LOCUS       NM_004050               3526 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BCL2 like 2 (BCL2L2), transcript variant 1, mRNA.
ACCESSION   NM_004050
VERSION     NM_004050.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Diepstraten,S.T., La Marca,J.E., Chang,C., Young,S., Strasser,A.
            and Kelly,G.L.
  TITLE     BCL-W makes only minor contributions to MYC-driven lymphoma
            development
  JOURNAL   Oncogene 42 (37), 2776-2781 (2023)
   PUBMED   37567974
  REMARK    GeneRIF: BCL-W makes only minor contributions to MYC-driven
            lymphoma development.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Deng,J., Ning,K., Liu,D., Wu,D., Wan,R. and Ge,J.
  TITLE     MiR-140 promotes the progression of intracranial aneurysms by
            targeting BCL2L2
  JOURNAL   Neuroreport 34 (1), 38-45 (2023)
   PUBMED   36441929
  REMARK    GeneRIF: MiR-140 promotes the progression of intracranial aneurysms
            by targeting BCL2L2.
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Zhang,L., Wang,D., Han,X., Guo,X., Cao,Y., Xia,Y. and Gao,D.
  TITLE     Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma
            cells
  JOURNAL   J Cell Mol Med 26 (17), 4686-4697 (2022)
   PUBMED   35894779
  REMARK    GeneRIF: Novel read-through fusion transcript Bcl2l2-Pabpn1 in
            glioblastoma cells.
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Zhou,Y., Zhang,S., Min,Z., Yu,Z., Zhang,H. and Jiao,J.
  TITLE     Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to
            regulate proliferation, migration, invasion and apoptosis of oral
            squamous cell carcinoma cells
  JOURNAL   BMC Cancer 21 (1), 1085 (2021)
   PUBMED   34620126
  REMARK    GeneRIF: Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis
            to regulate proliferation, migration, invasion and apoptosis of
            oral squamous cell carcinoma cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Middleton,G., Wyatt,S., Ninkina,N. and Davies,A.M.
  TITLE     Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L)
            in regulating sensory neuron survival
  JOURNAL   Development 128 (3), 447-457 (2001)
   PUBMED   11152643
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Hsu,S.Y., Lin,P. and Hsueh,A.J.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Ross,A.J., Waymire,K.G., Moss,J.E., Parlow,A.F., Skinner,M.K.,
            Russell,L.D. and MacGregor,G.R.
  TITLE     Testicular degeneration in Bclw-deficient mice
  JOURNAL   Nat Genet 18 (3), 251-256 (1998)
   PUBMED   9500547
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M.,
            Cory,S. and Huang,D.C.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
REFERENCE   10 (bases 1 to 3526)
  AUTHORS   Gibson,L., Holmgreen,S.P., Huang,D.C., Bernard,O., Copeland,N.G.,
            Jenkins,N.A., Sutherland,G.R., Baker,E., Adams,J.M. and Cory,S.
  TITLE     bcl-w, a novel member of the bcl-2 family, promotes cell survival
  JOURNAL   Oncogene 13 (4), 665-675 (1996)
   PUBMED   8761287
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049829.4.
            
            On Nov 30, 2019 this sequence version replaced NM_004050.4.
            
            Summary: This gene encodes a member of the BCL-2 protein family.
            The proteins of this family form hetero- or homodimers and act as
            anti- and pro-apoptotic regulators. Expression of this gene in
            cells has been shown to contribute to reduced cell apoptosis under
            cytotoxic conditions. Studies of the related gene in mice indicated
            a role in the survival of NGF- and BDNF-dependent neurons. Mutation
            and knockout studies of the mouse gene demonstrated an essential
            role in adult spermatogenesis. Alternative splicing results in
            multiple transcript variants. Read-through transcription also
            exists between this gene and the neighboring downstream PABPN1
            (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87461.1, SRR11853558.6795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250405.10/ ENSP00000250405.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL049829.4         88891-88952
            63-150              AL049829.4         89250-89337
            151-590             AL049829.4         89818-90257
            591-3526            AL049829.4         90874-93809
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3526
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /note="BCL2 like 2"
                     /db_xref="GeneID:599"
                     /db_xref="HGNC:HGNC:995"
                     /db_xref="MIM:601931"
     exon            1..62
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /inference="alignment:Splign:2.1.0"
     exon            63..150
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /inference="alignment:Splign:2.1.0"
     exon            151..590
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..740
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /note="apoptosis regulator BCL-W; protein phosphatase 1,
                     regulatory subunit 51"
                     /codon_start=1
                     /product="bcl-2-like protein 2"
                     /protein_id="NP_004041.2"
                     /db_xref="CCDS:CCDS9591.1"
                     /db_xref="GeneID:599"
                     /db_xref="HGNC:HGNC:995"
                     /db_xref="MIM:601931"
                     /translation="MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQ
                     AMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVF
                     GAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEAR
                     RLREGNWASVRTVLTGAVALGALVTVGAFFASK"
     exon            591..3526
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /note="hexamer: AATAAA"
     polyA_site      3526
                     /gene="BCL2L2"
                     /gene_synonym="BCL-W; BCL2-L-2; BCLW; PPP1R51"
                     /note="major polyA site"
ORIGIN      
        1 ctctccctcc ctcccagctc ctgcaccagg aaacggcccg gatcccggca gcggcctgac
       61 ccggctccac gctggccagg aggatgaaag gccccagctg ggggctcctt gccaccagtg
      121 ctgtgtctta agagctgcca tcccggctgg ccgcccggat ggcgacccca gcctcggccc
      181 cagacacacg ggctctggtg gcagactttg taggttataa gctgaggcag aagggttatg
      241 tctgtggagc tggccccggg gagggcccag cagctgaccc gctgcaccaa gccatgcggg
      301 cagctggaga tgagttcgag acccgcttcc ggcgcacctt ctctgatctg gcggctcagc
      361 tgcatgtgac cccaggctca gcccaacaac gcttcaccca ggtctccgat gaactttttc
      421 aagggggccc caactggggc cgccttgtag ccttctttgt ctttggggct gcactgtgtg
      481 ctgagagtgt caacaaggag atggaaccac tggtgggaca agtgcaggag tggatggtgg
      541 cctacctgga gacgcagctg gctgactgga tccacagcag tgggggctgg gcggagttca
      601 cagctctata cggggacggg gccctggagg aggcgcggcg tctgcgggag gggaactggg
      661 catcagtgag gacagtgctg acgggggccg tggcactggg ggccctggta actgtagggg
      721 ccttttttgc tagcaagtga aagtccaggg ccaggtgggg ctaggtgtgg ctgggggcca
      781 ggagagcagg aacagaacag agaaatgccc ttggaagaag tggagttggt ggatgggtgg
      841 gcatggaaca ggatgggcag agaaagggta gtgtgtgagg gagctgagta ggccaggtag
      901 gcgattggaa gagtgagcag gacacagagg ggaggggaat gttttggcaa gtttaggggc
      961 acaggagatg tagtcgttcc agggctgggg gaggtgggag ggatcacgcc tataggtgtg
     1021 ggcacatgaa acgacctgga acttgcttca cagccctgag gaaggtggac ttacataagc
     1081 agctgtattc cattagatga gtgggattta gggaacgcag aaggcacatc cctttggaat
     1141 ggaagcttag gggttctcag gtgataggga gaggtggctg ttaacagtgg gctgcttgga
     1201 cacgcgtgtg catgtgcacg catgctggtg tgcatgctgg gctgcctggc aaatctggtg
     1261 gtgatgggat tcctcaagga gaaaacattc cctcttgcaa tggcaagaac taggggcagt
     1321 tctctgtccc tcctcccaac ccctcctttc ccctgccctt gtcctgatgc ctcaaggctt
     1381 agagagaaac attgtatcca gaccgagggc tctgctgctt ctttccagaa agtgattggc
     1441 aaggctttgg agagaagagc agttctgcag ctggccttgt tccttcatca tcccccttcc
     1501 ttgtgcatta tgcacttgct gctgcctcct gggctctgat agaagggcag ggctgttgag
     1561 cctggatggg tggaggctta ggtagccgga cctgcctgcc accctcctct cccactcagg
     1621 cacaatggtg cctaaagtgt ttccaatctc tgggacctct gtacccaaac tgaaactcta
     1681 aattggggcc ctaactaatt ttccttttga ggttgtgggc ataagtgctg atctagaata
     1741 cagtctgggt cccacactgt gtctcagtga gactgttgat gccttgagat gaccatttca
     1801 gatctgaatc ccatgggtgt gagggtgatg ggtactccag gactggccta tgctgtgttg
     1861 tgggctttgg ttcggcttta tcaggggcca ggcatatggg ttctagagta cctaccatga
     1921 cctagaagca tttatgattt atttgaagcc acactgtttg catgggtgtt acttgtctgt
     1981 acctcagagt ctgaggatgt taactttgga actcgcagtc ctctagaaca gcttcagatt
     2041 atggcttttt cttttgagga agaaattatt cactccagat gcatgccctg agccagacct
     2101 cactgctgca ctttccaagg tgctaagatt gctgctctcc aatgctaact ttctgacaca
     2161 gtgctctaga accctgcctg tggtcctgag cactgatcac cttagctaga ccatggttga
     2221 ctcttcttgg agattttcac ttggtcctag aatgtggcaa cgtagttgtg ctcgccagaa
     2281 cgtgggacca aattggcctc aggtgttgag tccagacttc tgcttttgag agagggctgc
     2341 actttttcat ggtatttcta ggggaggtgg taggctgcat gtgccacttg gtcttgttgt
     2401 gagtatgctg acaccagaaa ctcagagcca gcttgtggca agcagttggg gtggggggtc
     2461 tctgacttgc tcaggacaaa ctaggccagt ggttttcaaa ctgcttggca gagccctgaa
     2521 gtttcctagg ggttgcctca ggagtccttg gggagatgaa gggggtgggg agctgagcag
     2581 gctgggcaat ttgccctcaa acagaacagc tccccttgta gctgtcttac atattggggt
     2641 tcagggtaag attttatttg cattaagggg tttgctgctg aaaaaaagtt ggaaaaccac
     2701 tgactagacc atcggctcca aattggagtc tgtgcttcct tccccaggta tggagcacac
     2761 tcttcaccct accctctacc acaggacaca tatccctgtt agcattcccc gggaccttta
     2821 gccaagagga gctgcaggga ccatggccag gttaccaaaa tgccctgctc tgaagccttg
     2881 acacctgggt ggaaagagag gctgttttct gaaagggtaa agggcttggt ctggattccc
     2941 agaagcatag cttagatggg accacagtgg gcaattttga cctgtcctgc ccttcttagc
     3001 ttgaagggaa accccagaga ctcttctgtc agggaaaact agggactctc ttctagagcc
     3061 atatagttcc ttgggattag ctcttggcca agaaggctga gtatggttcc caatttttaa
     3121 atccatttca ttttttaaaa aataagggaa ataaatgtaa ttgccatttt tcaaagatta
     3181 agtaggagga gaggggtttc ttgctctcca gagcccaaag ggacaaatag ggactttgtt
     3241 taggccaagg aaggagcgga agtagggcaa ctcggtcctg cgattattaa tcccactccc
     3301 cacttattct agggcacaca aacactattt tactttttta aaatcataaa acggcagaac
     3361 agatttggtt agtttagaag aaaagaaagc tctataaata taaatctata ttcctgtatt
     3421 tttatttaat aatttataaa taccaagttc atttgacttt tatttttgtg taatatgtaa
     3481 tgatcgtatt aaaaacaata aataaagccc agaagtttaa tgagaa
//
