LOCUS       NP_005495                386 aa            linear   PRI 27-APR-2025
DEFINITION  branched-chain-amino-acid aminotransferase, cytosolic isoform 1
            [Homo sapiens].
ACCESSION   NP_005495
VERSION     NP_005495.2
DBSOURCE    REFSEQ: accession NM_005504.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 386)
  AUTHORS   Kang,Y.J., Song,W., Lee,S.J., Choi,S.A., Chae,S., Yoon,B.R.,
            Kim,H.Y., Lee,J.H., Kim,C., Cho,J.Y., Kim,H.J. and Lee,W.W.
  TITLE     Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates
            Th17 responses via the mTORC1-HIF1alpha pathway
  JOURNAL   Exp Mol Med 56 (8), 1776-1790 (2024)
   PUBMED   39085353
  REMARK    GeneRIF: Inhibition of BCAT1-mediated cytosolic leucine metabolism
            regulates Th17 responses via the mTORC1-HIF1alpha pathway.
REFERENCE   2  (residues 1 to 386)
  AUTHORS   Wang,W., Li,Y., Tang,L., Shi,Y., Li,W., Zou,L., Zhang,L., Cheng,Y.,
            Yuan,Z., Zhu,F. and Duan,Q.
  TITLE     Cross-talk between BCKDK-mediated phosphorylation and
            STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM
            progression
  JOURNAL   Cancer Lett 591, 216849 (2024)
   PUBMED   38621458
  REMARK    GeneRIF: Cross-talk between BCKDK-mediated phosphorylation and
            STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM
            progression.
REFERENCE   3  (residues 1 to 386)
  AUTHORS   Pan,J., Wang,Y., Huang,S., Mao,S., Ling,Q., Li,C., Li,F., Yu,M.,
            Huang,X., Huang,J., Lv,Y., Li,X., Ye,W., Wang,H., Wang,J. and
            Jin,J.
  TITLE     High expression of BCAT1 sensitizes AML cells to PARP inhibitor by
            suppressing DNA damage response
  JOURNAL   J Mol Med (Berl) 102 (3), 415-433 (2024)
   PUBMED   38340163
  REMARK    GeneRIF: High expression of BCAT1 sensitizes AML cells to PARP
            inhibitor by suppressing DNA damage response.
REFERENCE   4  (residues 1 to 386)
  AUTHORS   You,H., Song,G., Xu,Z., Chen,S., Shen,W., Liu,H., Deng,B., Li,J.
            and Huang,G.
  TITLE     HuR promotes castration-resistant prostate cancer progression by
            altering ERK5 activation via posttranscriptional regulation of
            BCAT1
  JOURNAL   J Transl Med 22 (1), 178 (2024)
   PUBMED   38369471
  REMARK    GeneRIF: HuR promotes castration-resistant prostate cancer
            progression by altering ERK5 activation via posttranscriptional
            regulation of BCAT1.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 386)
  AUTHORS   Zheng,J., Liu,Y., Wang,J., Shi,J., Li,L., Jiang,X. and Tao,L.
  TITLE     Integrated single-cell and bulk characterization of branched chain
            amino acid metabolism-related key gene BCAT1 and association with
            prognosis and immunogenicity of clear cell renal cell carcinoma
  JOURNAL   Aging (Albany NY) 16 (3), 2715-2735 (2024)
   PUBMED   38309289
  REMARK    GeneRIF: Integrated single-cell and bulk characterization of
            branched chain amino acid metabolism-related key gene BCAT1 and
            association with prognosis and immunogenicity of clear cell renal
            cell carcinoma.
REFERENCE   6  (residues 1 to 386)
  AUTHORS   Eden,A. and Benvenisty,N.
  TITLE     Involvement of branched-chain amino acid aminotransferase
            (Bcat1/Eca39) in apoptosis
  JOURNAL   FEBS Lett 457 (2), 255-261 (1999)
   PUBMED   10471790
REFERENCE   7  (residues 1 to 386)
  AUTHORS   Ben-Yosef,T., Eden,A. and Benvenisty,N.
  TITLE     Characterization of murine BCAT genes: Bcat1, a c-Myc target, and
            its homolog, Bcat2
  JOURNAL   Mamm Genome 9 (7), 595-597 (1998)
   PUBMED   9657861
REFERENCE   8  (residues 1 to 386)
  AUTHORS   Bledsoe,R.K., Dawson,P.A. and Hutson,S.M.
  TITLE     Cloning of the rat and human mitochondrial branched chain
            aminotransferases (BCATm)
  JOURNAL   Biochim Biophys Acta 1339 (1), 9-13 (1997)
   PUBMED   9165094
REFERENCE   9  (residues 1 to 386)
  AUTHORS   Schuldiner,O., Eden,A., Ben-Yosef,T., Yanuka,O., Simchen,G. and
            Benvenisty,N.
  TITLE     ECA39, a conserved gene regulated by c-Myc in mice, is involved in
            G1/S cell cycle regulation in yeast
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7143-7148 (1996)
   PUBMED   8692959
REFERENCE   10 (residues 1 to 386)
  AUTHORS   Naylor,S.L. and Shows,T.B.
  TITLE     Branched-chain aminotransferase deficiency in Chinese hamster cells
            complemented by two independent genes on human chromosomes 12 and
            19
  JOURNAL   Somatic Cell Genet 6 (5), 641-652 (1980)
   PUBMED   6933702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056255.1, BX474651.1,
            AC023796.22 and BU618839.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 5, 2003 this sequence version replaced NP_005495.1.
            
            Summary: This gene encodes the cytosolic form of the enzyme
            branched-chain amino acid transaminase. This enzyme catalyzes the
            reversible transamination of branched-chain alpha-keto acids to
            branched-chain L-amino acids essential for cell growth. Two
            different clinical disorders have been attributed to a defect of
            branched-chain amino acid transamination: hypervalinemia and
            hyperleucine-isoleucinemia. As there is also a gene encoding a
            mitochondrial form of this enzyme, mutations in either gene may
            contribute to these disorders. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647122.1, SRR1660809.157590.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261192.12/ ENSP00000261192.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     Protein         1..386
                     /product="branched-chain-amino-acid aminotransferase,
                     cytosolic isoform 1"
                     /EC_number="2.6.1.42"
                     /note="branched chain aminotransferase 1, cytosolic;
                     placental protein 18; branched chain amino-acid
                     transaminase 1, cytosolic"
                     /calculated_mol_wt=42835
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (P54687.3)"
     Region          32..378
                     /region_name="PRK13357"
                     /note="branched-chain amino acid aminotransferase;
                     Provisional"
                     /db_xref="CDD:237363"
     CDS             1..386
                     /gene="BCAT1"
                     /gene_synonym="BCATC; BCT1; ECA39; MECA39; PNAS121; PP18"
                     /coded_by="NM_005504.7:170..1330"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS44845.1"
                     /db_xref="GeneID:586"
                     /db_xref="HGNC:HGNC:976"
                     /db_xref="MIM:113520"
ORIGIN      
        1 mkdcsngcsa ectgeggske vvgtfkakdl ivtpatilke kpdpnnlvfg tvftdhmltv
       61 ewssefgwek phikplqnls lhpgssalhy avelfeglka frgvdnkirl fqpnlnmdrm
      121 yrsavratlp vfdkeellec iqqlvkldqe wvpystsasl yirptfigte pslgvkkptk
      181 allfvllspv gpyfssgtfn pvslwanpky vrawkggtgd ckmggnygss lfaqceavdn
      241 gcqqvlwlyg edhqitevgt mnlflywine dgeeelatpp ldgiilpgvt rrcildlahq
      301 wgefkvsery ltmddlttal egnrvremfg sgtacvvcpv sdilykgeti hiptmengpk
      361 lasrilsklt diqygreesd wtivls
//
