LOCUS       NM_001379692            3996 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens bradykinin receptor B2 (BDKRB2), transcript variant 1,
            mRNA.
ACCESSION   NM_001379692
VERSION     NM_001379692.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Yi,J., Bertels,Z., Del Rosario,J.S., Widman,A.J., Slivicki,R.A.,
            Payne,M., Susser,H.M., Copits,B.A. and Gereau,R.W. 4th.
  TITLE     Bradykinin receptor expression and bradykinin-mediated
            sensitization of human sensory neurons
  JOURNAL   Pain 165 (1), 202-215 (2024)
   PUBMED   37703419
  REMARK    GeneRIF: Bradykinin receptor expression and bradykinin-mediated
            sensitization of human sensory neurons.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Shen,J.K. and Zhang,H.T.
  TITLE     Function and structure of bradykinin receptor 2 for drug discovery
  JOURNAL   Acta Pharmacol Sin 44 (3), 489-498 (2023)
   PUBMED   36075965
  REMARK    GeneRIF: Function and structure of bradykinin receptor 2 for drug
            discovery.
            Review article
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Dyga,W., Obtulowicz,A., Mikolajczyk,T., Bogdali,A., Dubiela,P. and
            Obtulowicz,K.
  TITLE     The Role of Bradykinin Receptors in Hereditary Angioedema Due to
            C1-Inhibitor Deficiency
  JOURNAL   Int J Mol Sci 23 (18), 10332 (2022)
   PUBMED   36142237
  REMARK    GeneRIF: The Role of Bradykinin Receptors in Hereditary Angioedema
            Due to C1-Inhibitor Deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Portales,A.E., Mustafa,E.R., McCarthy,C.I., Cornejo,M.P.,
            Couto,P.M., Gironacci,M.M., Caramelo,J.J., Perello,M. and Raingo,J.
  TITLE     ACE2 internalization induced by a SARS-CoV-2 recombinant protein is
            modulated by angiotensin II type 1 and bradykinin 2 receptors
  JOURNAL   Life Sci 293, 120284 (2022)
   PUBMED   35038454
  REMARK    GeneRIF: ACE2 internalization induced by a SARS-CoV-2 recombinant
            protein is modulated by angiotensin II type 1 and bradykinin 2
            receptors.
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Shen,J., Zhang,D., Fu,Y., Chen,A., Yang,X. and Zhang,H.
  TITLE     Cryo-EM structures of human bradykinin receptor-Gq proteins
            complexes
  JOURNAL   Nat Commun 13 (1), 714 (2022)
   PUBMED   35132089
  REMARK    GeneRIF: Cryo-EM structures of human bradykinin receptor-Gq
            proteins complexes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Eggerickx,D., Raspe,E., Bertrand,D., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning, functional expression and pharmacological
            characterization of a human bradykinin B2 receptor gene
  JOURNAL   Biochem Biophys Res Commun 187 (3), 1306-1313 (1992)
   PUBMED   1329734
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Hess,J.F., Borkowski,J.A., Young,G.S., Strader,C.D. and Ransom,R.W.
  TITLE     Cloning and pharmacological characterization of a human bradykinin
            (BK-2) receptor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 260-268 (1992)
   PUBMED   1314587
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Yang,H.Y., Erdos,E.G. and Levin,Y.
  TITLE     A dipeptidyl carboxypeptidase that converts angiotensin I and
            inactivates bradykinin
  JOURNAL   Biochim Biophys Acta 214 (2), 374-376 (1970)
   PUBMED   4322742
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Yang,H.Y. and Erdos,E.G.
  TITLE     Second kininase in human blood plasma
  JOURNAL   Nature 215 (5108), 1402-1403 (1967)
   PUBMED   6055465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355102.5.
            
            Summary: This gene encodes a receptor for bradykinin. The 9 aa
            bradykinin peptide elicits many responses including vasodilation,
            edema, smooth muscle spasm and pain fiber stimulation. Bradykinin
            is released upon activation by pathophysiologic conditions such as
            trauma and inflammation, and binds to its kinin receptors, B1 and
            B2. The B2 receptor associates with G proteins that stimulate a
            phosphatidylinositol-calcium second messenger system. [provided by
            RefSeq, Apr 2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.10679.1,
                                           SRR11853563.10635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000554311.2/ ENSP00000450482.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL355102.5         98403-98523         c
            122-234             AL355102.5         66181-66293         c
            235-3996            AL355102.5         59198-62959         c
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..3996
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /note="bradykinin receptor B2"
                     /db_xref="GeneID:624"
                     /db_xref="HGNC:HGNC:1030"
                     /db_xref="MIM:113503"
     exon            1..121
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..234
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1336
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /note="BK-2 receptor"
                     /codon_start=1
                     /product="B2 bradykinin receptor"
                     /protein_id="NP_001366621.1"
                     /db_xref="CCDS:CCDS9942.1"
                     /db_xref="GeneID:624"
                     /db_xref="HGNC:HGNC:1030"
                     /db_xref="MIM:113503"
                     /translation="MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQ
                     SKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAA
                     DLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALV
                     KTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSL
                     IWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVL
                     LLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVI
                     VGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ"
     exon            235..3996
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="BDKRB2"
                     /gene_synonym="B2R; BK-2; BK2; BKR2; BRB2"
                     /note="major polyA site"
ORIGIN      
        1 actccagctc tggcttctgg gctccgagga ggggtgggga cggtggggac ggtggggaca
       61 tcaggctgcc ccgcagtacc agggagcgac tgaagtgccc atgccgcttg ctccggagaa
      121 gcccaggtgt ggcctcactc acatcccact ctgagtccaa atgttctctc cctggaagat
      181 atcaatgttt ctgtctgttc gtgaggactc cgtgcccacc acggcctctt tcagcgccga
      241 catgctcaat gtcaccttgc aagggcccac tcttaacggg acctttgccc agagcaaatg
      301 cccccaagtg gagtggctgg gctggctcaa caccatccag ccccccttcc tctgggtgct
      361 gttcgtgctg gccaccctag agaacatctt tgtcctcagc gtcttctgcc tgcacaagag
      421 cagctgcacg gtggcagaga tctacctggg gaacctggcc gcagcagacc tgatcctggc
      481 ctgcgggctg cccttctggg ccatcaccat ctccaacaac ttcgactggc tctttgggga
      541 gacgctctgc cgcgtggtga atgccattat ctccatgaac ctgtacagca gcatctgttt
      601 cctgatgctg gtgagcatcg accgctacct ggccctggtg aaaaccatgt ccatgggccg
      661 gatgcgcggc gtgcgctggg ccaagctcta cagcttggtg atctgggggt gtacgctgct
      721 cctgagctca cccatgctgg tgttccggac catgaaggag tacagcgatg agggccacaa
      781 cgtcaccgct tgtgtcatca gctacccatc cctcatctgg gaagtgttca ccaacatgct
      841 cctgaatgtc gtgggcttcc tgctgcccct gagtgtcatc accttctgca cgatgcagat
      901 catgcaggtg ctgcggaaca acgagatgca gaagttcaag gagatccaga cagagaggag
      961 ggccacggtg ctagtcctgg ttgtgctgct gctattcatc atctgctggc tgcccttcca
     1021 gatcagcacc ttcctggata cgctgcatcg cctcggcatc ctctccagct gccaggacga
     1081 gcgcatcatc gatgtaatca cacagatcgc ctccttcatg gcctacagca acagctgcct
     1141 caacccactg gtgtacgtga tcgtgggcaa gcgcttccga aagaagtctt gggaggtgta
     1201 ccagggagtg tgccagaaag ggggctgcag gtcagaaccc attcagatgg agaactccat
     1261 gggcacactg cggacctcca tctccgtgga acgccagatt cacaaactgc aggactgggc
     1321 agggagcaga cagtgagcaa acgccagcag ggctgctgtg aatttgtgta aggattgagg
     1381 gacagttgct tttcagcatg ggcccaggaa tgccaaggag acatctatgc acgaccttgg
     1441 gaaatgagtt gatgtctccg gtaaaacacc ggagactaat tcctgccctg cccaattttg
     1501 cagggagcat ggctgtgagg atggggtgaa ctcacgcaca gccaaggact ccaaaatcac
     1561 aacagcatta ctgttcttat ttgctgccac acctgagcca gcctgctcct tcccaggagt
     1621 ggaggaggcc tgggggcagg gagaggagtg actgagcttc cctcccgtgt gttctccgtc
     1681 cctgccccag caagacaact tagatctcca ggagaactgc catccagctt tggtgcaatg
     1741 gctgagtgca caagtgagtt gttgccctgg gtttctttaa tctattcagc tagaactttg
     1801 aaggacaatt tcttgcatta ataaaggtta agccctgagg ggtccctgat aacaacctgg
     1861 agaccaggat tttatggctc ccctcactga tggacaagga ggtctgtgcc aaagaagaat
     1921 ccaataagca catattgagc acttgctgta tatgcagtat tgagcactgt aggcaagagg
     1981 gaagaaagag aaggagccat ctccatcttg aaggaactca aagactcaag tgggaacgac
     2041 tgggcactgc caccaccaga aagctgttcg acgagacggt cgagcagggt gctgtgggtg
     2101 atatggacag cagaaggggg agaccaaggt tccagctcaa ccaataacta ttgcacaacc
     2161 atctgtccct gcctcagttc cctcttctgt aacatgaagt cgttgtgagg gttaaaggca
     2221 gtaacaggta taaagtactt agaaaagcaa agggtgctac gtacatgtga ggcatcatta
     2281 cgcagacgta actgggatat gtttactata aggaaaagac actgaggtct agaaatagct
     2341 ccgtggagca gaatcagtat tgggagccgg tggcggtgtg aagcaccagt gtctggcaca
     2401 cagtaggtgc tcattggctc ccttccacct gtcattccca ccaccctgag gccccaaccg
     2461 ccacacacac aggagcattt ggagagaagg ccatgtcttc aaagtctgat ttgtgatgag
     2521 gcagaggaag atatttctaa tcggtcttgc ccagaggatc acagtgctga gaccccccac
     2581 caccagccgg tacctgggaa gggggagagt gcaggcctgc tcagggactg ttcctgtctc
     2641 agcaaccaag ggattgttcc tgtcaatcaa tggtttattg gaaggtggcc cagtatgagc
     2701 cctagaagag tgtgaaaagg aatggcaatg gtgttcacca tcggcagtgc cagggcagca
     2761 ctcattcact tgataaatga atatttatta gctggttgga gagctagaac ctggagagct
     2821 agaacctgga gaactagaac ctggagggct agaactggag aggctagaac caagaagggc
     2881 tagaacctgg aggggctaga acctagagaa gctaaaacct gagctagaag ctggaggact
     2941 agaacctgga gggctggaat ctggagagct agaacctgga gggctagaac ctggagggct
     3001 agaatctgga gagctagaac ctggagggct agaatctgga gagctagaac ctggagggct
     3061 agaacctgga gagctagaac ctagaagggc tagaacctgg agggctggaa tctggagagc
     3121 tagaacctgg agggctagaa cctggagggc tagaacctag aagggctaga acctggaggg
     3181 ctggaatctg gagagctaga acctggaggg ctagaacctg gagggctaga acctagaagg
     3241 gctagaacct ggagggctag aacctggcag gttagaacct agaagggcta gaacctggag
     3301 agccagaacc tggagggcta gaacctggaa gggctagaac ctgtagagct agaacatgga
     3361 gagctagaac ccggcaggct agaacctggc aagctagaac ctggagggaa tgaacctgga
     3421 gggctagaac ctggagaatg agaaaaattt acatggcaaa gagcccataa atcctgacca
     3481 atccaactct gaattttaaa gcaaaagcgt caaaaaaaag attccctcct tacccccaac
     3541 ccactctttt ttcccaccac ccactctcct ctgcctcagt aagtatctgg aggaagaaaa
     3601 caggtgaaag aagaagtaaa aaccatttag tattagtatt agaatgaagt caaactgtgc
     3661 cacacatggt gaatgaaaaa aaaaaaaaga ggctgtgttt tgtcacacag ggcagtcatt
     3721 cagcaccaga gcacgtgatg gtctgagact ctcttaggag cagagctctg ccgcaatggc
     3781 catgtgggga tccacacctg gtctgagggg caactgagtc tgcgggagaa gagcggccct
     3841 atgcatggtg tagatgccct gataaagaac atctgtcctg tgaaagactc aatgagctgt
     3901 tatgttgtaa acaggaagca tttcacatcc aaacgagaaa atcatgtaaa catgtgtctt
     3961 ttctgtagag cataataaat ggatgaggtt tttgca
//
