LOCUS       NM_001123385            6910 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BCL6 corepressor (BCOR), transcript variant 5, mRNA.
ACCESSION   NM_001123385
VERSION     NM_001123385.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6910)
  AUTHORS   Batkova,M., Havlovicova,M., Nocar,A., Dudakova,L., Macek,M.,
            Liskova,P. and Dostalova,T.
  TITLE     Dental abnormalities observed in the oculo-facio-cardio-dental
            (OFCD) syndrome present in two Czech families bearing novel de novo
            BCOR pathogenic variants
  JOURNAL   BMC Oral Health 24 (1), 1264 (2024)
   PUBMED   39438869
  REMARK    GeneRIF: Dental abnormalities observed in the
            oculo-facio-cardio-dental (OFCD) syndrome present in two Czech
            families bearing novel de novo BCOR pathogenic variants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6910)
  AUTHORS   Giner,F., Medina-Ceballos,E., Lopez-Reig,R., Machado,I.,
            Lopez-Guerrero,J.A., Navarro,S., Rubio-Martinez,L.A., Espino,M.,
            Mayordomo-Aranda,E. and Llombart-Bosch,A.
  TITLE     The Combined Immunohistochemical Expression of GLI1 and BCOR in
            Synovial Sarcomas for the Identification of Three Risk Groups and
            Their Prognostic Outcomes: A Study of 52 Patients
  JOURNAL   Int J Mol Sci 25 (14), 7615 (2024)
   PUBMED   39062853
  REMARK    GeneRIF: The Combined Immunohistochemical Expression of GLI1 and
            BCOR in Synovial Sarcomas for the Identification of Three Risk
            Groups and Their Prognostic Outcomes: A Study of 52 Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6910)
  AUTHORS   Mavridou,E., Lema Fernandez,A.G., Nardelli,C., Pierini,V.,
            Quintini,M., Arniani,S., Di Giacomo,D., Crescenzi,B., Matteucci,C.,
            Sambani,C. and Mecucci,C.
  TITLE     A novel t(X;21)(p11.4;q22.12) translocation adds to the role of
            BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid
            leukemias
  JOURNAL   Genes Chromosomes Cancer 63 (4), e23235 (2024)
   PUBMED   38656651
  REMARK    GeneRIF: A novel t(X;21)(p11.4;q22.12) translocation adds to the
            role of BCOR and RUNX1 in myelodysplastic syndromes and acute
            myeloid leukemias.
REFERENCE   4  (bases 1 to 6910)
  AUTHORS   Pierron,G., Tirode,F., Lucchesi,C., Reynaud,S., Ballet,S.,
            Cohen-Gogo,S., Perrin,V., Coindre,J.M. and Delattre,O.
  TITLE     A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
  JOURNAL   Nat Genet 44 (4), 461-466 (2012)
   PUBMED   22387997
  REMARK    GeneRIF: A new fusion was observed between BCOR (encoding the BCL6
            co-repressor) and CCNB3 (encoding the testis-specific cyclin B3) on
            the X chromosome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6910)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   6  (bases 1 to 6910)
  AUTHORS   Ng,D., Hadley,D.W., Tifft,C.J. and Biesecker,L.G.
  TITLE     Genetic heterogeneity of syndromic X-linked recessive
            microphthalmia-anophthalmia: is Lenz microphthalmia a single
            disorder?
  JOURNAL   Am J Med Genet 110 (4), 308-314 (2002)
   PUBMED   12116202
REFERENCE   7  (bases 1 to 6910)
  AUTHORS   Tang,T.T., Dowbenko,D., Jackson,A., Toney,L., Lewin,D.A., Dent,A.L.
            and Lasky,L.A.
  TITLE     The forkhead transcription factor AFX activates apoptosis by
            induction of the BCL-6 transcriptional repressor
  JOURNAL   J Biol Chem 277 (16), 14255-14265 (2002)
   PUBMED   11777915
  REMARK    GeneRIF: The forkhead transcription factor AFX activates apoptosis
            by induction of the BCL-6 transcriptional repressor.
REFERENCE   8  (bases 1 to 6910)
  AUTHORS   Huynh,K.D., Fischle,W., Verdin,E. and Bardwell,V.J.
  TITLE     BCoR, a novel corepressor involved in BCL-6 repression
  JOURNAL   Genes Dev 14 (14), 1810-1823 (2000)
   PUBMED   10898795
  REMARK    GeneRIF: Function:BCoR is a transcriptional corepressor for BCL-6.
            Nomenclature:BCoR (BCL-6 corepressor)
REFERENCE   9  (bases 1 to 6910)
  AUTHORS   Ng,D.
  TITLE     Lenz Microphthalmia Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301694
REFERENCE   10 (bases 1 to 6910)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591802.28, AL698729.1,
            BC114220.1, AC092198.5, AK056538.1 and AY316592.1.
            
            On Aug 6, 2019 this sequence version replaced NM_001123385.1.
            
            Summary: The protein encoded by this gene was identified as an
            interacting corepressor of BCL6, a POZ/zinc finger transcription
            repressor that is required for germinal center formation and may
            influence apoptosis. This protein selectively interacts with the
            POZ domain of BCL6, but not with eight other POZ proteins. Specific
            class I and II histone deacetylases (HDACs) have been shown to
            interact with this protein, which suggests a possible link between
            the two classes of HDACs. Several transcript variants encoding
            different isoforms have been found for this gene. A pseudogene of
            this gene is found on chromosome Y.[provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (5) represents the longest
            transcript and encodes the longest isoform (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY316592.1, SRR14038193.1143473.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378444.9/ ENSP00000367705.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               AL591802.28        13168-13659         c
            493-1063            AL698729.1         1-571
            1064-2043           BC114220.1         643-1622
            2044-2044           AC092198.5         146244-146244       c
            2045-4286           AK056538.1         1378-3619
            4287-6343           AY316592.1         3754-5810
            6344-6910           BC114220.1         5767-6333
FEATURES             Location/Qualifiers
     source          1..6910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..6910
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /note="BCL6 corepressor"
                     /db_xref="GeneID:54880"
                     /db_xref="HGNC:HGNC:20893"
                     /db_xref="MIM:300485"
     exon            1..744
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..870
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..6052
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /note="isoform c is encoded by transcript variant 5; BCL-6
                     interacting corepressor; BCL6 interacting corepressor;
                     BCL-6 coreceptor"
                     /codon_start=1
                     /product="BCL-6 corepressor isoform c"
                     /protein_id="NP_001116857.1"
                     /db_xref="CCDS:CCDS48093.1"
                     /db_xref="GeneID:54880"
                     /db_xref="HGNC:HGNC:20893"
                     /db_xref="MIM:300485"
                     /translation="MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLE
                     LREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGR
                     EAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAV
                     ATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMY
                     KALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAI
                     PPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLP
                     PSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGK
                     YPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDV
                     DASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSS
                     WVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGR
                     PASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEP
                     SFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPH
                     PVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKE
                     EKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVV
                     KSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALR
                     EELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTF
                     GKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGY
                     VGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKE
                     REGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKH
                     RDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTE
                     TTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIELTGLH
                     PKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRA
                     EAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAK
                     QQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLP
                     LTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPC
                     SSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRD
                     NAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSY
                     GADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDD
                     ESGYDVLANPPGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSD
                     VLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDL
                     VEFTNEIQTLLGSSVEWLHPSDLASDNYW"
     exon            871..949
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..3781
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3835
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..4022
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4286
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4631
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4957
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5212
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5213..5379
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5380..5525
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5603
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5604..5760
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..6910
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6884..6889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /note="hexamer: AATAAA"
     polyA_site      6910
                     /gene="BCOR"
                     /gene_synonym="ANOP2; MAA2; MCOPS2"
                     /note="major polyA site"
ORIGIN      
        1 agacggagcc tgggctccca gcggcaaggt gaggcagagc tgcgctcctc gctgaacgcg
       61 ggccgagctc ggcggctgcg ggggagacgc gcaggagccc agaccgcgac cgagagcggg
      121 agctaggcgg gcggcggcgg cggaggggga gcccgcgagc cgccgggcgg agagcccaag
      181 ccgcgctgtc gccgcgcagg gacgacttgg ccaacactca cacacactca cacacaccca
      241 gcccgagcgg gcgctcgcgg cgaaccgtca acatggcgct ggggctcctg cccgagcgcg
      301 ggcggcggcg gcagcgcggg agctgctgag ctcggccaag cccagtccag ctgcgggagc
      361 ccggaggatc gcacggggct gtcgccacct gcccggaggc cccgagcccg ccccgccccg
      421 cccccacccg gcccagagcc cacccctcgg cggggccgac cccgagggca gccggctgcc
      481 agcagacggc gagggagtcg agtgagcgcg gcgccgcgag cgggctgcgg gcagccgggg
      541 accgcaaact ttgctgctcg ccgcgcttct ccggcccggc tccttctccg ctcgttaacg
      601 tcgccaaccc cccccacccc tcatatctct ctccacccac ccaaccgccc cccgctcctt
      661 ctcgccgcct cgagtccgct tgggggaaaa cttcaaagag ccggatcgca ggctccctgc
      721 ctactccccc accggggatt tcagactaga cgcttgaagc aaagctgcca tcccagaaga
      781 cgacatgctc tcagcaaccc ccctgtatgg gaacgttcac agctggatga acagcgagag
      841 ggtccgcatg tgtggggcga gcgaagacag gaaaatcctt gtaaatgatg gtgacgcttc
      901 aaaagccaga ctggaactga gggaagagaa tcccttgaac cacaacgtgg tggatgcgag
      961 cacggcccat aggatcgatg gcctggcagc actgagcatg gaccgcactg gcctgatccg
     1021 ggaagggctg cgggtcccgg gaaacatcgt ctattctagc ttgtgtggac tgggctcaga
     1081 gaaaggtcgg gaggctgcca caagcactct aggtggcctt gggttttctt cggaaagaaa
     1141 tccagagatg cagttcaaac cgaatacacc cgagacagtg gaggcttctg ccgtctctgg
     1201 aaaaccccca aatggcttca gtgctatata caaaacaccg cctggaatac aaaaaagtgc
     1261 tgtagccaca gcagaagcgc tgggcttgga caggcctgcc agcgacaaac agagccctct
     1321 caacatcaat ggtgctagtt atctgcggct gccctgggtc aatccttaca tggagggtgc
     1381 cacgccagcc atctaccctt tcctcgactc gccaaataag tattcactga acatgtacaa
     1441 ggccttgcta cctcagcagt cctacagctt ggcccagccg ctgtattctc cagtctgcac
     1501 caatggggag cgctttctct acctgccgcc acctcactac gtcggtcccc acatcccatc
     1561 gtccttggca tcacccatga ggctctcgac accttcggcc tccccagcca tcccgcctct
     1621 cgtccattgc gcagacaaaa gcctcccgtg gaagatgggc gtcagccctg ggaatcctgt
     1681 tgattcccac gcctatcctc acatccagaa cagtaagcag cccagggttc cctctgccaa
     1741 ggcggtcacc agtggcctgc cgggggacac agctctcctg ttgcccccct cgcctcggcc
     1801 gtcaccccga gtccaccttc ccacccagcc tgctgcagac acctactcgg agttccacaa
     1861 gcactatgcc aggatctcca cctctccttc agttgccctg tcaaagccat acatgacagt
     1921 tagcagcgag ttccccgcgg ccaggctctc caatggcaag tatcccaagg ctccggaagg
     1981 gggcgaaggt gcccagccag tgcccgggca tgcccggaag acagcggttc aagacagaaa
     2041 agatggcagc tcacctcctc tgttggagaa gcagaccgtt accaaagacg tcacagataa
     2101 gccactagac ttgtcttcta aagtggtgga tgtagatgct tccaaagctg accacatgaa
     2161 aaagatggct cccacggtcc tggttcacag cagggctgga agtggcttag tgctctccgg
     2221 aagtgagatt ccgaaagaaa cactatctcc tccaggaaat ggttgtgcta tctatagatc
     2281 tgaaatcatc agcactgctc cctcatcctg ggtggtgccc gggccaagtc ctaacgaaga
     2341 gaacaatggc aaaagcatgt cgctgaaaaa caaggcattg gactgggcga taccacagca
     2401 gcggagttca tcatgcccgc gcatgggcgg caccgatgct gtcatcacta acgtttcagg
     2461 gtcagtgtcg agtgcaggcc gcccagcctc cgcatcaccc gcccccaatg ccaatgcaga
     2521 tggcaccaaa accagcagga gctctgtaga aaccacacca tccgttattc agcacgtggg
     2581 ccagcccccg gccactcctg ccaagcacag tagcagcacc agcagcaagg gcgccaaagc
     2641 cagcaaccca gaaccgagtt tcaaagcaaa cgagaacggc cttccaccaa gctctatatt
     2701 tctgtctcca aatgaggcat tcaggtcccc accaattccc taccccagga gttacctccc
     2761 ttacccagcc cctgagggca ttgctgtaag tcccctctcc ttacatggca aaggacctgt
     2821 ctaccctcac ccagttttgt tacccaatgg cagtctgttt cctgggcacc ttgccccaaa
     2881 gcctgggctg ccctatgggc ttcccaccgg ccgtccagag tttgtgacct accaagatgc
     2941 cctggggttg ggcatggtgc atcccatgtt gataccacac acgcccatag agattactaa
     3001 agaggagaaa ccagagagga gatcccggtc ccatgagaga gcccgttacg aggacccaac
     3061 cctccggaat cggttttccg agattttgga aactagcagc accaagttac atccagatgt
     3121 ccccaccgac aagaacctaa agccgaaccc caactggaat caagggaaga ctgttgtcaa
     3181 aagcgacaag cttgtctacg tagaccttct ccgagaagaa ccagatgcta aaactgacac
     3241 aaacgtgtcc aaacccagct ttgcagcaga gagtgttggc cagagcgctg agccccccaa
     3301 gccctcagtt gagccggccc tgcagcagca ccgtgatttc atcgccctga gagaggagtt
     3361 ggggcgcatc agtgacttcc acgaaactta tactttcaaa cagccagtct tcaccgtaag
     3421 caaggacagt gttctggcag gtaccaacaa agagaaccta gggttgccag tctcgactcc
     3481 attcctggag ccacctctgg ggagcgatgg ccctgctgta acttttggta aaacccaaga
     3541 ggatcccaaa ccattttgtg tgggcagtgc cccaccaagt gtggatgtga cccccaccta
     3601 taccaaagat ggagctgatg aggctgaatc aaatgatggc aaagttctga aaccgaagcc
     3661 atctaagctg gcaaagagaa tcgccaactc agcgggttac gtgggtgacc gattcaaatg
     3721 tgtcactacc gaactgtatg cagattccag tcagctcagc cgggagcaac gggcattgca
     3781 gatggaagga ttacaagagg acagtatttt atgtctaccc gctgcttact gtgagcgtgc
     3841 aatgatgcgc ttctcagagt tggagatgaa agaaagagaa ggtggccacc cagcaaccaa
     3901 agactccgag atgtgcaaat tcagcccagc cgactgggaa aggttgaaag gaaatcagga
     3961 caaaaagcca aagtcggtca ccctggagga ggccattgca gaacagaacg aaagtgagag
     4021 atgcgagtat agtgttggaa acaagcaccg tgatcccttt gaagccccag aggacaaaga
     4081 tcttcctgtg gagaagtact ttgtggagag gcagcctgtg agcgagcctc ccgcagacca
     4141 ggtggcctcg gacatgcctc acagccccac cctccgggtg gacaggaaac gcaaagtctc
     4201 aggtgacagc agccacactg agaccactgc ggaggaggtg ccagaggacc ctctgctgaa
     4261 agccaaacgc cgacgagtct ctaaagatga ctggcctgag agggaaatga caaacagttc
     4321 ctctaaccac ttagaagacc cacattatag tgagctgacc aacctgaagg tgtgcattga
     4381 attaacaggg ctccatccta aaaaacaacg ccacttgctg caccttagag aacgatggga
     4441 gcagcaggtg tcggcagcag atggcaaacc tggccggcaa agcaggaagg aagtgaccca
     4501 ggccactcag cctgaggcca ttcctcaggg gactaacatc actgaagaga aacctggcag
     4561 gaaaagggca gaggccaaag gcaacagaag ctggtcggaa gagtctctta aacccagtga
     4621 caatgaacaa ggcttgcctg tgttctccgg ctctccgccc atgaagagtc tttcatccac
     4681 cagtgcaggc ggcaaaaagc aggctcagcc aagctgcgca ccagcctcca ggccgcctgc
     4741 caaacagcag aaaattaaag aaaaccagaa gacagatgtg ctgtgtgcag acgaagaaga
     4801 ggattgccag gctgcctccc tgctgcagaa atacaccgac aacagcgaga agccatccgg
     4861 gaagagactg tgcaaaacca aacacttgat ccctcaggag tccaggcggg gattgccact
     4921 gacaggggaa tactacgtgg agaatgccga tggcaaggtg actgtccgga gattcagaaa
     4981 gcggccggag cccagttcgg actatgatct gtcaccagcc aagcaggagc caaagccctt
     5041 cgaccgcttg cagcaactgc taccagcctc ccagtccaca cagctgccat gctcaagttc
     5101 ccctcaggag accacccagt ctcgccctat gccgccggaa gcacggagac ttattgtcaa
     5161 taagaacgct ggcgagaccc ttctgcagcg ggcagccagg cttggctatg aggaagtggt
     5221 cctgtactgc ttagagaaca agatttgtga tgtaaatcat cgggacaacg caggttactg
     5281 cgccctgcat gaagcttgtg ctaggggctg gctcaacatt gtgcgacacc tccttgaata
     5341 tggcgctgat gtcaactgta gtgcccagga tggaaccagg cctctgcacg atgctgttga
     5401 gaacgatcac ttggaaattg tccgactact tctctcttat ggtgctgacc ccaccttggc
     5461 tacgtactca ggtagaacca tcatgaaaat gacccacagt gaacttatgg aaaagttctt
     5521 aacagattat ttaaatgacc tccagggtcg caatgatgat gacgccagtg gcacttggga
     5581 cttctatggc agctctgttt gtgaaccaga tgatgaaagt ggctatgatg ttttagccaa
     5641 ccccccagga ccagaagacc aggatgatga tgacgatgcc tatagcgatg tgtttgaatt
     5701 tgaattttca gagacccccc tcttaccgtg ttataacatc caagtatctg tggctcaggg
     5761 gccacgaaac tggctactgc tttcggatgt ccttaagaaa ttgaaaatgt cctcccgcat
     5821 atttcgctgc aattttccaa acgtggaaat tgtcaccatt gcagaggcag aattttatcg
     5881 gcaggtttct gcaagtctct tgttctcttg ctccaaagac ctggaagcct tcaaccctga
     5941 aagtaaggag ctgttagatc tggtggaatt cacgaacgaa attcagactc tgctgggctc
     6001 ctctgtagag tggctccacc ccagtgatct ggcctcagac aactactggt gagcaagctg
     6061 gacccaccat gtacagtgtg ttatagtgtt aatccttgtg catatgtgtc ataatacaac
     6121 tatttctgta aagaaaggac actattacat atgaaaatat ctcttcttta tataagagaa
     6181 attactccag tcagaaggac ttagaaacat gtttttttcc ttttaaactt ttaagtcagt
     6241 ttttatgaag ttgttataat gtttctttac ttttcaatgc acacatgctt tgggatacgt
     6301 ttgtttttac ttggaacatt tgtttctttt cttttttaag gagaaaaaaa aatgagtaaa
     6361 aggagctcca cactttgact taatttcata caaagctctg atgacaggcc atgactgtag
     6421 agtggtcaga actgtgtggt tggtttgagg gagcgaattc ggggaaggca cttggtgata
     6481 taactttgtt ttgtttacag agtacctgct cgggccaggt aaatgctatt ggatgtaatc
     6541 cagtagtgtg taatataaat tcaaaccata tccacacaca acaactaatt gtatgaaact
     6601 tttatatcct aatttaaaag ctgtgaaatt agttttcacg catcaaaccg gattgtttat
     6661 atgtttaaac attttatgct cttatttaaa gaagactttg agctattttt ttctgtaccc
     6721 tgtaaaatat tgaaaactaa cataatatgt tgaggttgct tggaaatgta cataaaacta
     6781 aaattttctg aatcgtgtgt ttatgtttga aatctgtgtt ttaactttgt aagtaaattc
     6841 tctgcctttg tatttatatt ttacaaaaat tttcttaaaa ggcaataaaa ctgttgagga
     6901 aaggagaaaa
//
