LOCUS       NM_005178               1877 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens BCL3 transcription coactivator (BCL3), mRNA.
ACCESSION   NM_005178
VERSION     NM_005178.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Carbo-Meix,A., Guijarro,F., Wang,L., Grau,M., Royo,R., Frigola,G.,
            Playa-Albinyana,H., Buhler,M.M., Clot,G., Duran-Ferrer,M., Lu,J.,
            Granada,I., Baptista,M.J., Navarro,J.T., Espinet,B., Puiggros,A.,
            Tapia,G., Bandiera,L., De Canal,G., Bonoldi,E., Climent,F.,
            Ribera-Cortada,I., Fernandez-Caballero,M., De la Banda,E., Do
            Nascimento,J., Pineda,A., Vela,D., Rozman,M., Aymerich,M.,
            Syrykh,C., Brousset,P., Perera,M., Yanez,L., Ortin,J.X., Tuset,E.,
            Zenz,T., Cook,J.R., Swerdlow,S.H., Martin-Subero,J.I., Colomer,D.,
            Matutes,E., Bea,S., Costa,D., Nadeu,F. and Campo,E.
  TITLE     BCL3 rearrangements in B-cell lymphoid neoplasms occur in two
            breakpoint clusters associated with different diseases
  JOURNAL   Haematologica 109 (2), 493-508 (2024)
   PUBMED   37560801
  REMARK    GeneRIF: BCL3 rearrangements in B-cell lymphoid neoplasms occur in
            two breakpoint clusters associated with different diseases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   Liu,H., Zeng,L., Pan,M., Huang,L., Li,H., Liu,M., Niu,X., Zhang,C.
            and Wang,H.
  TITLE     Bcl-3 regulates T cell function through energy metabolism
  JOURNAL   BMC Immunol 24 (1), 35 (2023)
   PUBMED   37794349
  REMARK    GeneRIF: Bcl-3 regulates T cell function through energy metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1877)
  AUTHORS   Ge,P., Chen,X., Liu,J., Jing,R., Zhang,X. and Li,H.
  TITLE     Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by
            regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT
            signaling
  JOURNAL   Mol Carcinog 62 (7), 1073-1085 (2023)
   PUBMED   37132942
  REMARK    GeneRIF: Hsa_circ_0088036 promotes nonsmall cell lung cancer
            progression by regulating miR-1343-3p/Bcl-3 axis through
            TGFbeta/Smad3/EMT signaling.
REFERENCE   4  (bases 1 to 1877)
  AUTHORS   Gehrke,N., Worns,M.A., Mann,A., Hovelmeyer,N., Waisman,A.,
            Straub,B.K., Galle,P.R. and Schattenberg,J.M.
  TITLE     Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis
            and subsequent acute liver failure
  JOURNAL   Cell Death Dis 13 (5), 510 (2022)
   PUBMED   35641486
  REMARK    GeneRIF: Hepatocyte Bcl-3 protects from death-receptor mediated
            apoptosis and subsequent acute liver failure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1877)
  AUTHORS   Liu,H., Zeng,L., Yang,Y., Guo,C. and Wang,H.
  TITLE     Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation
  JOURNAL   Front Immunol 13, 847699 (2022)
   PUBMED   35355979
  REMARK    GeneRIF: Bcl-3: A Double-Edged Sword in Immune Cells and
            Inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1877)
  AUTHORS   Crossen,P.E., Kennedy,M.A., Heaton,D.C. and Morrison,M.J.
  TITLE     Cloning and sequencing of a t(14;19) breakpoint that involves the C
            mu switch region
  JOURNAL   Genes Chromosomes Cancer 8 (1), 60-62 (1993)
   PUBMED   7691160
REFERENCE   7  (bases 1 to 1877)
  AUTHORS   Franzoso,G., Bours,V., Park,S., Tomita-Yamaguchi,M., Kelly,K. and
            Siebenlist,U.
  TITLE     The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa
            B-mediated inhibition
  JOURNAL   Nature 359 (6393), 339-342 (1992)
   PUBMED   1406939
REFERENCE   8  (bases 1 to 1877)
  AUTHORS   Wulczyn,F.G., Naumann,M. and Scheidereit,C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   9  (bases 1 to 1877)
  AUTHORS   Bhatia,K., Huppi,K., McKeithan,T., Siwarski,D., Mushinski,J.F. and
            Magrath,I.
  TITLE     Mouse bcl-3: cDNA structure, mapping and stage-dependent expression
            in B lymphocytes
  JOURNAL   Oncogene 6 (9), 1569-1573 (1991)
   PUBMED   1923524
  REMARK    GeneRIF: Characterization of the mouse BCL3 ortholog and comparison
            to the human gene.
REFERENCE   10 (bases 1 to 1877)
  AUTHORS   Ohno,H., Takimoto,G. and McKeithan,T.W.
  TITLE     The candidate proto-oncogene bcl-3 is related to genes implicated
            in cell lineage determination and cell cycle control
  JOURNAL   Cell 60 (6), 991-997 (1990)
   PUBMED   2180580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092066.4, BU501187.1 and
            BC064993.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005178.4.
            
            Summary: This gene is a proto-oncogene candidate. It is identified
            by its translocation into the immunoglobulin alpha-locus in some
            cases of B-cell leukemia. The protein encoded by this gene contains
            seven ankyrin repeats, which are most closely related to those
            found in I kappa B proteins. This protein functions as a
            transcriptional co-activator that activates through its association
            with NF-kappa B homodimers. The expression of this gene can be
            induced by NF-kappa B, which forms a part of the autoregulatory
            loop that controls the nuclear residence of p50 NF-kappa B.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064993.1, SRR1163658.355456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000164227.10/ ENSP00000164227.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC092066.4         85376-85388
            14-15               BU501187.1         1-2
            16-1877             BC064993.1         1-1862
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1877
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /note="BCL3 transcription coactivator"
                     /db_xref="GeneID:602"
                     /db_xref="HGNC:HGNC:998"
                     /db_xref="MIM:109560"
     exon            1..339
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1448
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /note="B-cell lymphoma 3-encoded protein; B-cell
                     leukemia/lymphoma 3; chronic lymphatic leukemia protein;
                     BCL-3; proto-oncogene BCL3; B cell CLL/lymphoma 3"
                     /codon_start=1
                     /product="B-cell lymphoma 3 protein"
                     /protein_id="NP_005169.2"
                     /db_xref="CCDS:CCDS12642.2"
                     /db_xref="GeneID:602"
                     /db_xref="HGNC:HGNC:998"
                     /db_xref="MIM:109560"
                     /translation="MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEP
                     AAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFP
                     LVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQ
                     GGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSP
                     TCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSG
                     RSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGAD
                     SSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSN
                     GLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPA
                     PGGS"
     exon            340..493
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            494..602
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            603..807
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            808..896
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            897..974
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1142
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1260
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1877
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /note="hexamer: AATAAA"
     polyA_site      1877
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /note="major polyA site"
ORIGIN      
        1 aggggaagtc ccggcgcccg gcgaaaccac cctcccgtgc agccgagccc agccgctctc
       61 cggccgccgt ccccggcggc cccatgcccc gatgccccgc gggggccatg gacgaggggc
      121 ccgtggacct gcgcacccgg cccaaggccg ccggactccc gggcgccgcg ctgccgctcc
      181 gcaagcgccc gctgcgcgcg ccctccccgg agcccgccgc tccccgcggc gctgcgggcc
      241 ttgtcgtccc cctggaccct ctgcgcggcg gctgcgacct gccggcggtc cccgggcccc
      301 cccacggcct ggcccggccg gaggcgcttt actaccccgg agccttactg cctttgtacc
      361 ccactcgggc catgggctcc ccgtttcctc tggtgaacct gcctacaccc ctatacccca
      421 tgatgtgccc catggaacac cccctttctg ctgacatcgc catggccacc cgtgcagatg
      481 aggacggaga cacgcctctc catattgctg tggtgcaggg taacctgcca gctgtgcacc
      541 ggctggtcaa cctcttccag caggggggcc gggagctcga catctacaac aacctacggc
      601 agacaccgct ccacctggct gtgatcacca cattaccgtc tgtggtccgg ctcctggtga
      661 cagctggtgc cagccccatg gcgctggacc gccatggcca gacggccgct cacctggcgt
      721 gcgagcaccg cagcccgacc tgcctgcgag ccctgctgga cagcgcagct ccgggcacgt
      781 tggacctgga ggcccgcaat tatgacgggc tcaccgccct gcacgtggca gtgaacaccg
      841 agtgccaaga aaccgtgcag ctcttgctag agcgcggtgc cgacatcgac gcagtggaca
      901 ttaagagcgg ccgctccccg ctcatccacg ccgtggaaaa caacagcctt agcatggtgc
      961 agctgctgct gcagcacggc gccaacgtga acgcgcaaat gtactccggc agctccgccc
     1021 tgcactcagc gtccggccgc gggctcctcc cgctggtgcg cacgctggtc cgcagcggcg
     1081 ctgacagcag cctcaagaac tgccacaacg acacgccgct catggtggcg cgcagccgca
     1141 gggtcatcga catcctgagg gggaaggcca cccggcctgc ttccacctcc cagccagacc
     1201 cctcccctga ccggagcgcc aacacctccc ccgagagcag cagccgcctc agctccaatg
     1261 gtcttctctc cgcatcacca tcctcctcac cctcccagtc tccccccagg gacccccctg
     1321 gattccccat ggctcctccc aatttcttcc ttccttcccc atctccaccc gccttcctgc
     1381 cctttgctgg ggtcctccga ggccctggcc ggccggtgcc cccctcccca gctccaggag
     1441 gcagctgagg gggatggggg ggcagatctt ggactcatga ggaggggccc ccctgccctg
     1501 tggggtcaac ccttctggaa actgtgaaga tctcactctg cccccccccc ccatcttcgg
     1561 gaccaggatt tgcacagaag cacatgcacc tacccataca ccccctcttc tgagcacaga
     1621 tgttccccca tctcgctccc tcccaggact ctgaccccag cattctcagg caccagtccc
     1681 tgtccggaat gccacccaca tcttccattt ccatgtcccc tcccagagct ggtggaccca
     1741 gggaacagcc actcccctcc actctctacc agataactga ggaggggaga ggtgggccgt
     1801 aacgggcacg gatcacgatg taaattatta agcattttgg ttggatttct tttgtaataa
     1861 actatttttg taccata
//
