LOCUS       NP_005169                454 aa            linear   PRI 28-APR-2025
DEFINITION  B-cell lymphoma 3 protein [Homo sapiens].
ACCESSION   NP_005169
VERSION     NP_005169.2
DBSOURCE    REFSEQ: accession NM_005178.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Carbo-Meix,A., Guijarro,F., Wang,L., Grau,M., Royo,R., Frigola,G.,
            Playa-Albinyana,H., Buhler,M.M., Clot,G., Duran-Ferrer,M., Lu,J.,
            Granada,I., Baptista,M.J., Navarro,J.T., Espinet,B., Puiggros,A.,
            Tapia,G., Bandiera,L., De Canal,G., Bonoldi,E., Climent,F.,
            Ribera-Cortada,I., Fernandez-Caballero,M., De la Banda,E., Do
            Nascimento,J., Pineda,A., Vela,D., Rozman,M., Aymerich,M.,
            Syrykh,C., Brousset,P., Perera,M., Yanez,L., Ortin,J.X., Tuset,E.,
            Zenz,T., Cook,J.R., Swerdlow,S.H., Martin-Subero,J.I., Colomer,D.,
            Matutes,E., Bea,S., Costa,D., Nadeu,F. and Campo,E.
  TITLE     BCL3 rearrangements in B-cell lymphoid neoplasms occur in two
            breakpoint clusters associated with different diseases
  JOURNAL   Haematologica 109 (2), 493-508 (2024)
   PUBMED   37560801
  REMARK    GeneRIF: BCL3 rearrangements in B-cell lymphoid neoplasms occur in
            two breakpoint clusters associated with different diseases.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Liu,H., Zeng,L., Pan,M., Huang,L., Li,H., Liu,M., Niu,X., Zhang,C.
            and Wang,H.
  TITLE     Bcl-3 regulates T cell function through energy metabolism
  JOURNAL   BMC Immunol 24 (1), 35 (2023)
   PUBMED   37794349
  REMARK    GeneRIF: Bcl-3 regulates T cell function through energy metabolism.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Ge,P., Chen,X., Liu,J., Jing,R., Zhang,X. and Li,H.
  TITLE     Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by
            regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT
            signaling
  JOURNAL   Mol Carcinog 62 (7), 1073-1085 (2023)
   PUBMED   37132942
  REMARK    GeneRIF: Hsa_circ_0088036 promotes nonsmall cell lung cancer
            progression by regulating miR-1343-3p/Bcl-3 axis through
            TGFbeta/Smad3/EMT signaling.
REFERENCE   4  (residues 1 to 454)
  AUTHORS   Gehrke,N., Worns,M.A., Mann,A., Hovelmeyer,N., Waisman,A.,
            Straub,B.K., Galle,P.R. and Schattenberg,J.M.
  TITLE     Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis
            and subsequent acute liver failure
  JOURNAL   Cell Death Dis 13 (5), 510 (2022)
   PUBMED   35641486
  REMARK    GeneRIF: Hepatocyte Bcl-3 protects from death-receptor mediated
            apoptosis and subsequent acute liver failure.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 454)
  AUTHORS   Liu,H., Zeng,L., Yang,Y., Guo,C. and Wang,H.
  TITLE     Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation
  JOURNAL   Front Immunol 13, 847699 (2022)
   PUBMED   35355979
  REMARK    GeneRIF: Bcl-3: A Double-Edged Sword in Immune Cells and
            Inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 454)
  AUTHORS   Crossen,P.E., Kennedy,M.A., Heaton,D.C. and Morrison,M.J.
  TITLE     Cloning and sequencing of a t(14;19) breakpoint that involves the C
            mu switch region
  JOURNAL   Genes Chromosomes Cancer 8 (1), 60-62 (1993)
   PUBMED   7691160
REFERENCE   7  (residues 1 to 454)
  AUTHORS   Franzoso,G., Bours,V., Park,S., Tomita-Yamaguchi,M., Kelly,K. and
            Siebenlist,U.
  TITLE     The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa
            B-mediated inhibition
  JOURNAL   Nature 359 (6393), 339-342 (1992)
   PUBMED   1406939
REFERENCE   8  (residues 1 to 454)
  AUTHORS   Wulczyn,F.G., Naumann,M. and Scheidereit,C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   9  (residues 1 to 454)
  AUTHORS   Bhatia,K., Huppi,K., McKeithan,T., Siwarski,D., Mushinski,J.F. and
            Magrath,I.
  TITLE     Mouse bcl-3: cDNA structure, mapping and stage-dependent expression
            in B lymphocytes
  JOURNAL   Oncogene 6 (9), 1569-1573 (1991)
   PUBMED   1923524
  REMARK    GeneRIF: Characterization of the mouse BCL3 ortholog and comparison
            to the human gene.
REFERENCE   10 (residues 1 to 454)
  AUTHORS   Ohno,H., Takimoto,G. and McKeithan,T.W.
  TITLE     The candidate proto-oncogene bcl-3 is related to genes implicated
            in cell lineage determination and cell cycle control
  JOURNAL   Cell 60 (6), 991-997 (1990)
   PUBMED   2180580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092066.4, BU501187.1 and
            BC064993.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 13, 2008 this sequence version replaced NP_005169.1.
            
            Summary: This gene is a proto-oncogene candidate. It is identified
            by its translocation into the immunoglobulin alpha-locus in some
            cases of B-cell leukemia. The protein encoded by this gene contains
            seven ankyrin repeats, which are most closely related to those
            found in I kappa B proteins. This protein functions as a
            transcriptional co-activator that activates through its association
            with NF-kappa B homodimers. The expression of this gene can be
            induced by NF-kappa B, which forms a part of the autoregulatory
            loop that controls the nuclear residence of p50 NF-kappa B.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064993.1, SRR1163658.355456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000164227.10/ ENSP00000164227.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     Protein         1..454
                     /product="B-cell lymphoma 3 protein"
                     /note="B-cell lymphoma 3-encoded protein; B-cell
                     leukemia/lymphoma 3; chronic lymphatic leukemia protein;
                     BCL-3; proto-oncogene BCL3; B cell CLL/lymphoma 3"
                     /calculated_mol_wt=47453
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P20749.2)"
     Region          121..359
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          134..169
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..163
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          171..202
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          171..200
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          204..239
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          204..235
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Site            order(241,243,247..248,251..253,255..256,260,263,272,275,
                     277,281..282,285..287,289..290,294,297,306,308,310,
                     314..315,318..320,322..323,327,330,339)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          241..272
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          241..270
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          275..306
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          275..304
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          308..339
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          308..337
                     /region_name="ANK 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          338..367
                     /region_name="ANK 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Region          360..454
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P20749.2)"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P20749.2)"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3.
                     /evidence=ECO:0000269|PubMed:15469820; propagated from
                     UniProtKB/Swiss-Prot (P20749.2)"
     Site            406
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3.
                     /evidence=ECO:0000269|PubMed:15469820; propagated from
                     UniProtKB/Swiss-Prot (P20749.2)"
     CDS             1..454
                     /gene="BCL3"
                     /gene_synonym="BCL4; D19S37"
                     /coded_by="NM_005178.5:84..1448"
                     /db_xref="CCDS:CCDS12642.2"
                     /db_xref="GeneID:602"
                     /db_xref="HGNC:HGNC:998"
                     /db_xref="MIM:109560"
ORIGIN      
        1 mprcpagamd egpvdlrtrp kaaglpgaal plrkrplrap spepaaprga aglvvpldpl
       61 rggcdlpavp gpphglarpe alyypgallp lyptramgsp fplvnlptpl ypmmcpmehp
      121 lsadiamatr adedgdtplh iavvqgnlpa vhrlvnlfqq ggreldiynn lrqtplhlav
      181 ittlpsvvrl lvtagaspma ldrhgqtaah lacehrsptc lralldsaap gtldlearny
      241 dgltalhvav ntecqetvql llergadida vdiksgrspl ihavennsls mvqlllqhga
      301 nvnaqmysgs salhsasgrg llplvrtlvr sgadsslknc hndtplmvar srrvidilrg
      361 katrpastsq pdpspdrsan tspesssrls sngllsasps sspsqspprd ppgfpmappn
      421 fflpspsppa flpfagvlrg pgrpvppspa pggs
//
