LOCUS       NM_020139               2920 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens 3-hydroxybutyrate dehydrogenase 2 (BDH2), mRNA.
ACCESSION   NM_020139
VERSION     NM_020139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Liu,J.Z., Hu,Y.L., Feng,Y., Jiang,Y., Guo,Y.B., Liu,Y.F., Chen,X.,
            Yang,J.L., Chen,Y.Y., Mao,Q.S. and Xue,W.J.
  TITLE     BDH2 triggers ROS-induced cell death and autophagy by promoting
            Nrf2 ubiquitination in gastric cancer
  JOURNAL   J Exp Clin Cancer Res 39 (1), 123 (2020)
   PUBMED   32605589
  REMARK    GeneRIF: BDH2 triggers ROS-induced cell death and autophagy by
            promoting Nrf2 ubiquitination in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Yang,W.C., Lin,S.F., Wang,S.C., Tsai,W.C., Wu,C.C. and Wu,S.C.
  TITLE     The Effects of Human BDH2 on the Cell Cycle, Differentiation, and
            Apoptosis and Associations with Leukemia Transformation in
            Myelodysplastic Syndrome
  JOURNAL   Int J Mol Sci 21 (9), 3033 (2020)
   PUBMED   32344823
  REMARK    GeneRIF: The Effects of Human BDH2 on the Cell Cycle,
            Differentiation, and Apoptosis and Associations with Leukemia
            Transformation in Myelodysplastic Syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Li,B., Liao,Z., Mo,Y., Zhao,W., Zhou,X., Xiao,X., Cui,W., Feng,G.,
            Zhong,S., Liang,Y., Du,C., Huang,G., Li,P., Xiao,X., Zhou,X.,
            Wang,R. and Zhang,Z.
  TITLE     Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes
            proliferation and metastasis of nasopharyngeal carcinoma by iron
            retention
  JOURNAL   Br J Cancer 122 (1), 102-110 (2020)
   PUBMED   31819181
  REMARK    GeneRIF: BDH2 expression is downregulated in nasopharyngeal
            carcinoma. Overexpression of BDH2 in nasopharyngeal carcinoma cells
            decreased the levels of intracellular iron, thereby inhibiting cell
            proliferation. In addition, overexpression of BDH2 reduced invasion
            and migration of nasopharyngeal carcinoma cells by reversing
            epithelial-mesenchymal transition.
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Cui,X.P., Wang,C.X., Wang,Z.Y., Li,J., Tan,Y.W., Gu,S.T. and
            Qin,C.K.
  TITLE     LncRNA TP73-AS1 sponges miR-141-3p to promote the migration and
            invasion of pancreatic cancer cells through the up-regulation of
            BDH2
  JOURNAL   Biosci Rep 39 (3) (2019)
   PUBMED   30643007
  REMARK    GeneRIF: LncRNA TP73 antisense RNA 1T (TP73-AS1) positively
            regulates 3-hydroxybutyrate dehydrogenase type 2 (BDH2) by
            regulating miR-141.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Guo,K., Lukacik,P., Papagrigoriou,E., Meier,M., Lee,W.H.,
            Adamski,J. and Oppermann,U.
  TITLE     Characterization of human DHRS6, an orphan short chain
            dehydrogenase/reductase enzyme: a novel, cytosolic type 2
            R-beta-hydroxybutyrate dehydrogenase
  JOURNAL   J Biol Chem 281 (15), 10291-10297 (2006)
   PUBMED   16380372
  REMARK    GeneRIF: DHRS6 is an orphan short chain dehydrogenase/ reductase
            enzyme
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI544872.1, BC001953.1, BC095414.1, AW136198.1 and AC097485.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020139.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.187435.1,
                                           SRR1803611.224475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296424.9/ ENSP00000296424.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               BI544872.1         55-594
            541-760             BC001953.1         567-786
            761-2415            BC095414.1         762-2416
            2416-2887           AW136198.1         17-488              c
            2888-2920           AC097485.2         58304-58336         c
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2920
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="3-hydroxybutyrate dehydrogenase 2"
                     /db_xref="GeneID:56898"
                     /db_xref="HGNC:HGNC:32389"
     exon            1..52
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            53..144
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..810
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /EC_number="1.1.1.30"
                     /EC_number="1.1.1.104"
                     /note="oxidoreductase UCPA; short chain
                     dehydrogenase/reductase family 15C member 1;
                     R-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate
                     dehydrogenase, type 2; 4-oxo-L-proline reductase;
                     (R)-beta-hydroxybutyrate dehydrogenase"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 6"
                     /protein_id="NP_064524.3"
                     /db_xref="CCDS:CCDS3663.1"
                     /db_xref="GeneID:56898"
                     /db_xref="HGNC:HGNC:32389"
                     /translation="MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQ
                     ELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSM
                     NLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKS
                     VAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIA
                     MLCVYLASDESAYVTGNPVIIDGGWSL"
     exon            145..223
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            224..320
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            321..429
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            430..490
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            491..604
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            605..663
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            664..756
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2920
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1016..1021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="major polyA site"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="major polyA site"
     regulatory      2397..2402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="hexamer: AATAAA"
     polyA_site      2418
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
                     /note="hexamer: AATAAA"
     polyA_site      2920
                     /gene="BDH2"
                     /gene_synonym="DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR;
                     UNQ6308"
ORIGIN      
        1 agtttgttgc tcaaaccgag ttctggagaa cgccatcagc tcgctgctta aaattaaacc
       61 acaggttcca ttatgggtcg acttgatggg aaagtcatca tcctgacggc cgctgctcag
      121 gggattggcc aagcagctgc cttagctttt gcaagagaag gtgccaaagt catagccaca
      181 gacattaatg agtccaaact tcaggaactg gaaaagtacc cgggtattca aactcgtgtc
      241 cttgatgtca caaagaagaa acaaattgat cagtttgcca atgaagttga gagacttgat
      301 gttctcttta atgttgctgg ttttgtccat catggaactg tcctggattg tgaggagaaa
      361 gactgggact tctcgatgaa tctcaatgtg cgcagcatgt acctgatgat caaggcattc
      421 cttcctaaaa tgcttgctca gaaatctggc aatattatca acatgtcttc tgtggcttcc
      481 agcgtcaaag gagttgtgaa cagatgtgtg tacagcacaa ccaaggcagc cgtgattggc
      541 ctcacaaaat ctgtggctgc agatttcatc cagcagggca tcaggtgcaa ctgtgtgtgc
      601 ccaggaacag ttgatacgcc atctctacaa gaaagaatac aagccagagg aaatcctgaa
      661 gaggcacgga atgatttcct gaagagacaa aagacgggaa gattcgcaac tgcagaagaa
      721 atagccatgc tctgcgtgta tttggcttct gatgaatctg cttatgtaac tggtaaccct
      781 gtcatcattg atggaggctg gagcttgtga ttttaggatc tccatggtgg gaaggaaggc
      841 aggcccttcc tatccacagt gaacctggtt acgaagaaaa ctcaccaatc atctccttcc
      901 tgttaatcac atgttaatga aaataagctc tttttaatga tgtcactgtt tgcaagagtc
      961 tgattcttta agtatattaa tctctttgta atctcttctg aaatcattgt aaagaaataa
     1021 aaatattgaa ctcatagcag gagaatagtt tttaaaataa atctcgattt gttagcatct
     1081 gtcttagtca ctttgggctg ctataacaaa ttaccataga tggagtgtca tagacaacaa
     1141 acatttattt ttcagtctgg aggctaggaa gtgcaagata aaggtgccag cagatatagt
     1201 ttctggttag ggcccacttc ctggtttgca gatggtcctc ttcttgctgt atcctcacat
     1261 agcaagagca gagaaaaaaa gcgagcgctc atgtgtcttt ttataaggac actaatcctg
     1321 ttcatgaggg cactaccctt atgacctgat tacctcccaa aggccccacc tcctaatgta
     1381 tcatattgca ggttaggatg tcaacacatg actctggggt gatacaaata ggccattgca
     1441 gcatatacaa ttaaaatgta aatatgaaga aaaaaggaag tttttgtttt tttgtggggg
     1501 agatgggggt taaggaagaa gatagtaatt tcaggactag gcatggtagc tcatgcctat
     1561 aattcctgca ctttgggagg ccaaggcagg aggatcactt gcggccagga gttcaggacc
     1621 agcatggtta acagaggcta aggcaggagg attacttgag cccaagagtt tgaggctgca
     1681 gtgagctgta atcatgccac tgcactccag ggtgacagag caagaccctg tacctaaata
     1741 ataataataa tttccacttc atttttcaat attcaaatat ttttatataa ttctgcattg
     1801 ttctgtatgt agatcctaat tttaaaattt tacaccatca taaatgaaca aaggtaggaa
     1861 ggagtttggc ttcaatagct tacagtaaaa ggagtaaagg agttcagcct caaaacgata
     1921 ttgttgacct gttatgttat gaaaaataat ccagtgttta tacttaacgg atgccatccc
     1981 ttattattta ctattttctt agtctaacta aacaatcttt attaaaataa gcaatgatat
     2041 ttgacatggg cctaagaaat atatagttag ctaacaatat tgtcagttag agggatttct
     2101 tttctaaatt aagtacagat ttcttcacca aactccagga taacagaaaa gaggacataa
     2161 aatttggaca tagtttctgg ataaataaat gtaaatttaa atataaatta tgtaacagga
     2221 aacaaacgaa attaaagaaa ataaattttt caagaaaagt aaatttatgg atgttaattc
     2281 tgtaacattg tcagggcaaa gttttttgtt tttattttaa tttaagggtt ttatgtttgt
     2341 tttttacttg ttgcaacctc aaatgaccaa atggtatgat gcacactgag atactcaata
     2401 aatgtgcagt gattcttagc cttttttcct agaactttaa tattaacatg gaaaattctg
     2461 aaatggacaa caaaaagata acactttgtg tatggggaag aatatcatgc agttgatgac
     2521 ggtacattaa aattcacaca aaaggacatt ttgactagca ttcagaaaga gtccattgat
     2581 tataagatta tctatgaggt tttggaccgg gcactacact accgaattat ggctaacttt
     2641 ggtttgtgat ctagaccaag tcacccaatc tatcttggat tttagttttc tggtttatga
     2701 aattaaggag ttaagctaaa tgacttgggt ttcttttcgt gtatcataat caaaatgctg
     2761 taacttctct agtgaattca tagaacactg actcttacaa gtatgtcatg aaatacttta
     2821 tgctgtgagc aggtatacat gtataatata tgtatagcta tgaacaaata aattttaaat
     2881 aaatgcacaa cgaattctac aaaatgggct ccaacattaa
//
