LOCUS       NM_000710               1301 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens bradykinin receptor B1 (BDKRB1), transcript variant 1,
            mRNA.
ACCESSION   NM_000710
VERSION     NM_000710.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Yi,J., Bertels,Z., Del Rosario,J.S., Widman,A.J., Slivicki,R.A.,
            Payne,M., Susser,H.M., Copits,B.A. and Gereau,R.W. 4th.
  TITLE     Bradykinin receptor expression and bradykinin-mediated
            sensitization of human sensory neurons
  JOURNAL   Pain 165 (1), 202-215 (2024)
   PUBMED   37703419
  REMARK    GeneRIF: Bradykinin receptor expression and bradykinin-mediated
            sensitization of human sensory neurons.
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Wang,H., Sun,W., Li,F., Jiang,P., Wang,L., Zhou,N. and Feng,L.
  TITLE     Bradykinin-bradykinin receptor (B1R) signalling is involved in the
            blood-brain barrier disruption in moyamoya disease
  JOURNAL   J Cell Mol Med 27 (24), 4069-4079 (2023)
   PUBMED   37818853
  REMARK    GeneRIF: Bradykinin-bradykinin receptor (B1R) signalling is
            involved in the blood-brain barrier disruption in moyamoya disease.
REFERENCE   3  (bases 1 to 1301)
  AUTHORS   Dyga,W., Obtulowicz,A., Mikolajczyk,T., Bogdali,A., Dubiela,P. and
            Obtulowicz,K.
  TITLE     The Role of Bradykinin Receptors in Hereditary Angioedema Due to
            C1-Inhibitor Deficiency
  JOURNAL   Int J Mol Sci 23 (18), 10332 (2022)
   PUBMED   36142237
  REMARK    GeneRIF: The Role of Bradykinin Receptors in Hereditary Angioedema
            Due to C1-Inhibitor Deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1301)
  AUTHORS   Bertolini,F., Carriero,V., Bullone,M., Sprio,A.E., Defilippi,I.,
            Sorbello,V., Gani,F., Di Stefano,A. and Ricciardolo,F.L.M.
  TITLE     Correlation of matrix-related airway remodeling and bradykinin B1
            receptor expression with fixed airflow obstruction in severe asthma
  JOURNAL   Allergy 76 (6), 1886-1890 (2021)
   PUBMED   33284471
  REMARK    GeneRIF: Correlation of matrix-related airway remodeling and
            bradykinin B1 receptor expression with fixed airflow obstruction in
            severe asthma.
REFERENCE   5  (bases 1 to 1301)
  AUTHORS   Sriramula,S.
  TITLE     Kinin B1 receptor: A target for neuroinflammation in hypertension
  JOURNAL   Pharmacol Res 155, 104715 (2020)
   PUBMED   32087235
  REMARK    GeneRIF: Kinin B1 receptor: A target for neuroinflammation in
            hypertension.
            Review article
REFERENCE   6  (bases 1 to 1301)
  AUTHORS   van de Veerdonk,F.L., Netea,M.G., van Deuren,M., van der Meer,J.W.,
            de Mast,Q., Bruggemann,R.J. and van der Hoeven,H.
  TITLE     Kallikrein-kinin blockade in patients with COVID-19 to prevent
            acute respiratory distress syndrome
  JOURNAL   Elife 9, e57555 (2020)
   PUBMED   32338605
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1301)
  AUTHORS   Yang,X. and Polgar,P.
  TITLE     Genomic structure of the human bradykinin B1 receptor gene and
            preliminary characterization of its regulatory regions
  JOURNAL   Biochem Biophys Res Commun 222 (3), 718-725 (1996)
   PUBMED   8651911
REFERENCE   8  (bases 1 to 1301)
  AUTHORS   MacNeil,T., Bierilo,K.K., Menke,J.G. and Hess,J.F.
  TITLE     Cloning and pharmacological characterization of a rabbit bradykinin
            B1 receptor
  JOURNAL   Biochim Biophys Acta 1264 (2), 223-228 (1995)
   PUBMED   7495867
REFERENCE   9  (bases 1 to 1301)
  AUTHORS   Menke,J.G., Borkowski,J.A., Bierilo,K.K., MacNeil,T., Derrick,A.W.,
            Schneck,K.A., Ransom,R.W., Strader,C.D., Linemeyer,D.L. and
            Hess,J.F.
  TITLE     Expression cloning of a human B1 bradykinin receptor
  JOURNAL   J Biol Chem 269 (34), 21583-21586 (1994)
   PUBMED   8063797
REFERENCE   10 (bases 1 to 1301)
  AUTHORS   Hess,J.F., Borkowski,J.A., Young,G.S., Strader,C.D. and Ransom,R.W.
  TITLE     Cloning and pharmacological characterization of a human bradykinin
            (BK-2) receptor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 260-268 (1992)
   PUBMED   1314587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB130642.1, AL355102.5 and
            AJ238044.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000710.3.
            
            Summary: Bradykinin, a 9 aa peptide, is generated in
            pathophysiologic conditions such as inflammation, trauma, burns,
            shock, and allergy. The protein encoded by this gene belongs to the
            G-protein coupled receptor 1 family. Two types of G-protein coupled
            receptors have been found which bind bradykinin and mediate
            responses to these pathophysiologic conditions. The protein encoded
            by this gene is one of these receptors and is synthesized de novo
            following tissue injury. Receptor binding leads to an increase in
            the cytosolic calcium ion concentration, ultimately resulting in
            chronic and acute inflammatory responses. [provided by RefSeq, Aug
            2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238044.1, AK291970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000216629.11/ ENSP00000216629.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               CB130642.1         1-342
            343-343             AL355102.5         39557-39557         c
            344-1301            AJ238044.1         327-1284
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..1301
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /note="bradykinin receptor B1"
                     /db_xref="GeneID:623"
                     /db_xref="HGNC:HGNC:1029"
                     /db_xref="MIM:600337"
     exon            1..91
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..210
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1301
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1282
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /note="bradykinin receptor 1; BK-1 receptor; bradykinin B1
                     receptor"
                     /codon_start=1
                     /product="B1 bradykinin receptor"
                     /protein_id="NP_000701.2"
                     /db_xref="CCDS:CCDS9943.1"
                     /db_xref="GeneID:623"
                     /db_xref="HGNC:HGNC:1029"
                     /db_xref="MIM:600337"
                     /translation="MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFI
                     ISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFN
                     WPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVL
                     IWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAI
                     VFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLF
                     QVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKS
                     LAPISSSHRKEIFQLFWRN"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /note="hexamer: ATTAAA"
     polyA_site      1301
                     /gene="BDKRB1"
                     /gene_synonym="B1BKR; B1R; BKB1R; BKR1; BRADYB1"
                     /note="major polyA site"
ORIGIN      
        1 agcacttccc agaagagaaa actcctccaa aagcagctct cactatcaga aaacccaact
       61 acagttgtga acgccttcat tttctgcctg aggtctcagt ccgtcggccc agactgaagt
      121 gcagtggcac aatcatagct cgctgcagcc tcgaccttcc aggcttaaac gattctccca
      181 cctcagcctc tcgagttgct gggaccacag gtcactgtgc atggcatcat cctggccccc
      241 tctagagctc caatcctcca accagagcca gctcttccct caaaatgcta cggcctgtga
      301 caatgctcca gaagcctggg acctgctgca cagagtgctg ccaacattta tcatctccat
      361 ctgtttcttc ggcctcctag ggaacctttt tgtcctgttg gtcttcctcc tgccccggcg
      421 gcaactgaac gtggcagaaa tctacctggc caacctggca gcctctgatc tggtgtttgt
      481 cttgggcttg cccttctggg cagagaatat ctggaaccag tttaactggc ctttcggagc
      541 cctcctctgc cgtgtcatca acggggtcat caaggccaat ttgttcatca gcatcttcct
      601 ggtggtggcc atcagccagg accgctaccg cgtgctggtg caccctatgg ccagccggag
      661 gcagcagcgg cggaggcagg cccgggtcac ctgcgtgctc atctgggttg tggggggcct
      721 cttgagcatc cccacattcc tgctgcgatc catccaagcc gtcccagatc tgaacatcac
      781 cgcctgcatc ctgctcctcc cccatgaggc ctggcacttt gcaaggattg tggagttaaa
      841 tattctgggt ttcctcctac cactggctgc gatcgtcttc ttcaactacc acatcctggc
      901 ctccctgcga acgcgggagg aggtcagcag gacaaggtgc gggggccgca aggatagcaa
      961 gaccacagcg ctgatcctca cgctcgtggt tgccttcctg gtctgctggg ccccttacca
     1021 cttctttgcc ttcctggaat tcttattcca ggtgcaagca gtccgaggct gcttttggga
     1081 ggacttcatt gacctgggcc tgcaattggc caacttcttt gccttcacta acagctccct
     1141 gaatccagta atttatgtct ttgtgggccg gctcttcagg accaaggtct gggaacttta
     1201 taaacaatgc acccctaaaa gtcttgctcc aatatcttca tcccatagga aagaaatctt
     1261 ccaacttttc tggcggaatt aaaacagcat tgaaccaaga a
//
