LOCUS       NM_138576               8528 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens BCL11 transcription factor B (BCL11B), transcript
            variant 1, mRNA.
ACCESSION   NM_138576
VERSION     NM_138576.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8528)
  AUTHORS   Li,X., Zhang,J., Zhang,H., Ren,J., Cao,H., Xu,Y., Zhang,D. and
            Duan,H.
  TITLE     Association between BCL11B gene polymorphisms and age-related
            hearing loss in the elderly: A case-control study in Qingdao, China
  JOURNAL   PLoS One 19 (6), e0304770 (2024)
   PUBMED   38829888
  REMARK    GeneRIF: Association between BCL11B gene polymorphisms and
            age-related hearing loss in the elderly: A case-control study in
            Qingdao, China.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8528)
  AUTHORS   Matsumoto,K., Okuyama,K., Sidwell,T., Yamashita,M., Endo,T.,
            Satoh-Takayama,N., Ohno,H., Morio,T., Rothenberg,E.V. and
            Taniuchi,I.
  TITLE     A Bcl11bN797K variant isolated from an immunodeficient patient
            inhibits early thymocyte development in mice
  JOURNAL   Front Immunol 15, 1363704 (2024)
   PUBMED   38495886
  REMARK    GeneRIF: A Bcl11b[N797K] variant isolated from an immunodeficient
            patient inhibits early thymocyte development in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8528)
  AUTHORS   Vickridge,E., Faraco,C.C.F., Lo,F., Rahimian,H., Liu,Z.Y.,
            Tehrani,P.S., Djerir,B., Ramdzan,Z.M., Leduy,L., Marechal,A.,
            Gingras,A.C. and Nepveu,A.
  TITLE     The function of BCL11B in base excision repair contributes to its
            dual role as an oncogene and a haplo-insufficient tumor suppressor
            gene
  JOURNAL   Nucleic Acids Res 52 (1), 223-242 (2024)
   PUBMED   37956270
  REMARK    GeneRIF: The function of BCL11B in base excision repair contributes
            to its dual role as an oncogene and a haplo-insufficient tumor
            suppressor gene.
REFERENCE   4  (bases 1 to 8528)
  AUTHORS   Wang,Y., Zhang,F., Gao,N., Bu,P., Cui,W. and Xi,Y.
  TITLE     Differential expression of BCL11b and CDKN2A in CD30-positive
            peripheral T cell lymphoma: Retrospective study
  JOURNAL   Medicine (Baltimore) 102 (46), e35531 (2023)
   PUBMED   37986346
  REMARK    GeneRIF: Differential expression of BCL11b and CDKN2A in
            CD30-positive peripheral T cell lymphoma: Retrospective study.
REFERENCE   5  (bases 1 to 8528)
  AUTHORS   Liao,R., Wu,Y., Qin,L., Jiang,Z., Gou,S., Zhou,L., Hong,Q., Li,Y.,
            Shi,J., Yao,Y., Lai,L., Li,Y., Liu,P., Thiery,J.P., Qin,D.,
            Graf,T., Liu,X. and Li,P.
  TITLE     BCL11B and the NuRD complex cooperatively guard T-cell fate and
            inhibit OPA1-mediated mitochondrial fusion in T cells
  JOURNAL   EMBO J 42 (21), e113448 (2023)
   PUBMED   37737560
  REMARK    GeneRIF: BCL11B and the NuRD complex cooperatively guard T-cell
            fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
REFERENCE   6  (bases 1 to 8528)
  AUTHORS   Rohr,O., Lecestre,D., Chasserot-Golaz,S., Marban,C., Avram,D.,
            Aunis,D., Leid,M. and Schaeffer,E.
  TITLE     Recruitment of Tat to heterochromatin protein HP1 via interaction
            with CTIP2 inhibits human immunodeficiency virus type 1 replication
            in microglial cells
  JOURNAL   J Virol 77 (9), 5415-5427 (2003)
   PUBMED   12692243
REFERENCE   7  (bases 1 to 8528)
  AUTHORS   Wakabayashi,Y., Inoue,J., Takahashi,Y., Matsuki,A.,
            Kosugi-Okano,H., Shinbo,T., Mishima,Y., Niwa,O. and Kominami,R.
  TITLE     Homozygous deletions and point mutations of the Rit1/Bcl11b gene in
            gamma-ray induced mouse thymic lymphomas
  JOURNAL   Biochem Biophys Res Commun 301 (2), 598-603 (2003)
   PUBMED   12565905
REFERENCE   8  (bases 1 to 8528)
  AUTHORS   Avram,D., Fields,A., Senawong,T., Topark-Ngarm,A. and Leid,M.
  TITLE     COUP-TF (chicken ovalbumin upstream promoter transcription
            factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA
            binding protein
  JOURNAL   Biochem J 368 (Pt 2), 555-563 (2002)
   PUBMED   12196208
REFERENCE   9  (bases 1 to 8528)
  AUTHORS   Satterwhite,E., Sonoki,T., Willis,T.G., Harder,L., Nowak,R.,
            Arriola,E.L., Liu,H., Price,H.P., Gesk,S., Steinemann,D.,
            Schlegelberger,B., Oscier,D.G., Siebert,R., Tucker,P.W. and
            Dyer,M.J.
  TITLE     The BCL11 gene family: involvement of BCL11A in lymphoid
            malignancies
  JOURNAL   Blood 98 (12), 3413-3420 (2001)
   PUBMED   11719382
REFERENCE   10 (bases 1 to 8528)
  AUTHORS   Avram,D., Fields,A., Pretty On Top,K., Nevrivy,D.J., Ishmael,J.E.
            and Leid,M.
  TITLE     Isolation of a novel family of C(2)H(2) zinc finger proteins
            implicated in transcriptional repression mediated by chicken
            ovalbumin upstream promoter transcription factor (COUP-TF) orphan
            nuclear receptors
  JOURNAL   J Biol Chem 275 (14), 10315-10322 (2000)
   PUBMED   10744719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109767.7, AB041218.1,
            AJ404614.1 and AB043584.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138576.3.
            
            Summary: This gene encodes a C2H2-type zinc finger protein and is
            closely related to BCL11A, a gene whose translocation may be
            associated with B-cell malignancies. Although the specific function
            of this gene has not been determined, the encoded protein is known
            to be a transcriptional repressor, and is regulated by the NURD
            nucleosome remodeling and histone deacetylase complex. Four
            alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Aug
            2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041218.1, AB043584.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357195.8/ ENSP00000349723.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               AL109767.7         146980-147463
            485-682             AB041218.1         1-198
            683-712             AB041218.1         200-229
            713-969             AJ404614.1         1-257
            970-3962            AB043584.1         1-2993
            3963-8528           AJ404614.1         3038-7603
FEATURES             Location/Qualifiers
     source          1..8528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..8528
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /note="BCL11 transcription factor B"
                     /db_xref="GeneID:64919"
                     /db_xref="HGNC:HGNC:13222"
                     /db_xref="MIM:606558"
     exon            1..1037
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /inference="alignment:Splign:2.1.0"
     CDS             980..3664
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell lymphoma/leukaemia 11B; zinc finger protein hRit1
                     alpha; B-cell lymphoma/leukemia 11B; BCL11B/TRDC fusion;
                     B-cell CLL/lymphoma 11B/T-cell receptor delta constant
                     region fusion protein; BCL-11B; COUP-TF-interacting
                     protein 2; radiation-induced tumor suppressor gene 1
                     protein; B-cell CLL/lymphoma 11B (zinc finger protein); B
                     cell CLL/lymphoma 11B; BCL11B, BAF complex component; BAF
                     chromatin remodeling complex subunit BCL11B"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 11B isoform 1"
                     /protein_id="NP_612808.1"
                     /db_xref="CCDS:CCDS9950.1"
                     /db_xref="GeneID:64919"
                     /db_xref="HGNC:HGNC:13222"
                     /db_xref="MIM:606558"
                     /translation="MSRRKQGNPQHLSQRELITPEADHVEAAILEEDEGLEIEEPSGL
                     GLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKRKQCGGSLGACYDKALDKDSPPPSS
                     RSELRKVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPAVAPIAASS
                     HPHSSVITSPLRALGALPPCLPLPCCSARPVSGDGTQGEGQTEAPFGCQCQLSGKDEP
                     SSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASSSLTPRLTIPPPLGPEAVAQ
                     SPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEE
                     MGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLL
                     NPFQPSPKSPFLSTPPLPPMPPGGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHT
                     GEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELAGE
                     GLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDSELSRNR
                     ENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAFL
                     KRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLN
                     SAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATS
                     SEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTC
                     EYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRC
                     DICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS"
     exon            1038..1406
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1619
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..8528
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8498..8503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /note="hexamer: AATAAA"
     polyA_site      8528
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /note="major polyA site"
ORIGIN      
        1 agccatagag agaccgagag ctcccagaga acccggactc cgccatcttc acgttgcaat
       61 ctatagctcc cagtctgcgc ccgcaccgac ccaggcgcac tgggcgagcc gcccctccgc
      121 cccgctcccc ccgggcccgc ggcgccaggg gagcgctggg gagcgctcgc ggggactcgg
      181 cagcccctcc ggccggcgcc agcctgccag gtgaactggg aaggagcctc tcctggtgtc
      241 cccccagagc ctcggaaggg tcagtctccg agaaaaaaca aaaacaaaaa caaaaacagg
      301 cagcccgcag aaaacccaga aacaaccgaa ccggggcagt tttacattgc tttgggtttt
      361 ttgagggggc ggggtgaggg ggtacgagac aagtccccaa gttttctttg cttttttttt
      421 tcctttgctt tttcttcttt tattttttta tttgtttgca ttttttttcc cctcctggta
      481 gaagtgcgct ttccacctac cagaccctga aagaaagtgt caggagccgg tgcaaaaccc
      541 agtttaagtt caagaagaca tttgcaagtg caagaggcca agcagtttga agaagtgtaa
      601 gagatttttt ttccttcgaa agaatatatt tttaaagaaa ccagccagtc cgcggaaagc
      661 aacagcagtt tttttttttt ttgcctcttt ttcttatttt agatcgagag gtttttcttg
      721 cttttcttcc cttttttttc tttttgcaaa caaaacaaaa aacagcatag aagaaagagc
      781 aaaataaaga agaagaagag gaggaagaga gggaaagaga ggaagggaaa aaaaacacca
      841 acccgggcag aggaggaggt gcggcggcgg cggcggcggc ggcagcggcg gcagcggcgc
      901 ggcggcggct cggaccccct cccccggctc cccccatcag tgcagctctc cgggcgatgc
      961 cagaatagat gccggggcaa tgtcccgccg caaacagggc aacccgcagc acttgtccca
     1021 gagggagctc atcaccccag aggctgacca tgtggaggcc gccatcctcg aagaagacga
     1081 gggtctggag atagaggagc caagtggcct ggggctgatg gtgggtggcc ccgaccctga
     1141 cctgctcacc tgtggccagt gtcaaatgaa cttccccttg ggggacatcc tggtttttat
     1201 agagcacaaa aggaagcagt gtggcggcag cttgggtgcc tgctatgaca aggccctgga
     1261 caaggacagc ccgccaccct cctcacgctc cgagctcagg aaagtgtccg agccggtgga
     1321 gatcgggatc caagtcaccc ccgacgaaga tgaccacctg ctctcaccca cgaaaggcat
     1381 ctgtcccaag caggagaaca ttgcagggcc gtgcaggcct gcccagctgc cagcggtggc
     1441 ccccatagct gcctcctccc accctcactc atccgtgatc acttcacctc tgcgtgccct
     1501 gggcgctctc ccgccctgcc tccccctgcc gtgctgcagc gcgcgcccgg tctcgggtga
     1561 cgggactcag ggtgagggtc agacggaggc tccctttgga tgccagtgtc agttgtcagg
     1621 taaagatgag ccttccagct acatttgcac aacatgcaag cagcccttca acagcgcgtg
     1681 gttcctgctg cagcacgcgc agaacacgca cggcttccgc atctacctgg agcccgggcc
     1741 ggccagcagc tcgctcacgc cgcggctcac catcccgccg ccgctcgggc cggaggccgt
     1801 ggcgcagtcc ccgctcatga atttcctggg cgacagcaac cccttcaacc tgctgcgcat
     1861 gacgggcccc atcctgcggg accacccggg cttcggcgag ggccgcctgc cgggcacgcc
     1921 gcctctcttc agtcccccgc cgcgccacca cctggacccg caccgcctca gtgccgagga
     1981 gatggggctc gtcgcccagc accccagtgc cttcgaccga gtcatgcgcc tgaaccccat
     2041 ggccatcgac tcgcccgcca tggacttctc gcggcggctc cgcgagctgg cgggcaacag
     2101 ctccacgccg ccgcccgtgt ccccgggccg cggcaaccct atgcaccggc tcctgaaccc
     2161 cttccagccc agccccaagt ccccgttcct gagcacgccg ccgctgccgc ccatgccccc
     2221 tggcggcacg ccgcccccgc agccgccagc caagagcaag tcgtgcgagt tctgcggcaa
     2281 gaccttcaag ttccagagca atctcatcgt gcaccggcgc agtcacacgg gcgagaagcc
     2341 ctacaagtgc cagctgtgcg accacgcgtg ctcgcaggcc agcaagctca agcgccacat
     2401 gaagacgcac atgcacaagg ccggctcgct ggccggccgc tccgacgacg ggctctcggc
     2461 cgccagctcc cccgagcccg gcaccagcga gctggcgggc gagggcctca aggcggccga
     2521 cggtgacttc cgccaccacg agagcgaccc gtcgctgggc cacgagccgg aggaggagga
     2581 cgaggaggag gaggaggagg aggaggagct gctactggag aacgagagcc ggcccgagtc
     2641 gagcttcagc atggactcgg agctgagccg caaccgcgag aacggcggtg gtggggtgcc
     2701 cggggtcccg ggcgcggggg gcggcgcggc caaggcgctg gctgacgaga aggcgctggt
     2761 gctgggcaag gtcatggaga acgtgggcct aggcgcactg ccgcagtacg gcgagctcct
     2821 ggccgacaag cagaagcgcg gcgccttcct gaagcgtgcg gcgggcggcg gggacgcggg
     2881 cgacgacgac gacgcgggcg gctgcgggga cgcgggcgcg ggcggcgcgg tcaacgggcg
     2941 cgggggcggc ttcgcgccag gcaccgagcc cttccccggg ctcttcccgc gcaagcccgc
     3001 gccgctgccc agccccgggc tcaacagcgc cgccaagcgc atcaaggtgg agaaggacct
     3061 ggagctgccg cccgccgcgc tcatcccgtc cgagaacgtg tactcgcagt ggctggtggg
     3121 ctacgcggcg tcgcggcact tcatgaagga ccccttcctg ggcttcacgg acgcacgaca
     3181 gtcgcccttc gccacgtcgt ccgagcactc gtccgagaac ggcagcctgc gcttctccac
     3241 gccgcccggg gacctgctgg acggcggcct ctcgggccgc agcggcacgg ccagcggagg
     3301 cagcaccccg cacctgggcg gcccgggccc cgggcggccc agctccaagg agggccgccg
     3361 cagcgacacg tgcgagtact gcggcaaggt gttcaagaac tgcagcaact tgacggtgca
     3421 ccggcggagc cacaccggcg agcggcctta caagtgcgag ctgtgcaact acgcgtgcgc
     3481 gcagagcagc aagctcacgc gccacatgaa gacgcacggg cagatcggca aggaggtgta
     3541 ccgctgcgac atctgccaga tgcccttcag cgtctacagc accctggaga aacacatgaa
     3601 aaagtggcac ggcgagcact tgctgactaa cgacgtcaaa atcgagcagg ccgagaggag
     3661 ctaagcgcgc gggccccggc gccccgcacc tgtacagtgg aaccgttgcc aaccgagaga
     3721 atgctgacct gacttgcctc cgtgtcaccg ccaccccgca ccccgcgtgt ccccggggcc
     3781 caggggaggc ggcactccaa cctaacctgt gtctgcgaag tcctatggaa acccgagggt
     3841 tgattaaggc agtacaaatt gtggagcctt ttaactgtgc aataatttct gtatttattg
     3901 ggttttgtaa tttttttggc atgtgcaggt actttttatt attatttttt ctgtttgaat
     3961 tcctttaaga gattttgttg ggtatccatc ccttctttgt ttttttttta acccggtagt
     4021 agcctgagca atgactcgca agcaatgtta gaggggaagc atatctttta aattataatt
     4081 tggggggagg ggtggtgctg cttttttgaa atttaagcta agcatgtgta atttcttgtg
     4141 aagaagccaa cactcaaatg acttttaaag ttgtttactt tttcattcct tccttttttt
     4201 tgtcctgaaa taaaaagtgg catgcagttt tttttttaat tattttttaa tttttttttt
     4261 ggtttttgtt tttggggtgg ggggtgtgga tgtacagcgg ataacaatct ttcaagtcgt
     4321 agcactttgt ttcagaactg gaatggagat gtagcactca tgtcgtcccg agtcaagcgg
     4381 ccttttctgt gttgatttcg gctttcatat tacataaggg aaaccttgag tggtggtgct
     4441 gggggaggca ccccacagac tcagcgccgc cagagatagg gtttttggag ggctcctctg
     4501 ggaaatggcc cgacagcatt ctgaggttgt gcatgaccag cagatactat cctgttggtg
     4561 tgccctgggg tgccatggct gctattcgct gtagattagg ctacataaaa tgggctgagg
     4621 gtaccttttt ggggagatgg ggtggcctgc agtgacacag aaaggaagaa actagcggtg
     4681 ttcttttagg cgttttctgg cttgacggct tctctctttt tttaaatcac ccccaccaca
     4741 taaatctcaa atcctatgtt gctacaaggg gtcatccatc atttcccaag cagacgaatg
     4801 ccctaattaa ttgaagttag tgttctctca tttaatgcac actgatgata ttgtagggat
     4861 gggtggggtg gggatcttgc aaatttctat tctcttttac tgaaaaagca ggggatgagt
     4921 tccatcagaa ggtgcccagc gctacttccc aggtttttat tttttttttc ctatctcatt
     4981 aggttggaag gtactaaata ttgaactgtt aagattagac atttgaattc tgttgacccg
     5041 cactttaaag cttttgtttg catttaaatt aaatggcttc taaacaagaa attgcagcat
     5101 attcttctct ttggcccaga ggtgggttaa actgtaaggg acagctgaga ttgagtgtca
     5161 gtattgctaa gcgtggcatt cacaatactg gcactataaa gaacaaaata aaataataat
     5221 ttataggaca gtttttctac tgccattcaa tttgatgtga gtgccttgaa aactgatctt
     5281 cctatttgag tctcttgaga caaatgcaaa actttttttt tgaaatgaaa agacttttta
     5341 aaaaagtaaa acaagaaaag tacattcttt agaaactaac aaagccacat ttactttaag
     5401 taaaaaaaaa aaaaattctg gttgaagata gaggatatga aatgccataa gacccaatca
     5461 aatgaagaaa taaacccagc acaaccttgg acatccatta gctgaattat cctcagcccc
     5521 ttttgttttt gggacaacgc tgcttagata tggagtggag gtgatttact gctgaattaa
     5581 aactcaagtg acacaagtta caagttgata tcgttgaatg aaaagcaaaa caaaaacaat
     5641 tcaggaacaa cggctaattt tttctaaagt taaatttagt gcactctgtc ttaaaaatac
     5701 gtttacagta ttgggtacat acaagggtaa aaaaaaaatt gtgtgtatgt gtgttggagc
     5761 gatctttttt tttcaaagtt tgcttaatag gttatacaaa aatgccacag tggccgcgtg
     5821 tatattgttt tcttttggtg acggggtttt agtatatatt atatatatta aaatttcttg
     5881 attactgtaa aagtggacca gtatttgtaa taatcgagaa tgcctgggca ttttacaaaa
     5941 caagaaaaaa aatacccttt tcttttcctt gaaaatgttg cagtaaaatt taaatggtgg
     6001 gtctataaat ttgttcttgt tacagtaact gtaaagtcgg agttttagta aatttttttc
     6061 tgccttgggt gttgaatttt tatttcaaaa aaaatgtata gaaacttgta tttggggatt
     6121 caaaggggat tgctacacca tgtagaaaaa gtatgtagaa aaaaagtgct taatattgtt
     6181 attgctttgc agaaaaaaaa aaaatcacat ttctgacctg tacttatttt tctcttcccg
     6241 cctccctctg gaatggatat attggttggt tcatatgatg taggcacttg ctgtattttt
     6301 actggagctc gtaatttttt aactgtaagc ttgtcctttt aaagggattt aatgtacctt
     6361 tttgttagtg aatttggaaa taaaaagaaa aaaaaaacaa aaacaaacag gctgccataa
     6421 tatatttttt taatttggca ggataaaata ttgcaaaaaa aacacatttg tatgttaagt
     6481 cctattgtac aggagaaaaa gggttgtttg acaacctttg agaaaaagaa acaaaaggaa
     6541 gtagttaaat gctttggttc acaaatcatt tagttgtata tattttttgt cggaattggc
     6601 ctacacagag aaccgttcgt gttgggcttc tctctgaacg ccccgaacct tgcatcaagg
     6661 ctccttggtg tggccacagc agaccagatg ggaaattatt tgtgttgagt ggaaaaaaat
     6721 cagtttttgt aaagatgtca gtaacattcc acatcgtcct ccctttctct aagaggccat
     6781 ctctaagatg tcagatgtag aggagagaga gcgagagaac atcttccttc tctaccatca
     6841 ctcctgtggc ggtcaccacc accacctctc ccgcccttac cagcagaaag caatgcaaac
     6901 tgagctgctt tagtccttga gaaattgtga aacaaacaca aatatcataa aaggagctgg
     6961 tgattcagct gggtccaggt gaagtgacct gctgttgaga ccggtacaaa ttggatttca
     7021 ggaaggagac tccatcacag ccaggacctt tcgtgccatg gagagtgttg gcctcttgtc
     7081 tttcttccct gctttgctgc tttgctctct gaaacctaca ttccgtcagt ttccgaatgc
     7141 gagggcctgg gatgaatttg gtgcctttcc atatctcgtt ctctctcctt cccctgcgtt
     7201 tcctctccat ccttcatcct ccattggtcc tttttttttc tttcattttt tatttaattt
     7261 cttttcttcc tgtctgttcc tcccctaatc ctctatttta tttttatttt ttgtaaagcc
     7321 aagtagcttt aagataaagt ggtggtcttt tggatgaggg aataatgcat ttttaaataa
     7381 aataccaata tcaggaagcc attttttatt tcaggaaatg taagaaacca ttatttcagg
     7441 ttatgaaagt ataaccaagc atccttttgg gcaattcctt accaaatgca gaagcttttc
     7501 tgttcgatgc actctttcct ccttgccact tacctttgca aagttaaaaa aaagggggga
     7561 gggaatggga gagaaagctg agatttcagt ttcctactgc agtttcctac ctgcagatcc
     7621 aggggctgct gttgcctttg gatgccccac tgaggtccta gagtgcctcc agggtggtct
     7681 tcctgtagtc ataacagcta gccagtgctc accagcttac cagattgcca ggactaagcc
     7741 atcccaaagc acaagcattg tgtgtctctg tgactgcaga gaagagagaa ttttgcttct
     7801 gttttgtgtt taaaaaacca acacggaagc agatgatccc gagagagagg cctctagcat
     7861 gggtgaccca gccgacctca ggccggtttc cgcactgcca caactttgtt caaagttgcc
     7921 cccaattgga acctgccact tggcattaga gggtctttca tggggagaga aggagactga
     7981 attactctaa gcaaaatgtg aaaagtaagg aaatcagcct ttcatcccgg tcctaagtaa
     8041 ccgtcagccg aaggtctcgt ggaacacagg caaacccgtg attttggtgc tccttgtaac
     8101 tcagccctgc aaagcaaagt cccattgatt taagttgttt gcatttgtac tggcaaggca
     8161 aaatattttt attacctttt ctattactta ttgtatgagc ttttgttgtt tacttggagg
     8221 ttttgtcttt tactacaagt ttggaactat ttattattgc ttggtatttg tgctctgttt
     8281 aagaaacagg cacttttttt tattatggat aaaatgttga gatgacagga ggtcatttca
     8341 atatggctta gtaaaatatt tattgttcct ttattctctg tacaagattt tgggcctctt
     8401 tttttcctta atgtcacaat gttgagttca gcatgtgtct gccatttcat ttgtacgctt
     8461 gttcaaaacc aagtttgttc tggtttcaag ttataaaaat aaattggaca tttaacttga
     8521 tctccaaa
//
