LOCUS       NM_001024808            3722 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BAF chromatin remodeling complex subunit BCL7A
            (BCL7A), transcript variant 2, mRNA.
ACCESSION   NM_001024808
VERSION     NM_001024808.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Liu,J., Gao,L., Ji,B., Geng,R., Chen,J., Tao,X., Cai,Q. and Chen,Z.
  TITLE     BCL7A as a novel prognostic biomarker for glioma patients
  JOURNAL   J Transl Med 19 (1), 335 (2021)
   PUBMED   34362400
  REMARK    GeneRIF: BCL7A as a novel prognostic biomarker for glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3722)
  AUTHORS   Dai,J., Lu,L., Kang,L. and Zhang,J.
  TITLE     MiR-501-3p promotes osteosarcoma cell proliferation, migration and
            invasion by targeting BCL7A
  JOURNAL   Hum Cell 34 (2), 624-633 (2021)
   PUBMED   33415690
  REMARK    GeneRIF: MiR-501-3p promotes osteosarcoma cell proliferation,
            migration and invasion by targeting BCL7A.
REFERENCE   3  (bases 1 to 3722)
  AUTHORS   Balinas-Gavira,C., Rodriguez,M.I., Andrades,A., Cuadros,M.,
            Alvarez-Perez,J.C., Alvarez-Prado,A.F., de Yebenes,V.G.,
            Sanchez-Hernandez,S., Fernandez-Vigo,E., Munoz,J., Martin,F.,
            Ramiro,A.R., Martinez-Climent,J.A. and Medina,P.P.
  TITLE     Frequent mutations in the amino-terminal domain of BCL7A impair its
            tumor suppressor role in DLBCL
  JOURNAL   Leukemia 34 (10), 2722-2735 (2020)
   PUBMED   32576963
  REMARK    GeneRIF: Frequent mutations in the amino-terminal domain of BCL7A
            impair its tumor suppressor role in DLBCL.
REFERENCE   4  (bases 1 to 3722)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3722)
  AUTHORS   Sun,Z., Sun,L., He,M., Pang,Y., Yang,Z. and Wang,J.
  TITLE     Low BCL7A expression predicts poor prognosis in ovarian cancer
  JOURNAL   J Ovarian Res 12 (1), 41 (2019)
   PUBMED   31077237
  REMARK    GeneRIF: Survival analysis showed that, compared with those who had
            higher levels of BCL7A expression, patients with ovarian cancer and
            low levels of BCL7A generally had shorter overall/relapse-free
            survival times.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3722)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   7  (bases 1 to 3722)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   8  (bases 1 to 3722)
  AUTHORS   Jadayel,D.M., Osborne,L.R., Coignet,L.J., Zani,V.J., Tsui,L.C.,
            Scherer,S.W. and Dyer,M.J.
  TITLE     The BCL7 gene family: deletion of BCL7B in Williams syndrome
  JOURNAL   Gene 224 (1-2), 35-44 (1998)
   PUBMED   9931421
REFERENCE   9  (bases 1 to 3722)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   10 (bases 1 to 3722)
  AUTHORS   Zani,V.J., Asou,N., Jadayel,D., Heward,J.M., Shipley,J.,
            Nacheva,E., Takasuki,K., Catovsky,D. and Dyer,M.J.
  TITLE     Molecular cloning of complex chromosomal translocation
            t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line
            defines a new gene (BCL7A) with homology to caldesmon
  JOURNAL   Blood 87 (8), 3124-3134 (1996)
   PUBMED   8605326
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069503.25, AK296159.1 and
            AC156455.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001024808.2.
            
            Summary: This gene is directly involved, with Myc and IgH, in a
            three-way gene translocation in a Burkitt lymphoma cell line. As a
            result of the gene translocation, the N-terminal region of the gene
            product is disrupted, which is thought to be related to the
            pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma.
            The N-terminal segment involved in the translocation includes the
            region that shares a strong sequence similarity with those of BCL7B
            and BCL7C. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2091741.1,
                                           SRR7346977.1872706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261822.5/ ENSP00000261822.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC069503.25        35775-35851         c
            78-1031             AK296159.1         78-1031
            1032-3722           AC156455.1         21688-24378         c
FEATURES             Location/Qualifiers
     source          1..3722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3722
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /note="BAF chromatin remodeling complex subunit BCL7A"
                     /db_xref="GeneID:605"
                     /db_xref="HGNC:HGNC:1004"
                     /db_xref="MIM:601406"
     exon            1..300
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..841
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /note="isoform b is encoded by transcript variant 2;
                     B-cell CLL/lymphoma-7; B-cell CLL/lymphoma 7 protein
                     family member A; B-cell CLL/lymphoma 7A; BCL tumor
                     suppressor 7A; BCL7A, BAF complex component"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 7 protein family member A
                     isoform b"
                     /protein_id="NP_001019979.1"
                     /db_xref="CCDS:CCDS53841.1"
                     /db_xref="GeneID:605"
                     /db_xref="HGNC:HGNC:1004"
                     /db_xref="MIM:601406"
                     /translation="MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLR
                     IYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADA
                     SPIKQENSSNSSPAPEPNSAVPSDGTEAKVDEAQADGKEHPGAEDASDEQNSQSSMEH
                     SMNSSEKVDRQPSGDSGLAAETSAISQDLEGVPPSKKMKLEASQQNSEEM"
     exon            301..382
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..479
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..647
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..769
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..3722
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /note="hexamer: AATATA"
     polyA_site      2255
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
     regulatory      3701..3706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /note="hexamer: AATAAA"
     polyA_site      3722
                     /gene="BCL7A"
                     /gene_synonym="BCL7; SMARCJ1"
                     /note="major polyA site"
ORIGIN      
        1 gcactgggcc aggcgcgcgg cggccccggg ctttgtgtgt gtgtgtatgt gtgtgtgtgt
       61 gtgtgtgtgt gtgtgagtgt gtgcgtgtga gagtgcgagt gtctgtgcgc gagtgagtga
      121 gcggcgggcg ggcgcgagtg tggccgccgc ggagcgcgag caggacccgg cgggcgcgct
      181 ccccagcctc cgtctccccg ccggaaccat gtcgggcagg tcggttcgag ccgagacgag
      241 gagccgggcc aaagatgata tcaagagggt catggcggcg atcgagaaag tgcgcaaatg
      301 ggagaagaaa tgggtgaccg ttggtgacac atccctacga atctacaaat gggtccctgt
      361 gacggagccc aaggttgatg acaaaaacaa gaataagaaa aaaggcaagg acgagaagtg
      421 tggctcagag gtgaccactc cggagaacag ttcctcccca gggatgatgg acatgcatga
      481 cgataacagc aaccagagct ccatcgcaga tgcctccccc atcaaacagg agaacagcag
      541 caactccagc cccgctccag agcccaactc ggctgtgccc agcgacggca ccgaggccaa
      601 ggtggatgag gcccaggctg atgggaagga gcacccagga gctgaagatg cttctgatga
      661 gcagaattca cagtcctcga tggaacattc gatgaacagc tcagagaaag tagatcggca
      721 gccgtctgga gactcgggtc tggccgcaga gacgtctgca atctctcagg atttggaagg
      781 agtgccaccc tctaaaaaga tgaaactgga ggcctctcaa caaaactccg aagagatgta
      841 gacgatgctt taaagcctcc gatccatgtt ccatggaagg tacatcagca attaattcta
      901 gagcaacttt gccccagcga ttcctcttgg gtgcgaacag aactactaac gtttcaagtt
      961 taccaagtgc aaatccaaga agacccagaa cggcgtcact tctcagacac tgaagaactc
     1021 tgctgtgaag caaaacactc aaacctttaa gggactgtcc ttggggaggc aggcggggct
     1081 gacagctcag gagtgtctgc acactgtctc ggaagccagg attccatttg tgttgctgct
     1141 gtattttccc cccacttctc tatgtaacga tataagctat cggagggtgg taccgatcag
     1201 gaacgctttt tggcggggct ttccactgtt caaccgattc cttccgcttt ctttttttgt
     1261 gccttgtgcc cttgaggtga cctctggcat gtatcctggt ggttcttaca tccccctctg
     1321 caaagtgccc tcttggtttg gttcgggcgg cggctgccac cctactcacc gctctcctcc
     1381 ctgccccagg acttcatcgg agcaggcagg gtggagcgaa ggagctcctt agcccacctg
     1441 gtttgcaggt gcagggggac cttaggcacg ccccaagcac caggcaccag ggcccaagga
     1501 cgcgcaggtg ttggggcaca gtccccaagg gctcggcccc ttggatcagg ctgggcactc
     1561 gctgtgctct cccctccttg gggcgtttag gactgggcgt ctccaagccc accatggccc
     1621 agatggacgt gcaaagccct tggaattttc tggcacttcc tctctattgc ccccaccacc
     1681 accaccccca tcactgcttt ctcccagacc tccgaatacg aaatggcttc tctggctgac
     1741 tgcaaggctg tctccttaag gcactgagtg ggccggggag gctgggagcc ggcggcagga
     1801 ttagctggtg ctgaactttc tctcatagga cgtcgcttgg atttcaaatc cacggtcacc
     1861 tgctgccctt tgcctccccc gacgccccag cctgtgcccc ggagaggcag gatcgcagtg
     1921 gtcagaatcc acgtgctttc ctattctcag gctgttctga ctctgagcca acagctggac
     1981 cgtgtctcat ccccagaaca tgccgtctgt ccccaccggg gagtgggcct tgatggccgg
     2041 gcctcgaagg ccacaaacaa ggcgtcgagg aattggaaag atttgcacac cctccagaaa
     2101 ggagagacgc aatctcccct ccctcccatc ccccaccttc gctggaacag cttcctctca
     2161 ctgaacggag acgccccctt ggacgaactg cctaatcgtt tggttctgag gcctggtttg
     2221 ctcttaatta atatatgaac tcctcagacc ttaaaccttt tcctaagctt tctttactgc
     2281 actggagttc tgactccctt tgagttgtgt gttactgggg gtggggtggg gtcatgggtt
     2341 ttgttgtttt tgggggctaa ttggtgcata ttcaggtacc acctttgacg tgtggctctt
     2401 tctcctgacc atcatgggaa gtgtctgctg gattccattt tctaagagtt tctgagggtg
     2461 aggctcttat tttttttttt aagggatcct gtctatttcc tgcacttcga gaagaatcaa
     2521 aatgttcctg aatttcaaat acctcatgca aaatgtctcc tgaaataagg gaaaaaaaaa
     2581 aaaccacaac tttgaaaatc ttaatgttga agttagcaat gccgaaaggt ttctgtctta
     2641 aaaaaaaaaa tccttgtact tatcaatttt gccccttagg cagtcagttt tgttgagaac
     2701 tgtgtcctgc atcctggcgc agaacctacc tgatgcggtt cctctccacg catctcgagg
     2761 cggcgttacc tccagattcc gtagagttag agtcacattt ttctttgcag cgaaactcca
     2821 tcttggtgag agatgaattt ggatatttat ttccttctct gtttttggga aacgagaggc
     2881 tacaaccaag acagctgaag gagaatgaaa cacacacatc cacagaaaca gagaggcgta
     2941 ggtggccctg ccgttgaccg cagcctctct ggacaggcaa ggggagttgg cgcaggtgag
     3001 gactcagacg acgtccaccg tcccaaggct gtcactagta tttctctgaa gtgcctgaag
     3061 gtaggaatgg gccggcgatt gggaccagct gggccccacc acggccacgc caggcaaagc
     3121 gccagcagcc ctgcactcca cgctggccaa gaaggccttc cacgcagaat gacaagactg
     3181 caaaaatccg atgtgcttcc ttccctggcg cagtcgctcc tcgagccgct gccccccacc
     3241 caccctgcac ccctcgccct ccccccacca cagaatctaa gacctttcag cttcgagcca
     3301 gggggcgggg gatcccgagc aaaagccttc cgtggacatc aggccccgtg gcctcaaggg
     3361 ctcccagggc aaacctaatt ccccccaaaa cgtgaagtcg gggaagctgc ggctacacat
     3421 tccacaaagt gctggcactt acacccacaa cccggaaggc tgtggaccga ttcctctagg
     3481 gtggtgacct cccattagca aacggtgtca tggtttggaa tgttcattat cgccaagaac
     3541 ctggttagag gcataaagac cttttttcac cgttacctaa ttttttcccc tttcaagaat
     3601 tttttttttt tttggtgtgt tgtacagcag tataattttt cacttattta ttccatcagt
     3661 agatatggtt tgtacaatgt acaattgttt catttcagaa aataaaaatt tcaaatcatg
     3721 aa
//
