LOCUS       NM_001379451            7465 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens BCL6 corepressor like 1 (BCORL1), transcript variant
            3, mRNA.
ACCESSION   NM_001379451 XM_005262454
VERSION     NM_001379451.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7465)
  AUTHORS   Luo,C., Chen,Z., Meng,L., Tan,C., He,W., Tu,C., Du,J., Lu,G.X.,
            Lin,G., Tan,Y.Q. and Hu,T.Y.
  TITLE     A hemizygous loss-of-function variant in BCORL1 is associated with
            male infertility and oligoasthenoteratozoospermia
  JOURNAL   Clin Genet 106 (1), 27-36 (2024)
   PUBMED   38342987
  REMARK    GeneRIF: A hemizygous loss-of-function variant in BCORL1 is
            associated with male infertility and oligoasthenoteratozoospermia.
REFERENCE   2  (bases 1 to 7465)
  AUTHORS   Kommoss,F.K.F., Chiang,S., Kobel,M., Koelsche,C., Chang,K.T.,
            Irving,J.A., Dickson,B., Thiryayi,S., Rouzbahman,M., Rasty,G., von
            Deimling,A., Lee,C.H. and Turashvili,G.
  TITLE     Endometrial Stromal Sarcomas With BCOR Internal Tandem Duplication
            and Variant BCOR/BCORL1 Rearrangements Resemble High-grade
            Endometrial Stromal Sarcomas With Recurrent CDK4 Pathway
            Alterations and MDM2 Amplifications
  JOURNAL   Am J Surg Pathol 46 (8), 1142-1152 (2022)
   PUBMED   35499168
  REMARK    GeneRIF: Endometrial Stromal Sarcomas With BCOR Internal Tandem
            Duplication and Variant BCOR/BCORL1 Rearrangements Resemble
            High-grade Endometrial Stromal Sarcomas With Recurrent CDK4 Pathway
            Alterations and MDM2 Amplifications.
REFERENCE   3  (bases 1 to 7465)
  AUTHORS   Schaefer,E.J., Wang,H.C., Karp,H.Q., Meyer,C.A., Cejas,P.,
            Gearhart,M.D., Adelman,E.R., Fares,I., Apffel,A., Lim,K., Xie,Y.,
            Gibson,C.J., Schenone,M., Murdock,H.M., Wang,E.S., Gondek,L.P.,
            Carroll,M.P., Vedula,R.S., Winer,E.S., Garcia,J.S., Stone,R.M.,
            Luskin,M.R., Carr,S.A., Long,H.W., Bardwell,V.J., Figueroa,M.E. and
            Lindsley,R.C.
  TITLE     BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and
            Oncogenic Signaling by Unlinking PRC1.1 from Target Genes
  JOURNAL   Blood Cancer Discov 3 (2), 116-135 (2022)
   PUBMED   35015684
  REMARK    GeneRIF: BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming
            and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes.
REFERENCE   4  (bases 1 to 7465)
  AUTHORS   Gafner,M., Michelson,M., Argilli,E., Yosovich,K., Sherr,E.H.,
            Parks,K.C., England,E.M., Hady-Cohen,R., Leibovitz,Z., Lev,D.,
            Michaeli-Yosef,Y., Lerman-Sagie,T. and Blumkin,L.
  TITLE     Major brain malformations: corpus callosum dysgenesis, agenesis of
            septum pellucidum and polymicrogyria in patients with
            BCORL1-related disorders
  JOURNAL   J Hum Genet 67 (2), 95-101 (2022)
   PUBMED   34400773
  REMARK    GeneRIF: Major brain malformations: corpus callosum dysgenesis,
            agenesis of septum pellucidum and polymicrogyria in patients with
            BCORL1-related disorders.
REFERENCE   5  (bases 1 to 7465)
  AUTHORS   Rotunno,G., Guglielmelli,P., Biamonte,F., Rumi,E., Cazzola,M. and
            Vannucchi,A.M.
  TITLE     Mutational analysis of BCORL1 in the leukemic transformation of
            chronic myeloproliferative neoplasms
  JOURNAL   Ann Hematol 93 (3), 523-524 (2014)
   PUBMED   23793880
  REMARK    GeneRIF: genetic association study in population in Italy: Data
            suggest BCORL1 mutations/single nucleotide polymorphisms are not
            associated with leukemic transformation of chronic
            myeloproliferative neoplasms (MPN) into acute myeloid leukemia
            (AML). [LETTER]
REFERENCE   6  (bases 1 to 7465)
  AUTHORS   Junco,S.E., Wang,R., Gaipa,J.C., Taylor,A.B., Schirf,V.,
            Gearhart,M.D., Bardwell,V.J., Demeler,B., Hart,P.J. and Kim,C.A.
  TITLE     Structure of the polycomb group protein PCGF1 in complex with BCOR
            reveals basis for binding selectivity of PCGF homologs
  JOURNAL   Structure 21 (4), 665-671 (2013)
   PUBMED   23523425
REFERENCE   7  (bases 1 to 7465)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   8  (bases 1 to 7465)
  AUTHORS   Li,M., Collins,R., Jiao,Y., Ouillette,P., Bixby,D., Erba,H.,
            Vogelstein,B., Kinzler,K.W., Papadopoulos,N. and Malek,S.N.
  TITLE     Somatic mutations in the transcriptional corepressor gene BCORL1 in
            adult acute myelogenous leukemia
  JOURNAL   Blood 118 (22), 5914-5917 (2011)
   PUBMED   21989985
  REMARK    GeneRIF: BCORL1 by genetic criteria is a novel candidate tumor
            suppressor gene, joining the growing list of genes recurrently
            mutated in acute myelogenous leukemia.
REFERENCE   9  (bases 1 to 7465)
  AUTHORS   Pagan,J.K., Arnold,J., Hanchard,K.J., Kumar,R., Bruno,T.,
            Jones,M.J., Richard,D.J., Forrest,A., Spurdle,A., Verdin,E.,
            Crossley,M., Fanciulli,M., Chenevix-Trench,G., Young,D.B. and
            Khanna,K.K.
  TITLE     A novel corepressor, BCoR-L1, represses transcription through an
            interaction with CtBP
  JOURNAL   J Biol Chem 282 (20), 15248-15257 (2007)
   PUBMED   17379597
REFERENCE   10 (bases 1 to 7465)
  AUTHORS   Lose,F., Arnold,J., Young,D.B., Brown,C.J., Mann,G.J., Pupo,G.M.,
            Khanna,K.K., Chenevix-Trench,G. and Spurdle,A.B.
  CONSRTM   Kathleen Cuningham Foundation Consortium for Research into Familial
            Breast Cancer
  TITLE     BCoR-L1 variation and breast cancer
  JOURNAL   Breast Cancer Res 9 (4), R54 (2007)
   PUBMED   17697391
  REMARK    GeneRIF: Dysregulated BCoR-L1 expression is associated with breast
            cancer
            Erratum:[Breast Cancer Res. 2008;10(5):406]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034405.16, Z82208.1,
            KF459400.1 and AL136450.8.
            
            On Apr 16, 2020 this sequence version replaced XM_005262454.3.
            
            Summary: The protein encoded by this gene is a transcriptional
            corepressor that is found tethered to promoter regions by
            DNA-binding proteins. The encoded protein can interact with several
            different class II histone deacetylases to repress transcription.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.30094.1,
                                           SRR14038195.1293360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540052.6/ ENSP00000437775.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AL034405.16        152626-152753
            129-258             Z82208.1           18690-18819
            259-349             Z82208.1           26080-26170
            350-371             Z82208.1           26452-26473
            372-668             KF459400.1         1-297
            669-3613            Z82208.1           26771-29715
            3614-3779           Z82208.1           34486-34651
            3780-3860           Z82208.1           36398-36478
            3861-4250           Z82208.1           38491-38880
            4251-4477           Z82208.1           42136-42362
            4478-4699           AL136450.8         3230-3451
            4700-4866           AL136450.8         6142-6308
            4867-5012           AL136450.8         7912-8057
            5013-5090           AL136450.8         19492-19569
            5091-5247           AL136450.8         20635-20791
            5248-7465           AL136450.8         24629-26846
FEATURES             Location/Qualifiers
     source          1..7465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..7465
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /note="BCL6 corepressor like 1"
                     /db_xref="GeneID:63035"
                     /db_xref="HGNC:HGNC:25657"
                     /db_xref="MIM:300688"
     exon            1..128
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            129..258
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..5530
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /note="isoform 1a is encoded by transcript variant 3;
                     BCoR-like protein 1"
                     /codon_start=1
                     /product="BCL-6 corepressor-like protein 1 isoform 1a"
                     /protein_id="NP_001366380.1"
                     /db_xref="CCDS:CCDS94663.1"
                     /db_xref="GeneID:63035"
                     /db_xref="HGNC:HGNC:25657"
                     /db_xref="MIM:300688"
                     /translation="MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQ
                     HFGSQEFCVSSSFSKVELTAVGSGSNARGADPDGSATEKLGHKSEDKPDDPQPKMDYA
                     GNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVK
                     ALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVP
                     DAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLS
                     VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVP
                     TPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTP
                     APTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLV
                     YIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSV
                     ARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQP
                     LLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDL
                     SSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRTTQAAGGNVTSCLGS
                     TSSPFVIFPEIVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNLGLNR
                     DPRHLPKQEPISIIDQGEPKGTGATCGKKGSQAGAEGQPSTVKRYTPARIAPGLPGCQ
                     TKELSLWKPTGPANIYPRCSVNGKPTSTQVLPVGWSPYHQASLLSIGISSAGQLTPSQ
                     GAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPEQDPVTKNKTCRIAAKP
                     YEEQVNPVLLTLSPQTGTLALSVQPSGGDIRMNQGPEESESHLCSDSTPKMEGPQGAC
                     GLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKELILDVVPSSR
                     RGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQAEVRAKAGQ
                     ARVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEKDSEEQQLQPQAKAVVRSSHRP
                     KCRKLPSDPQESTKKSPRGASDSGKEHNGVRGKHKHRKPTKPESQSPGKRADSHEEGS
                     LEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTPTP
                     AKRRKVRKTQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEE
                     EEEEGLLKRKKRRRQKSRKYQTGEYLTEQEDEQRRKGRADLKARKQKTSSSQSLEHRL
                     RNRNLLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKG
                     KGRWSQQKTRSPKSPTPVKPTEPCTPSKSRSASSEEASESPTARQIPPEARRLIVNKN
                     AGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEH
                     GANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKR
                     FLSDHLSDLQGRAEGDPGVSWDFYSSSVLEEKDGFACDLLHNPPGSSDQEGDDPMEED
                     DFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMP
                     KAEFYRQVASSQLLTPAERPGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVEFQSCN
                     S"
     exon            259..349
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            350..3613
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3779
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3860
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4250
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4477
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4699
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4866
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            4867..5012
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            5013..5090
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            5091..5247
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     exon            5248..7465
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7465
                     /gene="BCORL1"
                     /gene_synonym="BCoR-L1; CXorf10; SHUVER"
                     /note="major polyA site"
ORIGIN      
        1 actctttcgc tcgccgcggc tgctgccagt gtgtggctct gtctctcctc cgctttgctg
       61 agccctccct tcttcctctc agttcctaga gtccgaccgc cgccgccgcc gagagagagg
      121 agaaggaggg ggagtggcca cagcaggtcc tatctggtgg tgagtggctg tcatgatctc
      181 tacagcaccg ctctacagcg gcgtgcacaa ctggaccagt tctgaccgga ttcgcatgtg
      241 tggcatcaac gaggagagaa gagcacctct ttctgatgag gagtcaacga caggcgactg
      301 ccagcacttt ggatctcagg agttttgtgt cagcagcagt ttttccaagg tggagctcac
      361 ggcagttgga agtggcagca atgcccgggg ggcagaccca gatggcagtg ctacagaaaa
      421 acttgggcac aagtcagaag acaagcctga cgatccccag ccaaaaatgg actacgctgg
      481 gaacgtggca gaggctgagg gcctcttggt gcccctgagc agcccaggag acgggctcaa
      541 gcttcccgca tctgacagcg ccgaggccag caacagcagg gccgactgct cctggactcc
      601 actcaacacc caaatgagca aacaggttga ctgctcaccc gccggagtaa aggctttgga
      661 ctctcggcaa ggtgttggag agaagaatac tttcattttg gcaactctgg gaactggagt
      721 ccctgtggag gggaccctgc ccctggttac cactaacttc agtcctctgc cagcccctat
      781 ctgtccccct gctcccggtt cggcctctgt gccccactct gttccagatg cattccaggt
      841 tcccctctcc gtccctgccc cagtccccca ttcagggctt gttccagtcc aagttgccac
      901 ttcggttcca gctccttccc ctcccttagc acctgtcccg gctctggctc cagcgccacc
      961 gtcagtgccc acgctcatct ctgactcgaa ccccctttct gtttcggcct cagtcttggt
     1021 gcctgtgcca gcttctgctc ccccttcagg cccggttccc ttgtcggctc cagctcctgc
     1081 cccgctttca gtcccagttt cagctcctcc cttggctctc atccaggctc ctgtgccccc
     1141 ttcagctccg accttggttc tcgctcccgt ccccactccg gttctggctc ccatgccagc
     1201 atccacgcct ccagcggccc ctgcccctcc gtctgtgccc atgcccactc caaccccatc
     1261 ttccggccca ccttctaccc ccaccctcat ccccgccttt gctcctacac cggtgcctgc
     1321 acccacccca gcccccatct ttactccagc ccctacaccc atgcctgctg ccacgccagc
     1381 tgccattccc acctctgcac ccatcccggc ctccttcagt ttgagtagag tgtgctttcc
     1441 tgcagctcag gcaccagcta tgcaaaaagt ccccctgtcc tttcagccag ggacagtgct
     1501 gaccccgagc cagccgctgg tatatatccc gcctccaagc tgtgggcagc cactcagtgt
     1561 ggccacactg ccaaccactc taggggtttc ctccactctt acgctccctg tcctgccgtc
     1621 ctacctgcag gacaggtgtc tcccaggcgt gctagcctcc cccgagctcc gttcttaccc
     1681 gtatgcattt tctgtggccc ggcctctgac ttcggattcc aagctggtat ctctggaggt
     1741 gaacaggctc ccctgcactt ccccatccgg tagcaccacc acccagcctg cacccgatgg
     1801 ggtccctggg cctttggcag atacctccct tgttactgct tctgccaagg tgcttccaac
     1861 tccacagcct ctgctgccag cccccagtgg gagctcagcc ccaccgcacc ccgccaagat
     1921 gcccagtggc accgagcagc aaacagaagg gacttccgtt accttctctc ctcttaagtc
     1981 accgccacag ctggaacgag agatggcctc tccacctgag tgcagcgaga tgccccttga
     2041 tctgtcctcc aagtccaacc gccagaagct tccattgccg aaccagcgca agacaccccc
     2101 catgcctgtg ttgacccccg tgcacaccag cagcaaggcc ctcctctcca cagtcctgtc
     2161 taggtctcag cgcacaaccc aggctgccgg tggcaatgtc acctcctgcc tgggctccac
     2221 ttcctcgccc tttgtcatct ttcccgagat cgtgaggaat ggggacccga gcacctgggt
     2281 gaagaactca actgcactga tcagcaccat tcctggcacc tacgtgggag tggccaaccc
     2341 agtgcctgca tccctgctgc tgaacaaaga ccccaacctg ggcctcaacc gtgacccccg
     2401 ccatctcccc aagcaggagc ccatctccat cattgatcaa ggagagccta agggcactgg
     2461 tgccacgtgt ggcaaaaagg gcagccaggc tggtgctgag ggacagccaa gcacagtgaa
     2521 acgatatact ccagcccgca ttgcccctgg gctgccaggg tgccaaacca aggaactctc
     2581 tttgtggaaa cccacggggc cggcaaatat ttatccccgg tgttcagtca atgggaaacc
     2641 taccagcacc caggtcctgc ctgttggctg gtccccgtac caccaggcgt ctctgctttc
     2701 cattggcatt tccagtgccg ggcagctgac ccccagtcag ggggcgccca tcaggcccac
     2761 cagcgttgtt tcggagtttt ctggtgtgcc atctctcagc tccagcgaag ccgtgcacgg
     2821 acttcctgag gggcaaccac ggcctggggg ctccttcgtt ccagagcagg accctgttac
     2881 aaagaacaaa acttgccgga ttgctgccaa gccttatgaa gaacaagtca atcctgtcct
     2941 cttgaccctc agccctcaga ctgggaccct ggcactgtct gttcagccta gcggtgggga
     3001 cattcgaatg aatcaggggc ctgaggaatc agagagccac ctctgctctg acagcactcc
     3061 taagatggaa ggcccccagg gggcttgtgg cctgaagctg gcaggagaca cgaagcctaa
     3121 gaaccaagtg ctggccacct acatgtccca tgagctggtc ctggccaccc cccagaacct
     3181 gcctaagatg cctgagctgc ctttgctacc tcacgacagc caccccaagg aacttatatt
     3241 ggacgtggtt ccgagcagca ggaggggctc cagcacagag cgcccacagc ttggaagcca
     3301 ggtggatctg gggcgagtga aaatggagaa ggtggatggt gatgtggtct tcaatttagc
     3361 cacctgcttc cgggctgatg gcctcccagt ggctccccag aggggccaag ctgaagttcg
     3421 ggctaaggcc gggcaggctc gagtgaaaca ggaaagcgta ggggtctttg cttgcaagaa
     3481 caagtggcag ccagatgatg tgacggaatc tctgccgccc aagaagatga agtgcggcaa
     3541 agagaaggac agtgaagagc agcagctcca gccacaagcc aaggccgtgg tccggagttc
     3601 ccacagaccc aagtgccgga agctgcccag tgacccccag gaatccacca agaaaagccc
     3661 caggggggct tcagattcag gaaaagagca caatggagtc aggggaaagc acaagcaccg
     3721 gaagccgaca aagccggagt cccagtctcc aggaaaacga gccgacagcc acgaggaagg
     3781 ttccttggaa aagaaagcaa agagcagttt ccgtgacttt attcctgtgg ttctgagcac
     3841 ccgcacgcgc agtcagtctg gaagcatctg tagctccttt gctggcatgg cagacagtga
     3901 catgggaagc caggaagtct tccccacaga agaagaagag gaggtaaccc ccaccccagc
     3961 taagcgtcga aaggtgagaa agacccaacg ggacacccag tatcgcagcc accatgccca
     4021 ggacaagtct ctgctgagcc agggccgaag gcacctgtgg cgagcccgag aaatgccctg
     4081 gaggacagag gctgcccggc aaatgtggga caccaatgag gaggaggagg aagaagagga
     4141 ggagggcctg ctgaagagga agaaacgaag acggcagaag agccgaaaat atcagactgg
     4201 ggagtacctg acagagcaag aagacgagca gcggcggaaa gggagagcag atttaaaggc
     4261 ccgtaagcag aagacttcct cctcccaaag tttggagcac cgcctcagga acaggaacct
     4321 tctcttgccc aacaaagtcc aggggatctc ggattcacca aacggtttcc tcccaaataa
     4381 cctggaagag ccagcctgcc ttgaaaattc agaaaagcca tcaggaaaac gaaagtgcaa
     4441 gaccaagcac atggcaaccg tctcagaaga ggcaaagggc aaaggtcgtt ggagccagca
     4501 gaagacacga tctcccaaat ctcccacccc agtgaaaccc acagaaccat gtacaccctc
     4561 taagtcccga agtgccagct cagaggaggc ctcagagtca cctacagccc ggcagatccc
     4621 cccagaggca cgtcggctca tagtgaacaa aaatgctggt gagaccctcc tgcagagggc
     4681 ggcgcgtctt ggctataagg atgttgttct ctactgcctc cagaaagaca gtgaagatgt
     4741 gaatcaccgt gacaatgctg gctacacagc cctgcatgag gcttgttccc ggggctggac
     4801 cgacatcctg aacatcctgc tggagcacgg ggccaacgtg aactgcagtg cgcaggacgg
     4861 cacgaggcca gttcatgatg cggtggtcaa tgacaacctg gagaccatct ggctcctgct
     4921 gtcctatggg gccgatccca cactggctac ctactcgggt cagacagcca tgaagctggc
     4981 cagcagcgac accatgaagc gctttctcag tgatcacctc tcggatcttc agggccgggc
     5041 agagggtgat cccggtgtat cctgggattt ttacagcagt tctgtgttgg aggaaaaaga
     5101 cgggtttgcc tgtgacctcc tacataatcc tcctgggagc tcagatcaag aaggagacga
     5161 tccgatggag gaggatgatt tcatgtttga actctcagac aagcctcttc tcccttgcta
     5221 caacctccaa gtgtcagtgt cccgcgggcc ctgcaactgg ttcctctttt ccgatgtctt
     5281 gaagaggctg aagctttcct cgaggatctt tcaggcccgg ttcccgcact ttgaaatcac
     5341 caccatgccc aaggccgagt tctacaggca ggtggcctcc agtcagctgc tgacccctgc
     5401 cgagaggcct ggaggcttgg acgacagatc ccccccaggc tcctctgaga ctgtggagct
     5461 ggtgcggtac gagccagacc tacttcggct cctagggtcc gaggtggaat tccagtcttg
     5521 caacagttga ccgggaaaac agcccctcct cttctttctc cttccgagtt cgcccttccc
     5581 ccacctcctt gtctttcccc gaccgagcac cagactgcag aatgaggcaa taatacggac
     5641 caacaagaag ccgccttatc aatgccagca ttagcgactg gactgttttt gtttttttgg
     5701 ttacaattag ttctcatctc cctgtcgtcg tcattgttat cgtggttgct gatgggggtg
     5761 gaaagttgaa ctccatgtct gaggacaaga ggtcccgggg gtggtgggag gtggcgccgg
     5821 ggtcccttgg actggcctcc ttgttcatga ccaagaccaa acctgggccc tggatggcct
     5881 tggcctgtcc cgaggagaaa tgagaaaatc ccagatctct gagcgccccc caactccatt
     5941 cccctgtgtt cttctgtctt ctgtagtatt tattttatta gtatttaatt tgtattgttt
     6001 cattggtttc tgataagtct gtatcactgt gacgatttga gacaacttgt tgtattgagg
     6061 gactttctgt acctcctttt ctttttcttt gttgatgagc tctgacaaag ctattccctg
     6121 gtgttttttt cccccactgg ggagggggtg aggtggaatg gggtggggga acatggactt
     6181 gtgactaacg aagctggttg ctgctggccc agggctgggg gcttgggggt aaatcctgag
     6241 gctttggtgc tcccccaccc acccattccc gccctttgca gcagccccgc tatcttgaga
     6301 ttagtgttga cagggagggg aggattgtga ggtgaggggt taataagtta ctctaataaa
     6361 ggagcgtgga gaagggatct gaggggtgag ggtggccccc ctcctcacgc cttcttcact
     6421 gcccccctca gagtgcacaa tacgagtttg ttcctgcctc cactctccca ccccgttctg
     6481 gcctccctgt ctcaagatac tgagcctctc acctcccagc cctcagccac ccccatccct
     6541 gccccttctg agactcacag cacccctttc cttcctctcc tcccacctcc tccctcagcc
     6601 cctcattctc cttgggaatc tgcagagggc tctgggactc actgccggat gtgaaatcca
     6661 ggcgtcagct gtttcctagg caagggcagg aaagtggtct ccagcccttg ctccactcat
     6721 gcctgggggc ctggggctga gtggtatccc tacctggcct ccccctggcc tctgggcctc
     6781 cagcgctggg tttgtcgagt gagagagaga gaggagcttg ggttgcttcc ctgtccccgc
     6841 cccctctgtg gcattgtccc tcccactctt atttttctac caattgctat ttttccgaac
     6901 aatccttgta gagtatgtac catccaaagg caggagggcc tcgccgtggc cggctctggt
     6961 tggagatggt acagttttat tgtacaggtg ctaaaacaac aacaacaaaa aagaaaatgg
     7021 aaaaaaaaaa gattaaaaaa aaaaggaaaa aaaaaaagcc agtttgagga tgggacaatc
     7081 tgttctctag aggctcctga gccatgcggg agcattggtg gttattttct ttgtattgtg
     7141 tttgttcttt gttcctgggg gggaagttct cggccccctt ctgtaggact gctccccacc
     7201 cccaccatac tgcccagttg gttttgaaca gttgttttcc ctttttaaga aaaaaaaata
     7261 catatatata tacatatata tatataaagt tgaggggttt tggactttaa tttgttggtt
     7321 ttgttggggt tcctggtatt gtgtagttta tttcatgttc tgtttgcctt tccttttttc
     7381 gcatttgggt gtatattctg gctgcccttt atgtttcatt ttaagcaact ggctgtggag
     7441 tcaaaaacac ttgcatactg aaaaa
//
