LOCUS       NM_138639               1064 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BCL2 like 12 (BCL2L12), transcript variant 1, mRNA.
ACCESSION   NM_138639
VERSION     NM_138639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1064)
  AUTHORS   Li,J., Yang,G., Luo,X.Q., Mo,L.H., Qiu,S.Y., Yang,L.T., Liu,D.B.,
            An,Y.F. and Yang,P.C.
  TITLE     Interaction between Ras and Bcl2L12 in B cells suppresses IL-10
            expression
  JOURNAL   Clin Immunol 229, 108775 (2021)
   PUBMED   34116211
  REMARK    GeneRIF: Interaction between Ras and Bcl2L12 in B cells suppresses
            IL-10 expression.
REFERENCE   2  (bases 1 to 1064)
  AUTHORS   Xu,J., Qian,X. and Ding,R.
  TITLE     MiR-24-3p attenuates IL-1beta-induced chondrocyte injury associated
            with osteoarthritis by targeting BCL2L12
  JOURNAL   J Orthop Surg Res 16 (1), 371 (2021)
   PUBMED   34116684
  REMARK    GeneRIF: MiR-24-3p attenuates IL-1beta-induced chondrocyte injury
            associated with osteoarthritis by targeting BCL2L12.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1064)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1064)
  AUTHORS   Karousi,P., Artemaki,P.I., Sotiropoulou,C.D., Christodoulou,S.,
            Scorilas,A. and Kontos,C.K.
  TITLE     Identification of Two Novel Circular RNAs Deriving from BCL2L12 and
            Investigation of Their Potential Value as a Molecular Signature in
            Colorectal Cancer
  JOURNAL   Int J Mol Sci 21 (22), 8867 (2020)
   PUBMED   33238574
  REMARK    GeneRIF: Identification of Two Novel Circular RNAs Deriving from
            BCL2L12 and Investigation of Their Potential Value as a Molecular
            Signature in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1064)
  AUTHORS   Kontos,C.K. and Scorilas,A.
  TITLE     Molecular cloning of novel alternatively spliced variants of
            BCL2L12, a new member of the BCL2 gene family, and their expression
            analysis in cancer cells
  JOURNAL   Gene 505 (1), 153-166 (2012)
   PUBMED   22664385
  REMARK    GeneRIF: Molecular cloning of novel alternatively spliced variants
            of BCL2L12, a new member of the BCL2 gene family, and their
            expression analysis in cancer cells.
REFERENCE   6  (bases 1 to 1064)
  AUTHORS   Stegh,A.H. and DePinho,R.A.
  TITLE     Beyond effector caspase inhibition: Bcl2L12 neutralizes p53
            signaling in glioblastoma
  JOURNAL   Cell Cycle 10 (1), 33-38 (2011)
   PUBMED   21200141
  REMARK    Review article
REFERENCE   7  (bases 1 to 1064)
  AUTHORS   Mathioudaki,K., Scorilas,A., Papadokostopoulou,A., Xynopoulos,D.,
            Arnogianaki,N., Agnanti,N. and Talieri,M.
  TITLE     Expression analysis of BCL2L12, a new member of apoptosis-related
            genes, in colon cancer
  JOURNAL   Biol Chem 385 (9), 779-783 (2004)
   PUBMED   15493871
  REMARK    GeneRIF: The BCL2L12-A transcript appears to be of importance for
            colon cancer since its expression is associated with disease
            progression.
REFERENCE   8  (bases 1 to 1064)
  AUTHORS   Talieri,M., Diamandis,E.P., Katsaros,N., Gourgiotis,D. and
            Scorilas,A.
  TITLE     Expression of BCL2L12, a new member of apoptosis-related genes, in
            breast tumors
  JOURNAL   Thromb Haemost 89 (6), 1081-1088 (2003)
   PUBMED   12783122
  REMARK    GeneRIF: RT-PCR in 70 breast cancer tissues demonstrated that
            BCL2L12 positive breast tumors are mainly of lower stage (I/II) or
            grade (I/II) and BCL2L12 expression is positively related to
            disease-free and overall survival
REFERENCE   9  (bases 1 to 1064)
  AUTHORS   Hammond,P.W., Alpin,J., Rise,C.E., Wright,M. and Kreider,B.L.
  TITLE     In vitro selection and characterization of Bcl-X(L)-binding
            proteins from a mix of tissue-specific mRNA display libraries
  JOURNAL   J Biol Chem 276 (24), 20898-20906 (2001)
   PUBMED   11283018
REFERENCE   10 (bases 1 to 1064)
  AUTHORS   Scorilas,A., Kyriakopoulou,L., Yousef,G.M., Ashworth,L.K.,
            Kwamie,A. and Diamandis,E.P.
  TITLE     Molecular cloning, physical mapping, and expression analysis of a
            novel gene, BCL2L12, encoding a proline-rich protein with a highly
            conserved BH2 domain of the Bcl-2 family
  JOURNAL   Genomics 72 (2), 217-221 (2001)
   PUBMED   11401436
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC104006.1 and AC011495.8.
            
            On Jul 24, 2020 this sequence version replaced NM_138639.1.
            
            Summary: This gene encodes a member of a family of proteins
            containing a Bcl-2 homology domain 2 (BH2). The encoded protein is
            an anti-apoptotic factor that acts as an inhibitor of caspases 3
            and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor
            suppressor protein, preventing its association with target genes.
            Overexpression of this gene has been detected in a number of
            different cancers. There is a pseudogene for this gene on
            chromosome 3. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007724.2, SRR14038193.3446634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246784.8/ ENSP00000246784.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1007              BC104006.1         368-1374
            1008-1064           AC011495.8         99670-99726
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1064
                     /gene="BCL2L12"
                     /note="BCL2 like 12"
                     /db_xref="GeneID:83596"
                     /db_xref="HGNC:HGNC:13787"
                     /db_xref="MIM:610837"
     exon            1..135
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     exon            136..250
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..896
                     /gene="BCL2L12"
                     /note="isoform 1 is encoded by transcript variant 1; Bcl-2
                     related proline-rich protein; bcl-2-like protein 12;
                     BCL2-like 12 (proline rich)"
                     /codon_start=1
                     /product="bcl-2-like protein 12 isoform 1"
                     /protein_id="NP_619580.2"
                     /db_xref="CCDS:CCDS12776.2"
                     /db_xref="GeneID:83596"
                     /db_xref="HGNC:HGNC:13787"
                     /db_xref="MIM:610837"
                     /translation="MAGSEELGLREDTLRVLAAFLRRGEAAGSPVPTPPRSPAQEEPT
                     DFLSRLRRCLPCSLGRGAAPSESPRPCSLPIRPCYGLEPGPATPDFYALVAQRLEQLV
                     QEQLKSPPSPELQGPPSTEKEAILRRLVALLEEEAEVINQKLASDPALRSKLVRLSSD
                     SFARLVELFCSRDDSSRPSRACPGPPPPSPEPLARLALAMELSRRVAGLGGTLAGLSV
                     EHVHSFTPWIQAHGGWEGILAVSPVDLNLPLD"
     exon            251..393
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     exon            394..480
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     exon            481..572
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     exon            573..845
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1064
                     /gene="BCL2L12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L12"
                     /note="hexamer: ATTAAA"
     polyA_site      1064
                     /gene="BCL2L12"
                     /note="major polyA site"
ORIGIN      
        1 cctttctacg ctgggccggt tatcgacccg gcccagtgcg caggcgcggg aaagttgaac
       61 taataaagtt tgtacgagtt cagtggagga gaccgcaagt tgagtggagg aggcggcggt
      121 ggggccccgg accaggtgcc tccatggcag gctctgaaga gctggggctc cgggaagaca
      181 cgctgagggt cctagctgcc ttccttaggc gtggtgaggc tgccgggtct cctgttccaa
      241 ctccacctag aagccctgcc caagaagagc caacagactt cctgagccgc cttcgaagat
      301 gtcttccctg ctccctgggg cgaggagcag ccccctctga gtcccctcgg ccttgctctc
      361 tgcccatccg cccctgctat ggtttagagc ctggcccagc tactccagac ttctatgctt
      421 tggtggccca gcggctggaa cagctggtcc aagagcagct gaaatctccg cccagcccag
      481 aattacaggg tcccccatcg acagagaagg aagccatact gcggaggctg gtggccctgc
      541 tggaggagga ggcagaagtc attaaccaga agctggcctc ggaccccgcc ctgcgcagca
      601 agctggtccg cctgtcctcc gactctttcg cccgcctggt ggagctgttc tgtagccggg
      661 atgacagctc tcgcccaagc cgagcatgcc ccgggccccc gcctccttcc ccggagcccc
      721 tggcccgcct ggccctagcc atggagctga gccggcgcgt ggccgggctg gggggcaccc
      781 tggccggact cagcgtggag cacgtgcaca gcttcacgcc ctggatccag gcccacgggg
      841 gctgggaggg catcctggct gtttcacccg tggacttgaa cttgccattg gactgagctc
      901 tttctcagaa gctgctacaa gatgacacct catgtccctg ccctcttcgt gtgcttttcc
      961 aagtcttcct attccactca gggctgtggg gtggtggttg ccctacctgt ttttgccaaa
     1021 aataaattgt ttaaaacttt tcttattaaa aacgttacaa agta
//
