LOCUS       NP_060899               2624 aa            linear   PRI 29-SEP-2024
DEFINITION  transcription factor TFIIIB component B'' homolog [Homo sapiens].
ACCESSION   NP_060899
VERSION     NP_060899.2
DBSOURCE    REFSEQ: accession NM_018429.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 2624)
  AUTHORS   Son,H.J., Mo,H.Y., Yoo,N.J. and Lee,S.H.
  TITLE     Somatic mutations of cancer-related genes PELP1 and BDP1 in
            colorectal cancers
  JOURNAL   Pathol Res Pract 216 (10), 153107 (2020)
   PUBMED   32853945
  REMARK    GeneRIF: Somatic mutations of cancer-related genes PELP1 and BDP1
            in colorectal cancers.
REFERENCE   2  (residues 1 to 2624)
  AUTHORS   Kramm,K., Schroder,T., Gouge,J., Vera,A.M., Gupta,K., Heiss,F.B.,
            Liedl,T., Engel,C., Berger,I., Vannini,A., Tinnefeld,P. and
            Grohmann,D.
  TITLE     DNA origami-based single-molecule force spectroscopy elucidates RNA
            Polymerase III pre-initiation complex stability
  JOURNAL   Nat Commun 11 (1), 2828 (2020)
   PUBMED   32504003
  REMARK    GeneRIF: DNA origami-based single-molecule force spectroscopy
            elucidates RNA Polymerase III pre-initiation complex stability.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2624)
  AUTHORS   Gouge,J., Guthertz,N., Kramm,K., Dergai,O., Abascal-Palacios,G.,
            Satia,K., Cousin,P., Hernandez,N., Grohmann,D. and Vannini,A.
  TITLE     Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase
            III transcription initiation
  JOURNAL   Nat Commun 8 (1), 130 (2017)
   PUBMED   28743884
  REMARK    GeneRIF: Data indicate the crystal structure of a Brf2-TBP-Bdp1
            complex bound to a DNA promoter.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2624)
  AUTHORS   Girotto,G., Abdulhadi,K., Buniello,A., Vozzi,D., Licastro,D.,
            d'Eustacchio,A., Vuckovic,D., Alkowari,M.K., Steel,K.P., Badii,R.
            and Gasparini,P.
  TITLE     Linkage study and exome sequencing identify a BDP1 mutation
            associated with hereditary hearing loss
  JOURNAL   PLoS One 8 (12), e80323 (2013)
   PUBMED   24312468
  REMARK    GeneRIF: Linkage study and exome sequencing identify a BDP1
            mutation associated with hereditary hearing loss.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2624)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (residues 1 to 2624)
  AUTHORS   Hu,P., Wu,S. and Hernandez,N.
  TITLE     A minimal RNA polymerase III transcription system from human cells
            reveals positive and negative regulatory roles for CK2
  JOURNAL   Mol Cell 12 (3), 699-709 (2003)
   PUBMED   14527415
REFERENCE   7  (residues 1 to 2624)
  AUTHORS   Kelter,A.R., Herchenbach,J. and Wirth,B.
  TITLE     The transcription factor-like nuclear regulator (TFNR) contains a
            novel 55-amino-acid motif repeated nine times and maps closely to
            SMN1
  JOURNAL   Genomics 70 (3), 315-326 (2000)
   PUBMED   11161782
REFERENCE   8  (residues 1 to 2624)
  AUTHORS   Schramm,L., Pendergrast,P.S., Sun,Y. and Hernandez,N.
  TITLE     Different human TFIIIB activities direct RNA polymerase III
            transcription from TATA-containing and TATA-less promoters
  JOURNAL   Genes Dev 14 (20), 2650-2663 (2000)
   PUBMED   11040218
REFERENCE   9  (residues 1 to 2624)
  AUTHORS   Chu,W.M., Wang,Z., Roeder,R.G. and Schmid,C.W.
  TITLE     RNA polymerase III transcription repressed by Rb through its
            interactions with TFIIIB and TFIIIC2
  JOURNAL   J Biol Chem 272 (23), 14755-14761 (1997)
   PUBMED   9169441
REFERENCE   10 (residues 1 to 2624)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     Three human RNA polymerase III-specific subunits form a subcomplex
            with a selective function in specific transcription initiation
  JOURNAL   Genes Dev 11 (10), 1315-1326 (1997)
   PUBMED   9171375
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP246483.1, BP347992.1,
            AB051476.3, AC138832.2 and AI537645.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 23, 2006 this sequence version replaced NP_060899.1.
            
            Summary: The product of this gene is a subunit of the TFIIIB
            transcription initiation complex, which recruits RNA polymerase III
            to target promoters in order to initiate transcription. The encoded
            protein localizes to concentrated aggregates in the nucleus, and is
            required for transcription from all three types of polymerase III
            promoters. It is phosphorylated by casein kinase II during mitosis,
            resulting in its release from chromatin and suppression of
            polymerase III transcription. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146792.1, AB051476.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358731.9/ ENSP00000351575.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     Protein         1..2624
                     /product="transcription factor TFIIIB component B''
                     homolog"
                     /note="TATA box binding protein (TBP)-associated factor,
                     RNA polymerase III, GTF3B subunit 1; transcription
                     factor-like nuclear regulator; transcription factor IIIB
                     150; RNA polymerase III transcription initiation factor
                     B''; B double prime 1, subunit of RNA polymerase III
                     transcription initiation factor IIIB"
                     /calculated_mol_wt=293755
     Region          1..299
                     /region_name="Interaction with ZBTB43.
                     /evidence=ECO:0000269|PubMed:16542149"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1..142
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          193..241
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          293..377
                     /region_name="Myb_DNA-bind_7"
                     /note="Myb DNA-binding like; pfam15963"
                     /db_xref="CDD:464956"
     Region          355..470
                     /region_name="Required for phosphorylation by CSNK2A1"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          379..449
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          544..567
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          606..663
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          729..759
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          823..1327
                     /region_name="9 X 55 AA repeats of
                     G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-
                     R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          <824..>1336
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     Site            915
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          930..1222
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1306..1348
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1365..1440
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1519..1543
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1684..1722
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          1819..1863
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          2130..2164
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          2181..2200
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          2207..2241
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          2444..2501
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     Region          2519..2566
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6H8Y1.3)"
     CDS             1..2624
                     /gene="BDP1"
                     /gene_synonym="DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB'';
                     TFIIIB150; TFIIIB90; TFNR"
                     /coded_by="NM_018429.3:228..8102"
                     /db_xref="CCDS:CCDS43328.1"
                     /db_xref="GeneID:55814"
                     /db_xref="HGNC:HGNC:13652"
                     /db_xref="MIM:607012"
ORIGIN      
        1 mfrrarlsvk pnvrpgvgar gstasnpqrg resprppdpa tdsaskpaep tdvptvdfgg
       61 aepqekaprs stektggdnd veessrssst vsqrrkriss tsslvkssvs vpseshplst
      121 inqeapqpta tstkekqpcs dryriykaqk lremlkeelr kekkqwknky ainesqrppd
      181 rskmtmrdfi yylpdnnpmt ssleqekkte kpstpvqtre qegkstpnae dnemeeetdd
      241 gpllvprvkv aedgsiilde esltvevlrt kgpcvveend pifergsttt yssfrknyys
      301 kpwsnketdm fflaismvgt dfsmigqlfp hrarieiknk fkreektngw ridkafqekr
      361 pfdfdffahl lqkvlaeeek rkqksvknhs lkekkstkpr knvkvkkvac egvnndpdes
      421 mssrisdter sqkdaqtvee esltlsreda eqvalevdln qkkrrrkkqd ganelgvnnl
      481 lenatvqagp skgekhknkc qairpelkeg ecskeqmlsc tqnidgivgf astekvekrt
      541 dpilslsnqq datsvatess esstsdlpsf evgiralcev nnaegsciee rnvdlknnsl
      601 eidqtenvkp mlrgrfqrpk pnlsragkks vlsqgktese sknshsktsv eknhvekdkm
      661 ntldilrmet terenpeaet vsvlgekncl qegsqlkalr pvqvrgrlqk pkpnagkaae
      721 rkeilisqee iganveknen escadrdtpq hmedqsrkdf eeedvilqpe kndsfqnvqp
      781 depkvlnecl svqennkank lnqvpilrtr fqkpkpnigr gtgrreissk eevlekilvs
      841 gemaaalret vrldtspkem vpaeintkem qsdlketgrr aisprekild viddtiemet
      901 glkamgreic lrektpevid ateeidkdle eagrreispq kngpeevkpl gevetdlkat
      961 gnessprekt pevtdateei dknleetgrr kisprengpe evkpvdemet dlnatgress
     1021 prektpevid ateeidleet erevspqeng leevkplgem etdlkatgrd sfprgktpev
     1081 idaieeieid leetereisp qengleevkp lgemqtdlka tgreisprek tpevidatee
     1141 idkdleetgr reispeengp eevkpvdeme tdlkttgreg ssrektrevi daaevietdl
     1201 eetereispq engpeevkpv gkmetdlkei reeisqrekv laefsairek eidlketgkr
     1261 dipimekvsg kmavveemea dlketgkenf rergseeicv teekvaelkq tgktdispre
     1321 neleetstsr qtdthlmqsg sndfsavpsl diqnissevl smmhtpveek rnsekevssh
     1381 fshfkissqt hesdktevqg iqspdvpeqf sdinlskslp qeqkpleikp apfvrsrfkr
     1441 pkpnlaraal kretteseky iyekksetkk metivmqenn eqtdtlpsqh deaslmisre
     1501 kdtlghrnee avilpctqte rnlspsnsce pkeesqsapv qkndsvvsvg tnnvntfqqe
     1561 mkesviqtar qvrgrlqrpr pnirktgqrq ivdkgeakgi ikegrtilpk detekkvltv
     1621 snsqieteie vpssavpehr myenqsqvvl venlhvnktn etirhenkpy vpssaqmtrr
     1681 kfqkakpnlg rahskkeepv lekvttdqsk egkpedhllq kgasntqlll kekaelltsl
     1741 evsarkdcvg skesalakid aeleevgpsr rvgeetvgdn spssvveeqy lnkltscpqp
     1801 lnetsyskia ldgkttisst seyernrger rshkkfkpnv trgrgskrvr gktskkepra
     1861 skamlvtlra sqeedddadd fesdyeeesy hlapeevnka pvfvpvglrs pepvsaqiee
     1921 tmeeleitvn vpdvgciavv ehelpntdvt teemkqeenl svpfemttse hiqdepgtnd
     1981 gsteaaitll tmgdlvlqse isseqgdvgv ciiphvhskd kshipssldn vnhkivhecq
     2041 elsspvitts pasfeenkiv leeqssreei slmekvkena tptrntiskv tsnlrirsrl
     2101 akpkpnlekt lgtnrlddyq evsslcvtkg aemetqrete knaskatele nknlgpvtta
     2161 enkdqsklac vhgikgtsis sevnlterne nqeessqevh mlsvapvass etgpctlgld
     2221 rglgensvee pqikdskgds vltlpvpeyt ptsipevqqe niinpqdltv nlvanvpqdg
     2281 edeqafiltl veipanavee ftdataqfmp npllpapilv ksvnteergd msiclpatsv
     2341 gqdamglsis grdnskkppd nldlvsrkrf qcrldkndhi ppakkrsltl rddcqeytte
     2401 vhskeltnvf eetgeshkgq difltsgstl ttpepqrqqv eaafqsrgsr spdacmdknv
     2461 pqlpqdemiv sdkeertdaa pksqqmdsrt ssskaslsrp grrplgflsl icsknslesd
     2521 epmqvhskkr lkplipglrk klkrsnpfne sqeknressd llpspsvitt qsenisssat
     2581 qvscdqpllk egyksaqkra pqgeattvse yffndifiev dete
//
