LOCUS       NM_138621               5098 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens BCL2 like 11 (BCL2L11), transcript variant 1, mRNA.
ACCESSION   NM_138621
VERSION     NM_138621.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5098)
  AUTHORS   Wang,Y., Zeng,H., Li,L., Liu,J., Lin,J., Bie,Y., Wang,S., Cheng,X.,
            Nashun,B., Yao,Y., Hu,X. and Zhao,Y.
  TITLE     Pokemon inhibits Bim transcription to promote the proliferation,
            anti-anoikis, invasion, histological grade, and dukes stage of
            colorectal neoplasms
  JOURNAL   J Cancer Res Clin Oncol 150 (8), 380 (2024)
   PUBMED   39095579
  REMARK    GeneRIF: Pokemon inhibits Bim transcription to promote the
            proliferation, anti-anoikis, invasion, histological grade, and
            dukes stage of colorectal neoplasms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5098)
  AUTHORS   Zhang,Q., Wu,Q., Huan,X.J., Song,S.S., Bao,X.B., Miao,Z.H. and
            Wang,Y.Q.
  TITLE     Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with
            augmented cancer therapeutic efficacy
  JOURNAL   Biochem Pharmacol 223, 116198 (2024)
   PUBMED   38588830
  REMARK    GeneRIF: Co-inhibition of BET and NAE enhances BIM-dependent
            apoptosis with augmented cancer therapeutic efficacy.
REFERENCE   3  (bases 1 to 5098)
  AUTHORS   Lu,L., Ma,D. and Xi,Z.
  TITLE     Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic
            Efficacy of Non-Small-Cell Lung Cancer
  JOURNAL   Biomacromolecules 25 (2), 792-808 (2024)
   PUBMED   38237562
  REMARK    GeneRIF: Coexpression of TP53, BIM, and PTEN Enhances the
            Therapeutic Efficacy of Non-Small-Cell Lung Cancer.
REFERENCE   4  (bases 1 to 5098)
  AUTHORS   Matsumoto,M., Ogawa,N., Fukuda,T., Bando,Y., Nishimura,T. and
            Usuda,J.
  TITLE     Protein interaction networks characterizing the A549 cells Klotho
            transfected are associated with activated pro-apoptotic Bim and
            suppressed Wnt/beta-catenin signaling pathway
  JOURNAL   Sci Rep 14 (1), 2130 (2024)
   PUBMED   38267588
  REMARK    GeneRIF: Protein interaction networks characterizing the A549 cells
            Klotho transfected are associated with activated pro-apoptotic Bim
            and suppressed Wnt/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5098)
  AUTHORS   Lambrecht,R., Rudolf,F., Uckert,A.K., Sladky,V.C., Phan,T.S.,
            Jansen,J., Naim,S., Kaufmann,T., Keogh,A., Kirschnek,S.,
            Mangerich,A., Stengel,F., Leist,M., Villunger,A. and Brunner,T.
  TITLE     Non-canonical BIM-regulated energy metabolism determines
            drug-induced liver necrosis
  JOURNAL   Cell Death Differ 31 (1), 119-131 (2024)
   PUBMED   38001256
  REMARK    GeneRIF: Non-canonical BIM-regulated energy metabolism determines
            drug-induced liver necrosis.
REFERENCE   6  (bases 1 to 5098)
  AUTHORS   Ng,K.P., Hillmer,A.M., Chuah,C.T., Juan,W.C., Ko,T.K., Teo,A.S.,
            Ariyaratne,P.N., Takahashi,N., Sawada,K., Fei,Y., Soh,S., Lee,W.H.,
            Huang,J.W., Allen,J.C. Jr., Woo,X.Y., Nagarajan,N., Kumar,V.,
            Thalamuthu,A., Poh,W.T., Ang,A.L., Mya,H.T., How,G.F., Yang,L.Y.,
            Koh,L.P., Chowbay,B., Chang,C.T., Nadarajan,V.S., Chng,W.J.,
            Than,H., Lim,L.C., Goh,Y.T., Zhang,S., Poh,D., Tan,P., Seet,J.E.,
            Ang,M.K., Chau,N.M., Ng,Q.S., Tan,D.S., Soda,M., Isobe,K.,
            Nothen,M.M., Wong,T.Y., Shahab,A., Ruan,X., Cacheux-Rataboul,V.,
            Sung,W.K., Tan,E.H., Yatabe,Y., Mano,H., Soo,R.A., Chin,T.M.,
            Lim,W.T., Ruan,Y. and Ong,S.T.
  TITLE     A common BIM deletion polymorphism mediates intrinsic resistance
            and inferior responses to tyrosine kinase inhibitors in cancer
  JOURNAL   Nat Med 18 (4), 521-528 (2012)
   PUBMED   22426421
  REMARK    GeneRIF: the heterogeneity of tyrosine kinase inhibitors responses
            across individuals and suggest the possibility of personalizing
            therapy with BH3 mimetics to overcome BIM-polymorphism-associated
            tyrosine kinase inhibitors resistance.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5098)
  AUTHORS   Huang,D.C., Adams,J.M. and Cory,S.
  TITLE     The conserved N-terminal BH4 domain of Bcl-2 homologues is
            essential for inhibition of apoptosis and interaction with CED-4
  JOURNAL   EMBO J 17 (4), 1029-1039 (1998)
   PUBMED   9463381
REFERENCE   8  (bases 1 to 5098)
  AUTHORS   O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M.,
            Cory,S. and Huang,D.C.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
REFERENCE   9  (bases 1 to 5098)
  AUTHORS   Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J.
  TITLE     Serine phosphorylation of death agonist BAD in response to survival
            factor results in binding to 14-3-3 not BCL-X(L)
  JOURNAL   Cell 87 (4), 619-628 (1996)
   PUBMED   8929531
REFERENCE   10 (bases 1 to 5098)
  AUTHORS   Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J.
  TITLE     BID: a novel BH3 domain-only death agonist
  JOURNAL   Genes Dev 10 (22), 2859-2869 (1996)
   PUBMED   8918887
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096670.1, BC033694.1 and
            AI268146.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138621.4.
            
            Summary: The protein encoded by this gene belongs to the BCL-2
            protein family. BCL-2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. The protein encoded by this
            gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to
            interact with other members of the BCL-2 protein family and to act
            as an apoptotic activator. The expression of this gene can be
            induced by nerve growth factor (NGF), as well as by the forkhead
            transcription factor FKHR-L1, which suggests a role of this gene in
            neuronal and lymphocyte apoptosis. Transgenic studies of the mouse
            counterpart suggested that this gene functions as an essential
            initiator of apoptosis in thymocyte-negative selection. Several
            alternatively spliced transcript variants of this gene have been
            identified. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1, also known as BimEL) encodes
            the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291269.1, BC033694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393256.8/ ENSP00000376943.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC096670.1         78200-78307         c
            109-3664            BC033694.1         91-3646
            3665-5081           AC096670.1         30794-32210         c
            5082-5098           AI268146.1         9-25                c
FEATURES             Location/Qualifiers
     source          1..5098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..5098
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /note="BCL2 like 11"
                     /db_xref="GeneID:10018"
                     /db_xref="HGNC:HGNC:994"
                     /db_xref="MIM:603827"
     exon            1..275
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /inference="alignment:Splign:2.1.0"
     exon            276..682
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..885
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /note="isoform 1 is encoded by transcript variant 1; bcl-2
                     interacting protein Bim; bcl-2 interacting mediator of
                     cell death; bcl-2-related ovarian death agonist; BCL2-like
                     11 (apoptosis facilitator)"
                     /codon_start=1
                     /product="bcl-2-like protein 11 isoform 1"
                     /protein_id="NP_619527.1"
                     /db_xref="CCDS:CCDS2089.1"
                     /db_xref="GeneID:10018"
                     /db_xref="HGNC:HGNC:994"
                     /db_xref="MIM:603827"
                     /translation="MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNP
                     EGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTD
                     RSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFN
                     AYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH"
     exon            683..786
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /inference="alignment:Splign:2.1.0"
     exon            787..5098
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5080..5085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /note="hexamer: AATAAA"
     polyA_site      5098
                     /gene="BCL2L11"
                     /gene_synonym="BAM; BIM; BOD"
                     /note="major polyA site"
ORIGIN      
        1 acttcgctcc gcgcagccgc ctggtctgca gtttgttgga gctctgcgtc cagcgccgct
       61 gccgctgccg ccgccgccgc cgccgccgcc gccgccgccg ccgccgccac taccaccact
      121 tgattcttgc agccaccctg cgaaccctgc cacactgcga tcgcatcatc gcggtattcg
      181 gttcgctgcg ttcccgccgc caccgcctcg gcgccctttc ttggcccttg ttcccccaaa
      241 tgtctgactc tgactctcgg actgagaaac gcaagaaaaa aagaccaaat ggcaaagcaa
      301 ccttctgatg taagttctga gtgtgaccga gaaggtagac aattgcagcc tgcggagagg
      361 cctccccagc tcagacctgg ggcccctacc tccctacaga cagagccaca aggtaatcct
      421 gaaggcaatc acggaggtga aggggacagc tgcccccacg gcagccctca gggcccgctg
      481 gccccacctg ccagccctgg cccttttgct accagatccc cgcttttcat ctttatgaga
      541 agatcctccc tgctgtctcg atcctccagt gggtatttct cttttgacac agacaggagc
      601 ccagcaccca tgagttgtga caaatcaaca caaaccccaa gtcctccttg ccaggccttc
      661 aaccactatc tcagtgcaat ggcttccatg aggcaggctg aacctgcaga tatgcgccca
      721 gagatatgga tcgcccaaga gttgcggcgt attggagacg agtttaacgc ttactatgca
      781 aggagggtat ttttgaataa ttaccaagca gccgaagacc acccacgaat ggttatctta
      841 cgactgttac gttacattgt ccgcctggtg tggagaatgc attgacaggt tctttgcgga
      901 gccgagatac catgcagaca ttttgcttgt tcaaaccaac aagacccagc accgcggtct
      961 cctggtgcca ttattatgca gccagcggtt ctcttgtgga gggggcaggt gacgtttcag
     1021 aagacaccga gctggatggg actacctttc tgttcatcac cacacagcag aatttctaat
     1081 ggaagtttgt tgtgaatgta aaggagggag cattctttgc tttttaatat acaaaccatg
     1141 gttttttgga gcaggatttt gtgtaagaat ggtgtttaca tgcagtgtgt tttccccctc
     1201 accttcaata aggtttttca aaaaggaaat ggaaactttt taaccaattt gtgaataact
     1261 tttgtattaa aattttaaga acctacggcc tattctcaga ggattatgta acccctgcag
     1321 tggaaactga gccagctaac ttaaaaagct gccttagttt atttttagag attacagaat
     1381 ttttaaacag ggagacgtgt gatatactcc ctcccttccc tactattgcc tctctgacct
     1441 ttttaaatta tttttaatac caaaagagtt cttttgaaat ggaactgatt aaaagggcag
     1501 agggtctgtt gccagcctgc attgatatac cagtcccatt tgtaaatatt tacgtacctt
     1561 tataaattca gttgcatctg tggcaaaatt tcagactatt tttgcgtctt tcctcatcac
     1621 tttttgtgat gcaactccag tctggactca gatgcataga tttggtccag tgtattttca
     1681 tgataaagtg aaattgagtc agaacaagag ttaatatctg cctgtatctt gcacagttcg
     1741 agcgatctgt tattaactgg gaagcatttg gtgttggttt tcattccatt tcgacgagca
     1801 tgttattggg aagtattctg aagaggcaat agcagtaata acaacagact taagtgctac
     1861 gcccctttgt gctgctggct tttctggttg caggctttcc catggtcaca ggatgcactg
     1921 tcagcatcag gtcccagagg gccaccgtgt ccattacagc agagtccagc tgcagcatcc
     1981 agctcacgcc ctcatgggaa ttggcacagg cctggggcag ggcttctgat ggccatttgc
     2041 ttggcctcct gcattttagt ccaactcaca gtccactagc ttcactcctt taaattcact
     2101 ttgaaacagg cctcatccca cttccaccag caccatagaa gaataattct gggcagaagt
     2161 ctgttttttt tcatttttcc aggacagttg gatattgtca ggccacttgt gaccccagcc
     2221 atgtagtgag ggtgctcttt ctctgtgcct gctccttatg agtgcagtgg aaggaagcca
     2281 cacactggtc agtcatttca gaggcagcag atgcccaggg agacccaaga aagagtcagg
     2341 ttagggagca gtgaaagtga ggagggaaga caattctgtg aactctgtaa ctcttaaaat
     2401 ttttgaaaac tccatcgtta aacaactttt aaaagaaata actaaatttt caaatgagta
     2461 agcagtgcca ccaactagtg ttttgcccga tagaagagcc agcatgttca cgttatttaa
     2521 attaggtgga aaaatctaaa catttttatc ttcataattt aaaaaatata tatgtatata
     2581 ttgcatattc actttttcct ttaggtagag atgatttcaa tccaaatact cttactttaa
     2641 aaaatttcct ttccccaaga atctccttgg gactttgact tatttttaaa gctgtgttgg
     2701 agctcatctt gttccctgat gtgtctcgag cccattggta gggtcataca aagcccacgg
     2761 ttacaagcag tggtaggatt gcagccgtgg gcctgctgga cacacacata caccaaagat
     2821 gtatttggat ctgggcaccc cctcccagga tccctgtact cacgtgccag tctcctgact
     2881 agagcacttt actctgtttc ctcagccctg cagcccctgg gagcacacac tgggtgcagc
     2941 cctgggccag gcacgggagg ccctgccctg tgctgcccag gggctgtgtg caccacatga
     3001 gcacatttcc ctctggcctg gcggcctcca ggctggctgt ggaaacagtt cctgaggaaa
     3061 ttagagattc tatgaattgt aggagtatta aagaccaggc tgttggcacc agaacttaaa
     3121 gcgatgactg gatgtctctg tactgtatgt atctggttat caagatgcct ctgtgcagaa
     3181 agtatgcctc ccgtgggtat acgtttttac cttttttaaa aaacattttt gtagaaaaaa
     3241 taattaaatc ccctttttgg aaacttactg caggttttgt gccttgacaa cctctcccta
     3301 tgtgaggttt gtaaaaagtg tcctgtgact taacacagaa acgcaataaa cacacacaaa
     3361 atagtttcat gagtgattct tcagatgccc ttcccaactg gttagttgat caagaatttt
     3421 gggggtgggg gttgcggaga aatcaagttt aaaattcctt ctgattaaaa aaatatagtg
     3481 gaatacaatt gtctgccgtt tccccttctt aatgtatata ttgtgagtat ttattagatt
     3541 cgtaggtcat attacttatc aactgagcca aatgtctgtg tgcaattgtg tttcctttac
     3601 cttgtaaaat tttgtacagc ataaataagt aaaaaaatca ctgtttttct caactttttc
     3661 aaaatcaagg attgtaaata ttgtagattc tttttctgtg tgatgtgtcc tactgtttca
     3721 taatgctgta acttgtagaa atattgtata tttattttct gcttatttaa tgtcttaatt
     3781 tctgaaaagt attaacatcc ctgtctccca ctcccctgcc gtcccatgaa gttaactcct
     3841 gagagttgtc gggggtgact ggagagctca ttgcagacca cgtggtcctc cagggtggct
     3901 ctccaccttc gggtcctggt atttccagtc aagtgggttt caattcttgg gctttgccgc
     3961 ccttatgatg aagtgtgtgt ttgatgccag tgagaaactc agtctggcag gctacaaaat
     4021 tctactccaa gaaataccca gcaaccttct gtttgttcca aagcaactag cttatcatgc
     4081 aagcaaattt tgctgactcc aggctttatc tttaggaaaa caaaaaaacc aaagtattat
     4141 cagcaggtgg gaaagatttt tctattgaaa atttatccct gacaactcag cgtttagaaa
     4201 agaaataaaa tgtgccactt ccagaggtgc tgcattgcag ttgttcaggg ctagggccag
     4261 gcaggacaag tgaatgggtg ggacaggtgg ctcctgccta aggaccacct caggccacta
     4321 accccttgtg gacaactgtg agtagctggg ttttccccca cctgctgtgc aacttcctgt
     4381 gctttgaggt tggactaact tgtcttcagg agctaattaa ctgtacagcc ctccccacgc
     4441 cccacccata cggtcactgc atttggtcag cctgcttctt caggtcgatg ccctccttct
     4501 gatactccat ctccttcagg ggaggttggg gccccactgg actgggtgtc aagatgtgaa
     4561 agcttatggg agctttaagg agacttcatg gtggttccat gcaggtggtt ctgccatccc
     4621 tgctgattta gcctggtgcc tgtgtgtgtc cactcacgta cacgtggggt gggggaaacg
     4681 tgtctacaga tgacgctaaa tcagttgggg tctactctaa acagcattgt gtgtaagaag
     4741 catcctcaag ctcccagtta agtaacttga ctacttttat ttgggaattt cagactatag
     4801 aagctctctt atgttttatg tccagattct gtgaccacta gttactgtat cagaactcat
     4861 caggtaccca cttataaata gcactgatct ggctgtatac tgatccatca ctaacctgtt
     4921 ttctaggacc cagcgtatgt agcatttgta ttgcagtttc cctggcttac ttgtgttttg
     4981 cactgatgaa ttttgacagg gtaattgcca ctttacttgt gcaatactgc tgtaaataac
     5041 tgcagatttt taaacaatct tttatgttaa ttttataaaa ataaaacttt caactagt
//
