LOCUS       NM_001378213            7598 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens BCL9 like (BCL9L), transcript variant 1, mRNA.
ACCESSION   NM_001378213 XM_005271511
VERSION     NM_001378213.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7598)
  AUTHORS   Kotolloshi,R., Gajda,M., Grimm,M.O. and Steinbach,D.
  TITLE     Wnt/beta-Catenin Signalling and Its Cofactor BCL9L Have an
            Oncogenic Effect in Bladder Cancer Cells
  JOURNAL   Int J Mol Sci 23 (10), 5319 (2022)
   PUBMED   35628130
  REMARK    GeneRIF: Wnt/beta-Catenin Signalling and Its Cofactor BCL9L Have an
            Oncogenic Effect in Bladder Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7598)
  AUTHORS   Vafaizadeh,V., Buechel,D., Rubinstein,N., Kalathur,R.K.R.,
            Bazzani,L., Saxena,M., Valenta,T., Hausmann,G., Cantu,C., Basler,K.
            and Christofori,G.
  TITLE     The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus
            promote breast cancer growth, invasion, and metastasis
  JOURNAL   Oncogene 40 (43), 6195-6209 (2021)
   PUBMED   34545187
  REMARK    GeneRIF: The interactions of Bcl9/Bcl9L with beta-catenin and
            Pygopus promote breast cancer growth, invasion, and metastasis.
REFERENCE   3  (bases 1 to 7598)
  AUTHORS   Lv,Y., Shan,Y., Song,L., Zhao,Y., Lai,R., Su,J. and Zhang,X.
  TITLE     Type I collagen promotes tumor progression of integrin beta1
            positive gastric cancer through a BCL9L/beta-catenin signaling
            pathway
  JOURNAL   Aging (Albany NY) 13 (14), 19064-19076 (2021)
   PUBMED   34319913
  REMARK    GeneRIF: Type I collagen promotes tumor progression of integrin
            beta1 positive gastric cancer through a BCL9L/beta-catenin
            signaling pathway.
REFERENCE   4  (bases 1 to 7598)
  AUTHORS   Wang,X., Feng,M., Xiao,T., Guo,B., Liu,D., Liu,C., Pei,J., Liu,Q.,
            Xiao,Y., Rosin-Arbesfeld,R., Shi,Y., Zhou,Y., Yang,M., Feng,Y.X.,
            Jiang,Y., Shao,Z., Yu,K. and Zhu,D.
  TITLE     BCL9/BCL9L promotes tumorigenicity through immune-dependent and
            independent mechanisms in triple negative breast cancer
  JOURNAL   Oncogene 40 (16), 2982-2997 (2021)
   PUBMED   33767438
  REMARK    GeneRIF: BCL9/BCL9L promotes tumorigenicity through
            immune-dependent and independent mechanisms in triple negative
            breast cancer.
REFERENCE   5  (bases 1 to 7598)
  AUTHORS   Sun,R., Liu,Z., Han,L., Yang,Y., Wu,F., Jiang,Q., Zhang,H., Ma,R.,
            Miao,J., He,K., Wang,X., Zhou,D. and Huang,C.
  TITLE     miR-22 and miR-214 targeting BCL9L inhibit proliferation,
            metastasis, and epithelial-mesenchymal transition by
            down-regulating Wnt signaling in colon cancer
  JOURNAL   FASEB J 33 (4), 5411-5424 (2019)
   PUBMED   30698996
  REMARK    GeneRIF: Dual-luciferase reporter confirmed that BCL9L is the
            target gene of both miR-22 and miR-214.
REFERENCE   6  (bases 1 to 7598)
  AUTHORS   Sakamoto,I., Ohwada,S., Toya,H., Togo,N., Kashiwabara,K., Oyama,T.,
            Nakajima,T., Ito,H., Adachi,S., Jigami,T. and Akiyama,T.
  TITLE     Up-regulation of a BCL9-related beta-catenin-binding protein, B9L,
            in different stages of sporadic colorectal adenoma
  JOURNAL   Cancer Sci 98 (1), 83-87 (2007)
   PUBMED   17129358
REFERENCE   7  (bases 1 to 7598)
  AUTHORS   Sampietro,J., Dahlberg,C.L., Cho,U.S., Hinds,T.R., Kimelman,D. and
            Xu,W.
  TITLE     Crystal structure of a beta-catenin/BCL9/Tcf4 complex
  JOURNAL   Mol Cell 24 (2), 293-300 (2006)
   PUBMED   17052462
  REMARK    GeneRIF: crystallographic analysis of how beta-catenin, BCL9,
            BCL9-2 and Tcf4 interact
REFERENCE   8  (bases 1 to 7598)
  AUTHORS   Adachi,S., Jigami,T., Yasui,T., Nakano,T., Ohwada,S., Omori,Y.,
            Sugano,S., Ohkawara,B., Shibuya,H., Nakamura,T. and Akiyama,T.
  TITLE     Role of a BCL9-related beta-catenin-binding protein, B9L, in
            tumorigenesis induced by aberrant activation of Wnt signaling
  JOURNAL   Cancer Res 64 (23), 8496-8501 (2004)
   PUBMED   15574752
REFERENCE   9  (bases 1 to 7598)
  AUTHORS   Brembeck,F.H., Schwarz-Romond,T., Bakkers,J., Wilhelm,S.,
            Hammerschmidt,M. and Birchmeier,W.
  TITLE     Essential role of BCL9-2 in the switch between beta-catenin's
            adhesive and transcriptional functions
  JOURNAL   Genes Dev 18 (18), 2225-2230 (2004)
   PUBMED   15371335
REFERENCE   10 (bases 1 to 7598)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human BCL9L gene and mouse
            Bcl9l gene in silico
  JOURNAL   Int J Mol Med 12 (4), 643-649 (2003)
   PUBMED   12964048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP004609.1.
            
            On Jan 31, 2020 this sequence version replaced XM_005271511.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352442.106792.1,
                                           SRR14038192.2196452.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683865.1/ ENSP00000507778.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-689               AP004609.1         142246-142934       c
            690-743             AP004609.1         135834-135887       c
            744-845             AP004609.1         126922-127023       c
            846-1231            AP004609.1         125278-125663       c
            1232-1351           AP004609.1         124491-124610       c
            1352-1568           AP004609.1         120244-120460       c
            1569-1653           AP004609.1         119998-120082       c
            1654-3943           AP004609.1         117627-119916       c
            3944-4225           AP004609.1         116925-117206       c
            4226-7598           AP004609.1         113144-116516       c
FEATURES             Location/Qualifiers
     source          1..7598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..7598
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /note="BCL9 like"
                     /db_xref="GeneID:283149"
                     /db_xref="HGNC:HGNC:23688"
                     /db_xref="MIM:609004"
     exon            1..689
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            690..743
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            744..845
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             820..5319
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /note="isoform a is encoded by transcript variant 1;
                     B-cell CLL/lymphoma 9-like protein; nuclear co-factor of
                     beta-catenin signalling; protein BCL9-2; BCL9-like
                     protein; B-cell lymphoma 9-like protein; B cell
                     CLL/lymphoma 9 like"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 9-like protein isoform a"
                     /protein_id="NP_001365142.1"
                     /db_xref="CCDS:CCDS8403.1"
                     /db_xref="GeneID:283149"
                     /db_xref="HGNC:HGNC:23688"
                     /db_xref="MIM:609004"
                     /translation="MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKL
                     TNHGKTGNGGAQSQHQNVNQGPTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVP
                     PFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEW
                     CSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLR
                     PDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKL
                     DQAPKVPPTPEPLPLSTPSAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDL
                     APNSVGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRS
                     LVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPP
                     PQQPPTAPPSGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPPGGDMGQQMNMMIQRL
                     GQDSLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGSRPLQDMMGMGGMMVRGPPPPYHS
                     KPGDQWPPGMGAQLRGPMDVQDPMQLRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEV
                     PMNAMQRPVRPGMGWTEDLPPMGGPSNFAQNTMPYPGGQGEAERFMTPRVREELLRHQ
                     LLEKRSMGMQRPLGMAGSGMGQSMEMERMMQAHRQMDPAMFPGQMAGGEGLAGTPMGM
                     EFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQ
                     KMRGPGDLMGPQGLSPEEMARVRAQNSSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPY
                     QAMSQDMGNTQDMFSPDQSSMPMSNVGTTRLSHMPLPPASNPPGTVHSAPNRGLGRRP
                     SDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGP
                     LKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNM
                     NSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMM
                     TQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMH
                     LNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMM
                     APGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYPSGMALP
                     PEDLPNQPPGPMPPQQHLMGKAMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTG
                     IPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQPPNLHLMNLQNMMAEQTPSRPPNLP
                     GQQGVQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM
                     KQRGVGGEVYSQPPHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMGYLPAPGGM
                     ANLPF"
     exon            846..1231
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1351
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1568
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1653
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..3943
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4225
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..7598
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7575..7580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /note="hexamer: ATTAAA"
     polyA_site      7598
                     /gene="BCL9L"
                     /gene_synonym="B9L; BCL9-2; DLNB11"
                     /note="major polyA site"
ORIGIN      
        1 attcaggctg gggagtggag ccgagtggag gggcaagcga ggctccggca gcgcagggga
       61 gcccggggag gcggcggcgc gcggcggagc cagtggctgg acatgccccg gacccggggc
      121 cgctgcacca ccgccgccgc ccggagccag ccggccggac gcccgcacgc ctgggtcccc
      181 cggcgccgcg ccgcccgggg gctgtgaccc ggaccctcgg agtccgacca acaataagcg
      241 cccagacagc ccctccccac ccagcgcccg gcattcccgc gggctttggg gaaaggaaag
      301 gagaggcgag gaaggaagga aggaagcaag caagcaagca agggaaggag gagcaggagc
      361 aggagccgga gccctgaggt tcggggccga gaccccggcc ccgcgccccg gccccggcgg
      421 gtgtgcgcgc tctcccgcca ctgcccggcg cccgcgacca tgctccgcgg ttgggaggca
      481 ggaacccagg cacccagcga tccccggata gcctctcccg ggccgggctg gtattgagat
      541 caaggcgtcc aggatcaaaa gatcaccgcc tgcccgcccc ctctgcatct ccaactggcg
      601 agcaggagga cccccatcca cacaacgacc ctgacctggt catggcgtcc agctccggcc
      661 tggcgtgagg accccccaat ccgcgtgagg gagcccccaa cccagaccac acccttgagc
      721 ctgagcccga cattattcct gagtccgtgc tccagtaccg agtacctggc tgggccctgg
      781 gcacgcacag gggccgtagc cccactgtgt gtgggagcca tgaggatcct ggctaacaag
      841 acaaggttac cccaccccag gaggagagaa gctccaggga gcccgccgct gtccccccgc
      901 ggtcattgcc cccctgcccc agccaagcca atgcacccag aaaataaatt gaccaatcat
      961 ggcaagacag ggaatggcgg ggcccaatct cagcaccaga atgtgaacca aggacccacc
     1021 tgcaacgtgg gctcgaaggg cgtgggggcg gggaaccatg gggccaaggc caaccagatc
     1081 tcgcctagca actcaagtct gaagaacccc caggcagggg tgcccccttt cagctcgctc
     1141 aagggcaagg tgaagaggga ccggagtgtg tctgtggact ctggagagca gcgagaggct
     1201 gggaccccat ccctggattc agaggccaaa gaggtggcgc cgcggagtaa gcggcgctgt
     1261 gtgctggagc ggaagcagcc gtacagtggg gacgaatggt gctctggacc ggacagtgag
     1321 gaggacgaca agcccattgg ggccacccac aattgtaatg tagcagaccc agccatggcg
     1381 gccccacagc tgggtcccgg ccaaaccacc caactgcccc tcagcgagag cagcgtgcca
     1441 ggcgccccgc acggccctcc tcctggcctt cggcctgatg cccctggggg cgggggcggg
     1501 ggcgggggcg tccccggaaa gcctccctcg cagttcgtat atgtcttcac cacccacctg
     1561 gccaacacgg ctgcagaggc agtgctgcag ggccgggccg actccatcct cgcctaccac
     1621 cagcagaacg tgccccgggc caagcttgac caggccccta aagtgccccc caccccagaa
     1681 ccgctacccc tgagcacgcc gtcagcaggc accccgcagt cccagccacc tccactgccg
     1741 ccgccgccac ccccggcccc tggcagtgcc ccgcctgctc tgcccccaga ggggcctcct
     1801 gaggacagca gtcaggacct ggcccccaac tcggtgggag ctgccagcac aggtggtggg
     1861 actgggggca cccaccctaa caccccgacg gctaccaccg ccaacaaccc tctgcctcct
     1921 ggaggagacc ccagcagtgc ccccggccct gccctgctgg gggaggcagc cgcccctgga
     1981 aatgggcagc gcagcctggt gggctcagag ggcttgtcca aagagcagct ggagcatcgg
     2041 gaacggtccc tccagacgct gcgagacatt gagcgactgc tgctccgcag cggagagact
     2101 gagcccttcc tcaaggggcc cccaggagga gcgggtgagg ggggcccacc agcacaagcc
     2161 ccccctcccc cccagcagcc acccacggcc cctcccagcg ggctgaagaa atatgaggaa
     2221 cccttgcagt ccatgatttc acagacacag agcctagggg gccccccgct ggagcatgaa
     2281 gtgcctgggc accccccggg tggggacatg gggcagcaga tgaacatgat gatacagagg
     2341 ctgggccagg acagcctcac gcctgagcag gtggcctggc gcaagctgca ggaggagtac
     2401 tacgaagaga aacggcggaa agaggaacag attgggctgc atgggagccg tcctctgcag
     2461 gacatgatgg gcatgggggg catgatggtg agggggcccc cgcctcctta ccacagcaag
     2521 cctggggatc agtggccacc tggaatgggt gcgcagctgc gggggcccat ggatgttcaa
     2581 gatcccatgc agctccgggg cggacctccc tttcctgggc cccgtttccc aggcaaccag
     2641 atacaacggg tacctgggtt tgggggcatg cagagtatgc ccatggaggt gcccatgaat
     2701 gccatgcaga ggcccgtgag accaggcatg ggctggaccg aagacttgcc ccctatgggg
     2761 ggacccagca attttgccca gaacaccatg ccctacccag gtgggcaggg tgaggcggag
     2821 cgattcatga ctccccgggt ccgtgaggag ctgctgcggc accagctgct ggagaagcgg
     2881 tcgatgggca tgcagcgccc cctgggcatg gcaggcagtg gcatgggaca gagcatggag
     2941 atggagcgga tgatgcaggc gcaccgacag atggatcctg ccatgtttcc cgggcagatg
     3001 gctggtggtg agggcctggc gggcactccc atgggcatgg agtttggtgg aggccggggc
     3061 ctcctgagcc ctcccatggg gcagtctggg ctgagggagg tggacccacc catggggcca
     3121 ggcaacctca acatgaacat gaatgtcaac atgaacatga acatgaacct gaacgtgcag
     3181 atgaccccgc agcagcagat gctgatgtcg cagaagatgc ggggccctgg ggacttgatg
     3241 gggccccagg gcctcagtcc tgaggagatg gcccgggttc gggcccagaa cagcagtggc
     3301 gtgatgggcg gcccgcagaa gatgctgatg ccttcacagt ttcccaacca gggccagcag
     3361 ggattctctg gaggccaggg accctaccaa gccatgtccc aggacatggg caatacccaa
     3421 gacatgttca gccctgatca gagctcaatg cccatgagca acgtgggcac cacccggctc
     3481 agccacatgc ctctgccccc tgcgtccaat cctcctggga ccgtgcattc agccccaaac
     3541 cgggggctag gcaggcggcc ttcggacctc accatcagta ttaatcagat gggctcaccg
     3601 ggcatggggc acttgaagtc gcccaccctt agccaggtgc actcacccct ggtcacctcg
     3661 ccctctgcca acctcaagtc accccagact ccctcacaga tggtgccctt gccttctgcc
     3721 aacccgccag gacctctcaa gtcgccccag gtcctcggct cctccctcag tgtccgttca
     3781 cccactggct cgcccagcag gctcaagtct ccttccatgg cggtgccttc tccaggctgg
     3841 gttgcctcac ctaagacggc catgcccagc ccgggggtct cccagaacaa gcagccgcct
     3901 ctcaacatga actcttccac caccctgagc aacatggaac agggtaccct cccgcctagc
     3961 ggcccccgga gcagctcctc agcacctccc gccaaccctc ccagcggcct catgaacccc
     4021 agcctaccat tcacttcctc cccagacccc acaccttccc agaaccccct gtcactgatg
     4081 atgacccaga tgtccaagta cgccatgccc agctccaccc cgctctacca caatgccatc
     4141 aagaccatcg ccacctcaga cgacgagctg ctgcccgacc ggcccctgct gcccccccca
     4201 ccaccaccgc agggctccgg gccagggatc agcaacagcc agcccagcca gatgcacctg
     4261 aactcagccg ctgcccagag ccctatgggc atgaacctgc caggccagca gcccctgtcc
     4321 catgagcccc cgcccgccat gctgccctcc cccacccctc tgggctccaa cattccactg
     4381 catcccaacg cacaggggac aggggggccc cctcaaaact ccatgatgat ggccccaggg
     4441 ggccccgact ccctgaatgc cccctgtggc ccagtgccca gctcctccca gatgatgccc
     4501 ttcccccctc ggctgcagca gccccatggt gccatggccc ccactggggg tgggggcggg
     4561 gggcctggcc tgcagcagca ctacccgtca ggcatggccc tgcctcccga ggacctgccc
     4621 aaccagccgc caggccccat gcctccccag cagcacctga tgggcaaagc catggctggg
     4681 cgcatgggcg acgcataccc accgggtgtg ctccctgggg tggcatcagt gctgaacgac
     4741 cccgagctga gcgaggtgat ccggcccacc ccaacgggga tccccgagtt cgacttgtcg
     4801 aggatcatcc cctctgagaa gccaagcagc accctccagt acttccccaa gagcgagaac
     4861 cagcccccca aggctcagcc ccctaatctg catctcatga acctgcagaa catgatggcg
     4921 gagcagactc cctctcggcc tcccaacctc ccaggccagc agggcgtcca gcgggggctc
     4981 aacatgtcca tgtgccaccc tggacagatg tccttgctgg gcaggacagg cgtgccccca
     5041 cagcagggga tggtgcccca tggcctgcac cagggggtca tgtcccctcc acaaggcctc
     5101 atgacccagc agaatttcat gctgatgaag cagcggggcg tggggggcga ggtctacagc
     5161 cagccgcccc acatgctctc cccgcagggc tccctcatgg gccccccgcc ccagcagaac
     5221 ctcatggtgt cccaccccct tcggcagcgc agtgtgtccc tggacagcca gatgggctac
     5281 ctcccggcac caggcggcat ggccaacctg cccttctaga agtcgctgcc agggctggag
     5341 ccggggcaat gttgcaaata cgataacctt aacaaagttc ttcccctcaa tgttgggatg
     5401 gcctgggtcg cggggtgggg tggagggggt gggagggggc ttgtgtaggg agtggcattt
     5461 gtggaaacca gatgtgctgg cagcttaggg ggaagtggca gtgtggggtg ggggattttg
     5521 cattggggtt ggttccattt cggccaccag gactgcccct cccccactcc tcccaattcc
     5581 tatggagcct ctctatttta cctctttccg tgcatccctg cacccgccac acccccttca
     5641 gctatgcttt tggagtcctg gatgggaatc tggggggaga gaggaaggac aggtcaggtc
     5701 tcccccagcc ccttctgctc ctgtctcctc gtgtccgcat tgctggagct ccacctccct
     5761 cttggtttct ccgcacccgc ccattttcct tctgtcttta cctgcttcgt atcctttccc
     5821 tgctgatgtg gctgacccct ctcccacccc tccctgcagg cggctggcca ggtgggcagg
     5881 tgccagccgg agctgtaaat agagcgctgc gcttttgtgc tggtttgtgc gtgtgctgta
     5941 tttctgtgtt ttgatagaag tcacacaaaa aaaaaaggat aaaagaaacc cttcccccct
     6001 tcttcaagtt attgctccct ccattcccct ggacccaggg acatgcagcc ctacatggcc
     6061 acccactgtt tgcagtgtct ctgggtccct aagggatacc attcctgtct cgtccccaaa
     6121 tggtaagatg acgtaaatga cccactccta aactgaggtc agaccaccta ggcttccacc
     6181 tggtgagccc tagcagggct gagaccccca gggcggcagc ctgtctgctg ctgagtgatt
     6241 cagggagaac atgtgtgcac gtgcatgtgt gtttgcccac accggtgaca cggggccctg
     6301 gctttccact ttggatgccc gggcatccgc tgctgctaca tcttagccag aacttgaagt
     6361 cttttgtccc agtttgggat gaaggaaagg aggaagaggc ggtggctgtg tggccccctt
     6421 gagtggagcc atggaagggg tggcatggtg ccactggggc ctgtggctgt agtagccctg
     6481 ggccaggtaa cctccagggc cctgactttt ccagaggctg ctgccaccta cttcttatca
     6541 aagaaggggg agaacagttc atctgagtca gtgcacctcc cctccagtct ccactccctg
     6601 aggatggaat cggggaaaca gcatcctgcc gcctcctctc tgcctgccca ctcaccggca
     6661 aggttgtccc tctgcccagg gctcagggcc atgtaccaga tctgtctgtg cccacccagg
     6721 cacagccact gcctccccct tggctccctg ctcctaccca ggagagctcc ctatccgcct
     6781 ttggtcagag ctgaagccat atacgactgg gtgtttgtcc ccctactttg gccccaggag
     6841 taaaaaaact tctccttttc tcacttcctt tcctgcctcg ggaggtggca gggcagttcc
     6901 ctggctgagg ccttttgcgc cccacctcca ggaccaaggg ccattctaga cagggtgtct
     6961 tctaccagga cccgtcccta gccttcctgg cctggagggc ctggtcttgc actggcagct
     7021 gtaatacaaa gggaactcgc cccacttctc ccagcctggt gctgtcctct cggcccacca
     7081 tcggccaggt ccagcgcttc ctctggggct gacaacaggc ccctgactca ccccggtcac
     7141 ctcccagggt ccatggccag ggcctctgtg tttggggggc cacttgccct tcatcctgcc
     7201 aggcgctttg cccgccctgc ctcagcctgg gccctgtgcc cttgagccct ccacccctgg
     7261 cccaagaccc ccccaaactg tctgactctg tgtttcctgc cctgaggaga gaggggtcag
     7321 attgcagcgg gccgagtgcc ctctccgtcc cctctcctcc cacccacgcc acaggccagc
     7381 ctactcttcc ctccatccat ggccacaccc ccagccattt tgtaccatta tataaatata
     7441 tatataaata taaatatata aatacaatat gtgaagacat cttcttggtt tttattttga
     7501 aacaattttt aggcttgttc cgggggtctc tgtgctgcct gtactgtatt gacctgtttt
     7561 ataggtgcct ttttattaaa aagaaaattc aaaatcca
//
