LOCUS       NM_001387340            2154 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens BCL2L2-PABPN1 readthrough (BCL2L2-PABPN1), transcript
            variant 1, mRNA.
ACCESSION   NM_001387340
VERSION     NM_001387340.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Kim,M.J., Kim,J.H., Kim,M.S., Yang,H.J., Lee,M. and Kwon,D.Y.
  TITLE     Metabolomics Associated with Genome-Wide Association Study Related
            to the Basal Metabolic Rate in Overweight/Obese Korean Women
  JOURNAL   J Med Food 22 (5), 499-507 (2019)
   PUBMED   30990731
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049829.4.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring BCL2L2 (BCL2-like 2) and
            PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14.
            The read-through transcript encodes a fusion protein that shares
            sequence identity with each individual gene product. [provided by
            RefSeq, Dec 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.534034.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 599, 8106
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL049829.4         88891-88952
            63-150              AL049829.4         89250-89337
            151-590             AL049829.4         89818-90257
            591-707             AL049829.4         90874-90990
            708-822             AL049829.4         104239-104353
            823-890             AL049829.4         105057-105124
            891-997             AL049829.4         105435-105541
            998-1085            AL049829.4         106023-106110
            1086-1237           AL049829.4         106196-106347
            1238-2154           AL049829.4         107305-108221
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2154
                     /gene="BCL2L2-PABPN1"
                     /note="BCL2L2-PABPN1 readthrough"
                     /db_xref="GeneID:100529063"
                     /db_xref="HGNC:HGNC:42959"
     exon            1..62
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..150
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..590
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1277
                     /gene="BCL2L2-PABPN1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="BCL2L2-PABPN1 protein isoform 1"
                     /protein_id="NP_001374269.1"
                     /db_xref="GeneID:100529063"
                     /db_xref="HGNC:HGNC:42959"
                     /translation="MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQ
                     AMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVF
                     GAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEAR
                     RLREGNWASVRTVLTGAVALGALELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPP
                     PGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSG
                     HPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRA
                     RTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY"
     exon            591..707
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..822
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..890
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..997
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1085
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1237
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..2154
                     /gene="BCL2L2-PABPN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L2-PABPN1"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="BCL2L2-PABPN1"
                     /note="major polyA site"
ORIGIN      
        1 ctctccctcc ctcccagctc ctgcaccagg aaacggcccg gatcccggca gcggcctgac
       61 ccggctccac gctggccagg aggatgaaag gccccagctg ggggctcctt gccaccagtg
      121 ctgtgtctta agagctgcca tcccggctgg ccgcccggat ggcgacccca gcctcggccc
      181 cagacacacg ggctctggtg gcagactttg taggttataa gctgaggcag aagggttatg
      241 tctgtggagc tggccccggg gagggcccag cagctgaccc gctgcaccaa gccatgcggg
      301 cagctggaga tgagttcgag acccgcttcc ggcgcacctt ctctgatctg gcggctcagc
      361 tgcatgtgac cccaggctca gcccaacaac gcttcaccca ggtctccgat gaactttttc
      421 aagggggccc caactggggc cgccttgtag ccttctttgt ctttggggct gcactgtgtg
      481 ctgagagtgt caacaaggag atggaaccac tggtgggaca agtgcaggag tggatggtgg
      541 cctacctgga gacgcagctg gctgactgga tccacagcag tgggggctgg gcggagttca
      601 cagctctata cggggacggg gccctggagg aggcgcggcg tctgcgggag gggaactggg
      661 catcagtgag gacagtgctg acgggggccg tggcactggg ggccctggag ctggaagcta
      721 tcaaagctcg agtcagggag atggaggaag aagctgagaa gctaaaggag ctacagaacg
      781 aggtagagaa gcagatgaat atgagtccac ctccaggcaa tgctggcccg gtgatcatgt
      841 ccattgagga gaagatggag gctgatgccc gttccatcta tgttggcaat gtggactatg
      901 gtgcaacagc agaagagctg gaagctcact ttcatggctg tggttcagtc aaccgtgtta
      961 ccatactgtg tgacaaattt agtggccatc ccaaagggtt tgcgtatata gagttctcag
     1021 acaaagagtc agtgaggact tccttggcct tagatgagtc cctatttaga ggaaggcaaa
     1081 tcaaggtgat cccaaaacga accaacagac caggcatcag cacaacagac cggggttttc
     1141 cacgagcccg ctaccgcgcc cggaccacca actacaacag ctcccgctct cgattctaca
     1201 gtggttttaa cagcaggccc cggggtcgcg tctacagggg ccgggctaga gcgacatcat
     1261 ggtattcccc ttactaaaaa aagtgtgtat taggaggaga gagaggaaaa aaagaggaaa
     1321 gaaggaaaaa aaaaagaatt aaaaaaaaaa aaaagaaaaa cagaagatga ccttgatgga
     1381 aaaaaaatat tttttaaaaa aaagatatac tgtggaaggg gggagaatcc cataactaac
     1441 tgctgaggag ggacctgctt tggggagtag gggaaggccc agggagtggg gcagggggct
     1501 gcttattcac tctggggatt cgccatggac acgtctcaac tgcgcaagct gctgcccatg
     1561 tttccctgcc ccacttcacc cccttggggg ctgctcaagg gtaggtgggc gtgggtggta
     1621 ggaggttttt ttttttaccc agggctctgg aaggacacca aactgttctg cttgttacct
     1681 tccctccgtc ttctcctcgc ctttcacagt cccctcctgc ctgctcctgt ccagccaggt
     1741 ctaccaccca ccccacccct cttctccggc tccctgcccc tccagattgc ctggtgatct
     1801 attttgtttc cttttgtgtt tctttttctg ttttgagtgt ctttctttgc aggtttctgt
     1861 agccggaaga tctccgttcc gctcccagcg gctccagtgt aaattcccct tccccctggg
     1921 gaaatgcact accttgtttt ggggggttta ggggtgtttt tgtttttcag ttgttttgtt
     1981 tttttgtttt tttttttttt cctttgcctt ttttcccttt tatttggagg gaatgggagg
     2041 aagtgggaac agggaggtgg gaggtggatt ttgtttattt ttttagctca tttccagggg
     2101 tgggaatttt tttttaatat gtgtcatgaa taaagttgtt tttgaaaata aaaa
//
