LOCUS       NM_015367               4959 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BCL2 like 13 (BCL2L13), transcript variant 1, mRNA.
ACCESSION   NM_015367
VERSION     NM_015367.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4959)
  AUTHORS   Jacobs,J., Iranpour,R., Behrooz,A.B., da Silva Rosa,S.C. and
            Ghavami,S.
  TITLE     The role of BCL2L13 in glioblastoma: turning a need into a target
  JOURNAL   Biochem Cell Biol 102 (2), 127-134 (2024)
   PUBMED   37988705
  REMARK    GeneRIF: The role of BCL2L13 in glioblastoma: turning a need into a
            target.
            Review article
REFERENCE   2  (bases 1 to 4959)
  AUTHORS   Xu,J., Hashino,T., Tanaka,R., Kawaguchi,K., Yoshida,H. and
            Kataoka,T.
  TITLE     The BCL-2 family protein BCL-RAMBO interacts and cooperates with
            GRP75 to promote its apoptosis signaling pathway
  JOURNAL   Sci Rep 13 (1), 14041 (2023)
   PUBMED   37640805
  REMARK    GeneRIF: The BCL-2 family protein BCL-RAMBO interacts and
            cooperates with GRP75 to promote its apoptosis signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4959)
  AUTHORS   Zhang,G., Guo,J., Zeng,J., Zhang,X., Chen,R., Wang,G. and Liang,W.
  TITLE     LncRNA SNHG14 is beneficial to oxygen glucose
            deprivation/reoxygenation-induced neuro-2a cell injury via
            mir-98-5p sequestration-caused BCL2L13 upregulation
  JOURNAL   Metab Brain Dis 37 (6), 2005-2016 (2022)
   PUBMED   35678981
  REMARK    GeneRIF: LncRNA SNHG14 is beneficial to oxygen glucose
            deprivation/reoxygenation-induced neuro-2a cell injury via
            mir-98-5p sequestration-caused BCL2L13 upregulation.
REFERENCE   4  (bases 1 to 4959)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 4959)
  AUTHORS   Jakiela,B., Szczeklik,W., Sokolowska,B., Mastalerz,L., Sanak,M.,
            Plutecka,H. and Szczeklik,A.
  TITLE     Intrinsic pathway of apoptosis in peripheral blood eosinophils of
            Churg-Strauss syndrome
  JOURNAL   Rheumatology (Oxford) 48 (10), 1202-1207 (2009)
   PUBMED   19643727
REFERENCE   6  (bases 1 to 4959)
  AUTHORS   Banga,S., Gao,P., Shen,X., Fiscus,V., Zong,W.X., Chen,L. and
            Luo,Z.Q.
  TITLE     Legionella pneumophila inhibits macrophage apoptosis by targeting
            pro-death members of the Bcl2 protein family
  JOURNAL   Proc Natl Acad Sci U S A 104 (12), 5121-5126 (2007)
   PUBMED   17360363
  REMARK    GeneRIF: SidF contributes to apoptosis resistance in L.
            pneumophila-infected cells by specifically interacting with and
            neutralizing the effects of BNIP3 and Bcl-rambo, two proapoptotic
            members of Bcl2 protein family.
REFERENCE   7  (bases 1 to 4959)
  AUTHORS   Holleman,A., den Boer,M.L., de Menezes,R.X., Cheok,M.H., Cheng,C.,
            Kazemier,K.M., Janka-Schaub,G.E., Gobel,U., Graubner,U.B.,
            Evans,W.E. and Pieters,R.
  TITLE     The expression of 70 apoptosis genes in relation to lineage,
            genetic subtype, cellular drug resistance, and outcome in childhood
            acute lymphoblastic leukemia
  JOURNAL   Blood 107 (2), 769-776 (2006)
   PUBMED   16189266
REFERENCE   8  (bases 1 to 4959)
  AUTHORS   Yi,P., Zhang,W., Zhai,Z., Miao,L., Wang,Y. and Wu,M.
  TITLE     Bcl-rambo beta, a special splicing variant with an insertion of an
            Alu-like cassette, promotes etoposide- and Taxol-induced cell death
  JOURNAL   FEBS Lett 534 (1-3), 61-68 (2003)
   PUBMED   12527362
  REMARK    GeneRIF: Our data support the speculation that the Alu element
            insertion during the splicing process may play an important role in
            the generation of protein diversity in primate cells by a yet
            uncharacterized mechanism
REFERENCE   9  (bases 1 to 4959)
  AUTHORS   Kataoka,T., Holler,N., Micheau,O., Martinon,F., Tinel,A.,
            Hofmann,K. and Tschopp,J.
  TITLE     Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its
            unique C-terminal extension
  JOURNAL   J Biol Chem 276 (22), 19548-19554 (2001)
   PUBMED   11262395
REFERENCE   10 (bases 1 to 4959)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006285.13.
            
            On May 17, 2019 this sequence version replaced NM_015367.3.
            
            Summary: This gene encodes a mitochondrially-localized protein with
            conserved B-cell lymphoma 2 homology motifs. Overexpression of the
            encoded protein results in apoptosis. Alternatively spliced
            transcript variants have been observed for this gene. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.84445.1,
                                           SRR1803615.212142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000317582.10/
                                                  ENSP00000318883.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC006285.13        26670-26799
            131-301             AC006285.13        43575-43745
            302-409             AC006285.13        71127-71234
            410-566             AC006285.13        76899-77055
            567-636             AC006285.13        84054-84123
            637-780             AC006285.13        90156-90299
            781-4959            AC006285.13        114590-118768
FEATURES             Location/Qualifiers
     source          1..4959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..4959
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="BCL2 like 13"
                     /db_xref="GeneID:23786"
                     /db_xref="HGNC:HGNC:17164"
                     /db_xref="MIM:619822"
     exon            1..130
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..301
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1638
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="isoform a is encoded by transcript variant 1;
                     Bcl-2-like protein 13; BCL2-like 13 (apoptosis
                     facilitator)"
                     /codon_start=1
                     /product="bcl-2-like protein 13 isoform a"
                     /protein_id="NP_056182.2"
                     /db_xref="CCDS:CCDS13746.1"
                     /db_xref="GeneID:23786"
                     /db_xref="HGNC:HGNC:17164"
                     /db_xref="MIM:619822"
                     /translation="MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQL
                     DIASQSLDQEILLKVKTEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMED
                     CLAHLGEKVSQELKEPLHKALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLL
                     RQMLLELTRRGQEPLSALLQFGVTYLEDYSAEYIIQQGGWGTVFSLESEEEEYPGITA
                     EDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESW
                     QQIAMDPEEVKSLDSNGAGEKSENNSSNSDIVHVEKEEVPEGMEEAAVASVVLPAREL
                     QEALPEAPAPLLPHITATSLLGTREPDTEVITVEKSSPATSLFVELDEEEVKAATTEP
                     TEVEEVVPALEPTETLLSEKEINAREESLVEELSPASEKKPVPPSEGKSRLSPAGEMK
                     PMPLSEGKSILLFGGAAAVAILAVAIGVALALRKK"
     exon            302..409
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..566
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..636
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..780
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..4959
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3211..3216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="hexamer: AATAAA"
     polyA_site      3244
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="major polyA site"
     regulatory      3289..3294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="hexamer: AATAAA"
     polyA_site      3329
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
     regulatory      3608..3613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
     regulatory      4703..4708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
                     /note="hexamer: AATAAA"
     polyA_site      4723
                     /gene="BCL2L13"
                     /gene_synonym="BCL-RAMBO; Bcl2-L-13; MIL1"
ORIGIN      
        1 accctccaac atggcggcgg cggtagatta gggccgcggg tcggagcact caccgccgct
       61 gggggaccct gtcggaagca actgccgccg ccgcctcttt catctcttct ggggcagggg
      121 ccagggccag gttttacaca tccataagta gacctttttg gagcctcacc agccaattca
      181 atggcgtcct cttctactgt gcctctggga tttcactatg aaacaaagta tgttgttctc
      241 agctacttgg gactcctctc tcaagagaag ctgcaagagc aacatctttc ctcaccccaa
      301 ggggttcaac tagatatagc ttcacaatct ctggatcaag aaattttatt aaaagttaaa
      361 actgaaattg aagaagagct aaaatctctg gacaaagaaa tttctgaagc cttcaccagc
      421 acaggctttg accgtcacac ttctccagtg ttcagccctg ccaatccaga aagctcaatg
      481 gaagactgct tggcccatct tggagaaaaa gtgtcccagg aactgaaaga gcctctccat
      541 aaagcattgc aaatgctcct gagccagcca gtgacatatc aggcatttcg ggaatgtaca
      601 ctggagacca cagttcatgc cagcggctgg aataagattt tggtgcctct ggttttgcta
      661 cgacaaatgc ttttggaatt gacaagacgt ggtcaagaac ctttgagcgc actgctgcag
      721 tttggcgtga catacctgga ggactattcg gcagagtaca tcattcagca aggtggctgg
      781 ggcactgtgt ttagtcttga gtcagaggag gaggaatacc ctggaatcac tgcagaagat
      841 agcaatgaca tttacatcct gcccagcgac aactctggac aagtcagtcc cccagagtct
      901 ccaactgtga ccacttcctg gcagtctgag agcttacctg tgtcactgtc agctagccag
      961 agttggcaca cagaaagcct gccagtgtca ctaggccctg agtcctggca gcagattgca
     1021 atggatcctg aagaagtgaa aagcttagac agcaacggag ctggagagaa gagtgagaac
     1081 aactcctcta attctgacat tgtgcacgtg gagaaagaag aggtgcccga gggcatggaa
     1141 gaggctgctg tggcttctgt ggtcttgcca gcgcgggagc tgcaagaggc acttcctgaa
     1201 gccccagctc ccttgcttcc acatatcact gccacctccc tgctggggac aagggaacct
     1261 gacacagaag tgatcacagt tgagaaatcc agccctgcta catctctgtt tgtagaactt
     1321 gatgaagaag aggtgaaagc agcaacaact gaacctactg aagtggagga ggtggtcccc
     1381 gcactggaac ccacagaaac gctgctgagt gagaaggaga taaacgcaag ggaagagagc
     1441 cttgtggaag agctgtcccc tgccagcgag aagaagcccg tgccgccgtc tgagggcaag
     1501 tctagactgt cccccgccgg tgagatgaag cccatgccgc tgtctgaggg caagtctata
     1561 ctgctgtttg gaggggctgc tgctgttgcc atcctggcag tggccatcgg ggtagccctg
     1621 gctctgagaa agaaatagga ggcttttcag aagagaaaga cagaaggatg taaggttgga
     1681 gttgtattgg ctggaatttg aacctccagc agctgtctgg acatttgtgg aacactctgg
     1741 gataattggg gacttctgct caacatggca gtggcatgtt aggcatgtta gggcttgagg
     1801 tggggcattc acattcatct gactgtaaat cccaagggcc tccgctcatg ctaaattgag
     1861 aatcttaggg gtaaagcacc ccctccagga ccgggtttct cagccttggc actagtgctg
     1921 ttctgaccat tctctgtgtt ggggctgtcc tgtgtgtggt gggctccacc cactagatgc
     1981 cagtggcacc ccctcccaga gatgacaaac gaaaatgtct ctagacattg ccaaatgtcc
     2041 cgtgtgaaca tcccctattg agacccactg ctttagcgag agagggttta cttaggaaga
     2101 attgggatag aaattcccag ctgagagaac ttagctgtgg gctcctcagc tactgacttc
     2161 ttagctctta atccccttag aatttcatct ttctcgatga gcaggctctg cacccactct
     2221 ttttttgccc cccgccctca tcctggagtg tgagggtgct cgcccgtact ctcagctgcc
     2281 tctcagggac tgcactgttc ctcttcaccc ccaggttcct gctaagatcc cacgggcgag
     2341 ggcttgctct ggactcagtc tgtcaagtcc ccgaagcttc ctgcagctcc accttgtaaa
     2401 aatgctgcct ttgggaatct tcgaaatatg tacacagaga aaatcacatg aaggagacct
     2461 ggggtcccca cttgtgagtg caactgcaag taactctggc tagagagaca catgtgtctt
     2521 gtgtcaaggc aggaggataa cctggatgac cttctgaggt ctcttcagcc cttttcgcta
     2581 gtggtcaccc accaccatgg ttacttgcca gcaacatctc tattgctgga tggtccctgt
     2641 ctataacctt gggctagtat attttttcca atatgggacc ttagtcttac tactgatgag
     2701 ttctatgggt ctcttgctag ggggtaagga tttttattct tgggcttata gagccagtta
     2761 gatcataatt cttatgaaat agagagtgtc ctaaatatca ctgaaataaa aagtaggaaa
     2821 aagaagcttg aattttaaga ctgaggctgc tctgcagatt ctagtttggc tttcagagtt
     2881 caagagtggt ggcatcttca cctgaattct tcaatgccag ggtaataaac caaaatagtc
     2941 ctaatcagta tatgctagtt gagcatcggc ataattttct ttcctctggc tgatcccagc
     3001 cctaaaggaa gggtagaccc gtgtctttcc agccctaaag gaagggtaga cccgtgtctt
     3061 tccagcccta aaggaagggc agacccgtgt ctttccatgc ccgagggcca cgacgtcact
     3121 atgcagggca cacgtggctt ggtttaaaaa ggtcatctta gatttatctt agtaaatgta
     3181 ataaattatt ttttagatct tgaaatttat aataaaaata ctttacctac cctgatcacc
     3241 aaaacctgat gttttaaatg tgctttcttt ttgaaattta tgttttcaaa taaaatctcc
     3301 ctaaagcaat atttaaaaat tggtcaaaac aaggtctggg agtatgtttg tgtgtctttc
     3361 cagctttatc ctgtagcgtg tctttgttct gtgttttagt gtcccattta gggagtgatg
     3421 ttttaagggt ttttgtgtac ttggattaag taattagagg tgagtggggg gaatgggatt
     3481 attgaggcaa tgattttttt cttcatgggc tctgatagtt gcattgattg ttctgtattc
     3541 taattgctat atttgtgttt gcataggtga agagcaaact ggtgcgttat cttgattttt
     3601 aaaaagtaat aaatcctatg agttccagta ttaacacttg ccagttctgg atcctcacac
     3661 ccattggctg agcgcattca agcaccaatc gaagccaggt tcatctctga gctgctgaaa
     3721 ggaggtgtga ggcttaggaa attggagcct gtgttgccca cgaaaggaaa gaataaggaa
     3781 gaaatgtggt atggaagcgg ctacttgctg ctttattttc ccacctgtta gacattcctc
     3841 cacagtgatt tggccagttg tatttcacgg taatggaact agatagtgtt ttccattggc
     3901 tttctctggt agctcttggt cagctcctga gttaacagga tgtggcagca tccctgttct
     3961 tccttcacgt cctcaccctc tgcctccagc agtggaaggg aacagccctc atgaggactg
     4021 cttcctactg cagctcctgc tttttgctca tacatttaaa aaactatttc tcaagcttcc
     4081 cctccttttg gggggaggag ctgatagtag gaggccattc cttccacctc caacttatac
     4141 cctctaagtc taaggtgaag gaaagattca gaataaatcc aacttgttta tagaaaagtt
     4201 cttgttagtc cttagacctc atctcaactg ctctgttgaa ggtaatgatt tattgggggg
     4261 aaaaaacaac gccaatttat cctctctgta ttaaagtgat aattctgggc ccacagaaat
     4321 cagtcagtac ctgcggtgtg ccttaagggg actctcatga tcatcattcc cttctagaga
     4381 acattctaga tgaagaaatg caactgttga ccttctggtt cacccatctc cccctcgagg
     4441 cattcttgat accccttctc acctgcattt ctgtcccagg gataccagat gcagccacta
     4501 cctaactagg cttgtcctgg gggagtgagc cgtgaacctg gagacatggc tttgacccac
     4561 agctactgtt catttcctca ggctttgcgc tgattccctc aataatatga cagtaaggca
     4621 agtagtctcc ttgcctttct cctgaaaggt atgagatgtg gacatttcag tgtttgaatt
     4681 attttaagag atgttttata gaaataaaac gttttgtagc taagaatttt ccctttctct
     4741 taatttctta catctttcca cacaaactta tctttccaag aatttgaggt ggtgatcata
     4801 cccatcaaga cggccttgta ggctatctga ttgctaacag acacgaccta gagcttctgc
     4861 ccaaattccc acacaagcat tatctcgttt aacatctcag cgacatactg gataccagaa
     4921 taatgtttcc tcttctctgg tgcaccaaaa cctgccctt
//
