LOCUS       NM_170732               4125 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens brain derived neurotrophic factor (BDNF), transcript
            variant 2, mRNA.
ACCESSION   NM_170732
VERSION     NM_170732.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4125)
  AUTHORS   Przybylska,I., Marusiak,J., Toczylowska,B., Stepien,A.,
            Brodacki,B., Langfort,J. and Chalimoniuk,M.
  TITLE     Association between the Val66Met (rs6265) polymorphism of the
            brain-derived neurotrophic factor (BDNF) gene, BDNF protein level
            in the blood and the risk of developing early-onset Parkinson's
            disease
  JOURNAL   Acta Neurobiol Exp (Wars) 84 (3), 296-308 (2024)
   PUBMED   39392027
  REMARK    GeneRIF: Association between the Val66Met (rs6265) polymorphism of
            the brain-derived neurotrophic factor (BDNF) gene, BDNF protein
            level in the blood and the risk of developing early-onset
            Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4125)
  AUTHORS   Gliwinska,A., Badenska,M., Dworak,M., Swietochowska,E.,
            Badenski,A., Bjanid,O., Trembecka-Dubel,E., Morawiec-Knysak,A. and
            Szczepanska,M.
  TITLE     Assessment of brain-derived neurotrophic factor and irisin
            concentration in children with chronic kidney disease: a pilot
            study
  JOURNAL   BMC Nephrol 25 (1), 318 (2024)
   PUBMED   39334009
  REMARK    GeneRIF: Assessment of brain-derived neurotrophic factor and irisin
            concentration in children with chronic kidney disease: a pilot
            study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4125)
  AUTHORS   Liu,B., Liu,Y., Li,S., Chen,P., Zhang,J. and Feng,L.
  TITLE     Depletion of placental brain-derived neurotrophic factor (BDNF) is
            attributed to premature ovarian insufficiency (POI) in mice
            offspring
  JOURNAL   J Ovarian Res 17 (1), 141 (2024)
   PUBMED   38982490
  REMARK    GeneRIF: Depletion of placental brain-derived neurotrophic factor
            (BDNF) is attributed to premature ovarian insufficiency (POI) in
            mice offspring.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4125)
  AUTHORS   Ton Loy,A.F., Adler,J.S., Merritt,V.C., Sorg,S.F., Bondi,M.W. and
            Delano-Wood,L.
  TITLE     APOExBDNF Interaction and Poorer Cognitive Outcomes Among Veterans
            With Mild Traumatic Brain Injury: An Exploratory Study
  JOURNAL   J Neuropsychiatry Clin Neurosci 36 (4), 300-305 (2024)
   PUBMED   38988190
  REMARK    GeneRIF: APOExBDNF Interaction and Poorer Cognitive Outcomes Among
            Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
REFERENCE   5  (bases 1 to 4125)
  AUTHORS   Rosenfeld,R.D., Zeni,L., Haniu,M., Talvenheimo,J., Radka,S.F.,
            Bennett,L., Miller,J.A. and Welcher,A.A.
  TITLE     Purification and identification of brain-derived neurotrophic
            factor from human serum
  JOURNAL   Protein Expr Purif 6 (4), 465-471 (1995)
   PUBMED   8527932
REFERENCE   6  (bases 1 to 4125)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 4125)
  AUTHORS   Shintani,A., Ono,Y., Kaisho,Y. and Igarashi,K.
  TITLE     Characterization of the 5'-flanking region of the human
            brain-derived neurotrophic factor gene
  JOURNAL   Biochem Biophys Res Commun 182 (1), 325-332 (1992)
   PUBMED   1339267
REFERENCE   8  (bases 1 to 4125)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   9  (bases 1 to 4125)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   10 (bases 1 to 4125)
  AUTHORS   Jones,K.R. and Reichardt,L.F.
  TITLE     Molecular cloning of a human gene that is a member of the nerve
            growth factor family
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8060-8064 (1990)
   PUBMED   2236018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EF674519.1.
            
            On Jan 9, 2009 this sequence version replaced NM_170732.3.
            
            Summary: This gene encodes a member of the nerve growth factor
            family of proteins. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed to generate the mature protein.
            Binding of this protein to its cognate receptor promotes neuronal
            survival in the adult brain. Expression of this gene is reduced in
            Alzheimer's, Parkinson's, and Huntington's disease patients. This
            gene may play a role in the regulation of the stress response and
            in the biology of mood disorders. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2), also known as IIc, BDNF2C, or
            2-5, differs in the 5' UTR and represents use of an alternate
            promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF674519.1, SRR1803614.104795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4125              EF674519.1         1-4125
FEATURES             Location/Qualifiers
     source          1..4125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..4125
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="brain derived neurotrophic factor"
                     /db_xref="GeneID:627"
                     /db_xref="HGNC:HGNC:1033"
                     /db_xref="MIM:113505"
     exon            1..434
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..4125
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1199
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 2; proBDNF; neurotrophin; abrineurin; neurotrophic
                     factor BDNF precursor form"
                     /codon_start=1
                     /product="neurotrophic factor BDNF precursor form isoform
                     a preproprotein"
                     /protein_id="NP_733928.1"
                     /db_xref="CCDS:CCDS7866.1"
                     /db_xref="GeneID:627"
                     /db_xref="HGNC:HGNC:1033"
                     /db_xref="MIM:113505"
                     /translation="MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLE
                     SVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPL
                     EPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMS
                     GGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRAL
                     TMDSKKRIGWRFIRIDTSCVCTLTIKRGR"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: AATAAA"
     polyA_site      1516
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: ATTAAA"
     polyA_site      1697
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="major polyA site"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: ATTAAA"
     polyA_site      4019
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
     regulatory      4102..4107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: AATATA"
     polyA_site      4125
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
ORIGIN      
        1 aatatcaagt atcacttaat tagagatttt taagcctttt cctcctgctg tgccgggtgt
       61 gtaatccggg cgataggagt ccattcagca ccttggacag agccaacgga tttgtccgag
      121 gtggcggtac ccccaggtag tcttcttggc cccgctgtaa agccaaccct gtgtcgccct
      181 taaaaagcgt cttttctgag gttcggctca cactgagatc ggggctggag agagagtcag
      241 attttggagc ggagcgtttg gaaagcgagc cccagtttgg tcccctcatt gagctcgctg
      301 aagttggctt cctagcggtg taggctggaa tagactcttg gcaagctccg ggttggtata
      361 ctgggttaac tttgggaaat gcaagtgttt atctccagga tctagccacc ggggtggtgt
      421 aagccgcaaa gaagttccac caggtgagaa gagtgatgac catccttttc cttactatgg
      481 ttatttcata ctttggttgc atgaaggctg cccccatgaa agaagcaaac atccgaggac
      541 aaggtggctt ggcctaccca ggtgtgcgga cccatgggac tctggagagc gtgaatgggc
      601 ccaaggcagg ttcaagaggc ttgacatcat tggctgacac tttcgaacac gtgatagaag
      661 agctgttgga tgaggaccag aaagttcggc ccaatgaaga aaacaataag gacgcagact
      721 tgtacacgtc cagggtgatg ctcagtagtc aagtgccttt ggagcctcct cttctctttc
      781 tgctggagga atacaaaaat tacctagatg ctgcaaacat gtccatgagg gtccggcgcc
      841 actctgaccc tgcccgccga ggggagctga gcgtgtgtga cagtattagt gagtgggtaa
      901 cggcggcaga caaaaagact gcagtggaca tgtcgggcgg gacggtcaca gtccttgaaa
      961 aggtccctgt atcaaaaggc caactgaagc aatacttcta cgagaccaag tgcaatccca
     1021 tgggttacac aaaagaaggc tgcaggggca tagacaaaag gcattggaac tcccagtgcc
     1081 gaactaccca gtcgtacgtg cgggccctta ccatggatag caaaaagaga attggctggc
     1141 gattcataag gatagacact tcttgtgtat gtacattgac cattaaaagg ggaagatagt
     1201 ggatttatgt tgtatagatt agattatatt gagacaaaaa ttatctattt gtatatatac
     1261 ataacagggt aaattattca gttaagaaaa aaataatttt atgaactgca tgtataaatg
     1321 aagtttatac agtacagtgg ttctacaatc tatttattgg acatgtccat gaccagaagg
     1381 gaaacagtca tttgcgcaca acttaaaaag tctgcattac attccttgat aatgttgtgg
     1441 tttgttgccg ttgccaagaa ctgaaaacat aaaaagttaa aaaaaataat aaattgcatg
     1501 ctgctttaat tgtgaattga taataaactg tcctctttca gaaaacagaa aaaaacacac
     1561 acacacacaa caaaaatttg aaccaaaaca ttccgtttac attttagaca gtaagtatct
     1621 tcgttcttgt tagtactata tctgttttac tgcttttaac ttctgatagc gttggaatta
     1681 aaacaatgtc aaggtgctgt tgtcattgct ttactggctt aggggatggg ggatgggggg
     1741 tatatttttg tttgttttgt gttttttttt cgtttgtttg ttttgttttt tagttcccac
     1801 agggagtaga gatggggaaa gaattcctac aatatatatt ctggctgata aaagatacat
     1861 ttgtatgttg tgaagatgtt tgcaatatcg atcagatgac tagaaagtga ataaaaatta
     1921 aggcaactga acaaaaaaat gctcacactc cacatcccgt gatgcacctc ccaggccccg
     1981 ctcattcttt gggcgttggt cagagtaagc tgcttttgac ggaaggacct atgtttgctc
     2041 agaacacatt ctttcccccc ctccccctct ggtctcctct ttgttttgtt ttaaggaaga
     2101 aaaatcagtt gcgcgttctg aaatatttta ccactgctgt gaacaagtga acacattgtg
     2161 tcacatcatg acactcgtat aagcatggag aacagtgatt tttttttaga acagaaaaca
     2221 acaaaaaata accccaaaat gaagattatt ttttatgagg agtgaacatt tgggtaaatc
     2281 atggctaagc ttaaaaaaaa ctcatggtga ggcttaacaa tgtcttgtaa gcaaaaggta
     2341 gagccctgta tcaacccaga aacacctaga tcagaacagg aatccacatt gccagtgaca
     2401 tgagactgaa cagccaaatg gaggctatgt ggagttggca ttgcatttac cggcagtgcg
     2461 ggaggaattt ctgagtggcc atcccaaggt ctaggtggag gtggggcatg gtatttgaga
     2521 cattccaaaa cgaaggcctc tgaaggaccc ttcagaggtg gctctggaat gacatgtgtc
     2581 aagctgcttg gacctcgtgc tttaagtgcc tacattatct aactgtgctc aagaggttct
     2641 cgactggagg accacactca agccgactta tgcccaccat cccacctctg gataattttg
     2701 cataaaattg gattagcctg gagcaggttg ggagccaaat gtggcatttg tgatcatgag
     2761 attgatgcaa tgagatagaa gatgtttgct acctgaacac ttattgcttt gaaactagac
     2821 ttgaggaaac cagggtttat cttttgagaa cttttggtaa gggaaaaggg aacaggaaaa
     2881 gaaaccccaa actcaggccg aatgatcaag gggacccata ggaaatcttg tccagagaca
     2941 agacttcggg aaggtgtctg gacattcaga acaccaagac ttgaaggtgc cttgctcaat
     3001 ggaagaggcc aggacagagc tgacaaaatt ttgctcccca gtgaaggcca cagcaacctt
     3061 ctgcccatcc tgtctgttca tggagagggt ccctgcctca cctctgccat tttgggttag
     3121 gagaagtcaa gttgggagcc tgaaatagtg gttcttggaa aaatggatcc ccagtgaaaa
     3181 ctagagctct aagcccattc agcccatttc acacctgaaa atgttagtga tcaccacttg
     3241 gaccagcatc cttaagtatc agaaagcccc aagcaattgc tgcatcttag tagggtgagg
     3301 gataagcaaa agaggatgtt caccataacc caggaatgaa gataccatca gcaaagaatt
     3361 tcaatttgtt cagtctttca tttagagcta gtctttcaca gtaccatctg aatacctctt
     3421 tgaaagaagg aagactttac gtagtgtaga tttgttttgt gttgtttgaa aatattatct
     3481 ttgtaattat ttttaatatg taaggaatgc ttggaatatc tgctatatgt caactttatg
     3541 cagcttcctt ttgagggaca aatttaaaac aaacaacccc ccatcacaaa cttaaaggat
     3601 tgcaagggcc agatctgtta agtggtttca taggagacac atccagcaat tgtgtggtca
     3661 gtggctcttt tacccaataa gatacatcac agtcacatgc ttgatggttt atgttgacct
     3721 aagatttatt ttgttaaaat ctctctctgt tgtgttcgtt cttgttctgt tttgttttgt
     3781 tttttaaagt cttgctgtgg tctctttgtg gcagaagtgt ttcatgcatg gcagcaggcc
     3841 tgttgctttt ttatggcgat tcccattgaa aatgtaagta aatgtctgtg gccttgttct
     3901 ctctatggta aagatattat tcaccatgta aaacaaaaaa caatatttat tgtattttag
     3961 tatatttata taattatgtt attgaaaaaa attggcatta aaacttaacc gcatcagaac
     4021 ctattgtaaa tacaagttct atttaagtgt actaattaac atataatata tgttttaaat
     4081 atagaatttt taatgttttt aaatatattt tcaaagtaca taaaa
//
