LOCUS       NM_001143811            4176 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens brain derived neurotrophic factor (BDNF), transcript
            variant 11, mRNA.
ACCESSION   NM_001143811
VERSION     NM_001143811.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Przybylska,I., Marusiak,J., Toczylowska,B., Stepien,A.,
            Brodacki,B., Langfort,J. and Chalimoniuk,M.
  TITLE     Association between the Val66Met (rs6265) polymorphism of the
            brain-derived neurotrophic factor (BDNF) gene, BDNF protein level
            in the blood and the risk of developing early-onset Parkinson's
            disease
  JOURNAL   Acta Neurobiol Exp (Wars) 84 (3), 296-308 (2024)
   PUBMED   39392027
  REMARK    GeneRIF: Association between the Val66Met (rs6265) polymorphism of
            the brain-derived neurotrophic factor (BDNF) gene, BDNF protein
            level in the blood and the risk of developing early-onset
            Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Gliwinska,A., Badenska,M., Dworak,M., Swietochowska,E.,
            Badenski,A., Bjanid,O., Trembecka-Dubel,E., Morawiec-Knysak,A. and
            Szczepanska,M.
  TITLE     Assessment of brain-derived neurotrophic factor and irisin
            concentration in children with chronic kidney disease: a pilot
            study
  JOURNAL   BMC Nephrol 25 (1), 318 (2024)
   PUBMED   39334009
  REMARK    GeneRIF: Assessment of brain-derived neurotrophic factor and irisin
            concentration in children with chronic kidney disease: a pilot
            study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4176)
  AUTHORS   Liu,B., Liu,Y., Li,S., Chen,P., Zhang,J. and Feng,L.
  TITLE     Depletion of placental brain-derived neurotrophic factor (BDNF) is
            attributed to premature ovarian insufficiency (POI) in mice
            offspring
  JOURNAL   J Ovarian Res 17 (1), 141 (2024)
   PUBMED   38982490
  REMARK    GeneRIF: Depletion of placental brain-derived neurotrophic factor
            (BDNF) is attributed to premature ovarian insufficiency (POI) in
            mice offspring.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4176)
  AUTHORS   Ton Loy,A.F., Adler,J.S., Merritt,V.C., Sorg,S.F., Bondi,M.W. and
            Delano-Wood,L.
  TITLE     APOExBDNF Interaction and Poorer Cognitive Outcomes Among Veterans
            With Mild Traumatic Brain Injury: An Exploratory Study
  JOURNAL   J Neuropsychiatry Clin Neurosci 36 (4), 300-305 (2024)
   PUBMED   38988190
  REMARK    GeneRIF: APOExBDNF Interaction and Poorer Cognitive Outcomes Among
            Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
REFERENCE   5  (bases 1 to 4176)
  AUTHORS   Rosenfeld,R.D., Zeni,L., Haniu,M., Talvenheimo,J., Radka,S.F.,
            Bennett,L., Miller,J.A. and Welcher,A.A.
  TITLE     Purification and identification of brain-derived neurotrophic
            factor from human serum
  JOURNAL   Protein Expr Purif 6 (4), 465-471 (1995)
   PUBMED   8527932
REFERENCE   6  (bases 1 to 4176)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 4176)
  AUTHORS   Shintani,A., Ono,Y., Kaisho,Y. and Igarashi,K.
  TITLE     Characterization of the 5'-flanking region of the human
            brain-derived neurotrophic factor gene
  JOURNAL   Biochem Biophys Res Commun 182 (1), 325-332 (1992)
   PUBMED   1339267
REFERENCE   8  (bases 1 to 4176)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   9  (bases 1 to 4176)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   10 (bases 1 to 4176)
  AUTHORS   Jones,K.R. and Reichardt,L.F.
  TITLE     Molecular cloning of a human gene that is a member of the nerve
            growth factor family
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8060-8064 (1990)
   PUBMED   2236018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104563.14, KF455346.1 and
            KF459669.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001143811.1.
            
            Summary: This gene encodes a member of the nerve growth factor
            family of proteins. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed to generate the mature protein.
            Binding of this protein to its cognate receptor promotes neuronal
            survival in the adult brain. Expression of this gene is reduced in
            Alzheimer's, Parkinson's, and Huntington's disease patients. This
            gene may play a role in the regulation of the stress response and
            in the biology of mood disorders. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (11), also known as V-VIII-VIIIh,
            differs in the 5' UTR and represents use of an alternate promoter
            compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the
            same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF689020.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2158188,
                                           SAMN03267771 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC104563.14        121600-121682       c
            84-344              AC104563.14        94711-94971         c
            345-366             KF455346.1         1-22
            367-483             AC104563.14        80785-80901         c
            484-825             AC104563.14        78873-79214         c
            826-965             KF459669.1         1-140
            966-4176            AC104563.14        75522-78732         c
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..4176
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="brain derived neurotrophic factor"
                     /db_xref="GeneID:627"
                     /db_xref="HGNC:HGNC:1033"
                     /db_xref="MIM:113505"
     exon            1..83
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..366
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..483
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..4176
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..1248
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 11; proBDNF; neurotrophin; abrineurin;
                     neurotrophic factor BDNF precursor form"
                     /codon_start=1
                     /product="neurotrophic factor BDNF precursor form isoform
                     a preproprotein"
                     /protein_id="NP_001137283.1"
                     /db_xref="CCDS:CCDS7866.1"
                     /db_xref="GeneID:627"
                     /db_xref="HGNC:HGNC:1033"
                     /db_xref="MIM:113505"
                     /translation="MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLE
                     SVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPL
                     EPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMS
                     GGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRAL
                     TMDSKKRIGWRFIRIDTSCVCTLTIKRGR"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
     regulatory      1727..1732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: ATTAAA"
     polyA_site      1747
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="major polyA site"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: ATTAAA"
     polyA_site      4069
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
                     /note="hexamer: AATATA"
     polyA_site      4176
                     /gene="BDNF"
                     /gene_synonym="ANON2; BULN2"
ORIGIN      
        1 gtaaaccaat agcccccatg ctctgtgcga tttcattgtg tgctcgcgtt cgcaagctcc
       61 gtagtgcagg aaggtgcggg aagttaagta attaaaagaa attatagagt gggatgcaaa
      121 aataacccga aggacaactg gatgtgtgga gccaccagtt ttctccatga gtgcacaagg
      181 ttaatccttg ttactactca gaatgctgag tttctacaga aagggttgca ggtccacaca
      241 tgttttggcg tctacccaca cgcttctgta tggcatgact gtgcatccca gaagaagggc
      301 tgtgctgtgt acctccacgt ttcagtggaa tttaacaaac tgatccctga aaatggtttc
      361 ataaagggat ggtaataaag tctcttagtg gttgaaaatg ttatttctta caaaagtgga
      421 gaacatttgc ttttcaatac cagagttttc agccatttct gcattctgac ctattgactg
      481 gagttccacc aggtgagaag agtgatgacc atccttttcc ttactatggt tatttcatac
      541 tttggttgca tgaaggctgc ccccatgaaa gaagcaaaca tccgaggaca aggtggcttg
      601 gcctacccag gtgtgcggac ccatgggact ctggagagcg tgaatgggcc caaggcaggt
      661 tcaagaggct tgacatcatt ggctgacact ttcgaacacg tgatagaaga gctgttggat
      721 gaggaccaga aagttcggcc caatgaagaa aacaataagg acgcagactt gtacacgtcc
      781 agggtgatgc tcagtagtca agtgcctttg gagcctcctc ttctctttct gctggaggaa
      841 tacaaaaatt acctagatgc tgcaaacatg tccatgaggg tccggcgcca ctctgaccct
      901 gcccgccgag gggagctgag cgtgtgtgac agtattagtg agtgggtaac ggcggcagac
      961 aaaaagactg cagtggacat gtcgggcggg acggtcacag tccttgaaaa ggtccctgta
     1021 tcaaaaggcc aactgaagca atacttctac gagaccaagt gcaatcccat gggttacaca
     1081 aaagaaggct gcaggggcat agacaaaagg cattggaact cccagtgccg aactacccag
     1141 tcgtacgtgc gggcccttac catggatagc aaaaagagaa ttggctggcg attcataagg
     1201 atagacactt cttgtgtatg tacattgacc attaaaaggg gaagatagtg gatttatgtt
     1261 gtatagatta gattatattg agacaaaaat tatctatttg tatatataca taacagggta
     1321 aattattcag ttaagaaaaa aataatttta tgaactgcat gtataaatga agtttataca
     1381 gtacagtggt tctacaatct atttattgga catgtccatg accagaaggg aaacagtcat
     1441 ttgcgcacaa cttaaaaagt ctgcattaca ttccttgata atgttgtggt ttgttgccgt
     1501 tgccaagaac tgaaaacata aaaagttaaa aaaaataata aattgcatgc tgctttaatt
     1561 gtgaattgat aataaactgt cctctttcag aaaacagaaa aaaaacacac acacacacaa
     1621 caaaaatttg aaccaaaaca ttccgtttac attttagaca gtaagtatct tcgttcttgt
     1681 tagtactata tctgttttac tgcttttaac ttctgatagc gttggaatta aaacaatgtc
     1741 aaggtgctgt tgtcattgct ttactggctt aggggatggg ggatgggggg tatatttttg
     1801 tttgttttgt gttttttttt cgtttgtttg ttttgttttt tagttcccac agggagtaga
     1861 gatggggaaa gaattcctac aatatatatt ctggctgata aaagatacat ttgtatgttg
     1921 tgaagatgtt tgcaatatcg atcagatgac tagaaagtga ataaaaatta aggcaactga
     1981 acaaaaaaat gctcacactc cacatcccgt gatgcacctc ccaggccccg ctcattcttt
     2041 gggcgttggt cagagtaagc tgcttttgac ggaaggacct atgtttgctc agaacacatt
     2101 ctttcccccc ctccccctct ggtctcctct ttgttttgtt ttaaggaaga aaaatcagtt
     2161 gcgcgttctg aaatatttta ccactgctgt gaacaagtga acacattgtg tcacatcatg
     2221 acactcgtat aagcatggag aacagtgatt tttttttaga acagaaaaca acaaaaaata
     2281 accccaaaat gaagattatt ttttatgagg agtgaacatt tgggtaaatc atggctaagc
     2341 ttaaaaaaaa ctcatggtga ggcttaacaa tgtcttgtaa gcaaaaggta gagccctgta
     2401 tcaacccaga aacacctaga tcagaacagg aatccacatt gccagtgaca tgagactgaa
     2461 cagccaaatg gaggctatgt ggagttggca ttgcatttac cggcagtgcg ggaggaattt
     2521 ctgagtggcc atcccaaggt ctaggtggag gtggggcatg gtatttgaga cattccaaaa
     2581 cgaaggcctc tgaaggaccc ttcagaggtg gctctggaat gacatgtgtc aagctgcttg
     2641 gacctcgtgc tttaagtgcc tacattatct aactgtgctc aagaggttct cgactggagg
     2701 accacactca agccgactta tgcccaccat cccacctctg gataattttg cataaaattg
     2761 gattagcctg gagcaggttg ggagccaaat gtggcatttg tgatcatgag attgatgcaa
     2821 tgagatagaa gatgtttgct acctgaacac ttattgcttt gaaactagac ttgaggaaac
     2881 cagggtttat cttttgagaa cttttggtaa gggaaaaggg aacaggaaaa gaaaccccaa
     2941 actcaggccg aatgatcaag gggacccata ggaaatcttg tccagagaca agacttcggg
     3001 aaggtgtctg gacattcaga acaccaagac ttgaaggtgc cttgctcaat ggaagaggcc
     3061 aggacagagc tgacaaaatt ttgctcccca gtgaaggcca cagcaacctt ctgcccatcc
     3121 tgtctgttca tggagagggt ccctgcctca cctctgccat tttgggttag gagaagtcaa
     3181 gttgggagcc tgaaatagtg gttcttggaa aaatggatcc ccagtgaaaa ctagagctct
     3241 aagcccattc agcccatttc acacctgaaa atgttagtga tcaccacttg gaccagcatc
     3301 cttaagtatc agaaagcccc aagcaattgc tgcatcttag tagggtgagg gataagcaaa
     3361 agaggatgtt caccataacc caggaatgaa gataccatca gcaaagaatt tcaatttgtt
     3421 cagtctttca tttagagcta gtctttcaca gtaccatctg aatacctctt tgaaagaagg
     3481 aagactttac gtagtgtaga tttgttttgt gttgtttgaa aatattatct ttgtaattat
     3541 ttttaatatg taaggaatgc ttggaatatc tgctgtatgt caactttatg cagcttcctt
     3601 ttgagggaca aatttaaaac aaacaacccc ccatcacaaa cttaaaggat tgcaagggcc
     3661 agatctgtta agtggtttca taggagacac atccagcaat tgtgtggtca gtggctcttt
     3721 tacccaataa gatacatcac agtcacatgc ttgatggttt atgttgacct aagatttatt
     3781 ttgttaaaat ctctctctgt tgtgttcgtt cttgttctgt tttgttttgt tttttaaagt
     3841 cttgctgtgg tctctttgtg gcagaagtgt ttcatgcatg gcagcaggcc tgttgctttt
     3901 ttatggcgat tcccattgaa aatgtaagta aatgtctgtg gccttgttct ctctatggta
     3961 aagatattat tcaccatgta aaacaaaaaa caatatttat tgtattttag tatatttata
     4021 taattatgtt attgaaaaaa attggcatta aaacttaacc gcatcagaag cctattgtaa
     4081 atacaagttc tatttaagtg tactaattaa catataatat atgttttaaa tatagaattt
     4141 ttaatgtttt taaatatatt ttcaaagtac ataaaa
//
