LOCUS       NM_020396               1249 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 2, mRNA.
ACCESSION   NM_020396
VERSION     NM_020396.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Pervushin,N.V., Kopeina,G.S. and Zhivotovsky,B.
  TITLE     Bcl-B: an 'unknown' protein of the Bcl-2 family
  JOURNAL   Biol Direct 18 (1), 69 (2023)
   PUBMED   37899453
  REMARK    GeneRIF: Bcl-B: an 'unknown' protein of the Bcl-2 family.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Duong,M.Q., Gadet,R., Treilleux,I., Borel,S., Nougarede,A.,
            Marcillat,O., Gonzalo,P., Mikaelian,I., Popgeorgiev,N., Rimokh,R.
            and Gillet,G.
  TITLE     Nrh L11R single nucleotide polymorphism, a new prediction biomarker
            in breast cancer, impacts endoplasmic reticulum-dependent Ca2+
            traffic and response to neoadjuvant chemotherapy
  JOURNAL   Cell Death Dis 14 (6), 392 (2023)
   PUBMED   37391438
  REMARK    GeneRIF: Nrh L11R single nucleotide polymorphism, a new prediction
            biomarker in breast cancer, impacts endoplasmic reticulum-dependent
            Ca[2+] traffic and response to neoadjuvant chemotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Liu,F., Pan,R., Ding,H., Gu,L., Yang,Y., Li,C., Xu,Y., Hu,R.,
            Chen,H., Zhang,X. and Nie,Y.
  TITLE     UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic
            proteins BCL2A1 and BCL2L10 in mesothelioma
  JOURNAL   Mol Oncol 15 (12), 3738-3752 (2021)
   PUBMED   34245648
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1249)
  AUTHORS   Lee,S.Y., Kwon,J. and Lee,K.A.
  TITLE     Bcl2l10 induces metabolic alterations in ovarian cancer cells by
            regulating the TCA cycle enzymes SDHD and IDH1
  JOURNAL   Oncol Rep 45 (4) (2021)
   PUBMED   33649794
  REMARK    GeneRIF: Bcl2l10 induces metabolic alterations in ovarian cancer
            cells by regulating the TCA cycle enzymes SDHD and IDH1.
REFERENCE   6  (bases 1 to 1249)
  AUTHORS   Ke,N., Godzik,A. and Reed,J.C.
  TITLE     Bcl-B, a novel Bcl-2 family member that differentially binds and
            regulates Bax and Bak
  JOURNAL   J Biol Chem 276 (16), 12481-12484 (2001)
   PUBMED   11278245
REFERENCE   7  (bases 1 to 1249)
  AUTHORS   van Oirschot,J.T.
  TITLE     Diva vaccines that reduce virus transmission
  JOURNAL   J Biotechnol 73 (2-3), 195-205 (1999)
   PUBMED   10486928
  REMARK    Review article
REFERENCE   8  (bases 1 to 1249)
  AUTHORS   Song,Q., Kuang,Y., Dixit,V.M. and Vincenz,C.
  TITLE     Boo, a novel negative regulator of cell death, interacts with
            Apaf-1
  JOURNAL   EMBO J 18 (1), 167-178 (1999)
   PUBMED   9878060
REFERENCE   9  (bases 1 to 1249)
  AUTHORS   Inohara,N., Gourley,T.S., Carrio,R., Muniz,M., Merino,J.,
            Garcia,I., Koseki,T., Hu,Y., Chen,S. and Nunez,G.
  TITLE     Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces
            BH3-independent cell death
  JOURNAL   J Biol Chem 273 (49), 32479-32486 (1998)
   PUBMED   9829980
REFERENCE   10 (bases 1 to 1249)
  AUTHORS   Pan,G., O'Rourke,K. and Dixit,V.M.
  TITLE     Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
  JOURNAL   J Biol Chem 273 (10), 5841-5845 (1998)
   PUBMED   9488720
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023906.7.
            
            On Jul 21, 2020 this sequence version replaced NM_020396.3.
            
            Summary: The protein encoded by this gene belongs to the BCL-2
            protein family. BCL-2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. The protein encoded by this
            gene contains conserved BH4, BH1 and BH2 domains. This protein can
            interact with other members of BCL-2 protein family including BCL2,
            BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been
            shown to suppress cell apoptosis possibly through the prevention of
            cytochrome C release from the mitochondria, and thus activating
            caspase-3 activation. The mouse counterpart of this protein is
            found to interact with Apaf1 and forms a protein complex with
            Caspase 9, which suggests the involvement of this protein in APAF1
            and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326964.1, BC104442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260442.3/ ENSP00000260442.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               AC023906.7         64454-64991         c
            539-1249            AC023906.7         61479-62189         c
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..1249
                     /gene="BCL2L10"
                     /gene_synonym="BCL-B; bcl2-L-10; Boo; Diva"
                     /note="BCL2 like 10"
                     /db_xref="GeneID:10017"
                     /db_xref="HGNC:HGNC:993"
                     /db_xref="MIM:606910"
     exon            1..538
                     /gene="BCL2L10"
                     /gene_synonym="BCL-B; bcl2-L-10; Boo; Diva"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..664
                     /gene="BCL2L10"
                     /gene_synonym="BCL-B; bcl2-L-10; Boo; Diva"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bcl-2-like protein 10; apoptosis regulator Bcl-B;
                     anti-apoptotic protein NrH; death inducer binding to
                     vBcl-2 and Apaf-1; BCL2-like 10 (apoptosis facilitator);
                     anti-apoptotic protein Boo"
                     /codon_start=1
                     /product="bcl-2-like protein 10 isoform 2"
                     /protein_id="NP_065129.1"
                     /db_xref="CCDS:CCDS10148.1"
                     /db_xref="GeneID:10017"
                     /db_xref="HGNC:HGNC:993"
                     /db_xref="MIM:606910"
                     /translation="MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTP
                     EAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVT
                     FAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQ
                     GGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL"
     exon            539..1249
                     /gene="BCL2L10"
                     /gene_synonym="BCL-B; bcl2-L-10; Boo; Diva"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggccaaga aaaccagcga aggcccggcc ccccagcaga ggccggacca tggttgacca
       61 gttgcgggag cgcaccacca tggccgaccc gctgcgggag cgcaccgagc tgttgctggc
      121 cgactacctg gggtactgcg cccgggaacc cggcaccccc gagccggcgc catccacgcc
      181 cgaggccgcc gtgctgcgct ccgcggccgc caggttacgg cagattcacc ggtccttttt
      241 ctccgcctac ctcggctacc ccgggaaccg cttcgagctg gtggcgctga tggcggattc
      301 cgtgctctcc gacagccccg gccccacctg gggcagagtg gtgacgctcg tgaccttcgc
      361 agggacgctg ctggagagag ggccgctggt gaccgcccgg tggaagaagt ggggcttcca
      421 gccgcggcta aaggagcagg agggcgacgt cgcccgggac tgccagcgcc tggtggcctt
      481 gctgagctcg cggctcatgg ggcagcaccg cgcctggctg caggctcagg gcggctggga
      541 tggcttttgt cacttcttca ggaccccctt tccactggct ttttggagaa aacagctggt
      601 ccaggctttt ctgtcatgct tgttaacaac agccttcatt tatctctgga cacgattatt
      661 atgagtttta aaacttttaa cccgcttcta cctgcccaac tgtgaccaac taaatgacag
      721 atgtgtgaga acaagaactg agggaaagca ccttccccca ccccagacgt ttttatctga
      781 atgcatacaa ggagtcctga ggtggtgatt tggccagtgt tttaacttgt gacaagtact
      841 caggtgtgag gacaagaatg caaatggctc ttccttgagt gaaagaaatg gggagtctag
      901 agcctcttta tgccaaagaa ccgcagaaga aactgcattc cattaaatgg gaaatacagt
      961 gctatttgct aaaacttgga taagagtgcg aacctctcat ctctccacaa cttcatgtgc
     1021 tgctgactaa ttttaaacat ggccacagct ggggcaaaat aatccccaaa gtagaaaaag
     1081 tcccagttta acaaagaatg taatgttaaa atcacttata aggaattctt tgaaaccaaa
     1141 tcctttgaaa tctaattcct gggacttcta ggtttttata gttaacatac taatttcttc
     1201 aataattgtt aactgcaaag ttttaataaa tttgtacctt taaaaaaaa
//
