LOCUS       NM_004326               6189 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BCL9 transcription coactivator (BCL9), mRNA.
ACCESSION   NM_004326
VERSION     NM_004326.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Youssef,S.S., El-Araby,R.E., Abbas,E.A.E., Hassany,M. and Elbaz,T.
  TITLE     Prognostic and survival impact of BCL9 and RPS6KB1 copy number
            variation detected from circulating free DNA in hepatocellular
            carcinoma
  JOURNAL   Expert Rev Mol Diagn 23 (3), 267-278 (2023)
   PUBMED   36803362
  REMARK    GeneRIF: Prognostic and survival impact of BCL9 and RPS6KB1 copy
            number variation detected from circulating free DNA in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Orikasa,S., Kawashima,N., Tazawa,K., Hashimoto,K., Sunada-Nara,K.,
            Noda,S., Fujii,M., Akiyama,T. and Okiji,T.
  TITLE     Hypoxia-inducible factor 1alpha induces osteo/odontoblast
            differentiation of human dental pulp stem cells via
            Wnt/beta-catenin transcriptional cofactor BCL9
  JOURNAL   Sci Rep 12 (1), 682 (2022)
   PUBMED   35027586
  REMARK    GeneRIF: Hypoxia-inducible factor 1alpha induces osteo/odontoblast
            differentiation of human dental pulp stem cells via
            Wnt/beta-catenin transcriptional cofactor BCL9.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Vafaizadeh,V., Buechel,D., Rubinstein,N., Kalathur,R.K.R.,
            Bazzani,L., Saxena,M., Valenta,T., Hausmann,G., Cantu,C., Basler,K.
            and Christofori,G.
  TITLE     The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus
            promote breast cancer growth, invasion, and metastasis
  JOURNAL   Oncogene 40 (43), 6195-6209 (2021)
   PUBMED   34545187
  REMARK    GeneRIF: The interactions of Bcl9/Bcl9L with beta-catenin and
            Pygopus promote breast cancer growth, invasion, and metastasis.
REFERENCE   4  (bases 1 to 6189)
  AUTHORS   Guan,B., Ma,J., Yang,Z., Yu,F. and Yao,J.
  TITLE     LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by
            targeting the miR-22-3p/BCL9 axis to activate the Wnt/beta-catenin
            signaling
  JOURNAL   Environ Toxicol 36 (8), 1640-1653 (2021)
   PUBMED   33974352
  REMARK    GeneRIF: LncRNA NCK1-AS1 exerts oncogenic property in gastric
            cancer by targeting the miR-22-3p/BCL9 axis to activate the
            Wnt/beta-catenin signaling.
REFERENCE   5  (bases 1 to 6189)
  AUTHORS   Chatziandreou,I., Psaraki,A., Paschidis,K., Lazaris,A.C. and
            Saetta,A.A.
  TITLE     Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy
            number amplification in squamous cell lung cancer
  JOURNAL   Pathol Res Pract 221, 153412 (2021)
   PUBMED   33862557
  REMARK    GeneRIF: Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene
            copy number amplification in squamous cell lung cancer.
REFERENCE   6  (bases 1 to 6189)
  AUTHORS   Townsley,F.M., Thompson,B. and Bienz,M.
  TITLE     Pygopus residues required for its binding to Legless are critical
            for transcription and development
  JOURNAL   J Biol Chem 279 (7), 5177-5183 (2004)
   PUBMED   14612447
REFERENCE   7  (bases 1 to 6189)
  AUTHORS   Kramps,T., Peter,O., Brunner,E., Nellen,D., Froesch,B.,
            Chatterjee,S., Murone,M., Zullig,S. and Basler,K.
  TITLE     Wnt/wingless signaling requires BCL9/legless-mediated recruitment
            of pygopus to the nuclear beta-catenin-TCF complex
  JOURNAL   Cell 109 (1), 47-60 (2002)
   PUBMED   11955446
REFERENCE   8  (bases 1 to 6189)
  AUTHORS   Knoll,A., Dvorak,J., Rohrer,G.A. and Cepica,S.
  TITLE     Linkage and cytogenetic mapping of the BCL9 gene to porcine
            chromosome 4
  JOURNAL   Anim Genet 33 (2), 162-163 (2002)
   PUBMED   12047235
REFERENCE   9  (bases 1 to 6189)
  AUTHORS   Busson-Le Coniat,M., Salomon-Nguyen,F., Dastugue,N., Maarek,O.,
            Lafage-Pochitaloff,M., Mozziconacci,M.J., Baranger,L., Brizard,F.,
            Radford,I., Jeanpierre,M., Bernard,O.A. and Berger,R.
  TITLE     Fluorescence in situ hybridization analysis of chromosome 1
            abnormalities in hematopoietic disorders: rearrangements of DNA
            satellite II and new recurrent translocations
  JOURNAL   Leukemia 13 (12), 1975-1981 (1999)
   PUBMED   10602418
REFERENCE   10 (bases 1 to 6189)
  AUTHORS   Willis,T.G., Zalcberg,I.R., Coignet,L.J., Wlodarska,I., Stul,M.,
            Jadayel,D.M., Bastard,C., Treleaven,J.G., Catovsky,D., Silva,M.L.
            and Dyer,M.J.
  TITLE     Molecular cloning of translocation t(1;14)(q21;q32) defines a novel
            gene (BCL9) at chromosome 1q21
  JOURNAL   Blood 91 (6), 1873-1881 (1998)
   PUBMED   9490669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA593760.1, AC242628.1,
            CN281038.1, BC116451.1, CN281037.1 and AW104430.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004326.3.
            
            Summary: BCL9 is associated with B-cell acute lymphoblastic
            leukemia. It may be a target of translocation in B-cell
            malignancies with abnormalities of 1q21. Its function is unknown.
            The overexpression of BCL9 may be of pathogenic significance in
            B-cell malignancies. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13620.1, SRR1803617.62371.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234739.8/ ENSP00000234739.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DA593760.1         1-91
            92-92               AC242628.1         94119-94119         c
            93-570              DA593760.1         93-570
            571-621             CN281038.1         7-57
            622-2870            BC116451.1         17-2265
            2871-3137           CN281037.1         387-653
            3138-4953           BC116451.1         2533-4348
            4954-5841           AC242628.1         9843-10730          c
            5842-6189           AW104430.1         4-351               c
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..6189
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /note="BCL9 transcription coactivator"
                     /db_xref="GeneID:607"
                     /db_xref="HGNC:HGNC:1008"
                     /db_xref="MIM:602597"
     exon            1..174
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            175..309
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            310..392
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            393..704
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     CDS             652..4932
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /note="bcl-9; protein legless homolog; B-cell lymphoma 9
                     protein; B cell CLL/lymphoma 9"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 9 protein"
                     /protein_id="NP_004317.2"
                     /db_xref="CCDS:CCDS30833.1"
                     /db_xref="GeneID:607"
                     /db_xref="HGNC:HGNC:1008"
                     /db_xref="MIM:602597"
                     /translation="MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDS
                     KFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERS
                     ISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
                     TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTA
                     PLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDR
                     ESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP
                     PVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNP
                     GVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSM
                     NSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPR
                     GVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFA
                     GMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNP
                     QGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPV
                     EGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREA
                     GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLR
                     NLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVH
                     SPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA
                     AASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP
                     PTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIK
                     TVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSH
                     SNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQS
                     PPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSF
                     TVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQ
                     PQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA
                     FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSP
                     GMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF"
     exon            705..1021
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1211
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1311
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..3553
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3814
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..6189
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6164..6169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /note="hexamer: AATAAA"
     regulatory      6169..6174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /note="hexamer: AATATA"
     polyA_site      6184
                     /gene="BCL9"
                     /gene_synonym="LGS"
     polyA_site      6189
                     /gene="BCL9"
                     /gene_synonym="LGS"
                     /note="major polyA site"
ORIGIN      
        1 agaccagagc agacaatagg cccctaaagt gttcccccta agttgctttg atgttgtcct
       61 ggtgtcttga taccaggagg ccagggattg cgggaaaagg gtcttttttg tcttcattca
      121 ctttcccccc tcagtttctg aaatgattct ccagaatttc tcctcataaa aaaggactga
      181 atgtgggccc agttggcgtc attctgcttt gacctaaaca ttcccatctg attgggtggc
      241 agagatcatt tttggaaagt tcttccgtgt cccgatgtag aagaaatagc aaattggaca
      301 tattgaaaga caagggtcat ctttgagaag ggggttcctg gactcctcac ctccaggatg
      361 agcactgcag tgtcgtgacc cttggggttt tgtatgccct ggagatgcga gattttcctc
      421 tggcagcagg aggcacgcac ccagagaatg ctggagctgc aaggggaaag gacccacttc
      481 cacagcagag aaaaacaaag aggaaaaagg catacaggca gcgagcgcta agggacgcac
      541 ccagcaagca gtgggccagt gccactgccc ccagcagctg tttctgctgc aacccgagag
      601 gaactcggtg agcctgtccc gtttgtgact gcaagctcag gatttcaatc aatgcattcc
      661 agtaacccta aagtgaggag ctctccatca ggaaacacac agagtagccc taagtcaaag
      721 caggaggtga tggtccgtcc ccctacagtg atgtccccat ctggaaaccc ccagctggat
      781 tccaaattct ccaatcaggg taaacagggg ggctcagcca gccaatccca gccatccccc
      841 tgtgactcca agagtggggg ccatacccct aaagcactcc ctggcccagg tgggagcatg
      901 gggctgaaga atggggctgg aaatggtgcc aagggcaagg ggaaaaggga gcgaagtatt
      961 tccgccgact cctttgatca gagagatcct gggactccaa acgatgactc tgacattaaa
     1021 gaatgtaatt ctgctgacca cataaagtcc caggattccc agcacacacc acactcgatg
     1081 accccatcaa atgctacagc ccccaggtct tctaccccct cccatggcca aactactgcc
     1141 acagagccca cacctgctca gaagactcca gccaaagtgg tgtacgtgtt ttctactgag
     1201 atggccaata aagctgcaga agctgttttg aagggccagg ttgaaactat cgtctctttc
     1261 cacatccaga acatttctaa caacaagaca gagagaagca cagcgcctct gaacacacag
     1321 atatctgccc ttcggaatga tccgaaacct ctcccacaac agcccccagc tccggccaac
     1381 caggaccaga attcttccca gaataccaga ctgcagccaa ctccacccat tccggcacca
     1441 gcacccaagc ctgccgcacc cccacgtccc ctggaccggg agagtcctgg ggtagaaaac
     1501 aaactgattc cttctgtagg aagtcctgcc agctccactc cactgccccc agatggtact
     1561 gggcccaact caactcccaa caatagggca gtgacccctg tctcccaggg gagcaatagc
     1621 tcttcagcag atcccaaagc ccctccgcct ccaccagtgt ccagtggcga gccccccaca
     1681 ctgggagaga atcccgatgg cctatctcag gagcagctgg agcaccggga gcgctcctta
     1741 caaactctca gagatatcca gcgcatgctt tttcctgatg agaaagaatt cacaggagca
     1801 caaagtgggg gaccgcagca gaatcctggg gtattagatg ggcctcagaa aaaaccagaa
     1861 gggccaatac aggccatgat ggcccaatcc caaagcctag gtaagggacc tgggccccgg
     1921 acagacgtgg gagctccatt tggccctcaa ggacatagag atgtaccctt ttctccagat
     1981 gaaatggttc caccttctat gaactcccag tctgggacca taggacccga ccaccttgac
     2041 catatgactc ccgagcagat agcgtggctg aaactgcagc aggagtttta tgaagagaag
     2101 aggaggaagc aggaacaagt ggttgtccag cagtgttccc tccaggacat gatggtccat
     2161 cagcacgggc ctcggggagt ggtccgagga cccccccctc cataccagat gacccctagt
     2221 gaaggctggg cacctggggg tacagagcca ttttctgatg gtatcaacat gccacattct
     2281 ctgcccccga ggggcatggc tccccacccc aacatgccag ggagccagat gcgcctccct
     2341 ggatttgcag gcatgataaa ctctgaaatg gaagggccga atgtccccaa ccctgcatct
     2401 agaccaggtc tttctggagt cagttggcca gatgatgtgc caaaaatccc agatggtcga
     2461 aattttcctc ctggccaggg cattttcagc ggtcctggcc gaggggaacg cttcccaaac
     2521 ccccaaggat tgtctgaaga gatgtttcag cagcagctgg cagagaaaca gctgggtctc
     2581 cccccaggga tggccatgga aggcatcagg cccagcatgg agatgaacag gatgattcca
     2641 ggctcccagc gccacatgga gcctgggaat aaccccattt tccctcgaat accagttgag
     2701 ggccctctga gtccttctag gggtgacttt ccaaaaggaa ttcccccaca gatgggccct
     2761 ggtcgggaac ttgagtttgg gatggttcct agtgggatga agggagatgt caatctaaat
     2821 gtcaacatgg gatccaactc tcagatgata cctcagaaga tgagagaggc tggggcgggc
     2881 cctgaggaga tgctgaaatt acgcccaggt ggctcagaca tgctgcctgc tcagcagaag
     2941 atggtgccac tgccatttgg tgagcacccc cagcaggagt atggcatggg ccccagacca
     3001 ttccttccca tgtctcaggg tccaggcagc aacagtggct tgcggaatct cagagaacca
     3061 attgggcccg accagaggac taacagccgg ctcagtcata tgccaccact acctctcaac
     3121 ccttccagta accccaccag cctcaacaca gctcctccag ttcagcgcgg cctggggcgg
     3181 aagcccttgg atatatctgt ggcaggcagc caggtgcatt ccccaggcat taaccctctg
     3241 aagtctccca cgatgcacca agtccagtca ccaatgctgg gctcgccctc ggggaacctc
     3301 aagtcccccc agactccatc gcagctggca ggcatgctgg cgggcccagc tgctgctgct
     3361 tccattaagt ccccccctgt tttggggtct gctgctgctt cacctgtcca cctcaagtct
     3421 ccatcacttc ctgccccgtc acctggatgg acctcttctc caaaacctcc ccttcagagt
     3481 cctgggatcc ctccaaacca taaagcaccc ctcaccatgg cctccccagc catgctggga
     3541 aatgtagagt caggtggccc cccacctcct acagccagcc agcctgcctc tgtgaatatc
     3601 cctggaagtc ttccctctag tacaccttat accatgcctc cagagccaac cctttcccag
     3661 aacccactct ctattatgat gtctcgaatg tccaagtttg caatgcccag ttccaccccg
     3721 ttataccatg atgctatcaa gactgtggcc agctcagatg acgactcccc tccagctcgt
     3781 tctcccaact tgccatcaat gaataatatg ccaggaatgg gcattaatac acagaatcct
     3841 cgaatttcag gtccaaaccc cgtggttccg atgccaaccc tcagcccaat gggaatgacc
     3901 cagccacttt ctcactccaa tcagatgccc tctccaaatg ccgtgggacc caacatacct
     3961 cctcatgggg tcccaatggg gcctggcttg atgtcacaca atcctatcat ggggcatggg
     4021 tcccaggagc caccgatggt acctcaagga cggatgggct tcccccaggg cttccctcca
     4081 gtacagtctc ccccacagca ggttccattc cctcacaatg gccccagtgg ggggcagggc
     4141 agcttcccag gagggatggg tttcccagga gaaggccccc ttggccgccc cagcaacctg
     4201 ccccaaagtt cagcagatgc agcactttgc aagcctggag gccccggggg tcctgactcc
     4261 ttcactgtcc tggggaacag catgccttcg gtgtttacag acccagatct gcaggaggtc
     4321 atccgacctg gagccaccgg aatacctgag tttgatctat cccgcattat tccatctgag
     4381 aagcccagcc agacgctgca atatttccct cgaggggaag ttccaggccg taaacagccc
     4441 cagggtcctg gacctgggtt ttcacacatg caggggatga tgggcgaaca agcccccaga
     4501 atgggactag cattacctgg catgggaggt ccagggccag tgggaactcc ggacatccct
     4561 cttggtacag ctccatccat gccaggccac aaccccatga gaccaccagc ctttctccaa
     4621 caaggcatga tgggacctca ccatcggatg atgtcaccag cacaatctac aatgcccggc
     4681 cagcccaccc tgatgagcaa tccagctgct gccgtgggca tgattcctgg caaggatcgg
     4741 gggcctgccg ggctctacac ccaccctggg cctgtgggct ctccaggcat gatgatgtcc
     4801 atgcagggca tgatgggacc ccaacagaac atcatgatcc ccccacagat gaggccccgg
     4861 ggcatggctg ctgacgtggg catgggtgga tttagccaag gacctggcaa cccaggaaac
     4921 atgatgtttt aagctgctaa gatgggatgt gccgatcctt gtcaagatga gattccaggt
     4981 cctgagagct gctttgaggg agttccagga gtacttacta ttggtcatgc aataggagaa
     5041 cagagacccg agggctgctt tgggggaggg gggaactcga gaatgtatgg atttacctga
     5101 aaacaaatta ttcatttaat caacaggtgt gtttttttta agatttattt tttaaaaatt
     5161 atttttgtgg acttgggtat caatgatggc acctactttt gggaatctgt agctgtgctt
     5221 tgagaattgc catcggtcat gtgttgcacc gttctctgta tgtttacgtc ctttggactg
     5281 gcttctccca ggattctttt ctgtttttgt ttttttgatt tgggctttat ttttttctgt
     5341 gtactgtact atattgtaaa agggatttta gcagagactt tagtctttgg ggcaagagga
     5401 gaacaggaat gctgggctgt ttactttagg tggagaatcc atcttcagac ctttggacta
     5461 ttttctttca actgcagtgt atagaaaaac caaactacga cctcagagca gagtattaat
     5521 gaaaagcaca aaaaaaggaa ctaagttcag cgaggggtgg ggggaggggg gagatttttc
     5581 ttttgaaaaa taatgactct taggacattt gtttttcagt tcaagtgctc ttcagcactg
     5641 tcttgtctcc caatatacca acccactggc acatttttct cttgttttct ctctccgatt
     5701 ttgctctgtc tcctcagtta agtgtttcct tcctttgtgc cccccgctgg tgaccctctg
     5761 cttccctctc tctttccctt tggcagctgc aatacacagt gttattttgg ggaaataaat
     5821 ctagcaaagc ctcgccttcc atgccgagcg tcctcttggc tctgagaggg aaaggtctgt
     5881 ccttgggatg ctctctggtc ttttttcccc ctaagtcttt ctctttccca tcataccctt
     5941 ccctgcccac cttgttttct gttctccttt tattaggaat tcccaagtga attttattaa
     6001 tgtgggagtg gaacagatgc taaaagctat ccaggatttt gtttctgttt gttttaaatt
     6061 ttgtggttcc ttccctttcc tccccctccc atgcgtaaga cgttctgtgt aacctccatt
     6121 aaatttggta caaaaccact cgccagagct gtggtgtcag aaaaataaaa tatattgttt
     6181 cttacaaaa
//
