LOCUS       NM_181844               3527 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens BCL6B transcription repressor (BCL6B), mRNA.
ACCESSION   NM_181844
VERSION     NM_181844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3527)
  AUTHORS   Li,Z., Wu,W., Li,Q., Heng,X., Zhang,W., Zhu,Y., Chen,L., Chen,Z.,
            Shen,M., Ma,N., Xiao,Q. and Yan,Y.
  TITLE     BCL6B-dependent suppression of ETV2 hampers endothelial cell
            differentiation
  JOURNAL   Stem Cell Res Ther 15 (1), 226 (2024)
   PUBMED   39075623
  REMARK    GeneRIF: BCL6B-dependent suppression of ETV2 hampers endothelial
            cell differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3527)
  AUTHORS   Tanaka,M., Nakamura,S., Sakaue,T., Yamamoto,T., Maekawa,M.,
            Nishinaka,A., Yasuda,H., Yunoki,K., Sato,Y., Sawa,M., Yoshino,K.,
            Shimazawa,M., Hatano,M., Tokuhisa,T., Higashiyama,S. and Hara,H.
  TITLE     BCL6B Contributes to Ocular Vascular Diseases via Notch Signal
            Silencing
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), 927-942 (2023)
   PUBMED   37078291
  REMARK    GeneRIF: BCL6B Contributes to Ocular Vascular Diseases via Notch
            Signal Silencing.
REFERENCE   3  (bases 1 to 3527)
  AUTHORS   Zhao,L., Xie,H., Li,P., Chen,H., He,J., Wang,L., Wang,Y. and Ni,B.
  TITLE     CircTFF1 Promotes Proliferation, Migration and Invasion of Lung
            Cancer Cells by Facilitating Methylation of BCL6B Promoter via
            miR-29c-3p/DNMT3A Axis
  JOURNAL   Mol Biotechnol 65 (6), 942-952 (2023)
   PUBMED   36376550
  REMARK    GeneRIF: CircTFF1 Promotes Proliferation, Migration and Invasion of
            Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via
            miR-29c-3p/DNMT3A Axis.
REFERENCE   4  (bases 1 to 3527)
  AUTHORS   Li,L., Gong,Y., Tang,J., Yan,C., Li,L., Peng,W., Cheng,Z., Yu,R.,
            Xiang,Q., Deng,C., Mu,J., Xia,J., Luo,X., Wu,Y. and Xiang,T.
  TITLE     ZBTB28 inhibits breast cancer by activating IFNAR and dual blocking
            CD24 and CD47 to enhance macrophages phagocytosis
  JOURNAL   Cell Mol Life Sci 79 (2), 83 (2022)
   PUBMED   35048182
  REMARK    GeneRIF: ZBTB28 inhibits breast cancer by activating IFNAR and dual
            blocking CD24 and CD47 to enhance macrophages phagocytosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3527)
  AUTHORS   Li,X., Guo,M., Yang,L., Cheng,Z., Yu,X., Han,Z., Liu,F., Sun,Q.,
            Han,X., Yu,J. and Liang,P.
  TITLE     BCL6B hypermethylation predicts metastasis and poor prognosis in
            early-stage hepatocellular carcinoma after thermal ablation
  JOURNAL   J Cancer Res Ther 17 (3), 644-651 (2021)
   PUBMED   34269294
  REMARK    GeneRIF: BCL6B hypermethylation predicts metastasis and poor
            prognosis in early-stage hepatocellular carcinoma after thermal
            ablation.
REFERENCE   6  (bases 1 to 3527)
  AUTHORS   Sakashita,C., Fukuda,T., Okabe,S., Kobayashi,H., Hirosawa,S.,
            Tokuhisa,T., Miyasaka,N., Miura,O. and Miki,T.
  TITLE     Cloning and characterization of the human BAZF gene, a homologue of
            the BCL6 oncogene
  JOURNAL   Biochem Biophys Res Commun 291 (3), 567-573 (2002)
   PUBMED   11855826
REFERENCE   7  (bases 1 to 3527)
  AUTHORS   Fitzgibbon,J., Neat,M.J., Jones,L., Foot,N., Lister,T.A. and
            Gupta,R.K.
  TITLE     Assignment of B-cell lymphoma 6, member B (zinc finger protein)
            gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 218-219 (2000)
   PUBMED   10965127
REFERENCE   8  (bases 1 to 3527)
  AUTHORS   Okabe,S., Fukuda,T., Ishibashi,K., Kojima,S., Okada,S., Hatano,M.,
            Ebara,M., Saisho,H. and Tokuhisa,T.
  TITLE     BAZF, a novel Bcl6 homolog, functions as a transcriptional
            repressor
  JOURNAL   Mol Cell Biol 18 (7), 4235-4244 (1998)
   PUBMED   9632807
REFERENCE   9  (bases 1 to 3527)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   10 (bases 1 to 3527)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059404.1, AB076580.1, AC040977.10 and AK122893.1.
            
            On Nov 20, 2018 this sequence version replaced NM_181844.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292878.1, AB076580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293805.10/ ENSP00000293805.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-793               BC059404.1         2-794
            794-951             BC059404.1         798-955
            952-1099            AB076580.1         935-1082
            1100-1100           AC040977.10        151449-151449
            1101-1935           AB076580.1         1084-1918
            1936-2371           BC059404.1         1938-2373
            2372-3525           BC059404.1         2426-3579
            3526-3527           AK122893.1         3575-3576
FEATURES             Location/Qualifiers
     source          1..3527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3527
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /note="BCL6B transcription repressor"
                     /db_xref="GeneID:255877"
                     /db_xref="HGNC:HGNC:1002"
                     /db_xref="MIM:608992"
     exon            1..50
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            51..241
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1502
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /note="zinc finger protein 62; B-cell CLL/lymphoma 6,
                     member B (zinc finger protein); bcl6-associated zinc
                     finger protein; B cell CLL/lymphoma 6B"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 6 member B protein"
                     /protein_id="NP_862827.2"
                     /db_xref="CCDS:CCDS42248.1"
                     /db_xref="GeneID:255877"
                     /db_xref="HGNC:HGNC:1002"
                     /db_xref="MIM:608992"
                     /translation="MGSPAAPEGALGYVREFTRHSSDVLGNLNELRLRGILTDVTLLV
                     GGQPLRAHKAVLIACSGFFYSIFRGRAGVGVDVLSLPGGPEARGFAPLLDFMYTSRLR
                     LSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPLEAEPPTPPTAPPPGS
                     PRRSEGHPDPPTESRSCSQGPPSPASPDPKACNWKKYKYIVLNSQASQAGSLVGERSS
                     GQPCPQARLPSGDEASSSSSSSSSSSEEGPIPGPQSRLSPTAATVQFKCGAPASTPYL
                     LTSQAQDTSGSPSERARPLPGSEFFSCQNCEAVAGCSSGLDSLVPGDEDKPYKCQLCR
                     SSFRYKGNLASHRTVHTGEKPYHCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSR
                     FVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFR
                     HKSQLRLHLRQKHGAATNTKVHYHILGGP"
     exon            242..463
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            464..826
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            827..951
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1116
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1247
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1385
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..3527
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /note="hexamer: AATAAA"
     polyA_site      3527
                     /gene="BCL6B"
                     /gene_synonym="BAZF; ZBTB28; ZNF62"
                     /note="major polyA site"
ORIGIN      
        1 gagaccccgc cccccttaag aagagaagcc gcggcccctg caggacgggg gcctgtgtcg
       61 ctatgggttc ccccgccgcc ccggagggag cgctgggcta cgtccgcgag ttcactcgcc
      121 actcctccga cgtgctgggc aacctcaacg agctgcgcct gcgcgggatc ctcactgacg
      181 tcacgctgct ggttggcggg caacccctca gagcacacaa ggcagttctc atcgcctgca
      241 gtggcttctt ctattcaatt ttccggggcc gtgcgggagt cggggtggac gtgctctctc
      301 tgcccggggg tcccgaagcg agaggcttcg cccctctatt ggacttcatg tacacttcgc
      361 gcctgcgcct ctctccagcc actgcaccag cagtcctagc ggccgccacc tatttgcaga
      421 tggagcacgt ggtccaggca tgccaccgct tcatccaggc cagctatgaa cctctgggca
      481 tctccctgcg ccccctggaa gcagaacccc caacaccccc aacggcccct ccaccaggta
      541 gtcccaggcg ctccgaagga cacccagacc cacctactga atctcgaagc tgcagtcaag
      601 gcccccccag tccagccagc cctgacccca aggcctgcaa ctggaaaaag tacaagtaca
      661 tcgtgctaaa ctctcaggcc tcccaagcag ggagcctggt cggggagaga agttctggtc
      721 aaccttgccc ccaagccagg ctccccagtg gagacgaggc ctccagcagc agcagcagca
      781 gcagcagcag cagtgaagaa ggacccattc ctggtcccca gagcaggctc tctccaactg
      841 ctgccactgt gcagttcaaa tgtggggctc cagccagtac cccctacctc ctcacatccc
      901 aggctcaaga cacctctgga tcaccctctg aacgggctcg tccactaccg ggaagtgaat
      961 ttttcagctg ccagaactgt gaggctgtgg cagggtgctc atcggggctg gactccttgg
     1021 ttcctgggga cgaagacaaa ccctataagt gtcagctgtg ccggtcttcg ttccgctaca
     1081 agggcaacct tgccagtcat cgtacagtgc acacagggga aaagccttac cactgctcaa
     1141 tctgcggagc ccgttttaac cggccagcaa acctgaaaac gcacagccgc atccattcgg
     1201 gagagaagcc gtataagtgt gagacgtgcg gctcgcgctt tgtacaggtg gcacatctgc
     1261 gggcgcacgt gctgatccac accggggaga agccctaccc ttgccctacc tgcggaaccc
     1321 gcttccgcca cctgcagacc ctcaagagcc acgttcgcat ccacaccgga gagaagcctt
     1381 accactgcga cccctgtggc ctgcatttcc ggcacaagag tcaactgcgg ctgcatctgc
     1441 gccagaaaca cggagctgct accaacacca aagtgcacta ccacattctc ggggggccct
     1501 agctgagcgc aggcccaggc cccacttgct tcctgcgggt gggaaagctg caggcccagg
     1561 ccttgcttcc ctatcaggct tgggcatagg ggtgtgccag gccactttgg tatcagaaat
     1621 tgccaccctc ttaatttctc actggggaga gcaggggtgg cagatcctgg ctagatctgc
     1681 ctctgttttg ctggtcaaaa cctcttcccc acaagccaga ttgtttctga ggagagagct
     1741 agctaggggc tgggaaaggg gagagattgg agtcctggtc tccctaaggg aatagccctc
     1801 cacctgtggc ccccattgca ttcagtttat ctgtaaatat aatttattga ggcctttggg
     1861 tggcaccggg gccttcattc gattgcattt cccactcccc tcttccacaa gtgtgattaa
     1921 aagtgaccag aaacacagaa ggtgagatca cagctctgct ggcagagatt actagccctt
     1981 ggctctctcg tttggcttgg gtattttata ttatttctgt cataactttt atctttagaa
     2041 ttgttctttc tcctgtttgt ttgcttgtta gtttgtttaa aatggaaaaa ggggttctct
     2101 gtgttctgcc cctgtaattc taggtctgga acctttattt gttctagggc agctctggga
     2161 acatgcggga ttgtggaatt gggtcaggaa ccctctctgg tattctggat gttgtaggtt
     2221 ctctagcagt ctagaaatgg atacagacat ttctctgttc ttcaagggtg ataggaacca
     2281 ttatgttgag cccaaaatgg aagtaataat aaatgcctcc tggaggctgt gggtgtgggg
     2341 gattctgtat ctggattccg tatcactcca agtggaggct ggcaggtttt tctgcaagat
     2401 ggtccagaat ctaaaatgtc ccattaatct ggtcacttgg gtttggctct gctgtatcca
     2461 tctatagtgg tagagaccca ccagggctca agtggagtcc atcatcctcc cacgggggcc
     2521 tgttcttagc actgagttga tcgctccatg ggggagagat cagacattcc ttatcagaga
     2581 tgatgtgacc ttttctgact ctgcccagtc tctatgaatg ttatggccta gggaagaatc
     2641 atgaaactct ttagcttgat tagatggtaa acagtgttaa cccatccttt actacagagg
     2701 catatgggtt tgaatgttac ctggggttct ctctattgag ttgagcccct tcttccttta
     2761 gtgggttttg gacatcttct ggcaagtgtc cagatgccag aaccttcttt tcctctagaa
     2821 gggatggtgc ttggtaacct taccttttaa aagctgggtc tgtgacctgg tcttcccatc
     2881 cctgcattcc tgtctggaac cagtgaatgc attagaacct tccataggaa aagaaaaggg
     2941 gctgagttcc attctgggtt tgctgtagtt tggttgggat tattgttggc attacagatg
     3001 taaaagattg actagcccat aggccaaagg cctgttctag ttgaccaagt ttcaagtagg
     3061 attaagaggt tggttgaggg gtgcagtttc tggtgtaggc caggtaggta gaaagtgagg
     3121 aacagggttg cctcttggct gggtggagtc tctgaaatgt tagaagaagc gctgaagcct
     3181 tgattgatag ttctgcccct tgttgccctg gggcttatct gattatggga cgagggtaga
     3241 aagtaagaag cacttttgaa tttgtggggt agaacttcaa caataagtca gttctagtgg
     3301 ctgtcgcctg gggactagtg agaaagctac tcttctccct cttccctctt tctccccatg
     3361 gccccactgc agaattaaag aaggaagaag ggaaggcgga ggagtctata agaaggaatc
     3421 atgatttcta tttagcagat tggatgggca ggtggagaat gcctgggggt agaaatgtta
     3481 gatcttgcaa catcagatcc ttggaataaa gaagcctctc tgtgctg
//
