LOCUS       NM_001706               3306 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BCL6 transcription repressor (BCL6), transcript
            variant 1, mRNA.
ACCESSION   NM_001706
VERSION     NM_001706.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Liongue,C., Almohaisen,F.L.J. and Ward,A.C.
  TITLE     B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and
            Beyond
  JOURNAL   Int J Mol Sci 25 (20), 10968 (2024)
   PUBMED   39456751
  REMARK    GeneRIF: B Cell Lymphoma 6 (BCL6): A Conserved Regulator of
            Immunity and Beyond.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Li,X., Sun,W., Huang,M., Gong,L., Zhang,X., Zhong,L., Calderon,V.,
            Bian,Z., He,Y., Suh,W.K., Li,Y., Song,T., Zou,Y., Lian,Z.X. and
            Gu,H.
  TITLE     Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T
            follicular helper cell responses and lupus by reducing BCL6
            degradation
  JOURNAL   Immunity 57 (7), 1603-1617 (2024)
   PUBMED   38761804
  REMARK    GeneRIF: Deficiency of CBL and CBLB ubiquitin ligases leads to
            hyper T follicular helper cell responses and lupus by reducing BCL6
            degradation.
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Gopalakrishnan,V., Roy,U., Srivastava,S., Kariya,K.M., Sharma,S.,
            Javedakar,S.M., Choudhary,B. and Raghavan,S.C.
  TITLE     Delineating the mechanism of fragility at BCL6 breakpoint region
            associated with translocations in diffuse large B cell lymphoma
  JOURNAL   Cell Mol Life Sci 81 (1), 21 (2024)
   PUBMED   38196006
  REMARK    GeneRIF: Delineating the mechanism of fragility at BCL6 breakpoint
            region associated with translocations in diffuse large B cell
            lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Blomme,S., De Paepe,P., Devos,H., Emmerechts,J., Snauwaert,S. and
            Cauwelier,B.
  TITLE     Alternative genetic alterations of MYC, BCL2, and/or BCL6 in
            high-grade B-cell lymphoma (HGBL) and diffuse large B-cell lymphoma
            (DLBCL): Can we identify different prognostic subgroups?
  JOURNAL   Genes Chromosomes Cancer 63 (1), e23211 (2024)
   PUBMED   37897298
  REMARK    GeneRIF: Alternative genetic alterations of MYC, BCL2, and/or BCL6
            in high-grade B-cell lymphoma (HGBL) and diffuse large B-cell
            lymphoma (DLBCL): Can we identify different prognostic subgroups?
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Tacho-Pinot,R., Stamper,C.T., King,J.I., Matei-Rascu,V.,
            Richardson,E., Li,Z., Roberts,L.B., Bassett,J.W., Melo-Gonzalez,F.,
            Fiancette,R., Lin,I.H., Dent,A., Harada,Y., Finlay,C., Mjosberg,J.,
            Withers,D.R. and Hepworth,M.R.
  TITLE     Bcl6 is a subset-defining transcription factor of lymphoid tissue
            inducer-like ILC3
  JOURNAL   Cell Rep 42 (11), 113425 (2023)
   PUBMED   37950867
  REMARK    GeneRIF: Bcl6 is a subset-defining transcription factor of lymphoid
            tissue inducer-like ILC3.
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Flenghi,L., Ye,B.H., Fizzotti,M., Bigerna,B., Cattoretti,G.,
            Venturi,S., Pacini,R., Pileri,S., Lo Coco,F., Pescarmona,E. et al.
  TITLE     A specific monoclonal antibody (PG-B6) detects expression of the
            BCL-6 protein in germinal center B cells
  JOURNAL   Am J Pathol 147 (2), 405-411 (1995)
   PUBMED   7639334
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Cattoretti,G., Chang,C.C., Cechova,K., Zhang,J., Ye,B.H.,
            Falini,B., Louie,D.C., Offit,K., Chaganti,R.S. and Dalla-Favera,R.
  TITLE     BCL-6 protein is expressed in germinal-center B cells
  JOURNAL   Blood 86 (1), 45-53 (1995)
   PUBMED   7795255
REFERENCE   8  (bases 1 to 3306)
  AUTHORS   Onizuka,T., Moriyama,M., Yamochi,T., Kuroda,T., Kazama,A.,
            Kanazawa,N., Sato,K., Kato,T., Ota,H. and Mori,S.
  TITLE     BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is
            highly expressed in germinal center B cells and their neoplastic
            counterparts
  JOURNAL   Blood 86 (1), 28-37 (1995)
   PUBMED   7795234
REFERENCE   9  (bases 1 to 3306)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   10 (bases 1 to 3306)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB079847.1, BC150184.1 and
            BC146796.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001706.4.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor and contains an N-terminal POZ domain. This
            protein acts as a sequence-specific repressor of transcription, and
            has been shown to modulate the transcription of STAT-dependent IL-4
            responses of B cells. This protein can interact with a variety of
            POZ-containing proteins that function as transcription
            corepressors. This gene is found to be frequently translocated and
            hypermutated in diffuse large-cell lymphoma (DLCL), and may be
            involved in the pathogenesis of DLCL. Alternatively spliced
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150184.1, AK308162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406870.7/ ENSP00000384371.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               DB079847.1         258-575
            319-2412            BC150184.1         292-2385
            2413-3306           BC146796.1         2416-3309
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..3306
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /note="BCL6 transcription repressor"
                     /db_xref="GeneID:604"
                     /db_xref="HGNC:HGNC:1001"
                     /db_xref="MIM:109565"
     exon            1..59
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            60..98
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            99..269
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2229
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphoma-associated zinc finger gene on chromosome 3; zinc
                     finger protein 51; cys-his2 zinc finger transcription
                     factor; zinc finger transcription factor BCL6S; B-cell
                     lymphoma 6 protein transcript; zinc finger and BTB
                     domain-containing protein 27; BCL-5; BCL-6; protein LAZ-3;
                     B-cell lymphoma 5 protein; B cell CLL/lymphoma 6"
                     /codon_start=1
                     /product="B-cell lymphoma 6 protein isoform 1"
                     /protein_id="NP_001697.2"
                     /db_xref="CCDS:CCDS3289.1"
                     /db_xref="GeneID:604"
                     /db_xref="HGNC:HGNC:1001"
                     /db_xref="MIM:109565"
                     /translation="MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFR
                     AHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNI
                     MAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGR
                     EVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRM
                     PVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYS
                     VAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSP
                     QKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKP
                     EGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIV
                     NRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEY
                     SDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKT
                     VHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIH
                     TGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHG
                     AITNTKVQYRVSATDLPPELPKAC"
     exon            270..491
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            492..1463
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1648
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1816
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1947
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2085
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..3306
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /note="hexamer: AATAAA"
     polyA_site      3306
                     /gene="BCL6"
                     /gene_synonym="BCL5; BCL6A; LAZ3; ZBTB27; ZNF51"
                     /note="major polyA site"
ORIGIN      
        1 agaactgggg ttcttagaag tggtgatgca agaagtttct aggaaaggcc ggacaccagg
       61 ttttgagcaa aattttggac tgtgaagcaa ggcattggtg aagacaaaat ggcctcgccg
      121 gctgacagct gtatccagtt cacccgccat gccagtgatg ttcttctcaa ccttaatcgt
      181 ctccggagtc gagacatctt gactgatgtt gtcattgttg tgagccgtga gcagtttaga
      241 gcccataaaa cggtcctcat ggcctgcagt ggcctgttct atagcatctt tacagaccag
      301 ttgaaatgca accttagtgt gatcaatcta gatcctgaga tcaaccctga gggattctgc
      361 atcctcctgg acttcatgta cacatctcgg ctcaatttgc gggagggcaa catcatggct
      421 gtgatggcca cggctatgta cctgcagatg gagcatgttg tggacacttg ccggaagttt
      481 attaaggcca gtgaagcaga gatggtttct gccatcaagc ctcctcgtga agagttcctc
      541 aacagccgga tgctgatgcc ccaagacatc atggcctatc ggggtcgtga ggtggtggag
      601 aacaacctgc cactgaggag cgcccctggg tgtgagagca gagcctttgc ccccagcctg
      661 tacagtggcc tgtccacacc gccagcctct tattccatgt acagccacct ccctgtcagc
      721 agcctcctct tctccgatga ggagtttcgg gatgtccgga tgcctgtggc caaccccttc
      781 cccaaggagc gggcactccc atgtgatagt gccaggccag tccctggtga gtacagccgg
      841 ccgactttgg aggtgtcccc caatgtgtgc cacagcaata tctattcacc caaggaaaca
      901 atcccagaag aggcacgaag tgatatgcac tacagtgtgg ctgagggcct caaacctgct
      961 gccccctcag cccgaaatgc cccctacttc ccttgtgaca aggccagcaa agaagaagag
     1021 agaccctcct cggaagatga gattgccctg catttcgagc cccccaatgc acccctgaac
     1081 cggaagggtc tggttagtcc acagagcccc cagaaatctg actgccagcc caactcgccc
     1141 acagagtcct gcagcagtaa gaatgcctgc atcctccagg cttctggctc ccctccagcc
     1201 aagagcccca ctgaccccaa agcctgcaac tggaagaaat acaagttcat cgtgctcaac
     1261 agcctcaacc agaatgccaa accagagggg cctgagcagg ctgagctggg ccgcctttcc
     1321 ccacgagcct acacggcccc acctgcctgc cagccaccca tggagcctga gaaccttgac
     1381 ctccagtccc caaccaagct gagtgccagc ggggaggact ccaccatccc acaagccagc
     1441 cggctcaata acatcgttaa caggtccatg acgggctctc cccgcagcag cagcgagagc
     1501 cactcaccac tctacatgca ccccccgaag tgcacgtcct gcggctctca gtccccacag
     1561 catgcagaga tgtgcctcca caccgctggc cccacgttcc ctgaggagat gggagagacc
     1621 cagtctgagt actcagattc tagctgtgag aacggggcct tcttctgcaa tgagtgtgac
     1681 tgccgcttct ctgaggaggc ctcactcaag aggcacacgc tgcagaccca cagtgacaaa
     1741 ccctacaagt gtgaccgctg ccaggcctcc ttccgctaca agggcaacct cgccagccac
     1801 aagaccgtcc ataccggtga gaaaccctat cgttgcaaca tctgtggggc ccagttcaac
     1861 cggccagcca acctgaaaac ccacactcga attcactctg gagagaagcc ctacaaatgc
     1921 gaaacctgcg gagccagatt tgtacaggtg gcccacctcc gtgcccatgt gcttatccac
     1981 actggtgaga agccctatcc ctgtgaaatc tgtggcaccc gtttccggca ccttcagact
     2041 ctgaagagcc acctgcgaat ccacacagga gagaaacctt accattgtga gaagtgtaac
     2101 ctgcatttcc gtcacaaaag ccagctgcga cttcacttgc gccagaagca tggcgccatc
     2161 accaacacca aggtgcaata ccgcgtgtca gccactgacc tgcctccgga gctccccaaa
     2221 gcctgctgaa gcatggagtg ttgatgcttt cgtctccagc cccttctcag aatctaccca
     2281 aaggatactg taacacttta caatgttcat cccatgatgt agtgcctctt tcatccacta
     2341 gtgcaaatca tagctggggg ttgggggtgg tgggggtcgg ggcctggggg actgggagcc
     2401 gcagcagctc cccctccccc actgccataa aacattaaga aaatcatatt gcttcttctc
     2461 ctatgtgtaa ggtgaaccat gtcagcaaaa agcaaaatca ttttatatgt caaagcaggg
     2521 gagtatgcaa aagttctgac ttgactttag tctgcaaaat gaggaatgta tatgttttgt
     2581 gggaacagat gtttcttttg tatgtaaatg tgcattcttt taaaagacaa gacttcagta
     2641 tgttgtcaaa gagagggctt taattttttt aaccaaaggt gaaggaatat atggcagagt
     2701 tgtaaatata taaatatata tatatataaa ataaatatat ataaacctaa aaaagatata
     2761 ttaaaaatat aaaactgcgt taaaggctcg attttgtatc tgcaggcaga cacggatctg
     2821 agaatcttta ttgagaaaga gcacttaaga gaatatttta agtattgcat ctgtataagt
     2881 aagaaaatat tttgtctaaa atgcctcagt gtatttgtat ttttttgcaa gtgaaggttt
     2941 acaatttaca aagtgtgtat taaaaaaaac aaaaagaaca aaaaaatctg cagaaggaaa
     3001 aatgtgtaat tttgttctag ttttcagttt gtatataccc gtacaacgtg tcctcacggt
     3061 gccttttttc acggaagttt tcaatgatgg gcgagcgtgc accatccctt tttgaagtgt
     3121 aggcagacac agggacttga agttgttact aactaaactc tctttgggaa tgtttgtctc
     3181 atcccattct gcgtcatgct tgtgttataa ctactccgga gacagggttt ggctgtgtct
     3241 aaactgcatt accgcgttgt aaaatatagc tgtacaaata taagaataaa atgttgaaaa
     3301 gtcaaa
//
