LOCUS       NM_001010922            5005 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BCL2 like 15 (BCL2L15), mRNA.
ACCESSION   NM_001010922 XM_496384
VERSION     NM_001010922.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5005)
  AUTHORS   Vivarelli,S., Falzone,L., Candido,S., Bonavida,B. and Libra,M.
  TITLE     YY1 Silencing Induces 5-Fluorouracil-Resistance and BCL2L15
            Downregulation in Colorectal Cancer Cells: Diagnostic and
            Prognostic Relevance
  JOURNAL   Int J Mol Sci 22 (16), 8481 (2021)
   PUBMED   34445183
  REMARK    GeneRIF: YY1 Silencing Induces 5-Fluorouracil-Resistance and
            BCL2L15 Downregulation in Colorectal Cancer Cells: Diagnostic and
            Prognostic Relevance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5005)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5005)
  AUTHORS   Zhang,J.X., Yan,X.J., Wu,S., Liu,Q. and Ma,J.M.
  TITLE     KLF16 overexpression deleteriously affects the proliferation and
            migration of retinoblastoma by transcriptionally repressing BCL2L15
  JOURNAL   Biochem Biophys Res Commun 529 (4), 977-983 (2020)
   PUBMED   32819608
  REMARK    GeneRIF: KLF16 overexpression deleteriously affects the
            proliferation and migration of retinoblastoma by transcriptionally
            repressing BCL2L15.
REFERENCE   4  (bases 1 to 5005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5005)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5005)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   7  (bases 1 to 5005)
  AUTHORS   Pujianto,D.A., Damdimopoulos,A.E., Sipila,P., Jalkanen,J.,
            Huhtaniemi,I. and Poutanen,M.
  TITLE     Bfk, a novel member of the bcl2 gene family, is highly expressed in
            principal cells of the mouse epididymis and demonstrates a
            predominant nuclear localization
  JOURNAL   Endocrinology 148 (7), 3196-3204 (2007)
   PUBMED   17412810
REFERENCE   8  (bases 1 to 5005)
  AUTHORS   Luo,H.Y., Yu,S.F. and Li,T.J.
  TITLE     Differential expression of apoptosis-related proteins in various
            cellular components of ameloblastomas
  JOURNAL   Int J Oral Maxillofac Surg 35 (8), 750-755 (2006)
   PUBMED   16690252
REFERENCE   9  (bases 1 to 5005)
  AUTHORS   Dempsey,C.E., Dive,C., Fletcher,D.J., Barnes,F.A., Lobo,A.,
            Bingle,C.D., Whyte,M.K. and Renshaw,S.A.
  TITLE     Expression of pro-apoptotic Bfk isoforms reduces during malignant
            transformation in the human gastrointestinal tract
  JOURNAL   FEBS Lett 579 (17), 3646-3650 (2005)
   PUBMED   15961081
  REMARK    GeneRIF: In the transition from normal tissue to tumour,
            pro-apoptotic Bfk isoform expression is substantially reduced in up
            to 80% of tumours isolated from the human gastrointestinal tract
            compared to tumours from outside the gastrointestinal tract.
REFERENCE   10 (bases 1 to 5005)
  AUTHORS   Coultas,L., Pellegrini,M., Visvader,J.E., Lindeman,G.J., Chen,L.,
            Adams,J.M., Huang,D.C. and Strasser,A.
  TITLE     Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family
            with a BH3 and a BH2 region
  JOURNAL   Cell Death Differ 10 (2), 185-192 (2003)
   PUBMED   12700646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137856.24, AI821052.1, AY265861.1 and BX116361.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289439.1, BM829833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393316.8/ ENSP00000376992.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL137856.24        94635-94668         c
            35-206              AI821052.1         1-172
            207-698             AY265861.1         1-492
            699-4683            AL137856.24        84225-88209         c
            4684-5005           BX116361.1         16-337              c
FEATURES             Location/Qualifiers
     source          1..5005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..5005
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="BCL2 like 15"
                     /db_xref="GeneID:440603"
                     /db_xref="HGNC:HGNC:33624"
                     /db_xref="MIM:619660"
     exon            1..333
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..698
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="pro-apoptotic Bcl-2 protein; bcl2-L-15; bcl-2
                     family kin"
                     /codon_start=1
                     /product="bcl-2-like protein 15"
                     /protein_id="NP_001010922.1"
                     /db_xref="CCDS:CCDS30809.1"
                     /db_xref="GeneID:440603"
                     /db_xref="HGNC:HGNC:33624"
                     /db_xref="MIM:619660"
                     /translation="MKSSQTFEEQTECIVNTLLMDFLSPTLQVASRNLCCVDEVDSGE
                     PCSFDVAIIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQ
                     DSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGMINGNQAIREFIQGQGGWEN
                     LES"
     exon            334..455
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:2.1.0"
     exon            456..680
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:2.1.0"
     exon            681..5005
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /inference="alignment:Splign:2.1.0"
     regulatory      781..786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="major polyA site"
     regulatory      3201..3206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="hexamer: AATAAA"
     polyA_site      3226
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="major polyA site"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="hexamer: AACAAA"
     polyA_site      3653
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
     regulatory      4985..4990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="hexamer: AATGAA"
     polyA_site      5005
                     /gene="BCL2L15"
                     /gene_synonym="Bfk; C1orf178"
                     /note="major polyA site"
ORIGIN      
        1 agttccaagt aggtaatcct tctgagaagt cccacctttc tgagcagctg tgtttgaaga
       61 aagctagtgg gaaaagttcc aggattacat gtcaggaaac tacaagaggt agaaacattt
      121 gttgatttac cagtgttttt aacttcctgc tgggctgaaa actgcttgtt tcgtggaaaa
      181 gcaaaacttg acagcaaaca tctaaaatga agagctccca aacttttgag gaacaaacgg
      241 aatgcattgt gaacactcta ctcatggact tcttgagccc aacattgcag gttgccagcc
      301 ggaacctatg ctgtgtagat gaagtagatt caggagagcc ttgttctttt gatgtggcta
      361 tcattgctgg tcgccttcgg atgttgggtg accagttcaa cggagaattg gaagcttctg
      421 ccaaaaacgt cattgcagaa accattaagg gacagacagg agctatactc caggacactg
      481 tggaatctct cagcaagacc tggtgtgctc aggattccag cttagcttat gagagagctt
      541 ttctggcagt gtcagtgaaa cttcttgagt acatggctca cattgctcct gaagtagtgg
      601 gacaggtggc tatccccatg acgggtatga tcaatgggaa ccaagccatc cgggagttca
      661 tccagggcca gggaggttgg gaaaatctgg agagctgaag agttggagct attcacgaga
      721 ctgaacatca cttccttgtt gactgattgg gtgattgatt cctgggaatt caaacaaaca
      781 aataaaaaag cacttttttc attttatcag aactgaactt agctgaataa gttatttttt
      841 actgattgtt aaagttggga gcagctgcca gaggcctgca gagttggttt ttgttttgtt
      901 ttgttttgtc aacttaatgc aaaccacaga gattttctac tttctgtttt cacatgagtt
      961 ttaatgaggt tctgttgaag caaagacccc tagacacaaa gtaatgactt gttagtagtg
     1021 gaattataag caacagggca ggcctttgct ggaggtattt tgagagaaag ggagaacaat
     1081 ggaaactatt tcttcagatg tagccctgtc ttttggtaag aattgtgcct actaattttg
     1141 caatttaaag gatttcagga agctttttgg ttgaaaaatc ttgttttttt ttttttagac
     1201 gtagtctcac tctgtcaccc aggctggagt gcagtggtgc gatctcagct cactgcaagc
     1261 tccacctccc ggtttcactc cattctcctg cctcagcctc ctgagtagct gggactacag
     1321 gagcccgcca tcacgcccgg ctaatttttt gtatttttag tagagatgag gtttcgccgt
     1381 gttagccagg atggtctgga tctcctgacc tcgtgattcg cccgccttgg cctcccaaag
     1441 tgctgggatt acaggcgtga gccaccacgc ccggcctaaa atcttgttat tttaagttga
     1501 gcattttcat tcaaaatcat ccctaaactt catgttaatt tcacctgaga aggactattt
     1561 tatgcatttt agaggttgga agcaaaaaac aaacaaacaa acaaaaacag ttgtttctac
     1621 taggaaggtc aaagaaaata aaagttactc catttttact gccacaggat gcaggaagtg
     1681 ctggcccaca tctaggacag caaggccacc ccagcttaga tgaagctagc tgcataacac
     1741 aaagctttaa aagtgtggtt cacacaccac ttgtggacct tattgaattg ctgattcgca
     1801 ttcctagaga ttctgattct gtaggggtag gctggagcct aggaacctac cttttaaact
     1861 agttccatag gtgattctga tgtacatata gagtgtgaca gccatcacta tagagaatag
     1921 attgataaat tacaacccac gcgtcaaatc tggcttgctg tcttattttg taaataaagt
     1981 tttattggaa tagagcaaca ttcacttgtt tacatattgt ccatggccgc ttttgtgcta
     2041 caatggcaga gttgaatgat tatagaagac catatggctg gttaagtcca aaatatttac
     2101 tagctggccc tttacagaaa aagttggctg accccttctc taaatcaaca tttctccttg
     2161 gtaactgaaa ctctattaca gtcctgacaa ttccagcaaa cacagctgta gatagggttt
     2221 aaactcaaag atatttaact cttctttggg aacttagtct ccatatgttt gttagttctt
     2281 gcataatcca cagtttctct gggtcttcag ccaatcagag agctctgtag ctcctgagta
     2341 gtccatttct ctggccctac aagtgagagt gattggaagc aaagcttatg atttgtatga
     2401 tcttgtatct caaaatagtc cttaatgatc taatagatta gtaggcagtc atcaggtaga
     2461 gactccaaaa accagactac tttcctaaat atcaagaaga aaggcattgc tacagtgatt
     2521 catgaaaagc agcattaata actttggcta aagtttaaca aagctaacca cttcccctct
     2581 atcagccagc catctatgta tctcctctaa atgcagagaa gtaaatatgt agtgctgtta
     2641 atacattttt gctttttaaa gttatgcttt gtcctggcgc agtggctcat gcctgtaatc
     2701 ccagcacttt gggaggccaa ggcgggtgga tcacctgagg ttaggagttt gagaccagcc
     2761 tggccaacat ggtgaaaccc tgtctctgct aaaaatacaa aaaattagcc aggcttggtg
     2821 gcacgtgcct gtaatgccag ctactcagga ggctgaggca ggagaatcac ttgaacctgg
     2881 gaggcggagg ttgctgtgag ctgagttcgc gccattgcac tccagcctgg gctacaaaag
     2941 cgaaactgtc taaaaaaaaa aaaagaaaat aaataaagtt atgctttttc ctctattcct
     3001 agttaaatca caacaagtta gtaatccata aatgatgtgt cctgtttctc tttagtagaa
     3061 attatatttt tggctaccag ttaagaaact tgtactcctt tgtcccttat gttactataa
     3121 actcaagatg atgagttttg tggtatttga cttcataggc aaaatcaaaa tttttacttt
     3181 gttgctattc tgttttatga aataaacttc tgtctatgca tttgaactaa gtttcagcaa
     3241 attcaatcta aattgaataa ttccagctcc cagttttatc ctatgttgct cataaaacag
     3301 ttccaagtat actgcattat cttgagattt gaagatatgg tgcccacggg gattatacta
     3361 ggcaaatgcg ttaagcagct ctggcctagg tgttgtgtat tttaagagac tctatcttag
     3421 gagagcttaa gtgattgggc tgcaggaaga agacattgta acccaggaat taaaaatgga
     3481 ttcagattgc ctgattttaa cactttagtt tcaccatagg ctaattatgt gacattgggc
     3541 aagagacata attcttctgt accttagttt ctacatttgt aaaatagaga tgatttggta
     3601 acttattaat aagatttttg tgagagataa ataaaacaaa tacattttgt aaagggtgag
     3661 tacttggaat attttaaaca ctgtgccatt agcaatttgg aattctgtgt tatgcagttc
     3721 ataaggttct agcttgactt ttttctctct ccattaaccc tgtctctcac agatgcaaac
     3781 cactcttaat ggctttactt tcacatcaat gtgagtgatt cctaaatatg atttatttcc
     3841 cttctcaatt ccatacccac agatgcttat tatttattta tgtgtacctt tcttatcccc
     3901 atactctccc tgtttgcgat acaactagct caaaacctca gtcattttta ccttgtctct
     3961 ctctctccag tccaactcac ccaactagtt tttctcattt gttacttcat ttttgtcctg
     4021 gttcttctac cagatttatt agcaactgcc tggactatta ataaagcctc ctacttaggc
     4081 tttcaataga ttgttctgtt cctgctccat tccagtctgt cctatatact gccatcagat
     4141 tgatcaaagc tgtggtttct ttgtctatta ttttgattca tttttagata tggtatcatt
     4201 catttttaaa tttaacatac caatgaagat tacaagactt aaacatctta tcagaagggg
     4261 gcatttattt tttaaatcaa gaaataactt tccaaaagca ttgctttgaa tgccattctc
     4321 ttaaagtcct tcagtggaac ttttgagtgt gattagacat gttcattatc ttgattgtag
     4381 tgattttatg ggtgatgatt tcacaccaac ttatcaaact gcatactttg aaatgtgtag
     4441 tttattgtac atcagcacta ccttaataag gttgtttttt ttaaaaaaaa aaaaaaaacc
     4501 ttcagctgct ccctactgtt catcaaataa cagtctgata ttcaaattcc cccagtatct
     4561 ggccctaact gccctatata gccttaatca atcatgattc tcctctacaa tcccaatgct
     4621 ctagtataac cgagccagtc actaaagctg ccctcctcct actgttccct atgtttcata
     4681 ttcctttttc tgaggctcta cctgtagaca tcttcaagac ccaacccaac tgtcatgaag
     4741 ccttctccat gaaggctatc catataacca gaataagaag tggtctttgc ctccttgaac
     4801 ttttgtttgt accactttta tgtttcttat ccaaaaaatg gccttaagtt gtaattatct
     4861 gtatagtcat cttccccact aggataaagg attgctgaat gatacaattt gttgtatact
     4921 tctgtaacac ccctcctctt cattatctgg catgtacatc gatattaaaa atattcatta
     4981 aatgaatgaa tagctgattg actca
//
