LOCUS       NM_198799               1114 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens breast carcinoma amplified sequence 4 (BCAS4),
            transcript variant 2, mRNA.
ACCESSION   NM_198799
VERSION     NM_198799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Barlund,M., Monni,O., Weaver,J.D., Kauraniemi,P., Sauter,G.,
            Heiskanen,M., Kallioniemi,O.P. and Kallioniemi,A.
  TITLE     Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo
            amplification, overexpression, and fusion in breast cancer
  JOURNAL   Genes Chromosomes Cancer 35 (4), 311-317 (2002)
   PUBMED   12378525
  REMARK    GeneRIF: BCAS3 (17q23) and BCAS4 (20q13) undergo amplification,
            overexpression, and fusion in breast cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031680.20 and AL133228.18.
            
            On May 18, 2020 this sequence version replaced NM_198799.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038381.1, ERR4643859.10210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371608.8/ ENSP00000360669.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL031680.20        77023-77135
            114-185             AL031680.20        100173-100244
            186-287             AL031680.20        112241-112342
            288-422             AL133228.18        6397-6531
            423-1114            AL133228.18        41117-41808
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..1114
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /note="breast carcinoma amplified sequence 4"
                     /db_xref="GeneID:55653"
                     /db_xref="HGNC:HGNC:14367"
                     /db_xref="MIM:607471"
     exon            1..113
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..545
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /note="isoform b is encoded by transcript variant 2;
                     BCAS4/BCAS3 fusion; breast carcinoma amplified sequence
                     4/3 fusion protein"
                     /codon_start=1
                     /product="breast carcinoma-amplified sequence 4 isoform b"
                     /protein_id="NP_942094.3"
                     /db_xref="CCDS:CCDS13432.3"
                     /db_xref="GeneID:55653"
                     /db_xref="HGNC:HGNC:14367"
                     /db_xref="MIM:607471"
                     /translation="MLLVDADQPEPMRSGARELALFLTPEPGAEAKEVEETIEGMLLR
                     LEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGIYAKVDRLEAFVKMVGHHVAFLE
                     ADVLQAERDHGAFPQALRRWLGSAGLPSFRNKSPAPVPVTYELPTLYRTEDYFPVDAG
                     EAQHHPRTCPRPL"
     exon            114..185
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /inference="alignment:Splign:2.1.0"
     exon            186..287
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /inference="alignment:Splign:2.1.0"
     exon            288..422
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /inference="alignment:Splign:2.1.0"
     exon            423..1114
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /note="hexamer: AATAAA"
     polyA_site      1114
                     /gene="BCAS4"
                     /gene_synonym="CNOL"
                     /note="major polyA site"
ORIGIN      
        1 agccggaccc cgtcgccctc ctgatgctgc tcgtggacgc tgatcagccg gagcccatgc
       61 gcagcggggc gcgcgagctc gcgctcttcc tgacccccga gcctggggcc gaggcgaagg
      121 aggtggagga gaccatcgag ggcatgctcc tcaggctgga agagttttgc agcctggctg
      181 acctgatcag gagtgatact tcacagatcc tggaggaaaa catcccagtc cttaaggcca
      241 aactgacaga aatgcgtggc atctatgcca aagtggaccg gctagaggcc ttcgtcaaga
      301 tggttggaca ccacgtcgcc ttcctggaag cagacgtgct tcaggctgag cgggaccatg
      361 gggccttccc tcaggccctg cggaggtggc tgggatccgc agggctcccc tccttcagga
      421 acaagtcacc tgcaccggtg cccgtgacgt acgagctgcc cacactgtat aggacggagg
      481 actattttcc tgtggacgcc ggggaagcac agcaccaccc ccgcacctgc cctcggcctt
      541 tgtgagcttt gtggtcttcc catcaggaac gctggaaagt gacattgtgt acacactgca
      601 gcttgggggt tttttctttg tattgctgtt tattttatat tttaaaaata tttaaaaaaa
      661 tgtcgagatg gggtctcact atgttgtcca gactgatctc aaactcctgg gctcaagtga
      721 tccacccacc ttggccttcc aaagtggtgg gattatgggc aggagcctcc gtgcccaggc
      781 tgctgccatt ttcaaatttc ctccctgcct catgtgagac cacagggttt ggagaagcag
      841 ttggaaccca cgtgtggtga tgcctcccac atcggcctgc ttggggttct acaggggttg
      901 agggaccagg cctggccggg gctgatggac agtggggact ttccttctct ccatgatggc
      961 tttgcagggg ctccatggtc cttctctctg tgatgggttt ttgcacgggg tgtgctctgc
     1021 cactgtggtg ggtgggtgga tgctgcttct gttgcctcca gacctcggtg cccacagcct
     1081 tgaggatcct tccaataaag gtgtcaagag ctca
//
