat ggagacaggt ctgaaagcaa
     2941 tgggaagaga gatttgtcta agggagaaga cgccagaggt gattgatgcc actgaggaaa
     3001 tagacaaaga tttggaagaa gctggaagaa gagaaatatc cccacagaaa aatggcccag
     3061 aggaggttaa gcctctaggt gaagtggaga cagatttgaa agcaactgga aatgagagtt
     3121 ccccaaggga gaagacacca gaggtgactg atgccactga ggaaatagac aaaaatttgg
     3181 aagaaactgg aagaagaaaa atatccccaa gggaaaatgg cccagaggag gtcaagcctg
     3241 tagatgaaat ggagacagat ttgaacgcaa ctggaagaga gagttctcca agggagaaga
     3301 caccagaggt gattgatgct actgaggaaa tagatttgga agaaactgaa agagaagtat
     3361 ccccacagga aaatggacta gaggaggtca agcctctagg tgaaatggag acggatttga
     3421 aagcaactgg aagagacagt ttcccaaggg ggaagacacc agaggtgatt gatgccattg
     3481 aggaaataga gatagatttg gaagaaactg aaagagaaat atccccacag gaaaatggcc
     3541 tagaggaggt taagcctcta ggtgaaatgc aaacagattt gaaagcaacc ggaagggaga
     3601 tttccccaag ggagaagaca ccagaggtga ttgatgccac tgaggaaata gacaaagatc
     3661 tggaagaaac tggaagaaga gaaatatccc cagaggaaaa tggcccagag gaggtcaagc
     3721 ctgtagatga aatggagaca gacttgaaaa caactggaag agagggttcc tcaagggaga
     3781 agacacgaga ggtgattgat gctgctgagg taatagagac agatttggaa gaaactgaaa
     3841 gagaaatatc gccacaggaa aatggcccag aggaggtcaa gcctgtaggt aaaatggaga
     3901 cagatttgaa agaaattaga gaagaaattt cccaaaggga aaaggtgcta gcagagttca
     3961 gtgctataag ggaaaaggag attgatttga aagaaactgg aaaaagagac attcccatca
     4021 tggagaaagt atcaggaaag atggctgttg ttgaagaaat ggaggcagat ttgaaagaaa
     4081 ctggaaaaga aaattttaga gagagaggat ctgaagagat ctgtgttact gaggaaaagg
     4141 tggcagaatt gaaacaaact ggaaaaacag acatttctcc aagggaaaac gagctagagg
     4201 agaccagtac ctcaagacaa actgacacac atttaatgca gagcggtagc aatgacttca
     4261 gtgctgtgcc ttcactagat attcagaaca ttagcagtga agtactgtcg atgatgcata
     4321 cacctgtaga agaaaaaaga aattctgaaa aagaagtatc aagtcacttc agtcatttca
     4381 agatttcttc acagactcat gaatctgata aaacagaagt ccaggggatt caatctccag
     4441 atgttccaga gcagttttca gatattaatt taagcaaatc tcttcctcaa gaacagaagc
     4501 cacttgaaat taaaccagca ccttttgtga ggagccgatt caaaagacca aaaccaaact
     4561 tagcaagagc agctttgaag agagagacta cagaatcaga aaaatatata tatgagaaga
     4621 aatcagaaac caagaaaatg gagactattg tgatgcaaga aaataatgaa caaactgata
     4681 ctctcccttc tcaacatgat gaagcttccc taatgatatc aagagaaaaa gacacattag
     4741 gtcacaggaa tgaggaggct gtgatattgc catgtacaca gactgaaagg aacctttcac
     4801 cttcaaattc ttgtgaacct aaagaggagt ctcagtcagc accagtccag aaaaatgact
     4861 cagttgtttc tgtggggact aataatgtaa acactttcca gcaagaaatg aaggaaagtg
     4921 ttatccaaac tgctcgacaa gtaaggggcc gacttcagag accgagacca aatataagaa
     4981 agacaggaca gaggcaaata gtagacaaag gtgaagccaa aggcataatt aaggaaggaa
     5041 gaacgatatt accaaaagat gaaactgaaa agaaagtctt aactgtgtca aattctcaaa
     5101 ttgaaactga aattgaagtt ccatcgtccg cagttccaga acacagaatg tatgaaaatc
     5161 aaagtcaggt ggttcttgta gaaaaccttc atgttaacaa aacaaatgaa acaatcagac
     5221 atgaaaataa accgtatgtt cctagttcag cacaaatgac aagaaggaaa ttccaaaagg
     5281 ctaagccaaa tttgggaaga gcacacagta agaaagagga accagtttta gaaaaagtca
     5341 caacagatca gagcaaggaa ggcaagccag aagatcattt gctgcagaaa ggagcttcca
     5401 acacccagct ccttctaaaa gaaaaagctg agcttctgac atctctggag gtttcagcaa
     5461 gaaaagattg tgtaggttcc aaagagtctg ctttggcaaa aatagatgcg gaattagaag
     5521 aagttggacc atcaagaagg gttggagagg aaactgtagg agataattca ccatcttcag
     5581 ttgttgaaga gcaatatctc aataaactaa caagctgtcc acaaccgtta aacgaaacaa
     5641 gttactctaa aattgccctg gatgggaaaa caactatctc ttctacatct gagtatgaga
     5701 gaaatcgtgg tgaaaggaga agtcataaaa agttcaaacc aaatgtcacc agaggtcgtg
     5761 gatcaaaacg agttcggggt aagacctcta agaaggaacc tagagcttcc aaggccatgc
     5821 tggtgactct tcgggcttcc caggaagaag atgatgatgc tgacgatttt gagtctgact
     5881 atgaggaaga aagctatcat cttgctcccg aagaagtaaa caaagctcca gtatttgtac
     5941 ctgttggtct cagatctcct gaacctgttt ctgctcagat tgaggaaaca atggaagagc
     6001 ttgaaataac tgtgaatgtc ccagatgtag gatgcatagc tgttgttgaa catgagctac
     6061 caaacacaga tgtgactact gaagaaatga aacaagaaga aaatttgagt gtaccgtttg
     6121 aaatgaccac aagtgaacat atccaagatg aaccaggtac caatgatgga agcaccgaag
     6181 ctgcaataac tttacttaca atgggagatc tagtattgca gtcagagatc agtagtgaac
     6241 agggtgatgt aggagtatgt ataattcctc atgttcattc aaaggataaa agccatattc
     6301 cttctagcct agataatgta aatcacaaaa ttgttcatga atgtcaggaa ctttcttcac
     6361 ctgtcattac tacatctcct gcatcatttg aagaaaacaa gattgtattg gaggaacaaa
     6421 gttccagaga agaaataagt ttaatggaga aagtaaagga gaatgctaca ccaaccagga
     6481 atacaatttc taaagtgacc agtaatttga gaataagaag taggcttgct aagcctaaac
     6541 caaatcttga gaagacttta gggaccaaca ggcttgatga ttatcaggaa gtttccagtt
     6601 tgtgtgtaac caaaggggca gaaatggaaa ctcaaagaga aacagagaaa aatgcttcca
     6661 aagcaacaga attggaaaat aaaaacctcg gaccagttac aacagcagag aataaggatc
     6721 agagcaaatt ggcatgtgta catggtatca aagggaccag tatttcttca gaagtaaacc
     6781 taactgaaag aaacgaaaat caagaagaga gctctcagga ggttcacatg ttgtcagttg
     6841 ctccagttgc ttcctctgag acagggccct gcacacttgg tttggatagg ggtcttggtg
     6901 aaaattctgt tgaagagccc cagataaagg actctaaagg agacagtgtg cttacacttc
     6961 ctgtgccaga gtatacacca acaagtattc cagaagtcca acaagagaat ataatcaatc
     7021 ctcaagacct aacagtgaat ctagttgcta atgtacctca agatggagaa gatgaacaag
     7081 cctttatttt aactctggtg gaaatcccag ccaatgcagt agaagaattt actgatgcca
     7141 ctgcacagtt catgccaaac cctttactgc cagctcccat attggtcaaa tcagtgaata
     7201 ccgaagaaag gggtgacatg agtatttgtt taccagcaac ttcagttggt caagatgcca
     7261 tgggtttatc tatttctgga agagataatt ctaaaaagcc gcctgataat ttggatcttg
     7321 tatctaggaa gagatttcaa tgcaggcttg ataaaaatga ccacattcct cctgccaaaa
     7381 aacgttcact cactttaaga gatgactgtc aagaatatac cactgaggtg cactcaaagg
     7441 aattaacaaa tgtttttgag gaaacagggg agtctcacaa gggacaagat atttttctta
     7501 cctcaggaag cacactgaca actccagaac ctcaaagaca gcaagttgaa gcagcttttc
     7561 agagtagagg atctagatct cctgatgcat gcatggacaa gaatgtgcct cagttacctc
     7621 aggatgaaat gattgtgtct gataaggaag aaagaactga tgctgctcct aagtctcagc
     7681 aaatggatag cagaacatcg tcttctaaag cctcactatc cagacctggc agaagacccc
     7741 tgggattttt atctttaata tgctcaaaga atagtttgga gtctgatgaa cctatgcaag
     7801 tccatagtaa gaaacgccta aaacctctta tacctggatt aagaaagaaa ttgaaaagat
     7861 ctaatccatt caatgaaagc caggaaaaaa atcgagagtc ctctgatctg cttccatctc
     7921 caagtgttat tactactcaa tctgagaata ttagcagctc agcaactcag gtttcttgtg
     7981 atcagccctt actgaaagaa ggatataaaa gtgcccaaaa gcgggcccct caaggggagg
     8041 caaccacagt ctctgaatat ttcttcaatg atatcttcat tgaagtggat gaaacagaat
     8101 aaaacaatct tttctctttt tcttttttaa attaggtcta ggatttccag agtcaattac
     8161 atcaacaaaa cagtatttag agcaaaatat cactgtctta tttttcttta ggttgatttt
     8221 gaatacttaa tgagcttgat ttgaagcttt tataatcagt ggaaaacatt tctgaggttc
     8281 ctttcattct gactgattca gcattttgca aatagcaagc aattaagact gctttctcag
     8341 acagaaataa caactcttgt ttacattttg actcttcctg tgctaagcac acatggacat
     8401 ttgggaatgt tgtggatata tgtctctgta tgaattgcag tgcagacaga tttgggggtt
     8461 aattgtatca tatttaacat ttagcaactt cttttgtgaa gattttttat ttttaggggg
     8521 agatgatgaa ggatgaaggc tttttcattt gcttctaagt acagtcatgt atcacataat
     8581 gaagtttaag tcaatgatgg accacatata ttacagtggt cccatgcaat taaaatggag
     8641 ataaattcct atcaactagt gacattatag ccatcataac acagtgcatt gcttttttat
     8701 gtttagatat gtttagatac acaaatactt actattgtgt tacaactgcc tacagtattc
     8761 agcatagtaa cacattgtag aggtttgtag ccgaggagca ataggctata ccacatagcc
     8821 tcagtctgta cggtgtgtag cagcctgtac catctcagtg tttgtaagta cactctgcgt
     8881 tgtttcacac aagatcacct aacaaggcaa ttcttagaac atgtagttaa gggacacgtg
     8941 actatatgtg aaaacaaatt gtcaaacttc actttagtat ggcaaatgtt aaagaacttt
     9001 tctattatca gctgtttgtc tgactgaaaa atacatattt ttctaattca tggtgatgta
     9061 acattagtcc taattgaaaa actagtattt aaacataatt atttataaag atgacacatc
     9121 aaagggctta tttattttta aattttttat ttaaaaggat attcagtttt agctattttt
     9181 acccctcaga ttgtagataa agaaggcatt aaatttatgt ttgtctcctt tttctgttta
     9241 attttaaaga tatttaaaat gatataacta aaaatgttta gctggtgtat atgttttgaa
     9301 tacctttttc ccctcagttt agtatattga ctttgtactg taaatttttc tgcttttctt
     9361 ggataatctc aggattttca tgaggatagg gggaactcaa ctttatttat gagacaaaat
     9421 ttccatacaa agctcaatct cctttataca cccacagaca taatattagt ttttaaaaag
     9481 ccaatttctt catagttttt tcccattaaa ttctcaagga acacttggat ctttaagcac
     9541 ggaacataat catgatgtta aaaacagaga aaataaggct ttataaagtt aatgattatc
     9601 atcagtatga atttaaggtt tgttttaatt tcaagatttg attttttata cgtgtaattc
     9661 tattatctac ccaagcagat ctgtagtggt tccaattaga cttctcaaac agcaaattta
     9721 tcctgatttt atttgaaaag cctcttggat tgatagtata gtagctcagg cattggaaac
     9781 tttctgcaaa ctgttttggg tttgcaggcc agatggtctc tgtggcagct actcagctct
     9841 gcaatttcag tgtgaaagaa gccatagaca gtacttgaat gaaggactgt ggctggattg
     9901 gccttttagt ttgaccccct acattaggcc ccaaattttc ttaccctgag gtgctgatat
     9961 ctgtatggat gagttatttg tcactaaagt tatgagttgt gcctaaaagt taaaactgtt
    10021 gactgtatta tgtaatgatc agtatttcag ttgggaagat attttagagt ctagataatt
    10081 atgtttgtat attgaaaaaa tggtggccag tttttaagtt ccttaataga agagaattat
    10141 gtctcagcac atataacagt aatgctaatt tattgaaact actgctgtta gagcacttct
    10201 tattcattgt cttttagtga aatttatggc gtaacacttt gtcagagagg aggctatata
    10261 attcggagcg gaaattgtct ataagtaggc atttatttca tgattgatat gtcacagaaa
    10321 tcatggtagt aaatcacatt gctatttgaa taccctgttt ttgtaagttt ttaaaactca
    10381 tattctgaaa agatttcatt ctcttagtgt tagcttggga gttagattgc catgattaaa
    10441 ctattattta tccttgtgta atattagttt ttaactttaa catctgtttc tttttaatct
    10501 ataatgagct agttttatgg aaaatggaat ttcttactat ataaagaata cagagactca
    10561 ttgtattaga gaatcaagtc agccagctaa agtatcctac tgttaaatcc ttaaacctaa
    10621 ttttggaaaa gagaaagtta atcaatgtat ttaccttaca tgttggaaag aactatgtta
    10681 ggtctgattc atgtgaagaa gatgttgcaa aggatttatt tcacaaattt taaaggagat
    10741 atgagtaaaa gtttttatct tttcttgact ttttctcctg aacacttatg tcttagcaag
    10801 tggtcaacat gaggatttga acgcctaatt gttggtaaat ggttgaggca tgacaaaaat
    10861 attaatatcc actgtttacc atcatgttat ttgaaacaaa agtgaccatg tatactatct
    10921 tgcttgaaga agtctttgac agaaaaagca atatcatgtc atttataaat tttcttgttc
    10981 taaagaaagc agttatatat atatataaat tatgtaaata aaagttattt tatatca
//
